Dependent Lindeberg central limit theorem and some applications

In this paper, a very useful lemma (in two versions) is proved: it simplifies notably the essential step to establish a Lindeberg central limit theorem for dependent processes. Then, applying this lemma to weakly dependent processes introduced in Doukhan and Louhichi (1999), a new central limit theorem is obtained for sample mean or kernel density estimator. Moreover, by using the subsampling, extensions under weaker assumptions of these central limit theorems are provided. All the usual causal or non causal time series: Gaussian, associated, linear, ARCH($\infty$), bilinear, Volterra processes,$...$, enter this frame

The geometry of flex tangents to a cubic curve and its parameterizations

International audienceWe show how the study of the geometry of the nine flex tangents to a cubic produces many pseudo-parameterizations, including the ones given by Icart, Kammerer, Lercier, Renault and Farashahi

Further characterization of the putative human isopeptidase T catalytic site

AbstractThe human isopeptidase T (isoT) is a zinc-binding deubiquitinating enzyme involved in the disassembly of free K48-linked polyubiquitin chains into ubiquitin monomers. The catalytic site of this enzyme is thought to be composed of Cys335, Asp435, His786 and His795. These four residues were site-directed mutagenized. None of the mutants were able to cleave a peptide-linked ubiquitin dimer. Similarly, C335S, D435N and H795N mutants had virtually no activity against a K48-linked isopeptide ubiquitin dimer, which is an isoT-specific substrate that mimics the K48-linked polyubiquitin chains. On the other hand, the H786N mutant retained a partial activity toward the K48-linked substrate, suggesting that the His786 residue might not be part of the catalytic site. None of the mutations significantly affected the capacity of isoT to bind ubiquitin and zinc. Thus, the catalytic site of UBPs could resemble that of other cysteine proteases, which contain one Cys, one Asp and one His

Nondestructive testing of open microscopic cracks in plasma-sprayed-coatings using ultrasound excited vibrothermography

Peer reviewed: YesNRC publication: Ye

Beneficial effects of reconstituted high-density lipoprotein (rHDL) on circulating CD34+ cells in patients after an acute coronary syndrome

Background: High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS). This study investigates the short-term effects of reconstituted HDL (rHDL) on circulating progenitor cells in patients with ACS. Methods and Findings: The study population consisted of 33 patients with recent ACS: 20 patients from the ERASE trial (randomized to receive 4 weekly intravenous infusions of CSL-111 40 mg/kg or placebo) and 13 additional patients recruited as controls using the same enrolment criteria. Blood was collected from 16 rHDL (CSL-111)-treated patients and 17 controls at baseline and at 6–7 weeks (i.e. 2–3 weeks after the fourth infusion of CSL-111 in ERASE). CD34+ and CD34+/kinase insert domain receptor (KDR+) progenitor cell counts were analyzed by flow cytometry. We found preserved CD34+ cell counts in CSL-111-treated subjects at follow-up (change of 1.6%), while the number of CD34+ cells was reduced (-32.9%) in controls (p = 0.017 between groups). The level of circulating SDF-1 (stromal cell-derived factor-1), a chemokine involved in progenitor cell recruitment, increased significantly (change of 21.5%) in controls, while it remained unchanged in CSL-111-treated patients (p = 0.031 between groups). In vitro exposure to CSL-111 of early EPC isolated from healthy volunteers significantly increased CD34+ cells, reduced early EPC apoptosis and enhanced their migration capacity towards SDF-1. Conclusions: The relative increase in circulating CD34+ cells and the low SDF-1 levels observed following rHDL infusions in ACS patients point towards a role of rHDL in cardiovascular repair mechanisms

Borylation and rearrangement of alkynyloxiranes: a stereospecific route to substituted α-enynes

International audienc

A Tighter Analysis of Work Stealing

Classical list scheduling is a very popular and efficient technique for scheduling jobs in parallel platforms. However, with the increasing number of processors, the cost for managing a single centralized list becomes prohibitive. The objective of this work is to study the extra cost that must be paid when the list is distributed among the processors. We present a general methodology for computing the expected makespan based on the analysis of an adequate potential function which represents the load unbalance between the local lists. A bound on the deviation from the mean is also derived. Then, we apply this technique to show that the expected makespan for scheduling W unit independent tasks on m processors is equal to W/m with an additional term in 3.65log_2 W. Moreover, simulations show that our bound is very close to the exact value, approximately 50\% off. This new analysis also enables to study the influence of the initial repartition of tasks and the reduction of the number of steals when several thieves can simultaneously steal work in the same processor's list

The EAGLE instrument for the E-ELT: developments since delivery of Phase A

The EAGLE instrument is a Multi-Object Adaptive Optics (MOAO) fed, multiple Integral Field Spectrograph (IFS), working in the Near Infra-Red (NIR), on the European Extremely Large Telescope (E-ELT). A Phase A design study was delivered to the European Southern Observatory (ESO) leading to a successful review in October 2009. Since that time there have been a number of developments, which we summarize here. Some of these developments are also described in more detail in other submissions at this meeting. The science case for the instrument, while broad, highlighted in particular: understanding the stellar populations of galaxies in the nearby universe, the observation of the evolution of galaxies during the period of rapid stellar build-up between redshifts of 2-5, and the search for 'first light' in the universe at redshifts beyond 7. In the last 2 years substantial progress has been made in these areas, and we have updated our science case to show that EAGLE is still an essential facility for the E-ELT. This in turn allowed us to revisit the science requirements for the instrument, confirming most of the original decisions, but with one modification. The original location considered for the instrument (a gravity invariant focal station) is no longer in the E-ELT Construction Proposal, and so we have performed some preliminary analyses to show that the instrument can be simply adapted to work at the E-ELT Nasmyth platform. Since the delivery of the Phase A documentation, MOAO has been demonstrated on-sky by the CANARY experiment at the William Herschel Telescope.Comment: 10 pages, SPIE Conference proceedings, Amsterdam, July 201