Tumor-associated neutrophils: new targets for cancer therapy

Na tumorsku progresiju utječu brojni tipovi imunosnih stanica domaćina, a važna uloga neutrofila nije još potpuno jasna. Iako rana istraživanja pokazuju da neutrofili mogu ispoljavati citotoksičnost prema tumorskim stanicama preko regulacije citotoksičnih stanica T, noviji radovi pokazuju da neutrofili promoviraju progresiju tumora razaranjem matriksa i pojačanom angiogenezom potiču proliferaciju tumorskih stanica i metastaziranje. Neka istraživanja pokazuju da neutrofili mogu biti modificirani ili „polarizirani“ tako da postanu više citotoksični prema tumorskim stanicama. Međutim, visoko aktivni neutrofili mogu predstavljati opasnost i za tkivo domaćina. Stoga novi pristup u terapiji temelji se na inhibiranju novačenja neutrofila ili neutrofil-izlučenih tvari za koje se zna da potiču rast tumora. Smatra se da je takav pristup učinkovitiji i bez opasnosti za domaćina.Tumor progression is modified with a wide range of immune cell types and important role of neutrophils is yet to be characterised. Although earlier studies indicated that neutrophils can express cytotoxicity towards tumor cells with their regulation of cytotoxic Tcells, recent studies have shown that neutrophils promote tumor progression via matrix degradation, and increased angiogenesis which enhances proliferation of tumor cells and metastasis. Some experiments have shown that neutrophils can be modified or polarised to become more cytotoxic towards tumor cells. However, highly activated neutrophils can also pose danger to host tissue. Therefore a new approach in therapy is based on inhibiting neutrophil recruitment or neutrophil-secreted substances which are known to promote tumor growth. It is considered that such approach is more effective and without danger for the host

The significance of the tourist destination of Zlatibor spatial planning

The territory of Zlatibor is known as a region of exquisite beauty, rich in natural and anthropogenic values, and as such it is a significant tourist destination. The tourism on Zlatibor started developing a long time ago, however, recently there has formed a type of settlement with tourism as its basic function, with no adequate planned development and control, which deviates from the natural and aesthetic environment, disturbing the rare and autochthonous quality of the territory. Zlatibor’s beauty has been disturbed with unplanned construction and the development of tourism which is not sustainable in the long-term. The aim of this paper is to point out to the significance of spatial planning for further development of tourism on this mountain and give suggestions on further development which would neutralise, revitalise and improve the already degraded territory. Only by managing the territory of Zlatibor properly, as a resource for tourism, will its economic, ecologic and aesthetic value increase, which will ensure a long term benefit on a local, regional and national level. [Projekat Ministarstva nauke Republike Srbije, br. 47007

Development potential of rural tourism (the case of "Tešnjarske vešeri" festival)

Rural tourism is a very broad concept which includes not only holidays in the countryside a range of other tourist activities in rural areas, such as traditional festivals. Tourist festivals are devoted to different local products which are famous in rural parts of Serbia. Some of the most popular Serbian festivals are the Grape Festivals in Sremski Karlovci, Erdevik, Banoštor, Irig, Erdevik, Vršac, Župa, Palić, Aleksandrovac, Hajdukovo, Smederevo, Topola; Plum Days in Osečina and Koštunići; Cabbage Days in Futog, Barbeque in Leskovac; BaconDdays in Kačarevo; Ham Days in Mačkat; Golden Pot of Danube in Petrovaradin, Apatin; Mushroom Days in Fruška gora, Valjevo and Divčibare, Medical Herbs Days in Soko Banja; Bee Days in Zaječar. This paper deals with the development potential of rural areas associated with these festivals by analyzing the case of “Tešnjarske večeri”. This festival provides a diverse cultural and ethnographic entertaining program, combining visual and performing arts, and celebrates the vibrant life of the local community

Lipid composition of liver in rats fed diets supplemented with egg yolks of modified composition

The aim of this study was to examine the effects of diets supplemented with egg yolks of modified composition on the fatty-acid composition and lipid content in rat’s liver. During four weeks of the experiment 64 Wistar rats were divided into four groups of 16 individuals each (eight individuals of both sexes) and fed a commercial feed mixture for rats (group C) or diet containing 70% commercial mixture for rats and 30% freshly cooked egg yolks from laying hens fed diets with 3% fish oil (group F), 3% palm olein (group P) or 3% lard (group L). Dietary supplementation with egg yolks significantly increased the hepatic cholesterol pool in rats, regardless of the type of fat in the diet of laying hens from which the eggs originated. The content of α-linolenic acid in the liver of male rats in group P was 4-6 times higher compared to males in the other groups. Liver lipids and their fatty-acid composition differ by both, sex and dietary modified egg yolk composition in rats

Tumor-associated neutrophils: new targets for cancer therapy

Na tumorsku progresiju utječu brojni tipovi imunosnih stanica domaćina, a važna uloga neutrofila nije još potpuno jasna. Iako rana istraživanja pokazuju da neutrofili mogu ispoljavati citotoksičnost prema tumorskim stanicama preko regulacije citotoksičnih stanica T, noviji radovi pokazuju da neutrofili promoviraju progresiju tumora razaranjem matriksa i pojačanom angiogenezom potiču proliferaciju tumorskih stanica i metastaziranje. Neka istraživanja pokazuju da neutrofili mogu biti modificirani ili „polarizirani“ tako da postanu više citotoksični prema tumorskim stanicama. Međutim, visoko aktivni neutrofili mogu predstavljati opasnost i za tkivo domaćina. Stoga novi pristup u terapiji temelji se na inhibiranju novačenja neutrofila ili neutrofil-izlučenih tvari za koje se zna da potiču rast tumora. Smatra se da je takav pristup učinkovitiji i bez opasnosti za domaćina.Tumor progression is modified with a wide range of immune cell types and important role of neutrophils is yet to be characterised. Although earlier studies indicated that neutrophils can express cytotoxicity towards tumor cells with their regulation of cytotoxic Tcells, recent studies have shown that neutrophils promote tumor progression via matrix degradation, and increased angiogenesis which enhances proliferation of tumor cells and metastasis. Some experiments have shown that neutrophils can be modified or polarised to become more cytotoxic towards tumor cells. However, highly activated neutrophils can also pose danger to host tissue. Therefore a new approach in therapy is based on inhibiting neutrophil recruitment or neutrophil-secreted substances which are known to promote tumor growth. It is considered that such approach is more effective and without danger for the host

Tumor-associated neutrophils: new targets for cancer therapy

Na tumorsku progresiju utječu brojni tipovi imunosnih stanica domaćina, a važna uloga neutrofila nije još potpuno jasna. Iako rana istraživanja pokazuju da neutrofili mogu ispoljavati citotoksičnost prema tumorskim stanicama preko regulacije citotoksičnih stanica T, noviji radovi pokazuju da neutrofili promoviraju progresiju tumora razaranjem matriksa i pojačanom angiogenezom potiču proliferaciju tumorskih stanica i metastaziranje. Neka istraživanja pokazuju da neutrofili mogu biti modificirani ili „polarizirani“ tako da postanu više citotoksični prema tumorskim stanicama. Međutim, visoko aktivni neutrofili mogu predstavljati opasnost i za tkivo domaćina. Stoga novi pristup u terapiji temelji se na inhibiranju novačenja neutrofila ili neutrofil-izlučenih tvari za koje se zna da potiču rast tumora. Smatra se da je takav pristup učinkovitiji i bez opasnosti za domaćina.Tumor progression is modified with a wide range of immune cell types and important role of neutrophils is yet to be characterised. Although earlier studies indicated that neutrophils can express cytotoxicity towards tumor cells with their regulation of cytotoxic Tcells, recent studies have shown that neutrophils promote tumor progression via matrix degradation, and increased angiogenesis which enhances proliferation of tumor cells and metastasis. Some experiments have shown that neutrophils can be modified or polarised to become more cytotoxic towards tumor cells. However, highly activated neutrophils can also pose danger to host tissue. Therefore a new approach in therapy is based on inhibiting neutrophil recruitment or neutrophil-secreted substances which are known to promote tumor growth. It is considered that such approach is more effective and without danger for the host

Islamic reality of Yemen - cultural, religious and political aspect

Докторска дисертација под насловом „Исламска стварност Јемена – Културни, религијски и политички аспект“ замишљена је као свеобухватна студија јеменске културе и друштва. Идеја аутора је била да се уради мултидисциплинарна студија која би служила као основа за даља, усмеренија, истраживања. У свом најширем смислу, предмет истраживања су јеменска култура и друштво, са фокусом на њихову разнолику и фрагментирану природу. Овај културни и друшвени диверзитет Јужних Арабљана рефлектује се на различтим пољима. Први јасан знак да се ради о хетерогеном друштву јесте то што богата историја Јемена не бележи постојање стабилне јединствене државе. И када је религија у питању, позната је чињеница да у Јемену коегзистирају две различите школе исламског верског права, шафиитска и зајдитска, при чему je прва верско-правна школа сунитског ислама, док је друга огранак шиитског ислама и присутна је у значајнијем облику само у том делу света. Такође, једна од кључних особина јеменског друштва је његова трибалистичка природа, која има снажан утицај на друштвени и политички живот, што може бити нарочито проблематично у ситуацији када став у земљи поводом учешћа племена у политичком животу није јединствен, а то је случај у Јемену. У складу са наведеним конципирана је и ова студија, у којој аутор настоји да анализира и прикаже главне карактеристике јеменске културе и друштва, али и да кроз ту анализу објасни крхку позицију Јемена као јединствене државеThe PhD thesis titled “Islamic Reality of Yemen – Cultural, Religious and Political Aspect” was conceived as a broad study of Yemeni culture and society. The idea was to write a multidisciplinary study that would serve as a basis for further, more focused, research. In its broadest sense, the subject of research is Yemeni culture and society with focus on their diverse and fragmented nature. This cultural and social diversity of the South Arabians is reflected through various aspects. In its rich history Yemen has never been a home to a stable unified state which is the first clear sign that we are dealing with heterogeneous society. When religion is concerned, it is a known fact that in Yemen coexist two different schools of Islamic jurisprudence, Shafi‘i and Zaydi, with the former being a Sunni maḏhab and the latter a Shia branch which is significantly present only in that part of the World. Also, one of the key features of Yemeni society is its tribal nature, which makes a strong impact on social and political life in Yemen. This could be highly problematic in a situation when in one country there is no consensus about the role of the tribe in political life, and this is the case in Yemen. This study is conceived in accordance with the abovementioned facts. The goal of the author is to analyse and present the main characteristics of Yemeni culture and society and also to use this analysis in order to explain the fragile position of Yemen as a unified state

The Analysis of off Street Parking and Parking Garages

Završnim radom je analizirana funkcija parkiranja u gradovima, provedena je općenita analiza funkcije izvanuličnih parkirališta i objekata za parkiranje s osvrtom na Grad Zagreb. Na temelju analize stanja izvanuličnih parkirališta i garaža u Gradu Zagrebu ističu se prijedlozi unaprjeđenja kvalitete usluge u odnosu na postojeće stanje kako bi se parkirališna ponuda približila višim standardima Europskih gradova. Istaknut je zasad neiskorišten potencijal povezivanja sustava javnog gradskog prijevoza i izvanulične parkirališne ponude u Park & Ride sustav. Prema dobrim primjerima nekih Europskih gradova potrebno je posvetiti se unaprjeđenju Park & Ride sustava. Navedenim unaprjeđenjima, moguće je promijeniti politiku parkiranja te samim time prometnu politiku Grada Zagreba čime bi se ostvario optimalni prometni sustav.This final study has analyzed the role of city parking in general. The study covers the analysis of off street parking and parking garages in cities with retrospect of Zagreb. Considering the data that has been gathered and regarding the state of the parking infrastructure in the city of Zagreb, multiple quality improvements have been observed in which the most noted one is the Park & Ride system. The above mentioned: Park & Ride system shows plenty of potential and consists of connecting the public transportation system and off-street parking. Considering the success of other European cities with the Park & Ride system promising improvements have been noted in the quality of service. By promoting the before mentioned system a change in parking and traffic policy could be made, which would result in optimizing the traffic system in the city of Zagreb

The Czechs in Belgrade and their social structure in years 1918-1941

Tato bakalářská práce se zabývá českou menšinou v meziválečném Bělehradě. Cílem práce bylo vytvořit jednotný a ucelený obraz života této minority. Ač zde byla primárně zkoumána jen určitá skupina příslušníků české menšiny, lze z tohoto zkoumání odvodit její celkový stav. Důležitým prvkem byla schopnost integrace a velká míra asimilace zdejších Čechů. Hlavním zdrojem při zpracování této problematiky byly výroční zprávy Československé obce v Bělehradě a další dosud nevydané prameny.This thesis deals with a Czech minority in interwar Belgrade. The aim was to examine and provide a comprehensive description of the life inside this community where important factors were an ability to integrate and a large degree of assimilation. Although the focus of my study is limited to a particular group of the Czech minority, a general view of the situation can be implied. The main sources of my work were annual reports of the Czechoslovakian village in Belgrade and other unpublished sources.Department of South Slavonic and Balkan StudiesKatedra jihoslovanských a balkanistických studiíFilozofická fakultaFaculty of Art

HARMONIZIRANOST POREZA NA DODANU VRIJEDNOST U RH SA ZAHTJEVIMA EU : završni rad

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