Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center.

INTRODUCTION AND AIM:Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and ethnic differences in HCC incidence have been observed, with Latinos showing the greatest increase over the past four decades, highlighting a concerning health disparity. The goal of the present study was to compare the clinical features at the time of diagnosis of HCC in Latino and Caucasian patients. MATERIAL AND METHODS:We retrospectively screened a total of 556 charts of Latino and Caucasian patients with HCC. RESULTS:The mean age of HCC diagnosis was not significantly different between Latinos and Caucasians, but Latinos presented with higher body mass index (BMI). Rates of hypertension, diabetes, and hyperlipidemia were similar in the two groups. The most common etiology of liver disease was alcohol drinking in Latinos, and chronic hepatitis C in Caucasian patients. Non-Alcoholic Steatohepatitis (NASH) was the associated diagnosis in 8.6% of Latinos and 4.7% of Caucasians. Interestingly, alpha-fetoprotein (AFP) levels at time of diagnosis were higher in Latino patients compared to Caucasians, but this difference was evident only in male patients. Multifocal HCC was slightly more frequent in Latinos, but the two groups had similar cancerous vascular invasion. Latino patients also presented with higher rates of both ascites and hepatic encephalopathy. CONCLUSION:Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos

Dualidad discursiva en el cuento "La casa dividida" del escritor sudafricano Alan Paton

El presente trabajo constituye un primer acercamiento al estudio de los cuentos comprendidos en Debbie, vete a casa del escritor sudafricano Alan Paton (1903 - 1988). A modo de introducción, haremos una breve reseña biográfica del escritor (Martínez Lirola, 2008). Esta información resultará, a nuestro entender, relevante al momento de hacer una primera lectura del cuento "La casa dividida". Asimismo, nos proponemos examinar las relaciones de poder que se gestan en el interior del cuento a partir de un estudio discursivo de los parlamentos de los dos personajes principales: por un lado, un joven delincuente reincidente y, por el otro, el narrador en calidad de director del reformatorio en el que cumple su condena. Para el análisis de la configuración del discurso y de las relaciones de poder que se dan cita dentro del texto, adoptamos la perspectiva teórico-metodológica que ofrece Michel Foucault (2008 (1969)). Según nuestra hipótesis, la oposición entre el deseo y la realidad estructura el (doble) discurso de ambos personajes pero lleva a la construcción de dos sujetos bien diferentes, los cuales, sin embargo, y en virtud del contexto social en el que están insertos, son producto de las mismas relaciones de poderFil: Iacoboni, Gabriela N.. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina

G51.04+0.07 and its environment: Identification of a new Galactic supernova remnant at low radio frequencies

We have identified a new supernova remnant (SNR), G51.04+0.07, using observations at 74 MHz from the Very Large Array Low-Frequency Sky Survey Redux (VLSSr). Earlier, higher frequency radio continuum, recombination line, and infrared data had correctly inferred the presence of nonthermal radio emission within a larger, complex environment including ionised nebulae and active star formation. However, our observations have allowed us to redefine at least one SNR as a relatively small source (7.05 × 30in size) located at the southern periphery of the originally defined SNR candidate G51.21+0.11. The integrated flux density of G51.04+0.07 at 74 MHz is 6.1 ± 0.8 Jy, while its radio continuum spectrum has a slope α = −0.52 ± 0.05 (Sν ∝ να), typical of a shell-type remnant. We also measured spatial variations in the spectral index between 74 and 1400 MHz across the source, ranging from a steeper spectrum (α = −0.50 ± 0.04) coincident with the brightest emission to a flatter component (α = −0.30 ± 0.07) in the surrounding fainter region. To probe the interstellar medium into which the redefined SNR is likely evolving, we have analysed the surrounding atomic and molecular gas using the 21 cm neutral hydrogen (HI) and 13CO(J = 1 − 0) emissions. We found that G51.04+0.07 is confined within an elongated HI cavity and that its radio emission is consistent with the remains of a stellar explosion that occurred ∼6300 yr ago at a distance of 7.7 ± 2.3 kpc. Kinematic data suggest that the newly discovered SNR lies in front of HII regions in the complex, consistent with the lack of a turnover in the low frequency continuum spectrum. The CO observations revealed molecular material that traces the central and northern parts of G51.04+0.07. The interaction between the cloud and the radio source is not conclusive and motivates further study. The relatively low flux density (∼1.5 Jy at 1400 MHz) of G51.04+0.07 is consistent with this and many similar SNRs lying hidden along complex lines of sight towards inner Galactic emission complexes. It would also not be surprising if the larger complex studied here hosted additional SNRs.Fil: Supán, Jorge Leonardo. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Castelletti, Gabriela Marta. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Peters, W. M.. Spece Sciences División. Naval Research Laboratory; Estados UnidosFil: Kassim, N. E.. Spece Sciences División. Naval Research Laboratory; Estados Unido

MINOS and CPT-violating neutrinos

We review the status of CPT violation in the neutrino sector. Apart from LSND, current data favors three flavors of light stable neutrinos and antineutrinos, with both halves of the spectrum having one smaller mass splitting and one larger mass splitting. Oscillation data for the smaller splitting is consistent with CPT. For the larger splitting, current data favor an antineutrino mass-squared splitting that is an order of magnitude larger than the corresponding neutrino splitting, with the corresponding mixing angle less-than-maximal. This CPT-violating spectrum is driven by recent results from MINOS, but is consistent with other experiments if we ignore LSND. We describe an analysis technique which, together with MINOS running optimized for muon antineutrinos, should be able to conclusively confirm the CPT-violating spectrum proposed here, with as little as three times the current data set. If confirmed, the CPT-violating neutrino mass-squared difference would be an order of magnitude less than the current most-stringent upper bound on CPT violation for quarks and charged leptons.Comment: 18 pages, title change, version to appear in Physical Review

Pengaruh Pengungkapan Corporate Social Reponsibility Terhadap Nilai Perusahaan Sub Sektor Grosir

This research was done in order to know the influence of Corporate Social Responsibility (CSR) on the firm value in wholesale sector. CSR was measured by using Global Reporting Initiative (GRI) Index 3.1 and firm value was measured by using TobinsQ. There were 3 control variables in this research, which were firm size, market share, and debt to equity ratio. Sample used in this research was taken from 78 companies years in the wholesale sector during 2009-2013.The result showed that CSR and debt to equity ratio had no significant influence on the firm value. While firm size had negative influence on the firm value and market share had significant influence on the firm value

PG 1700+518 Revisited: Adaptive Optics Imaging and a Revised Starburst Age for the Companion

We present the results of adaptive-optics imaging of the z=0.2923 QSO PG 1700+518 in the J and H bands. The extension to the north of the QSO is clearly seen to be a discrete companion with a well-defined tidal tail, rather than a feature associated with the host galaxy of PG 1700+518 itself. On the other hand, an extension to the southwest of the QSO (seen best in deeper, but lower-resolution, optical images) does likely comprise tidal material from the host galaxy. The SED derived from images in J, H, and two non-standard optical bands indicates the presence of dust intermixed with the stellar component. We use our previously reported Keck spectrum of the companion, the SED found from the imaging data, and updated spectral-synthesis models to constrain the stellar populations in the companion and to redetermine the age of the starburst. While our best-fit age of 0.085 Gyr is nearly the same as our earlier determination, the fit of the new models is considerably better. This age is found to be remarkably robust with respect to different assumptions about the nature of the older stellar component and the effects of dust.Comment: 11 pages; includes two eps figures. Latex (AASTEX). Two additional figures in gif format. Postscript version including all figs. (424 kb) can be obtained from http://www.ifa.hawaii.edu/~canaguby/preprints.html To appear in ApJ. Letter

Antimutagenic and antioxidant activity of a protein fraction from aerial parts of Urtica dioica

Abstract Context: Urtica dioica L. (Urticaceae), stinging nettle, has been employed as a folklore remedy for a wide spectrum of ailments, including urinary disorders, prostatic hyperplasia, and liver diseases. It has been also used traditionally for cancer treatment. Object: To evaluate the potential chemopreventive properties of a protein fraction from the aerial part of Urtica dioica (namely UDHL30). Materials and methods: UDHL30 has been tested for the antimutagenic activity in bacteria (50-800 μg/plate; Ames test by the preincubation method) and for the cytotoxicity on human hepatoma HepG2 cells (0.06-2 mg/mL; 24 and 48 h incubation). Moreover, the antioxidant activity of UDHL30 (0.1-1200 μg/mL; ABTS and superoxide-radical scavenger assays) was evaluated as potential protective mechanisms. Results: UDHL30 was not cytotoxic on HepG2 cells up to 2 mg/mL; conversely, it exhibited a strong antimutagenic activity against the mutagen 2-aminoanthracene (2AA) in all strains tested (maximum inhibition of 56, 78, and 61% in TA98, TA100, and WP2uvrA strains, respectively, at 800 μg/plate). In addition, a remarkable scavenging activity against ABTS radical and superoxide anion (IC50 values of 19.9 ± 1.0 μg/mL and 75.3 ± 0.9 μg/mL, respectively) was produced. Discussion and conclusions: UDHL30 possesses antimutagenic and radical scavenging properties. Being 2AA a pro-carcinogenic agent, we hypothesize that the antimutagenicity of UDHL30 can be due to the inhibition of CYP450-isoenzymes, involved in the mutagen bioactivation. The radical scavenger ability could contribute to 2AA-antimutagenicity. These data encourage further studies in order to better define the potential usefulness of UDHL30 in chemoprevention

Bioactive Compounds of Lactic Acid Bacteria. Case Study: Evaluation of Antimicrobial Activity of Bacteriocin-producing Lactobacilli Isolated from Native Ecological Niches of Ecuador

Food preservation through natural methods represents one of the concerns worldwide to solve economic losses due to microbial decomposition of raw materials and foodstuffs. However, public concern over the emergence of strains resistant to many antibiotics, particularly pathogens such as E. coli and Salmonella sp. draw much attention as new challenge in food industry is to find new alternative quality-control methods of food products. In Ecuador, the lack of quality control, bad storage condition, and insufficient preservation against spoilage bacteria had at higher extent repercussions on food safety and security. The most frequent pathogens detected in fresh meat and drinks along with traditional local food products, represent a serious problem producing sizable food damage and associated diseases. The capacity of lactobacilli to inhibit pathogens has been recently exploited to prevent microbial spoilage. Here we briefly review the principal biopeptides (i.e., bacteriocins) of lactic acid bacteria, their main mode of action, the classification, and its biotechnological applications. Moreover, we discussed the preliminary results on the evaluation of antimicrobial activity of some native lactic acid bacteria isolated from microbiota of Ecuador against frequent contaminants found in the local market