Electromagnetic Force in Dispersive and Transparent Media

A hydrodynamic-type, macroscopic theory was set up recently to simultaneously account for dissipation and dispersion of electromagnetic field, in nonstationary condensed systems of nonlinear constitutive relations~\cite{JL}. Since it was published in the letter format, some algebra and the more subtle reasonings had to be left out. Two of the missing parts are presented in this paper: How algebraically the new results reduce to the known old ones; and more thoughts on the range of validity of the new theory, especially concerning the treatment of dissipation.Comment: 10 pages, 0 figur

Relativistic ponderomotive force, uphill acceleration, and transition to chaos

Starting from a covariant cycle-averaged Lagrangian the relativistic oscillation center equation of motion of a point charge is deduced and analytical formulae for the ponderomotive force in a travelling wave of arbitrary strength are presented. It is further shown that the ponderomotive forces for transverse and longitudinal waves are different; in the latter, uphill acceleration can occur. In a standing wave there exists a threshold intensity above which, owing to transition to chaos, the secular motion can no longer be described by a regular ponderomotive force. PACS number(s): 52.20.Dq,05.45.+b,52.35.Mw,52.60.+hComment: 8 pages, RevTeX, 3 figures in PostScript, see also http://www.physik.th-darmstadt.de/tqe

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs

A NEW X-RAY AMPLIFIER PUMPED BY THE KINETIC ENERGY OF CLUSTERS

A new type of laser amplifier with high gain (80%) and high amplification in the visible and ultraviolet range will still provide sufficient amplification for wavelengths of 100 Angstroms or less by a sequence of injections of energetic solid particles (pellets or clusters). Based on the experimental fact that electrons are laterally emitted from the focus of a laser a free electron laser amplifier was proposed based on the inversion of this experiment. That consists in converting translational electron into optical and oscillation energy of the laser beam. An energy transfer can be expected only from the transient processes of laser pulses. The generalization of this free electron laser towards the injection of solid clusters or dust particles with synchronized and calibrated high kinetic energies and other diffraction properties leads to a very highly efficient (80%) laser with high gain even in the x-ray range. The transient switching process is then extended to the conditions of high density plasma clouds produced from the injected solid particles. In combination with this switching, it is the inversion of the ejection of plasma from the beam axis at nonlinear (ponderomotive) force self-focusing. The processes of the momentum transfer are then well understood and the deformation of phase fronts in plasma can be used for controlled bending, or focusing of x-ray beams, or for correcting of other insufficient beam quality. A proof of principle experiment is discussed