Probable aestivation burrows from the Eocene/Oligocene transition in south-eastern France and their palaeoenvironmental implications

International audienceEnigmatic biogenic structures are reported from the Palaeogene of south-eastern France in the Castellane-Blieux area (Alpes de Haute-Provence French Department). They occur at the Eocene/Oligocene transition at the top of the Marnes Bleues Formation, which corresponds to a clearly defined regressive sequence, where thick marls are overlain by lacustrine limestones or sandstones. The marls have abundant shallow marine fauna and the upper part of the Formation corresponds to a rapid transition to non-marine deposits. The studied structures exhibit three main morphologies: vertical shafts, furrows, and tunnels. They can also form dense clusters and cross-cut marginal marine crustacean burrows such as Psilonichnus. By comparison with modern and fossil examples, these trace fossils are interpreted as probably aestivation burrows. The possible trace-makers could be lungfish (in particular for the common vertical burrows) or amphibians (for the furrows and tunnels). The occurrence of these different aestivation burrows defines the border of a basin and probably indicates increasing droughts on the coastal plain. This could reflect the well-known development of arid conditions in south-eastern France at the beginning of the Oligocene

Prevention of urinary tract infection in spinal cord-injured patients: safety and efficacy of a weekly oral cyclic antibiotic (WOCA) programme with a 2 year follow-up--an observational prospective study.

POPULATION: Spinal cord injury (SCI) patients with neurogenic bladder have an increased risk for symptomatic urinary tract infection (UTI). Recurrent UTI requires multiple courses of antibiotic therapy, markedly increasing the incidence of multidrug-resistant (MDR) bacteria. METHODS: During an observational prospective study, we determined the safety and efficacy of a weekly oral cyclic antibiotic (WOCA) regimen to prevent UTI in SCI adult patients with neurogenic bladder undergoing clean intermittent catheterization. The WOCA regimen consisted of the alternate administration of an antibiotic once per week over a period of at least 2 years. The antibiotics chosen were efficient for UTI, well tolerated and with low selection pressure. RESULTS: There was a significant decrease in antimicrobial consumption linked to the dramatic decrease in the incidence of UTI. Before intervention, there were 9.4 symptomatic UTIs per patient-year, including 197 episodes of febrile UTI responsible for 45 hospitalizations. Under the WOCA regimen there were 1.8 symptomatic UTIs per patient-year, including 19 episodes of febrile UTI. No severe adverse events and no new cases of colonization with MDR bacteria were reported. CONCLUSIONS: In this prospective, observational pilot study a novel approach to the prevention and treatment of UTI in SCI was investigated. Our study shows the benefit of WOCA in preventing UTI in SCI patients

Validation of the French Version of the Yale Food Addiction Scale: An Examination of Its Factor Structure, Reliability and Construct Validity in a Nonclinical Sample

International audienceObjective: Food addiction is a concept that has recently been proposed by applying the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, criteria for substance dependence to eating behaviour. Food addiction has received increased attention given that it may play a role in binge eating, eating disorders, and the recent increase in obesity prevalence. Currently, there is no psychometrically sound tool for assessing food addiction in French. Our study aimed to test the psychometric properties of a French version of the Yale Food Addiction Scale (YFAS) by establishing its factor structure, internal consistency, and construct validity in a nonclinical population.Method: A total of 553 participants were assessed for food addiction (French version of the YFAS) and binge eating behaviour (Bulimic Investigatory Test, Edinburgh and Binge Eating Scale). We tested the scale’s factor structure (factor analysis for dichotomous data based on tetrachoric correlation coefficients), internal consistency, and construct validity with measures of binge eating.Results: Our results supported a 1-factor structure, which accounted for 54.1% of the variance. We demonstrated that this tool had adequate reliability and highly construct validity with measures of binge eating in this population, both in its diagnosis and symptom count version. A 2-factor structure explained an additional 9.1% of the variance, and could help to differentiate between patients with high, compared with low, levels of insight regarding addiction symptoms.Conclusions: In our study, we validated a psychometrically sound French version of the YFAS, both in its symptom count and diagnosis version. Future studies should validate this tool in clinical samples

Isopod trackways from the Crayssac Lagerstätte, upper Jurassic, France

International audienceWell-preserved arthropod trackways are described from the laminated limestones of the Crayssac Lagerstätte (south-west France, Lower Tithonian). They occur in sediments deposited in the temporary coastal mudflats of intertidal to supratidal zones. The trackways are referred to Pterichnus isopodicus isp. nov., and are interpreted as the locomotion traces of isopods. Different trackway morphotypes are recognized and clearly resulted from variations in the original consistency of the sediment. Sinuous trackways may correspond to vagrant activity on wet mud whereas numerous straight ones indicate a more rapid crawling on a soft-to-firm substratum (e.g. tidal flat during emersion). The preferred orientation of trackways indicates that isopods were crawling in a direction perpendicular to shoreline as a result of possible taxis induced by sediment wetness and ⁄ or by a migratory behaviour controlled by tidal rhythm. Unusually long emergence of the sediments may have favoured the preservation of dense networks of trackways. An isopod identity is supported by the general morphology of the tracks and the association of trackways with isopod body fossils. Archaeoniscus, which occurs abundantly in Late Jurassic deposit

Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss

Purpose: To assess speech processing for listeners with simulated age-related hearing loss (ARHL) and to investigate whether the observed performance can be replicated using an Automatic Speech Recognition (ASR) system. The long-term goal of this research is to develop a system that will assist audiologists/hearing-aid dispensers in the fine-tuning of hearing aids. Method: Sixty young normal-hearing participants listened to speech materials mimicking the perceptual consequences of ARHL at different levels of severity. Two intelligibility tests (repetition of words and sentences) and one comprehension test (responding to oral commands by moving virtual objects) were administered. Several language models were developed and used by the ASR system in order to fit human performances. Results: Strong significant positive correlations were observed between human and ASR scores, with coefficients up to .99. However, the spectral smearing used to simulate losses in frequency selectivity caused larger declines in ASR performance than in human performance. Conclusion: Both intelligibility and comprehension scores for listeners with simulated ARHL are highly correlated with the performances of an ASR-based system. In the future, it needs to be determined if the ASR system is similarly successful in predicting speech processing in noise and by older people with ARHL

Mesure de la durabilité à l’échelle de l’exploitation: quel instrument dans quel but?

Trois méthodes développées en Suisse sont disponibles pour évaluer la durabilité au niveau de l’exploitation: RISE, SMART et SALCAsustain. Le présent article compare les trois méthodes à l’aide d’un catalogue de critères et de quelques exemples concrets afin d’aider le lecteur à choisir l’outil le mieux adapté à son application spécifique et à son groupe cible. Les trois méthodes couvrent toutes les dimensions de la durabilité et les résultats obtenus permettent de déduire des mesures d’amélioration et des décisions concrètes pour les groupes d’intérêt concernés. Les arguments exposés montrent que SALCAsustain convient pour répondre à des questions de recherche et analyser différentes stratégies de gestion d’exploitation. La force de RISE réside dans sa souplesse, qui permet de l’utiliser pour le conseil, l’enseignement et la comparaison d’exploitations et de groupes d’exploitations. SMART permet un examen rapide de la durabilité à l’échelle de l’exploitation et fournit des résultats qui peuvent également être comparés entre les exploitations et facilement communiqués à des tiers. Le choix de la méthode appropriée dépend donc de la problématique en jeu et du groupe cible

Messung der Nachhaltigkeit auf Betriebsebene: welches Instrument für welchen Zweck?

Für die Bewertung der Nachhaltigkeit auf der Ebene des Landwirtschaftsbetriebes liegen drei in der Schweiz entwickelte Methoden vor: RISE, SMART und SALCAsustain. Im vorliegenden Artikel werden die drei Methoden anhand eines Kriterienkatalogs und einiger konkreter Beispiele miteinander verglichen, mit dem Ziel, dem Leser, der Leserin die Entscheidung zu erleichtern, welches Tool für die eigene spezifische Anwendung und Zielgruppe am besten geeignet ist. Alle drei Methoden decken die Nachhaltigkeit umfassend ab, und aus den Ergebnissen lassen sich für die entsprechenden Interessengruppen konkrete Verbesserungsmassnahmen und Entscheidungen ableiten. Die Ausführungen zeigen, dass sich SALCAsustain für die Beantwortung von Forschungsfragen sowie die Analyse unterschiedlicher betrieblicher Managementstrategien eignet. Die Stärke von RISE ist seine flexible Anwendbarkeit, die es ermöglicht, RISE in der Beratung, im Unterricht und zum Vergleich von Betrieben und Betriebsgruppen einzusetzen. SMART erlaubt ein rasches Screening der betrieblichen Nachhaltigkeit und liefert dabei Ergebnisse, die sich auch zwischen Betrieben vergleichen und einfach an Dritte kommunizieren lassen. Die Wahl der geeigneten Methode hängt daher von der Fragestellung und der Zielgruppe ab

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small-molecule and ATP-competitive PI(3)K inhibitors with a wide range of selectivities have entered clinical development. In order to understand the mechanisms underlying the isoform selectivity of these inhibitors, we developed a new expression strategy that enabled us to determine to our knowledge the first crystal structure of the catalytic subunit of the class IA PI(3)K p110 delta. Structures of this enzyme in complex with a broad panel of isoform- and pan-selective class I PI(3)K inhibitors reveal that selectivity toward p110 delta can be achieved by exploiting its conformational flexibility and the sequence diversity of active site residues that do not contact ATP. We have used these observations to rationalize and synthesize highly selective inhibitors for p110 delta with greatly improved potencies