The Economic Incidence of R&D and Promotion Investments in the Australian Beef Industry

The issue of the relative returns to farmers from R&D and promotion is examined using a multi-sectoral equilibrium displacement model of the Australian beef industry. Total economic surplus changes and their distributions among various industry groups resulting from 1% cost reductions in various farm and off-farm sectors, and from 1% price premiums from domestic and export market promotion, are estimated. The results are consistent with previous studies in showing that in general, the share of total benefits to farmers is larger from on-farm research than from most off-farm research, and is larger from most types of research than from domestic promotion. The share of total benefits to farmers is larger from export promotion than from off-farm research, and from domestic promotion. The net returns from the different cost-reduction or demand-enhancing scenarios depend on the costs of achieving them.Economics of R&D, promotion, beef industry, equilibrium displacement modelling.

Many worlds in one

A generic prediction of inflation is that the thermalized region we inhabit is spatially infinite. Thus, it contains an infinite number of regions of the same size as our observable universe, which we shall denote as \O-regions. We argue that the number of possible histories which may take place inside of an \O-region, from the time of recombination up to the present time, is finite. Hence, there are an infinite number of \O-regions with identical histories up to the present, but which need not be identical in the future. Moreover, all histories which are not forbidden by conservation laws will occur in a finite fraction of all \O-regions. The ensemble of \O-regions is reminiscent of the ensemble of universes in the many-world picture of quantum mechanics. An important difference, however, is that other \O-regions are unquestionably real.Comment: 9 pages, 2 figures, comments and references adde

Born reciprocity and the 1/r potential

Many structures in nature are invariant under the transformation (p,r)->(br,-p/b), where b is some scale factor. Born's reciprocity hypothesis affirms that this invariance extends to the entire Hamiltonian and equations of motion. We investigate this idea for atomic physics and galactic motion, where one is basically dealing with a 1/r potential and the observations are very accurate, so as to determine the scale $b = m\Omega$. We find that an $\Omega \sim 1.5\times 10^{-15}$ Hz has essentially no effect on atomic physics but might possibly offer an explanation for galactic rotation, without invoking dark matter.Comment: 14 pages, with 4 figures, Latex, requires epsf.tex and iop style file

A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage renal failure in humans and results from germline mutations in PKD1 or PKD2. Despite the recent approval of tolvaptan, safer and more effective alternative drugs are clearly needed to slow disease progression. As a first step in drug discovery, we conducted an unbiased chemical screen on zebrafish pkd2 mutant embryos using two publicly available compound libraries (Spectrum, PKIS) totalling 2,367 compounds to identify novel treatments for ADPKD. Using dorsal tail curvature as the assay readout, three major chemical classes (steroids, coumarins, flavonoids) were identified from the Spectrum library as the most promising candidates to be tested on human PKD1 cystic cells. Amongst these were an androgen, 5α−androstane 3,17-dione, detected as the strongest enhancer of the pkd2 phenotype but whose effect was found to be independent of the canonical androgen receptor pathway. From the PKIS library, we identified several ALK5 kinase inhibitors as strong suppressors of the pkd2 tail phenotype and in vitro cyst expansion. In summary, our results identify ALK5 and non-canonical androgen receptors as potential therapeutic targets for further evaluation in drug development for ADPKD

Prepotential and Instanton Corrections in N=2 Supersymmetric SU(N_1)xSU(N_2) Yang Mills Theories

In this paper we analyse the non-hyperelliptic Seiberg-Witten curves derived from M-theory that encode the low energy solution of N=2 supersymmetric theories with product gauge groups. We consider the case of a SU(N_1)xSU(N_2) gauge theory with a hypermultiplet in the bifundamental representation together with matter in the fundamental representations of SU(N_1) and SU(N_2). By means of the Riemann bilinear relations that hold on the Riemann surface defined by the Seiberg--Witten curve, we compute the logarithmic derivative of the prepotential with respect to the quantum scales of both gauge groups. As an application we develop a method to compute recursively the instanton corrections to the prepotential in a straightforward way. We present explicit formulas for up to third order on both quantum scales. Furthermore, we extend those results to SU(N) gauge theories with a matter hypermultiplet in the symmetric and antisymmetric representation. We also present some non-trivial checks of our results.Comment: 21 pages, 2 figures, minor changes and references adde

Aspects of electrostatics in a weak gravitational field

Several features of electrostatics of point charged particles in a weak, homogeneous, gravitational field are discussed using the Rindler metric to model the gravitational field. Some previously known results are obtained by simpler and more transparent procedures and are interpreted in an intuitive manner. Specifically: (i) We show that the electrostatic potential of a charge at rest in the Rindler frame is expressible as A_0=(q/l) where l is the affine parameter distance along the null geodesic from the charge to the field point. (ii) We obtain the sum of the electrostatic forces exerted by one charge on another in the Rindler frame and discuss its interpretation. (iii) We show how a purely electrostatic term in the Rindler frame appears as a radiation term in the inertial frame. (In part, this arises because charges at rest in a weak gravitational field possess additional weight due to their electrostatic energy. This weight is proportional to the acceleration and falls inversely with distance -- which are the usual characteristics of a radiation field.) (iv) We also interpret the origin of the radiation reaction term by extending our approach to include a slowly varying acceleration. Many of these results might have possible extensions for the case of electrostatics in an arbitrary static geometry. [Abridged Abstract]Comment: 26 pages; accepted for publication in Gen.Rel.Gra

Hidden sl(2,R) Symmetry in 2D CFTs and the Wave Function of 3D Quantum Gravity

We show that all two-dimensional conformal field theories possess a hidden sl(2,R) affine symmetry. More precisely, we add appropriate ghost fields to an arbitrary CFT, and we use them to construct the currents of sl(2,R). We then define a BRST operator whose cohomology defines a physical subspace where the extended theory coincides with the original CFT. We use the sl(2,R) algebra to construct candidate wave functions for 3-d quantum gravity coupled to matter, and we discuss their viability.Comment: Minor misprints corrected.Eight references added. To appear in JHEP.34 pages, LaTe

Closed geodesics and billiards on quadrics related to elliptic KdV solutions

We consider algebraic geometrical properties of the integrable billiard on a quadric Q with elastic impacts along another quadric confocal to Q. These properties are in sharp contrast with those of the ellipsoidal Birkhoff billiards. Namely, generic complex invariant manifolds are not Abelian varieties, and the billiard map is no more algebraic. A Poncelet-like theorem for such system is known. We give explicit sufficient conditions both for closed geodesics and periodic billiard orbits on Q and discuss their relation with the elliptic KdV solutions and elliptic Calogero systemComment: 23 pages, Latex, 1 figure Postscrip

A Web Map Service implementation for the visualization of multidimensional gridded environmental data

We describe ncWMS, an implementation of the Open Geospatial Consortium’s Web Map Service (WMS) specification for multidimensional gridded environmental data. ncWMS can read data in a large number of common scientific data formats – notably the NetCDF format with the Climate and Forecast conventions – then efficiently generate map imagery in thousands of different coordinate reference systems. It is designed to require minimal configuration from the system administrator and, when used in conjunction with a suitable client tool, provides end users with an interactive means for visualizing data without the need to download large files or interpret complex metadata. It is also used as a “bridging” tool providing interoperability between the environmental science community and users of geographic information systems. ncWMS implements a number of extensions to the WMS standard in order to fulfil some common scientific requirements, including the ability to generate plots representing timeseries and vertical sections. We discuss these extensions and their impact upon present and future interoperability. We discuss the conceptual mapping between the WMS data model and the data models used by gridded data formats, highlighting areas in which the mapping is incomplete or ambiguous. We discuss the architecture of the system and particular technical innovations of note, including the algorithms used for fast data reading and image generation. ncWMS has been widely adopted within the environmental data community and we discuss some of the ways in which the software is integrated within data infrastructures and portals

Diffeomorphisms as Symplectomorphisms in History Phase Space: Bosonic String Model

The structure of the history phase space $\cal G$ of a covariant field system and its history group (in the sense of Isham and Linden) is analyzed on an example of a bosonic string. The history space $\cal G$ includes the time map $\sf T$ from the spacetime manifold (the two-sheet) $\cal Y$ to a one-dimensional time manifold $\cal T$ as one of its configuration variables. A canonical history action is posited on $\cal G$ such that its restriction to the configuration history space yields the familiar Polyakov action. The standard Dirac-ADM action is shown to be identical with the canonical history action, the only difference being that the underlying action is expressed in two different coordinate charts on $\cal G$. The canonical history action encompasses all individual Dirac-ADM actions corresponding to different choices $\sf T$ of foliating $\cal Y$. The history Poisson brackets of spacetime fields on $\cal G$ induce the ordinary Poisson brackets of spatial fields in the instantaneous phase space ${\cal G}_{0}$ of the Dirac-ADM formalism. The canonical history action is manifestly invariant both under spacetime diffeomorphisms Diff$\cal Y$ and temporal diffeomorphisms Diff$\cal T$. Both of these diffeomorphisms are explicitly represented by symplectomorphisms on the history phase space $\cal G$. The resulting classical history phase space formalism is offered as a starting point for projection operator quantization and consistent histories interpretation of the bosonic string model.Comment: 45 pages, no figure