7,504 research outputs found
Turbulence, dynamic similarity and scale effects in high-velocity free-surface flows above a stepped chute
In high-velocity free-surface flows, air entrainment is common through the interface, and intense interactions take place between turbulent structures and entrained bubbles. Two-phase flow properties were measured herein in high-velocity open channel flows above a stepped chute. Detailed turbulence measurements were conducted in a large-size facility, and a comparative analysis was applied to test the validity of the Froude and Reynolds similarities. The results showed consistently that the Froude similitude was not satisfied using a 2:1 geometric scaling ratio. Lesser number of entrained bubbles and comparatively greater bubble sizes were observed at the smaller Reynolds numbers, as well as lower turbulence levels and larger turbulent length and time scales. The results implied that small-size models did underestimate the rate of energy dissipation and the aeration efficiency of prototype stepped spillways for similar flow conditions. Similarly a Reynolds similitude was tested. The results showed also some significant scale effects. However a number of self-similar relationships remained invariant under changes of scale and confirmed the analysis of Chanson and Carosi (Exp Fluids 42:385-401, 2007). The finding is significant because self-similarity may provide a picture general enough to be used to characterise the air– water flow field in large prototype channels
Life conditions for the elderly in the household sphere: aging and transferees in Montevideo-Uruguay
This work outlines the framework of the family configurations in which the elderly population of Montevideo lives as well as the transfers they are involved in. The main objective is to investigate how older people, who are recipients of a broad social protection system and have an economic situation relatively better than the younger groups, participate in the household intergenerational distribution dynamics. In order to achieve this goal, we elaborated a characterization of the households of the elderly, considering the life conditions, resources and service transfers in which they participate. The initial hypotheses is that socioeconomic inequality is the key to understand the transfer dynamics intra- and inter-households.187417120
Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes
Hmong Adults Self-Rated Oral Health: A Pilot Study
Since 1975, the Hmong refugee population in the U.S. has increased over 200%. However, little is known about their dental needs or self-rated oral health (SROH). The study aims were to: (1) describe the SROH, self-rated general health (SRGH), and use of dental/physician services; and (2) identify the factors associated with SROH among Hmong adults. A cross-sectional study design with locating sampling methodology was used. Oral health questionnaire was administered to assess SROH and SRGH, past dental and physician visits, and language preference. One hundred twenty adults aged 18–50+ were recruited and 118 had useable information. Of these, 49% rated their oral health as poor/fair and 30% rated their general health as poor/fair. Thirty-nine percent reported that they did not have a regular source of dental care, 46% rated their access to dental care as poor/fair, 43% visited a dentist and 66% visited a physician within the past 12 months. Bivariate analyses demonstrated that access to dental care, past dental visits, age and SRGH were significantly associated with SROH (P \u3c 0.05). Multivariate analyses demonstrated a strong association between access to dental care and good/excellent SROH. About half of Hmong adults rated their oral health and access to dental care as poor. Dental insurance, access to dental care, past preventive dental/physician visits and SRGH were associated with SROH
PCN17 A Budget Impact Model Estimating the Financial Impact of Increased Use of Generic Bortezomib Intravenous (Iv) in the Treatment of Relapsed/Refractory Multiple Myeloma (Mm) in Venezuela
Corrections to the Gell-Mann-Oakes-Renner relation and chiral couplings and
Next to leading order corrections to the
Gell-Mann-Oakes-Renner relation (GMOR) are obtained using weighted QCD Finite
Energy Sum Rules (FESR) involving the pseudoscalar current correlator. Two
types of integration kernels in the FESR are used to suppress the contribution
of the kaon radial excitations to the hadronic spectral function, one with
local and the other with global constraints. The result for the pseudoscalar
current correlator at zero momentum is , leading to the chiral corrections to GMOR: . The resulting uncertainties are mostly due to variations in the upper
limit of integration in the FESR, within the stability regions, and to a much
lesser extent due to the uncertainties in the strong coupling and the strange
quark mass. Higher order quark mass corrections, vacuum condensates, and the
hadronic resonance sector play a negligible role in this determination. These
results confirm an independent determination from chiral perturbation theory
giving also very large corrections, i.e. roughly an order of magnitude larger
than the corresponding corrections in chiral . Combining
these results with our previous determination of the corrections to GMOR in
chiral , , we are able to determine two low
energy constants of chiral perturbation theory, i.e. , and , both at the
scale of the -meson mass.Comment: Revised version with minor correction
Circle of Willis variation in a complex stroke presentation: a case report
BACKGROUND: The impact of circle of Willis anatomical variation upon the presentation of stroke is probably underrecognised. CASE PRESENTATION: A 63-year-old right-handed woman developed a left hemiparesis and right leg weakness sequentially following a road traffic accident (RTA). Despite initial concern about the possibility of cervical spinal cord injury, the final diagnosis was bilateral artery-to-artery embolic cerebral infarction with dominant right internal carotid artery. CONCLUSION: The case illustrates the complex presentation of stroke as a pseudo-cervical cord lesion and the impact of circle of Willis anatomical variation upon the expression of large vessel cerebrovascular disease
The Prognostic Significance of Whole Blood Global and Specific DNA Methylation Levels in Gastric Adenocarcinoma
Epigenetics, particularly DNA methylation, has recently been elucidated as important in gastric cancer (GC) initiation and progression. We investigated the clinical and prognostic importance of whole blood global and site-specific DNA methylation in GC. tests. Survival analyses were carried out using the Kaplan-Meier method and log rank test. A backward conditional Cox proportional hazards regression model was used to identify independent predictors of survival. = 0.02) respectively.Analysis of global and site-specific DNA methylation in peripheral blood by pyrosequencing provides quantitative DNA methylation values that may serve as important prognostic indicators
FindFoci: a focus detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis
Accurate and reproducible quantification of the accumulation of proteins into foci in cells is essential for data interpretation and for biological inferences. To improve reproducibility, much emphasis has been placed on the preparation of samples, but less attention has been given to reporting and standardizing the quantification of foci. The current standard to quantitate foci in open-source software is to manually determine a range of parameters based on the outcome of one or a few representative images and then apply the parameter combination to the analysis of a larger dataset. Here, we demonstrate the power and utility of using machine learning to train a new algorithm (FindFoci) to determine optimal parameters. FindFoci closely matches human assignments and allows rapid automated exploration of parameter space. Thus, individuals can train the algorithm to mirror their own assignments and then automate focus counting using the same parameters across a large number of images. Using the training algorithm to match human assignments of foci, we demonstrate that applying an optimal parameter combination from a single image is not broadly applicable to analysis of other images scored by the same experimenter or by other experimenters. Our analysis thus reveals wide variation in human assignment of foci and their quantification. To overcome this, we developed training on multiple images, which reduces the inconsistency of using a single or a few images to set parameters for focus detection. FindFoci is provided as an open-source plugin for ImageJ
A specific case in the classification of woods by FTIR and chemometric: discrimination of Fagales from Malpighiales
Fourier transform infrared (FTIR) spectroscopic data was used to classify wood samples from nine species within the Fagales and Malpighiales using a range of multivariate statistical methods. Taxonomic classification of the family Fagaceae and Betulaceae from Angiosperm Phylogenetic System Classification (APG II System) was successfully performed using supervised pattern recognition techniques. A methodology for wood sample discrimination was developed using both sapwood and heartwood samples. Ten and eight biomarkers emerged from the dataset to discriminate order and family, respectively. In the species studied FTIR in combination with multivariate analysis highlighted significant chemical differences in hemicelluloses, cellulose and guaiacyl (lignin) and shows promise as a suitable approach for wood sample classification
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