Rigorous steps towards holography in asymptotically flat spacetimes

Scalar QFT on the boundary $\Im^+$ at null infinity of a general asymptotically flat 4D spacetime is constructed using the algebraic approach based on Weyl algebra associated to a BMS-invariant symplectic form. The constructed theory is invariant under a suitable unitary representation of the BMS group with manifest meaning when the fields are interpreted as suitable extensions to $\Im^+$ of massless minimally coupled fields propagating in the bulk. The analysis of the found unitary BMS representation proves that such a field on $\Im^+$ coincides with the natural wave function constructed out of the unitary BMS irreducible representation induced from the little group $\Delta$, the semidirect product between SO(2) and the two dimensional translational group. The result proposes a natural criterion to solve the long standing problem of the topology of BMS group. Indeed the found natural correspondence of quantum field theories holds only if the BMS group is equipped with the nuclear topology rejecting instead the Hilbert one. Eventually some theorems towards a holographic description on $\Im^+$ of QFT in the bulk are established at level of $C^*$ algebras of fields for strongly asymptotically predictable spacetimes. It is proved that preservation of a certain symplectic form implies the existence of an injective $*$-homomorphism from the Weyl algebra of fields of the bulk into that associated with the boundary $\Im^+$. Those results are, in particular, applied to 4D Minkowski spacetime where a nice interplay between Poincar\'e invariance in the bulk and BMS invariance on the boundary at $\Im^+$ is established at level of QFT. It arises that the $*$-homomorphism admits unitary implementation and Minkowski vacuum is mapped into the BMS invariant vacuum on $\Im^+$.Comment: 62 pages, amslatex, xy package; revised section 2 and the conclusions; corrected some typos; added some references; accepted for pubblication on Rev. Math. Phy

Axion gauge symmetries and generalized Chern-Simons terms in N=1 supersymmetric theories

We compute the form of the Lagrangian of N=1 supersymmetric theories with gauged axion symmetries. It turns out that there appear generalized Chern-Simons terms that were not considered in previous superspace formulations of general N=1 theories. Such gaugings appear in supergravities arising from flux compactifications of superstrings, as well as from Scherk-Schwarz generalized dimensional reduction in M-theory. We also present the dual superspace formulation where axion chiral multiplets are dualized into linear multiplets.Comment: References added and few misprints correcte

New Gauged N=8, D=4 Supergravities

New gaugings of four dimensional N=8 supergravity are constructed, including one which has a Minkowski space vacuum that preserves N=2 supersymmetry and in which the gauge group is broken to $SU(3)xU(1)^2$. Previous gaugings used the form of the ungauged action which is invariant under a rigid $SL(8,R)$ symmetry and promoted a 28-dimensional subgroup ($SO(8),SO(p,8-p)$ or the non-semi-simple contraction $CSO(p,q,8-p-q)$) to a local gauge group. Here, a dual form of the ungauged action is used which is invariant under $SU^*(8)$ instead of $SL(8,R)$ and new theories are obtained by gauging 28-dimensional subgroups of $SU^*(8)$. The gauge groups are non-semi-simple and are different real forms of the $CSO(2p,8-2p)$ groups, denoted $CSO^*(2p,8-2p)$, and the new theories have a rigid SU(2) symmetry. The five dimensional gauged N=8 supergravities are dimensionally reduced to D=4. The $D=5,SO(p,6-p)$ gauge theories reduce, after a duality transformation, to the $D=4,CSO(p,6-p,2)$ gauging while the $SO^*(6)$ gauge theory reduces to the $D=4, CSO^*(6,2)$ gauge theory. The new theories are related to the old ones via an analytic continuation. The non-semi-simple gaugings can be dualised to forms with different gauge groups.Comment: 33 pages. Reference adde

The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana

To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 × 10−9 base substitutions per site per generation, the majority of which are G:C→A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light–induced mutagenesis

Towards the clinical implementation of pharmacogenetics in bipolar disorder.

BackgroundBipolar disorder (BD) is a psychiatric illness defined by pathological alterations between the mood states of mania and depression, causing disability, imposing healthcare costs and elevating the risk of suicide. Although effective treatments for BD exist, variability in outcomes leads to a large number of treatment failures, typically followed by a trial and error process of medication switches that can take years. Pharmacogenetic testing (PGT), by tailoring drug choice to an individual, may personalize and expedite treatment so as to identify more rapidly medications well suited to individual BD patients.DiscussionA number of associations have been made in BD between medication response phenotypes and specific genetic markers. However, to date clinical adoption of PGT has been limited, often citing questions that must be answered before it can be widely utilized. These include: What are the requirements of supporting evidence? How large is a clinically relevant effect? What degree of specificity and sensitivity are required? Does a given marker influence decision making and have clinical utility? In many cases, the answers to these questions remain unknown, and ultimately, the question of whether PGT is valid and useful must be determined empirically. Towards this aim, we have reviewed the literature and selected drug-genotype associations with the strongest evidence for utility in BD.SummaryBased upon these findings, we propose a preliminary panel for use in PGT, and a method by which the results of a PGT panel can be integrated for clinical interpretation. Finally, we argue that based on the sufficiency of accumulated evidence, PGT implementation studies are now warranted. We propose and discuss the design for a randomized clinical trial to test the use of PGT in the treatment of BD

Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice

Background: In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear. Methodology/Principal Findings: In this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation. Conclusion/Significance: These findings suggest that the continuous production of adult-generated neurons is involved i

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellular correlate for learning and memory. Early LTP (eLTP, <1 hour) had initially been explained either by presynaptic increases in glutamate release or by direct modification of post-synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) function. Compelling models have more recently proposed that synaptic potentiation can occur by the recruitment of additional post-synaptic AMPARs, sourced either from an intracellular reserve pool by exocytosis or from nearby extra synaptic receptors pre-existing on the neuronal surface. However, the exact mechanism through which synapses can rapidly recruit new AMPARs during eLTP is still unknown. In particular, direct evidence for a pivotal role of AMPAR surface diffusion as a trafficking mechanism in synaptic plasticity is still lacking. Using AMPAR immobilization approaches, we show that interfering with AMPAR surface diffusion dramatically impaired synaptic potentiation of Schaffer collateral/commissural inputs to cornu ammonis area 1 (CA1) in cultured slices, acute slices and in vivo. Our data also identifies distinct contributions of various AMPAR trafficking routes to the temporal profile of synaptic potentiation. In addition, AMPAR immobilization in vivo in the dorsal hippocampus (DH) before fear conditioning, indicated that AMPAR diffusion is important for the early phase of contextual learning. Therefore, our results provide a direct demonstration that the recruitment of new receptors to synapses by surface diffusion is a critical mechanism for the expression of LTP and hippocampal learning. Since AMPAR surface diffusion is dictated by weak Brownian forces that are readily perturbed by protein-protein interactions, we anticipate that this fundamental trafficking mechanism will be a key target for modulating synaptic potentiation and learning

Reproductive failure, possible maternal infanticide, and cannibalism in wild moustached tamarins, Saguinus mystax

Maternal infanticide in wild non-human primates has only been reported twice. In this paper, we report a possible new case of infanticide and cannibalism within a series of four successive reproductive failures in wild moustached tamarins, Saguinus mystax. Necropsy and genetic analyses of the corpses enabled us to rule out any pathology, and to determine paternity. The mother was seen biting and then eating the head of its own infant during a period when another female was pregnant and gave birth just 1 month later. Before that, the perpetrator had given birth to twins three times successfully when four to five adult and subadult males were present in the group. Although we do not know for certain that the infant was alive when the mother started biting it, our field observations preceding the event suggest it probably was. The possible infanticide case and the two cases of births and early death of the infants occurred while only two to three adult males were present in the group. This could be the second case of maternal infanticide reported in the genus Saguinus and the similar circumstances suggest a common pattern. We discuss these events in the light of the different functional explanations of infanticide and conclude that parental manipulation was the most likely: the mother could have terminated the investment in offspring that had low chances of survival in a group with low availability of helpers