"The European Community and Japan: Bi(tri)lateral Trade in World Context"

This paper first examines the institutional context of EC trade policy and assesses the real level of protection that policy has afforded. It then examines the question of how "common" the policy has in fact been and how it has related to competition policy, devoting a special section to the Common Agricultural Policy (CAP). The next two sections discuss crucial issues in the trilateral relationship between the EC, Japan, and the US by focusing on the manufacturing sectors of electronics and cars. In shifting the perspective towards the future this paper focuses first on the concept of "strategic trade policy" and then at the special issues raised by the reform process that "1992 has brought, if it has, in Eastern Europe. The paper ends by posing two fundamental and interrelated questions. Has "1992" brought the European Community closer to the rest of the world? And what is the future position of Europe in the international division of labor

Adaptive virtual MIMO single cluster optimization in a small cell

Adaptive Virtual MIMO optimized in a single cluster of small cells is shown in this paper to achieve near Shannon channel capacity when operating with partial or no Channel State Information. Although, access links have enormously increased in the recent years, the operational system complexity remains linear regardless of the number of access nodes in the system proposed. Adaptive Virtual MIMO optimized in a single cluster performs a theoretical information spectral efficiency, almost equal to that of the upper bounds of a typical mesh network, up to 43 bits/s/Hz at a SNR of 30dB while the BER performance remains impressively low hitting the 10−6 at an SNR of about 13 dB when the theoretical upper bound of an ideal small cell mesh network achieves the 10−6 at a SNR of 12.5 dB. In addition, in a sub-optimum channel condition, the channel capacity and BER performance of the proposed solution is shown to drastically delay saturation even for the very high SNR

Enhancing BER performance limit of BCH and RS codes using multipath diversity

Modern wireless communication systems suffer from phase shifting and, more importantly, from interference caused by multipath propagation. Multipath propagation results in an antenna receiving two or more copies of the signal sequence sent from the same source but that has been delivered via different paths. Multipath components are treated as redundant copies of the original data sequence and are used to improve the performance of forward error correction (FEC) codes without extra redundancy, in order to improve data transmission reliability and increase the bit rate over the wireless communication channel. For a proof of concept Bose, Ray-Chaudhuri, and Hocquenghem (BCH) and Reed-Solomon (RS) codes have been used as FEC to compare their bit error rate (BER) performances. The results showed that the wireless multipath components significantly improve the performance of FEC. Furthermore, FEC codes with low error correction capability and employing the multipath phenomenon are enhanced to perform better than FEC codes which have a bit higher error correction capability and did not utilise the multipath. Consequently, the bit rate is increased, and communication reliability is improved without extra redundancy

TEACHERS’ SELF-DETERMINED MOTIVATION IN RELATION TO NON-TEACHING WORK TASKS

The present article reports on two studies (pilot and main) aiming to examine the psychometric properties of two scales assessing (a) teachers’ work motivation and (b) their involvement in non-teaching work tasks, and to explore the associations between the two constructs under the theoretical framework of self-determination theory (SDT). A Greek version of Blais’ Work Motivation Inventory (BWMI-TGr) was adapted for teachers, and a new instrument measuring teacher behaviour relevant to non-teaching work tasks was developed. Rigorous analyses supported the construct validity and internal consistency of the scales used. The findings suggested that teachers’ intrinsic motivation presents the most optimal patterns of relationships with non-teaching work behaviours, such as preparation for teaching, professional training, education-related reading, collaboration with parents, and participation in the school’s cultural activities. Identified and introjected regulations exhibited positive relationships only with teacher involvement in cultural activities, whereas external regulation had no positive relationship with non-teaching work tasks. The findings are discussed through the lens of SDT and strategies are proposed for school climate improvements, which target the cultivation of teachers’ intrinsic motivation at work.  Article visualizations

Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance

Contains fulltext : 169891.pdf (publisher's version ) (Open Access)Activation of inflammatory pathways is known to accompany development of obesity-induced non-alcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutrophil serine proteases proteinase 3, neutrophil elastase and cathepsin G are able to process the inactive pro-inflammatory mediators IL-1beta and IL-18 to their bioactive forms, thereby regulating inflammatory responses. In the present study, we investigated whether proteinase 3 is involved in obesity-induced development of insulin resistance and NAFLD. We investigated the development of NAFLD and insulin resistance in mice deficient for neutrophil elastase/proteinase 3 and neutrophil elastase/cathepsin G and in wild-type mice treated with the neutrophil serine proteinase inhibitor human alpha-1 antitrypsin. Expression profiling of metabolically relevant tissues obtained from insulin resistant mice showed that expression of proteinase 3 was specifically upregulated in the liver, whereas neutrophil elastase, cathepsin G and caspase-1 were not. Neutrophil elastase/proteinase 3 deficient mice showed strongly reduced levels of lipids in the liver after fed a high fat diet. Moreover, these mice were resistant to high fat diet-induced weight gain, inflammation and insulin resistance. Injection of proteinase 3 exacerbated insulin resistance in caspase-1(-/-) mice, indicating that proteinase 3 acts independently of caspase-1. Treatment with alpha-1 antitrypsin during the last 10 days of a 16 week high fat diet reduced hepatic lipid content and decreased fasting glucose levels. We conclude that proteinase 3 is involved in NAFLD and insulin resistance and that inhibition of proteinase 3 may have therapeutic potential

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix molecule responsible for vessel compression because of its swelling behaviour. Here we show, unexpectedly, that hyaluronan compresses vessels only in collagen-rich tumours, suggesting that collagen and hyaluronan together are critical targets for decompressing tumour vessels. We demonstrate that the angiotensin inhibitor losartan reduces stromal collagen and hyaluronan production, associated with decreased expression of profibrotic signals TGF-β1, CCN2 and ET-1, downstream of angiotensin-II-receptor-1 inhibition. Consequently, losartan reduces solid stress in tumours resulting in increased vascular perfusion. Through this physical mechanism, losartan improves drug and oxygen delivery to tumours, thereby potentiating chemotherapy and reducing hypoxia in breast and pancreatic cancer models. Thus, angiotensin inhibitors—inexpensive drugs with decades of safe use—could be rapidly repurposed as cancer therapeutics.National Cancer Institute (U.S.) (Grant P01-CA080124)National Cancer Institute (U.S.) (Grant R01-CA126642)National Cancer Institute (U.S.) (Grant R01-CA085140)National Cancer Institute (U.S.) (Grant R01-CA115767)National Cancer Institute (U.S.) (Grant R01-CA098706)United States. Dept. of Defense. Breast Cancer Research Program (Innovator Award W81XWH-10-1-0016)Lustgarten Foundation (Dana-Farber Cancer Institute/David H. Koch Institute for Integrative Cancer Research at MIT Bridge Project Grant

A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction.

Exposure to β-Ν-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. Analytical chemistry plays a crucial role in determining human BMAA exposure and the associated health risk, but the performance of various analytical methods currently employed is rarely compared. A CYANOCOST initiated workshop was organized aimed at training scientists in BMAA analysis, creating mutual understanding and paving the way towards interlaboratory comparison exercises. During this workshop, we tested different methods (extraction followed by derivatization and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis, or directly followed by LC-MS/MS analysis) for trueness and intermediate precision. We adapted three workup methods for the underivatized analysis of animal, brain and cyanobacterial samples. Based on recovery of the internal standard D3BMAA, the underivatized methods were accurate (mean recovery 80%) and precise (mean relative standard deviation 10%), except for the cyanobacterium Leptolyngbya. However, total BMAA concentrations in the positive controls (cycad seeds) showed higher variation (relative standard deviation 21%-32%), implying that D3BMAA was not a good indicator for the release of BMAA from bound forms. Significant losses occurred during workup for the derivatized method, resulting in low recovery ( < 10%). Most BMAA was found in a trichloroacetic acid soluble, bound form and we recommend including this fraction during analysis

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery