The association between neuroticism and heart rate variability is not fully explained by cardiovascular disease and depression

Neuroticism is associated with cardiovascular disease, autonomic reactivity, and depression. Here we address the extent to which neuroticism accounts for the excess heart disease risk associated with depression and test whether cardiac autonomic tone plays a role as mediator. Subjects were derived from a nationally representative sample (n = 1,255: mean age 54.5, SD = 11.5). Higher neuroticism was associated with reduced heart rate variability equally under rest and stress. The baseline structural equation model revealed significant paths from neuroticism to heart rate variability, cardiovascular disease and depression, and between depression and cardiovascular disease, controlling for age, sex, height, weight, and BMI. Dropping both the neuroticism to heart rate variability, and neuroticism to heart disease paths significantly reduced the model fit (p < .001 in each case). We conclude that neuroticism has independent associations with both autonomic reactivity and cardiovascular disease, over and above its associations with depression and other related variables

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk

Seismic stratigraphy of late quaternary glacial to marine sediments offshore Bornholm, southern Baltic sea

The Quaternary history of the southern Baltic is marked by a complex sequence of glacial, lacustrine and marine phases. Consequently, a large number of unconformities and erosional and depositional surfaces are present in the stratigraphic record. Over 600 km of high-resolution, single-channel reflection seismic profiles were collected offshore Bornholm. A sequence stratigraphic interpretation of the seismic data, in combination with some available core data, has led to the identification of two Quaternary depositional sequences unconformably overlying the late Mesozoic deposits. The sequences contain up to nine different seismic-stratigraphic units, and are separated by sharp boundaries representing strong erosional events.The lower depositional sequence contains five units (A-E) of glacial and late-glacial origin. The unconformity, at its base is marked by a southward flowing channel drainage pattern, which may be related to the mid-Weichselian Alnarp River system. Units A and B contain till and moraine deposits, probably of middle or early-late Weichselian age. Units C-E consist of glaciolacustrine clays, and most likely represent different Baltic Ice Lake phases of the late Weichselian. The upper depositional sequence contains four units (F-I) of postglacial lacustrine and marine origin. Its sharp erosional base possibly indicates subaerial exposure. Unit F consists of backstepping delta or beach deposits, which are partially interfingered with the lacustrine clays of unit G. Both units can most likely be correlated with the Ancylus Lake. The marine mud deposits of units H and I represent the widespread Litorina transgression

A description of surface features in north Tyrrhena Terra, Mars: Evidence for extension and lava flooding

We studied north Tyrrhena Terra, an approximately 39,000 km2 area, located in the transition region straddling the Amenthes and Mare Tyrrhenum Mars Chart quadrangles 14 and 22, respectively. The study area comprises ancient terrains with infilled craters, ridges and valleys. Interpretation of orbiter data of ancient terrains is inherently difficult, but valuable information can be obtained using multiple datasets and analyzing various geological features. Using data from the High Resolution Stereo Camera on board Mars Express, complemented by Mars Global Surveyor MOLA DEM and MOC Narrow Angle datasets, we observed and interpreted surface morphologies at a scale suitable for geologic investigation. Morphometric examination of a 31 km diameter large impact crater indicated that tectonism and volcanism were responsible for its morphologic modification. Small impact crater depth/diameter relationships indicated that smooth surfaces of valleys are composed of highly consolidated material. Surface cracks and lobate fronts further suggested that the rocks are volcanic. Examination of tectonic features revealed that in the study area: a dominant NW-SE fabric is related to a ridge/bench-scarp-valley repetition consistent with synthetic and antithetic normal faulting; a NNW-SSE lineament represents the surface expression of normal faulting post-dating all other tectonic features. A weak NE-SW fabric is observable as small sublinear depressions, and at the contact between units internal to one large crater. One 20 km diameter crater in the study area was interpreted to be a caldera, infilled by thick volcanic rock layers. Identification of wrinkle ridges further indicated that thick layered lava flows infilled the main depressions of the study area. The available evidence suggests that the study area underwent multiple episodes of extension and volcanism. © 2007 Elsevier Inc. All rights reserved