112 research outputs found
Precision measurement of Compton scattering in silicon with a skipper CCD for dark matter detection
Experiments aiming to directly detect dark matter through particle recoils can achieve energy thresholds of O(10 eV). In this regime, ionization signals from small-angle Compton scatters of environmental γ rays constitute a significant background. Monte Carlo simulations used to build background models have not been experimentally validated at these low energies. We report a precision measurement of Compton scattering on silicon atomic shell electrons down to 23 eV. A skipper charge-coupled device with single-electron resolution, developed for the DAMIC-M experiment, was exposed to a 241Am γ-ray source over several months. Features associated with the silicon K-, L1-, and L2,3-shells are clearly identified, and scattering on valence electrons is detected for the first time below 100 eV. We find that the relativistic impulse approximation for Compton scattering, which is implemented in Monte Carlo simulations commonly used by direct detection experiments, does not reproduce the measured spectrum below 0.5 keV. The data are in better agreement with ab initio calculations originally developed for x-ray absorption spectroscopy
The Optical System for the Large Size Telescope of the Cherenkov Telescope Array
The Large Size Telescope (LST) of the Cherenkov Telescope Array (CTA) is
designed to achieve a threshold energy of 20 GeV. The LST optics is composed of
one parabolic primary mirror 23 m in diameter and 28 m focal length. The
reflector dish is segmented in 198 hexagonal, 1.51 m flat to flat mirrors. The
total effective reflective area, taking into account the shadow of the
mechanical structure, is about 368 m. The mirrors have a sandwich structure
consisting of a glass sheet of 2.7 mm thickness, aluminum honeycomb of 60 mm
thickness, and another glass sheet on the rear, and have a total weight about
47 kg. The mirror surface is produced using a sputtering deposition technique
to apply a 5-layer coating, and the mirrors reach a reflectivity of 94%
at peak. The mirror facets are actively aligned during operations by an active
mirror control system, using actuators, CMOS cameras and a reference laser.
Each mirror facet carries a CMOS camera, which measures the position of the
light spot of the optical axis reference laser on the target of the telescope
camera. The two actuators and the universal joint of each mirror facet are
respectively fixed to three neighboring joints of the dish space frame, via
specially designed interface plate.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
First Constraints from DAMIC-M on Sub-GeV Dark-Matter Particles Interacting with Electrons
We report constraints on sub-GeV dark matter particles interacting with electrons from the first underground operation of DAMIC-M detectors. The search is performed with an integrated exposure of 85.23 g days, and exploits the subelectron charge resolution and low level of dark current of DAMIC-M charge-coupled devices (CCDs). Dark-matter-induced ionization signals above the detector dark current are searched for in CCD pixels with charge up to 7e−. With this dataset we place limits on dark matter particles of mass between 0.53 and 1000 MeV/c2, excluding unexplored regions of parameter space in the mass ranges [1.6,1000] MeV/c2 and [1.5,15.1] MeV/c2 for ultralight and heavy mediator interactions, respectively
The Cherenkov Telescope Array Large Size Telescope
The two arrays of the Very High Energy gamma-ray observatory Cherenkov
Telescope Array (CTA) will include four Large Size Telescopes (LSTs) each with
a 23 m diameter dish and 28 m focal distance. These telescopes will enable CTA
to achieve a low-energy threshold of 20 GeV, which is critical for important
studies in astrophysics, astroparticle physics and cosmology. This work
presents the key specifications and performance of the current LST design in
the light of the CTA scientific objectives.Comment: 4 pages, 5 figures, In Proceedings of the 33rd International Cosmic
Ray Conference (ICRC2013), Rio de Janeiro (Brazil). All CTA contributions at
arXiv:1307.223
The DAMIC-M experiment: Status and first results
The DAMIC-M (DArk Matter In CCDs at Modane) experiment employs thick, fully depleted silicon charged-coupled devices (CCDs) to search for dark matter particles with a target exposure of 1 kg-year. A novel skipper readout implemented in the CCDs provides single electron resolution through multiple non-destructive measurements of the individual pixel charge, pushing the detection threshold to the eV-scale. DAMIC-M will advance by several orders of magnitude the exploration of the dark matter particle hypothesis, in particular of candidates pertaining to the so-called “hidden sector.” A prototype, the Low Background Chamber (LBC), with 20g of low background Skipper CCDs, has been recently installed at Laboratoire Souterrain de Modane and is currently taking data. We will report the status of the DAMIC-M experiment and first results obtained with LBC commissioning data
Search for Daily Modulation of MeV Dark Matter Signals with DAMIC-M
Dark Matter (DM) particles with sufficiently large cross sections may scatter
as they travel through Earth's bulk. The corresponding changes in the DM flux
give rise to a characteristic daily modulation signal in detectors sensitive to
DM-electron interactions. Here, we report results obtained from the first
underground operation of the DAMIC-M prototype detector searching for such a
signal from DM with MeV-scale mass. A model-independent analysis finds no
modulation in the rate of 1 events with periods in the range 1-48 h. We
then use these data to place exclusion limits on DM in the mass range [0.53,
2.7] MeV/c interacting with electrons via a dark photon mediator. Taking
advantage of the time-dependent signal we improve by 2 orders of
magnitude on our previous limit obtained from the total rate of 1 events,
using the same data set. This daily modulation search represents the current
strongest limit on DM-electron scattering via ultralight mediators for DM
masses around 1 MeV/c
Linking Inflammation to Natural Killer T Cell Activation
Immune activation is often associated with inflammation, but inflammation's role in the expansion of antigen-specific immune responses remains unclear. This primer focuses on recent findings that show how specific natural killer T cells are activated by inflammatory messengers, thus illuminating the cellular and molecular links between immunity and inflammation
Structure of a Classical MHC Class I Molecule That Binds “Non-Classical” Ligands
The chicken MHC YF1*7.1 X-ray structures reveal that this protein binds lipids and thus represents a "hybrid" class I complex with features of classical as well as non-classical MHC molecules
EBV Promotes Human CD8+ NKT Cell Development
The reports on the origin of human CD8+ Vα24+ T-cell receptor (TCR) natural killer T (NKT) cells are controversial. The underlying mechanism that controls human CD4 versus CD8 NKT cell development is not well-characterized. In the present study, we have studied total 177 eligible patients and subjects including 128 healthy latent Epstein-Barr-virus(EBV)-infected subjects, 17 newly-onset acute infectious mononucleosis patients, 16 newly-diagnosed EBV-associated Hodgkin lymphoma patients, and 16 EBV-negative normal control subjects. We have established human-thymus/liver-SCID chimera, reaggregated thymic organ culture, and fetal thymic organ culture. We here show that the average frequency of total and CD8+ NKT cells in PBMCs from 128 healthy latent EBV-infected subjects is significantly higher than in 17 acute EBV infectious mononucleosis patients, 16 EBV-associated Hodgkin lymphoma patients, and 16 EBV-negative normal control subjects. However, the frequency of total and CD8+ NKT cells is remarkably increased in the acute EBV infectious mononucleosis patients at year 1 post-onset. EBV-challenge promotes CD8+ NKT cell development in the thymus of human-thymus/liver-SCID chimeras. The frequency of total (3% of thymic cells) and CD8+ NKT cells (∼25% of NKT cells) is significantly increased in EBV-challenged chimeras, compared to those in the unchallenged chimeras (<0.01% of thymic cells, CD8+ NKT cells undetectable, respectively). The EBV-induced increase in thymic NKT cells is also reflected in the periphery, where there is an increase in total and CD8+ NKT cells in liver and peripheral blood in EBV-challenged chimeras. EBV-induced thymic CD8+ NKT cells display an activated memory phenotype (CD69+CD45ROhiCD161+CD62Llo). After EBV-challenge, a proportion of NKT precursors diverges from DP thymocytes, develops and differentiates into mature CD8+ NKT cells in thymus in EBV-challenged human-thymus/liver-SCID chimeras or reaggregated thymic organ cultures. Thymic antigen-presenting EBV-infected dendritic cells are required for this process. IL-7, produced mainly by thymic dendritic cells, is a major and essential factor for CD8+ NKT cell differentiation in EBV-challenged human-thymus/liver-SCID chimeras and fetal thymic organ cultures. Additionally, these EBV-induced CD8+ NKT cells produce remarkably more perforin than that in counterpart CD4+ NKT cells, and predominately express CD8αα homodimer in their co-receptor. Thus, upon interaction with certain viruses, CD8 lineage-specific NKT cells are developed, differentiated and matured intrathymically, a finding with potential therapeutic importance against viral infections and tumors
Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy
Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA
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