Qualität definieren. Fünf unterschiedliche Ansätze

Die Autoren untersuchen den Begriff der "Qualität" im Kontext von Bildung. "Zu diesem Zweck werden Denkweisen über Qualität analysiert und in ihrer Bedeutung für den Bildungsbereich herausgearbeitet. Das Verhältnis dieser Denkweisen untereinander wird erörtert, und schließlich werden ihre philosophischen und politischen Grundlagen verdeutlicht.... Die internationale Diskussion wird in systematischer Weise aufgearbeitet; die Möglichkeiten und Grenzen der Übertragung von Qualitäts(sicherungs) konzepten aus dem privatwirtschaftlichen Produktions- und Dienstleistungsbereich werden klar herausgearbeitet." (DIPF/Orig.

Preheating after Multi-field Inflation

In this note I study preheating after multi-field inflation to assess the feasibility of parametric resonance. An intuitive argument for the suppression of resonances due to dephasing of fields in generic multi-field models is presented. This effect is absent in effective single field models, rendering them inappropriate for the study of preheating.Comment: 4 pages, proceedings for work presented at Cargese 2008, COSMO08 and UniverseNet second annual meetin

\u3ci\u3eAPOE\u3c/i\u3e Genetics Influence Murine Gut Microbiome

Apolipoprotein E (APOE) alleles impact pathogenesis and risk for multiple human diseases, making them primary targets for disease treatment and prevention. Previously, we and others reported an association between APOE alleles and the gut microbiome. Here, we evaluated effects of APOE heterozygosity and tested whether these overall results extended to mice maintained under ideal conditions for microbiome analyses. To model human APOE alleles, this study used APOE targeted replacement (TR) mice on a C57Bl/6 background. To minimize genetic drift, homozygous APOE3 mice were crossed to homozygous APOE2 or homozygous APOE4 mice prior to the study, and the resulting heterozygous progeny crossed further to generate the study mice. To maximize environmental homogeneity, mice with mixed genotypes were housed together and used bedding from the cages was mixed and added back as a portion of new bedding. Fecal samples were obtained from mice at 3-, 5- and 7-months of age, and microbiota analyzed by 16S ribosomal RNA gene amplicon sequencing. Linear discriminant analysis of effect size (LefSe) identified taxa associated with APOE status, depicted as cladograms to show phylogenetic relatedness. The influence of APOE status was tested on alpha-diversity (Shannon H index) and beta-diversity (principal coordinate analyses and PERMANOVA). Individual taxa associated with APOE status were identified by classical univariate analysis. Whether findings in the APOE mice were replicated in humans was evaluated by using published microbiome genome wide association data. Cladograms revealed robust differences with APOE in male mice and limited differences in female mice. The richness and evenness (alpha-diversity) and microbial community composition (beta-diversity) of the fecal microbiome was robustly associated with APOE status in male but not female mice. Classical univariate analysis revealed individual taxa that were significantly increased or decreased with APOE, illustrating a stepwise APOE2-APOE3–APOE4 pattern of association with heterozygous animals trending as intermediate in the stepwise pattern. The relative abundance of bacteria from the class Clostridia, order Clostridiales, family Ruminococacceae and related genera increased with APOE2 status. The relative abundance of Erysipelotrichia increased with APOE4 status, a finding that extended to humans. In this study, wherein mice were maintained in an ideal fashion for microbiome studies, gut microbiome profiles were strongly and significantly associated with APOE status in male APOE-TR mice. Erysipelotrichia are increased with APOE4 in both mice and humans. APOE allelic effects appeared generally intermediate in heterozygous animals. Further evaluation of these findings in humans, as well as studies evaluating the impact of the APOE-associated microbiota on disease-relevant phenotypes, will be necessary to determine if alterations in the gut microbiome represent a novel mechanism whereby APOE alleles impact disease

Algal Growth Potentials and Heavy Metal Concentrations of the Primary Streams to Upper Beaver Lake

Meyer and Green (1984) demonstrated the probable inhibition of algal growth potential by heavy metals in upper Beaver Lake. Upper Beaver Lake receives water from three tributaries. One contains a small reservoir and the combined streams receive sewage input. Collections were made approximately monthly at eight sites for the Algal Assay Bottle Test (AABT) and heavy metal analysis. In general, AABT results indicated that the collections above the sewage lnput were phosphorus limited while those below were nitrogen or combined nitrogen and phosphorus limited. Growth inhibition occurred during summer and early fall at various sites with greater inhibition at the confluence of the streams. No inhibitions occurred, at the site below the sewage input. Heavy metal concentrations had an overall tendency to increase downstream. Values within the small reservoir were 50-100% higher than in the feeder stream. Highest values of Pb were observed below the reservoir. SO4 ,Cl, Mg, Ca, Na and K had high values during low flow in August-ctober. The low values were independent of high flow. Pb followed an independent pattern. Storm event results showed that the Ca maximum was before the hydrographic peak while Fe, Mn, Pb, In, Co, Ni, Cu and Cd attained their maximum just after the peak. Maximum values were 4-10 times background values. Mn, Pb and Fe exceeded EPA recommended standards for drinking water

Response to Angus Deaton’s award of the Nobel Prize in Economics

Faculty members in the Department of International Development respond to the news that Angus Deaton of Princeton University has been named the 2015 winner of the Nobel prize in economics

Vital Business Educators Perceptions about the Usefulness of Business Education Periodicals

Problem: The business education literature isn’t accessible. Research Questions: Which business education periodicals do vital business educators perceive to be more useful? In which databases and/or indices are they found? How much literature is fugitive? What strategies might increase literature accessibility? Research Method: Delphi technique. Data Collection Procedures:A survey was distributed to 25 vital business educators. Results: The Delta Pi Epsilon Journal and the NABTE Review were rated as essential to the profession; nine periodicals were rated as very useful; and six periodicals were rated as useful. Eleven databases and indices were identified as potentially useful. Conclusions: Approximately 37% of the studied periodicals are fugitive, confirming literature inaccessibility. Recommendations: Strategies to increase the accessibility of the business education literature include libraries carefully selecting complementary databases, getting periodicals indexed, placing periodical tables of contents on the web, improving fugitive-literature retrieval skills, and developing an electronic business education database

“Need to know” and the right temporal lobe: Impaired access to semantic knowledge in acquired obsessive-compulsive disorder?

Introduction : Idiopathic obsessive-compulsive disorder (I-OCD) has been linked to abnormalities in corticostriatal circuits. Few studies have examined if the same structures are also responsible of acquired OCD (A-OCD) or if damage to anatomically-connected brain regions (e.g., temporal lobes) are also implicated in its pathogenesis. Additionally, there are some discrete obsessive-compulsive (OC) symptoms that by virtue of their presumed low occurrence and difficultly of categorization have received less attention. Amongst these, one intriguing and potentially severe type of obsessive thinking is the so-called “need to know” (NtK), a strong drive to know and obtain given information. In some patients this specific symptom, presumably resulting from impaired access to conceptual knowledge for specific verbal information (proper names, names of places), may be the principal or major feature of OCD symptomatology. We here report the cases of two male patients who developed “NtK” as the only OC symptomatology in association with malignant neoplasms involving the right temporal lobe and connected corticostriatal circuits. Methods : We used Tractotron and Disconnectome map softwares in order to identify the regions of white matter damage overlap across both patients and the proportion of damage (lesion load) of each tract of interest for each patient. We quantified the severity of the disconnection by measuring the proportion of each tract of interest to be affected by each patient´s lesion by using Tractotron software. Additionally, Positron Emission Tomography was used in order to study metabolic abnormalities. The tracts of interest were: the uncinate fasciculus, the anterior commissure, the anterior thalamic radiations, the inferior fronto-occipital fasciculus and the inferior longitudinal fasciculus. Results : There was a high overlap across brain lesions in patients 1 and 2. There was also a high overlap between areas that were affected (disconnected) due to the lesion. As expected, all the a priori selected pathways in the right hemisphere were affected since they cross the anterior part of the temporal lobe. Disconnection maps and metabolic changes in our patients suggest that the expression of OC symptoms underpinned by a semantic deficit due to right temporal damage is secondary to involvement of the uncinate fasciculus linking the temporal pole with the orbitofrontal cortex. Discussion : Data from the present study concur with previous research on A-OCD and current findings in I-OCD which suggest that the temporal lobes participate in the phenomenological expression of OCD. Also, patients with lesions in the anterior temporal lobe are prone to show a specific “Need to Know” symptoms phenomenologically similar to patients with semantic dementia in later stages. The expression of OC symptoms underpinned by a semantic deficit because of anterior right temporal lobe lesion, are due to a disconnection of the uncinate fasciculus and the orbitofrontal cortex. Further research about the neurological underpinnings of specific OCD subtypes, its evaluation and treatment, are essential. References : Berthier ML et al. Neurology. (1996) 47: 353–61. Huey E et al. J Neuropsych Clin Neurosci (2008). 20(4):390-408 Keywords : Emotions & Social Cognition; patients; single case study; adults; psychiatric; lesion mapping, behavioural.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Tactics: Practical and Imagined

Since December 2017, a group of us (including Kim Solga, Sylvan Baker, Diana Damian Martin, Rebecca Hayes Laughton, and Katherine Low) have been convening working sessions at various schools and conferences that address the questions and problems animating this issue of RiDE. In this final article, a handful of our respondents from ASTR 2018 in San Diego ruminate upon, list, and re-member tactics they have used, or dreamed of using, to make it through the neoliberal academic day-to-day. Their thoughts are accompanied here by a handful of photos that document the documentation we produced at our first symposium