No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international study.

The multicenter international Society for Immunotherapy of Cancer (SITC) study of the consensus Immunoscore demonstrated the prediction of survival and response to chemotherapy in 763 Stage III colon cancer (CC) patients. Similar Immunoscore groups were found in elderly patients, and densities of immune cells and intratumoral T-cell repertoire were not decreasing with age in the tumor microenvironment. In two independent cohorts, Immunoscore significantly predicted time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS), including within high-risk (T4 or N2) and low-risk (T1-3, N1) patients. In stratified Cox multivariable analysis for TTR, DFS, and OS, Immunoscore\u27s association to outcomes was independent of the patient\u27s age, sidedness, gender, T-stage, N-stage, and microsatellite instability status. Furthermore, the relative contribution to the risk test showed that Immunoscore had the highest contribution to survival. Importantly Immunoscore predicted the likelihood of response to chemotherapy. Only patients with a high-Immunoscore significantly benefited from chemotherapy. The prognostic value of Immunoscore was confirmed in two independent phase 3 clinical trials (NCCTG-N0147, n = 559; Prodige-IDEA, n = 1062). Moreover, results from IDEA phase 3 randomized trial revealed the predictive value of Immunoscore for response to adjuvant FOLFOX chemotherapy duration. The latest edition of the WHO Digestive System Tumors classification introduced the immune response as measured by Immunoscore as essential and desirable diagnostic criteria for CC, and Immunoscore was introduced into the 2020 ESMO Clinical Practice Guidelines for CC to refine the prognosis and adjust chemotherapy decision-making process in stages II and III patients. These results highlight the clinical utility of Immunoscore

Phytosociological surveys: tools for weed science?

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Toward integrative cancer immunotherapy: targeting the tumor microenvironment

The development of cancer has historically been attributed to genomic alterations of normal host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the transformed cells themselves. There is now widespread appreciation that the progressive growth and metastatic spread of cancer cells requires the cooperation of normal host cells (endothelial cells, fibroblasts, other mesenchymal cells, and immune cells), both local to, and at sites distant from, the site at which malignant transformation occurs. It is the balance of these cellular interactions that both determines the natural history of the cancer, and influences its response to therapy. This active tumor-host dynamic has stimulated interest in the tumor microenvironment as a key target for both cancer diagnosis and therapy. Recent data has demonstrated both that the presence of CD8+ T cells within a tumor is associated with a good prognosis, and that the eradication of all malignantly transformed cells within a tumor requires that the intra-tumoral concentration of cytolytically active CD8+ effector T cells remain above a critical concentration until every tumor cell has been killed. These findings have stimulated two initiatives in the field of cancer immunotherapy that focus on the tumor microenvironment. The first is the development of the immune score as part of the routine diagnostic and prognostic evaluation of human cancers, and the second is the development of combinatorial immune-based therapies that reduce tumor-associated immune suppression to unleash pre-existing or therapeutically-induced tumor immunity. In support of these efforts, the Society for the Immunotherapy of Cancer (SITC) is sponsoring a workshop entitled "Focus on the Target: The Tumor Microenvironment" to be held October 24-25, 2012 in Bethesda, Maryland. This meeting should support development of the immune score, and result in a position paper highlighting opportunities for the development of integrative cancer immunotherapies that sculpt the tumor microenvironment to promote definitive tumor rejection

Resposta de Borreria latifolia e Richardia brasiliensis a doses do herbicida glyphosate em pós-emergência.

O objetivo deste trabalho foi avaliar e ajustar a resposta de plantas de ervaquente (Borreria latifolia) e poaia-branca (Richardia brasiliensis) a diferentes concentrações do herbicida glyphosate. O estudo foi desenvolvido em casa-de-vegetação, arranjado em delineamento inteiramente casualizado com quatro repetições. Foram avaliadas nove concentrações de do herbicida glyphosate (0, 43, 73, 124, 211, 360, 612, 1040 e 1768 g e.a. ha-1) para o controle de Borreria latifolia e Richardia brasiliensis. Realizou-se avaliações de controle aos 14 e 28 dias após a aplicação (DAA) e massa da parte aérea seca. Com os resultados obtidos, evidenciou-se controle satisfatório para as duas espécies estudadas com o emprego da dose 612 g e.a. ha-1. Em decorrência ao maior controle de erva-quente e poaia-branca, observou-se também uma maior redução da MPAS atingindo aproximadamente 100% com o emprego da dose de 1040 g e.a. ha-1

Resposta de biótipos de Borreria latifolia do Sudoeste do Paraná e Norte de Santa Catarina ao herbicida glyphosate.

A erva-quente (Borreria latifolia) tem sido uma das principais espécies selecionadas pelo herbicida glyphosate em lavoura de soja nos estados do Paraná e Santa Catarina. O objetivo deste trabalho foi avaliar a resposta de biótipos de ervaquente ao glyphosate. O experimento foi realizado em casa de vegetação, em delineamento experimental completamente casualizado, com quatro repetições. Os tratamentos constituíram-se de doses crescentes de glyphosate (0, 74, 163, 360, 792 e 1742 g e.a. ha-1), aplicadas sobre quatorze biótipos de erva-quente oriundos de lavouras de soja RR do Sudoeste do Paraná e Norte de Santa Catarina. Foram avaliados o controle e a massa da parte aérea seca (MPAS). Os resultados indicam variabilidade de resposta ao glyphosate entre os biótipos coletados. Os biótipos 277, 283 e 300 não foram controlados com dose acima da usualmente utilizada nas lavouras, evidenciando seleção pelo uso repetitivo de herbicida

Efeito das épocas de semeadura sobre os componentes biológicos de sorgo sacarino.

A época da semeadura do sorgo sacarino define várias características biológicas que influenciam no potencial produtivo. Com isto, o objetivo deste trabalho foi comparar o efeito de épocas de semeaduras sobre os componentes biológicos de duas cultivares (CMSXS 647 e BRS 506). Os experimentos foram realizados no município de Sinop/MT. As cultivares foram semeadas, durante dois anos agrícolas, 2011/2012 e 2012/13, nos meses de outubro, novembro, dezembro, janeiro, fevereiro e março. O delineamento experimental adotado foi blocos ao acaso, em parcelas subdivididas, com quatro repetições. No ano 2011/12, novembro e dezembro se caracterizaram como a melhor época de rendimento de colmos e a melhor cultivar foi a CMSXS 647. Já no ano agrícola 2012/13 as cultivares apresentaram rendimento bastante similar, caracterizando março como o mês de pior produtividade de massa verde. A produtividade de caldo apresentou comportamento decrescente com o avançar das datas de semeadura. CMSXS 647, de uma maneira geral, se caracterizou por apresentar melhor rendimento do que BRS 506, ao longo dos períodos de semeadura. Já os sólidos solúveis totais são maiores para as semeaduras tardias em março, do que para as precoces realizadas em outubro/novembro

Protophobic Fifth-Force Interpretation of the Observed Anomaly in \u3csup\u3e8\u3c/sup\u3eBe Nuclear Transitions

Recently a 6.8σ anomaly has been reported in the opening angle and invariant mass distributions of e+e− pairs produced in 8Be nuclear transitions. The data are explained by a 17 MeV vector gauge boson X that is produced in the decay of an excited state to the ground state, 8Be∗ → 8Be X, and then decays through X → e+e−. The X boson mediates a fifth force with a characteristic range of 12 fm and has millicharged couplings to up and down quarks and electrons, and a proton coupling that is suppressed relative to neutrons. The protophobic X boson may also alleviate the current 3.6σ discrepancy between the predicted and measured values of the muon’s anomalous magnetic moment

Protophobic Fifth-Force Interpretation of the Observed Anomaly in \u3csup\u3e8\u3c/sup\u3eBe Nuclear Transitions

Recently a 6.8σ anomaly has been reported in the opening angle and invariant mass distributions of e+e− pairs produced in 8Be nuclear transitions. The data are explained by a 17 MeV vector gauge boson X that is produced in the decay of an excited state to the ground state, 8Be∗ → 8Be X, and then decays through X → e+e−. The X boson mediates a fifth force with a characteristic range of 12 fm and has millicharged couplings to up and down quarks and electrons, and a proton coupling that is suppressed relative to neutrons. The protophobic X boson may also alleviate the current 3.6σ discrepancy between the predicted and measured values of the muon’s anomalous magnetic moment

Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer

<b>Background</b>: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer. <b>Methods</b>: Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jass’ and Klintrup’s criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time. <b>Results</b>: Low-grade inflammatory infiltrate assessed using Klintrup’s criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n = 179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin. <b>Conclusion</b>: Assessment of inflammatory infiltrate using Klintrup’s criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth