Cancer Subclones Derived from the Patient's Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy.

Studying on subclonal evolution of cancer stem cells can help illustrate how the immune system recognizes tumor cells, leading to subclonal treatment by immune-based therapies. Here, we discuss that cancer subclones derived from the patient's head and neck squamous cell carcinoma tumor stem cells can be used for the screening of personalized antitumor immunotherapy and chemotherapy, to maximize benefits and to minimize the adversary effects, toward personalized or precision medicine. We propose a "wait-and-watch" scheme for monitoring a lifetime cancer stem cell subclonal development evolved with local environments to cancer

CAPTCHaStar! A novel CAPTCHA based on interactive shape discovery

Over the last years, most websites on which users can register (e.g., email providers and social networks) adopted CAPTCHAs (Completely Automated Public Turing test to tell Computers and Humans Apart) as a countermeasure against automated attacks. The battle of wits between designers and attackers of CAPTCHAs led to current ones being annoying and hard to solve for users, while still being vulnerable to automated attacks. In this paper, we propose CAPTCHaStar, a new image-based CAPTCHA that relies on user interaction. This novel CAPTCHA leverages the innate human ability to recognize shapes in a confused environment. We assess the effectiveness of our proposal for the two key aspects for CAPTCHAs, i.e., usability, and resiliency to automated attacks. In particular, we evaluated the usability, carrying out a thorough user study, and we tested the resiliency of our proposal against several types of automated attacks: traditional ones; designed ad-hoc for our proposal; and based on machine learning. Compared to the state of the art, our proposal is more user friendly (e.g., only some 35% of the users prefer current solutions, such as text-based CAPTCHAs) and more resilient to automated attacks.Comment: 15 page

A limited feedback scheme for massive MIMO systems based on principal component analysis

Massive multiple-input multiple-output (MIMO) is becoming a key technology for future 5G cellular networks. Channel feedback for massive MIMO is challenging due to the substantially increased dimension of the channel matrix. This motivates us to explore a novel feedback reduction scheme based on the theory of principal component analysis (PCA). The proposed PCA-based feedback scheme exploits the spatial correlation characteristics of the massive MIMO channel models, since the transmit antennas are deployed compactly at the base station (BS). In the proposed scheme, the mobile station (MS) generates a compression matrix by operating PCA on the channel state information (CSI) over a long-term period, and utilizes the compression matrix to compress the spatially correlated high-dimensional CSI into a low-dimensional representation. Then, the compressed low-dimensional CSI is fed back to the BS in a short-term period. In order to recover the high-dimensional CSI at the BS, the compression matrix is refreshed and fed back from MS to BS at every long-term period. The information distortion of the proposed scheme is also investigated and a closed-form expression for an upper bound to the normalized information distortion is derived. The overhead analysis and numerical results show that the proposed scheme can offer a worthwhile tradeoff between the system capacity performance and implementation complexity including the feedback overhead and codebook search complexit

New Z-cyclic triplewhist frames and triplewhist tournament designs

AbstractTriplewhist tournaments are a specialization of whist tournament designs. The spectrum for triplewhist tournaments on v players is nearly complete. It is now known that triplewhist designs do not exist for v=5,9,12,13 and do exist for all other v≡0,1(mod4) except, possibly, v=17. Much less is known concerning the existence of Z-cyclic triplewhist tournaments. Indeed, there are many open questions related to the existence of Z-cyclic whist designs. A (triple)whist design is said to be Z-cyclic if the players are elements in Zm∪A where m=v, A=∅ when v≡1(mod4) and m=v-1, A={∞} when v≡0(mod4) and it is further required that the rounds also be cyclic in the sense that the rounds can be labelled, say, R1,R2,… in such a way that Rj+1 is obtained by adding +1(modm) to every element in Rj. The production of Z-cyclic triplewhist designs is particularly challenging when m is divisible by any of 5,9,11,13,17. Here we introduce several new triplewhist frames and use them to construct new infinite families of triplewhist designs, many for the case of m being divisible by at least one of 5,9,11,13,17

Reinstated episodic context guides sampling-based decisions for reward.

How does experience inform decisions? In episodic sampling, decisions are guided by a few episodic memories of past choices. This process can yield choice patterns similar to model-free reinforcement learning; however, samples can vary from trial to trial, causing decisions to vary. Here we show that context retrieved during episodic sampling can cause choice behavior to deviate sharply from the predictions of reinforcement learning. Specifically, we show that, when a given memory is sampled, choices (in the present) are influenced by the properties of other decisions made in the same context as the sampled event. This effect is mediated by fMRI measures of context retrieval on each trial, suggesting a mechanism whereby cues trigger retrieval of context, which then triggers retrieval of other decisions from that context. This result establishes a new avenue by which experience can guide choice and, as such, has broad implications for the study of decisions

Determination of incommensurate modulated structure in Bi2Sr1.6La0.4CuO6+{\delta} by aberration-corrected transmission electron microscopy

Incommensurate modulated structure (IMS) in Bi2Sr1.6La0.4CuO6+{\delta} (BSLCO) has been studied by aberration corrected transmission electron microscopy in combination with high-dimensional (HD) space description. Two images in the negative Cs imaging (NCSI) and passive Cs imaging (PCSI) modes were deconvoluted, respectively. Similar results as to IMS have been obtained from two corresponding projected potential maps (PPMs), but meanwhile the size of dots representing atoms in the NCSI PPM is found to be smaller than that in PCSI one. Considering that size is one of influencing factors of precision, modulation functions for all unoverlapped atoms in BSLCO were determined based on the PPM obtained from the NCSI image in combination with HD space description

Two-phase equilibrium and molecular hydrogen formation in damped Lyman-alpha systems

Molecular hydrogen is quite underabundant in damped Lyman-alpha systems at high redshift, when compared to the interstellar medium near the Sun. This has been interpreted as implying that the gas in damped Lyman-alpha systems is warm. like the nearby neutral intercloud medium, rather than cool, as in the clouds which give rise to most H I absorption in the Milky Way. Other lines of evidence suggest that the gas in damped Lyman-alpha systems -- in whole or part -- is actually cool; spectroscopy of neutral and ionized carbon, discussed here, shows that the damped Lyman-alpha systems observed at lower redshift z $$ 2.8 are warm (though not devoid of H2). To interpret the observations of carbon and hydrogen we constructed detailed numerical models of H2 formation under the conditions of two-phase thermal equilibrium, like those which account for conditions near the Sun, but with varying metallicity, dust-gas ratio, $etc$. We find that the low metallicity of damped Lyman-alpha systems is enough to suppress H2 formation by many orders of magnitude even in cool diffuse clouds, as long as the ambient optical/uv radiation field is not too small. For very low metallicity and under the most diffuse conditions, H2 formation will be dominated by slow gas-phase processes not involving grains, and a minimum molecular fraction in the range $10^{-8}-10^{-7}$ is expected.Comment: 13 pages, 7 figures; accepted 2002-04-30 by Astronomy and Astrophysic

Turbulence in Clusters of Galaxies and X-Ray Line Profiles

Large-scale bulk motions and hydrodynamic turbulence in the intergalactic gas inside clusters of galaxies significantly broaden X-ray emission lines. For lines of heavy ions (primarily helium-like and hydrogen-like iron ions), the hydrodynamic broadening is significantly larger than the thermal broadening. Since cluster of galaxies have a negligible optical depth for resonant scattering in forbidden and intercombination lines of these ions, these lines are not additionally broadened. At the same time, they are very intense, which allows deviations of the spectrum from the Gaussian spectrum in the line wings to be investigated. The line shape becomes an important indicator of bulk hydrodynamic processes because the cryogenic detectors of new generation of X-ray observatories will have a high energy resolution (from 5 eV for ASTRO-E2 to 1-2 eV for Constellation-X and XEUS). We use the spectral representation of a Kolmogorov cascade in the inertial range to calculate the characteristic shapes of X-ray lines. Significant deviations in the line profiles from the Gaussian profile (shape asymmetry, additional peaks, sharp breaks in the exponential tails) are expected for large-scale turbulence. The kinematic SZ effect and the X-ray line profile carry different information about the hydrodynamic velocity distribution in clusters of galaxies and complement each other, allowing the redshift, the peculiar velocity of the cluster, and the bulk velocity dispersion to be measured and separatedComment: 29 pages, 12 figures, Astronomy Letters 2003, v.29, p.79