Hybrid Manufacturing Processes Used in the Production of Complex Parts: A Comprehensive Review

Additive manufacturing is defined as a process based on the superposition of layers of materials in order to obtain 3D parts; however, the process does not allow achieve the adequate and necessary surface finishing. In addition, with the development of new materials with superior properties, some of them acquire high hardness and strength, consequently decreasing their ability to be machined. To overcome this shortcoming, a new technology assembling additive and subtractive processes, was developed and implemented. In this process, the additive methods are integrated into a single machine with subtractive processes, often called hybrid manufacturing. The additive manufacturing process is used to produce the part with high efficiency and flexibility, whilst machining is then triggered to give a good surface finishing and dimensional accuracy. With this, and without the need to transport the part from one machine to another, the manufacturing time of the part is reduced, as well as the production costs, since the waste of material is minimized, with the additive–subtractive integration. This work aimed to carry out an extensive literature review regarding additive manufacturing methods, such as binder blasting, directed energy deposition, material extrusion, material jetting, powder bed fusion, sheet laminating and vat polymerization, as well as machining processes, studying the additive-subtractive integration, in order to analyze recent developments in this area, the techniques used, and the results obtained. To perform this review, ScienceDirect, Web of Knowledge and Google Scholar were used as the main source of information because they are powerful search engines in science information. Specialized books have been also used, as well as several websites. The main keywords used in searching information were: “CNC machining”, “hybrid machining”, “hybrid manufacturing”, “additive manufacturing”, “high-speed machining” and “post-processing”. The conjunction of these keywords was crucial to filter the huge information currently available about additive manufacturing. The search was mainly focused on publications of the current century. The work intends to provide structured information on the research carried out about each one of the two considered processes (additive manufacturing and machining), and on how these developments can be taken into consideration in studies about hybrid machining, helping researchers to increase their knowledge in this field in a faster way. An outlook about the integration of these processes is also performed. Additionally, a SWOT analysis is also provided for additive manufacturing, machining and hybrid manufacturing processes, observing the aspects inherent to these technologies.The present work was done and funded under the scope of the projects ON-SURF (ANI | P2020 | POCI-01-0247-FEDER-024521 and MCTool21 “Manufacturing of cutting tools for the 21st century: from nano-scale material design to numerical process simulation” (ref.: “POCI-01-0247- FEDER-045940”) co-funded by Portugal 2020 and FEDER, through COMPETE 2020-Operational Programme for Competitiveness and Internationalisation. This work is also sponsored by FEDER National funds FCT under the project CEMMPRE ref. “UIDB/00285/2020”. F.J.G. Silva also thanks INEGI-Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Indústria due to its support.info:eu-repo/semantics/publishedVersio

Effects of gamma irradiation on instream leaf litter decomposition

Leaf litter decomposition is a key process in stream ecosystems, the rates of which can vary with changes in litter quality or its colonization by microorganisms. Decomposition in streams is increasingly used to compare ecosystem functioning globally, often requiring the distribution of litter across countries. It is important to understand whether litter sterilization, which is required by some countries, can alter the rates of decomposition and associated processes. We examined whether litter sterilization with gamma irradiation (25 kGy) influenced decomposition rates, litter stoichiometry, and colonization by invertebrates after weeks of instream incubation within coarse-mesh and fine-mesh litterbags. We used nine plant species from three families that varied widely in litter chemistry but found mostly consistent responses, with no differences in decomposition rates or numbers of invertebrates found at the end of the incubation period. However, litter stoichiometry differed between irradiated and control litter, with greater nutrient losses (mostly phosphorus) in the former. Therefore, the effects of irradiation on litter chemistry should be taken into account in studies focused on stoichiometry but not necessarily in those focused on decomposition rates, at least within the experimental timescale considered here

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

AIMS/HYPOTHESIS: Beta cell function in type 1 diabetes is commonly assessed as the average plasma C-peptide concentration over 2 h following a mixed-meal test (CPAVE). Monitoring of disease progression and response to disease-modifying therapy would benefit from a simpler, more convenient and less costly measure. Therefore, we determined whether CPAVE could be reliably estimated from routine clinical variables. METHODS: Clinical and fasting biochemical data from eight randomised therapy trials involving participants with recently diagnosed type 1 diabetes were used to develop and validate linear models to estimate CPAVE and to test their accuracy in estimating loss of beta cell function and response to immune therapy. RESULTS: A model based on disease duration, BMI, insulin dose, HbA1c, fasting plasma C-peptide and fasting plasma glucose most accurately estimated loss of beta cell function (area under the receiver operating characteristic curve [AUROC] 0.89 [95% CI 0.87, 0.92]) and was superior to the commonly used insulin-dose-adjusted HbA1c (IDAA1c) measure (AUROC 0.72 [95% CI 0.68, 0.76]). Model-estimated CPAVE (CPEST) reliably identified treatment effects in randomised trials. CPEST, compared with CPAVE, required only a modest (up to 17%) increase in sample size for equivalent statistical power. CONCLUSIONS/INTERPRETATION: CPEST, approximated from six variables at a single time point, accurately identifies loss of beta cell function in type 1 diabetes and is comparable to CPAVE for identifying treatment effects. CPEST could serve as a convenient and economical measure of beta cell function in the clinic and as a primary outcome measure in trials of disease-modifying therapy in type 1 diabetes

ANÁLISE PARAMÉTRICA DO COMPORTAMENTO DE ELEMENTOS DE MEMBRANA APLICADA A ESTRUTURAS DE CONCRETO ARMADO VIA CONFIABILIDADE ESTRUTURAL

A importância do conhecimento do nível de segurança de uma estrutura é crucial para a realização de um bom projeto estrutural. Este artigo tem como objetivo fazer uma análise paramétrica em elementos de membrana de estruturas de concreto armado via confiabilidade estrutural. Para obtenção do nível de segurança do elemento de membrana o método de simulação de Monte Carlo foi utilizado. Uma variação determinística nos carregamentos aplicados sobre o elemento de membrana é feita e a contribuição de cada modo de falha considerada, obtendo-se assim, o índice de confiabilidade e sua variação com determinados parâmetros de projeto. Por meio de uma análise comparativa, ilustrada graficamente, o trabalho mostra diferentes casos de carregamentos no elemento de membrana, ocasionando modos de falhas distintos em cada situação. Os modos de falha estudados podem ser o escoamento do aço na direção x e/ou y, esmagamento do concreto e a falha do sistema como um todo. A presente metodologia tem como resultado principal o “controle”, pelo projetista, do nível de ductilidade de cada elemento de membrana e sua relação com os tipos possíveis de carregamentos atuantes. É possível, assim, obter o escoamento da armadura anteriormente ao esmagamento do concreto na maioria dos casos de carregamento

Avaliação probabilística do nível de segurança e durabilidade de estruturas existentes em concreto armado com base em inspeções/ Probabilistic assessment of the safety and durability level of existing reinforced concrete structures based on inspections

O estudo de estruturas existentes é um desafio, visando fornecer técnicas de análise e cálculo que estejam próximos ao real contexto do desempenho que a estrutura e seus componentes se encontram. Este artigo aponta uma metodologia probabilística que associa uma análise de confiabilidade a um processo de inspeções e avaliações em estrutura existente de concreto armado. A investigação dos danos presentes nos elementos da estrutura acontece em fases, chegando-se a um nível de degradação para a realização de uma avaliação estrutural. Primeiramente deve ser feita uma inspeção visual com registro das condições de uso da estrutura e das patologias existentes. Para complementar os dados da inspeção, ensaios in situ ou em laboratório devem ser realizados. Através de uma metodologia, avalia-se a gravidade dos danos na estrutura e seu processo de degradação. Assim, é proposto um acoplamento dos níveis de segurança da estrutura, por confiabilidade, à um modelo de integridade de sua deterioração. A metodologia proposta viabiliza um diagnóstico dos processos de degradação e indica o nível de segurança da estrutura e seus componentes. Logo, é possível entender o funcionamento do sistema e prever possíveis comportamentos da estrutura. Um reservatório em concreto armado será utilizado como exemplo

In silico assessment of the bone regeneration potential of complex porous scaffolds

Mechanical environment plays a crucial role in regulating bone regeneration in bone defects. Assessing the mechanobiological behavior of patient-specific orthopedic scaffolds in-silico could help guide optimal scaffold designs, as well as intra- and post-operative strategies to enhance bone regeneration and improve implant longevity. Additively manufactured porous scaffolds, and specifically triply periodic minimal surfaces (TPMS), have shown promising structural properties to act as bone substitutes, yet their ability to induce mechanobiologially-driven bone regeneration has not been elucidated. The aim of this study is to i) explore the bone regeneration potential of TPMS scaffolds made of different stiffness biocompatible materials, to ii) analyze the influence of pre-seeding the scaffolds and increasing the post-operative resting period, and to iii) assess the influence of patient-specific parameters, such as age and mechanosensitivity, on outcomes. To perform this study, an in silico model of a goat tibia is used. The bone ingrowth within the scaffold pores was simulated with a mechano-driven model of bone regeneration. Results showed that the scaffold's architectural properties affect cellular diffusion and strain distribution, resulting in variations in the regenerated bone volume and distribution. The softer material improved the bone ingrowth. An initial resting period improved the bone ingrowth but not enough to reach the scaffold's core. However, this was achieved with the implantation of a pre-seeded scaffold. Physiological parameters like age and health of the patient also influence the bone regeneration outcome, though to a lesser extent than the scaffold design. This analysis demonstrates the importance of the scaffold's geometry and its material, and highlights the potential of using mechanobiological patient-specific models in the design process for bone substitutes

Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development.

It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination. Here we aimed to identify novel transchromosomal interactions in immune cells by high-resolution genome-wide chromosome conformation capture. Although we readily identified stable interactions in cis, and also between centromeres and telomeres on different chromosomes, surprisingly we identified no gene regulatory transchromosomal interactions in either mouse or human cells, including previously described interactions. We suggest that advances in the chromosome conformation capture technique and the unbiased nature of this approach allow more reliable capture of interactions between chromosomes than previous methods. Overall our findings suggest that stable transchromosomal interactions that regulate gene expression are not present in mammalian immune cells and that lineage identity is governed by cis, not trans chromosomal interactions