2,286 research outputs found

    Inequality and Procedural Justice in Social Dilemmas

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    This study investigates the influence of resource inequality and the fairness of the allocation procedure of unequal resources on cooperative behavior in social dilemmas. We propose a simple formal behavioral model that incorporates conflicting selfish and social motivations. This model allows us to predict how inequality influences cooperative behavior. Allocation of resources is manipulated by three treatments that vary in terms of procedural justice: allocating resources randomly, based on merit, and based on ascription. As predicted, procedural justice influences cooperation significantly. Moreover, gender is found to be an important factor interacting with the association between procedural justice and cooperative behavior.

    A novel human glucocorticoid receptor SNP results in increased transactivation potential.

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    Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or those that need higher dosages. Polymorphisms in the glucocorticoid receptor (GR) have been implicated in this variability. In this study, ninety-seven volunteers were surveyed for polymorphisms in the human GR-alpha (hGRĪ±), the accepted biologically active reference isoform. One isoform identified in our survey, named hGR DL-2, had four single nucleotide polymorphisms (SNPs), one synonymous and three non-synonymous, and a four base pair deletion resulting in a frame shift and early termination to produce a 743 amino acid putative protein. hGR DL-2 had a decrease in transactivation potential of more than 90%. Upon further analysis of the individual SNPs and deletion, one SNP, A829G, which results in a lysine to glutamic acid amino acid change at position 277, was found to increase the transactivation potential of hGR more than eight times the full-length reference. Furthermore, the hGRĪ±-A829G isoform had a differential hyperactive response to various exogenous steroids. Increasing our knowledge as to how various SNPs affect hGR activity may help in understanding the unpredictable patient response to steroid treatment, and is a step towards personalizing patient care

    Consumer Perspectives on Quality in Adult Day Care

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    Purpose: The purpose of this project was to gain insight into the quality of care and services provided through adult day care from the userā€™s perspective. Design and Methods: The project utilized 13 focus groups to explore aspects associated with user needs, preferences, and satisfaction with adult day care centers. Results: Focus group participants described aspects of adult day care that are important in delivering quality care, program features that are effective, and key areas in need of improvement. Ensuring the safety of clients; having caring, friendly, and compassionate staff available to provide one-on-one attention; engaging clients in stimulating activities; and providing the opportunity for clients to socialize with others were the most salient features of care. Potential areas of improvement for specific centers included enhanced communication with caregivers regarding clientsā€™ well being and program events and activities, modifications to the physical environment, improving the quality of food, and ensuring consistent transportation services. In addition, focus group respondents noted that adult day care programs need to be better publicized and made known to the community. Implications: Findings identify dimensions useful for provider organizations and regulatory agencies to use in their quality improvement efforts

    Spectroscopy from 2 to 200 keV

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    The astrophysical processes responsible for line and continuum emission in the spectra range 2 keV to 200 keV are examined from the viewpoint of designing a spectrometer which would operate in this regime. Phenomena considered include fluorescent line radiation in X-ray binaries, magnetically shifted iron lines and cyclotron emission from neutron star surfaces, line emission from cosmically abundant elements in thermal plasmas, and nuclear deexcitation lines in fresh nucleosynthetically produced matter. An instrument consisting of a approximately 10 sq cm array of planar germanium detectors surrounded by a large sodium-iodide anticoincidence shield is described and projected background rates and sensitivities are considered. A sample observing program for a two-day shuttle-based mission is included as an example of the wide range of scientific questions which could be addressed by such an instrument

    Building Psychosocial Assets And Wellbeing Among Adolescent Girls: A Randomized Controlled Trial

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    We conducted a randomized controlled trial of a 5-month resilience-based program (Girls First Resilience Curriculum or RC) among 2308 rural adolescent girls at 57 government schools in Bihar, India. Local women with at least a 10th grade education served as group facilitators. Girls receiving RC improved more (vs. controls) on emotional resilience, self-efficacy, social-emotional assets, psychological wellbeing, and social wellbeing. Effects were not detected on depression. There was a small, statistically significant negative effect on anxiety (though not likely clinically significant). Results suggest psychosocial assets and wellbeing can be improved for girls in high-poverty, rural schools through a brief school-day program. To our knowledge, this is one of the largest developing country trials of a resilience-based school-day curriculum for adolescents. (C) 2015 The Authors. Published by Elsevier Ltd on behalf of The Foundation for Professionals in Services for Adolescents. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

    Fostering Emotional, Social, Physical And Educational Wellbeing In Rural India: The Methods Of A Multi-Arm Randomized Controlled Trial Of Girls First

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    Background: There are 600 million girls in low and middle income countries (LMICs), many of whom are at great risk for poor health and education. There is thus great need for programs that can effectively improve wellbeing for these girls. Although many interventions have been developed to address these issues, most focus on health and education without integrating attention to social and emotional factors. This omission is unfortunate, as nascent evidence indicates that these factors are closely related to health and education. This paper describes the methods of a 4-arm randomized controlled trial among 3,560 adolescent girls in rural Bihar, India that tested whether adding an intervention targeting social-emotional issues (based on a ā€œresilience frameworkā€) to an adolescent health intervention would improve emotional, social, physical, and educational wellbeing to a greater extent than its components and a control group. Study arms were: (1) Girls First, a combination of the Girls First Resilience Curriculum (RC) and the Girls First Health Curriculum (HC); (2) Girls First Resilience Curriculum (RC) alone; (3) Girls First Health Curriculum (HC) alone; and (4) a school-as-usual control group (SC). Methods: Seventy-six schools were randomized (19 per condition) and 74 local women with a tenth grade education were trained and monitored to facilitate the program. Quantitative data were collected from 3,560 girls over 4 assessment points with very low rates of participant attrition. Qualitative assessments were conducted with a subset of 99 girls and 27 facilitators. Results and conclusions: In this article, we discuss guiding principles that facilitated trial implementation, including integrating diverse local and non-local sources of knowledge, focusing on flexibility of planning and implementation, prioritizing systematic measurement selection, and striking a balance between scientific rigor and real-world feasibility

    INTEGRAL/IBIS search for e-e+ annihilation radiation from the Galactic Center Region

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    Electron-positron annihilation radiation from the Galactic Center region has been detected since the seventies, but its astrophysical origin is still a topic of a scientific debate. We have analyzed data of the gamma-ray imager IBIS/ISGRI onboard of ESA's INTEGRAL platform in the eāˆ’^{-}e+^{+} line. During the first year of the missions Galactic Center Deep Exposure no evidence for point sources at 511 keV has been found in the ISGRI data; the 2Ļƒ2 \sigma upper limit for resolved single point sources is estimated to be 1.6Ɨ10āˆ’4phcmāˆ’2sāˆ’11.6\times 10^{-4} ph cm^{-2} s^{-1}.Comment: 6 pages, 3 figures; Cospar 2004. To be published in: Advances in Space Researc

    A comparison of the illness beliefs of people with angina and their peers: a questionnaire study

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    BACKGROUND: What people believe about their illness may affect how they cope with it. It has been suggested that such beliefs stem from those commonly held within society . This study compared the beliefs held by people with angina, regarding causation and coping in angina, with the beliefs of their friends who do not suffer from angina. METHODS: Postal survey using the York Angina Beliefs Questionnaire (version 1), which elicits stress attributions and misconceived beliefs about causation and coping. This was administered to 164 people with angina and their non-cohabiting friends matched for age and sex. 132 people with angina and 94 friends completed the questionnaire. RESULTS: Peers are more likely than people with angina to believe that angina is caused by a worn out heart (p <0.01), angina is a small heart attack (p = 0.02), and that it causes permanent damage to the heart (p <0.001). Peers were also more likely to believe that people with angina should take life easy (p <0.01) and avoid exercise (p = 0.04) and excitement (p <0.01). CONCLUSIONS: The beliefs of the peer group about causation and coping in angina run counter to professional advice. Over time this may contribute to a reduction in patient concordance with risk factor reduction, and may help to create cardiac invalids

    Obesity and COVID-19 in-hospital fatality in southern Brazil: impact by age and skin color

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    OBJECTIVES: To estimate the relative risk (RR) of death associated with obesity, the attributable fraction in the exposed/with obesity (AFo), and the hospitalized population attributable risk (hospitalized PAR) associated with obesity of death among all adults and among Black and non-Black adults hospitalized for severe COVID-19 in the state of Rio Grande do Sul, Brazil. METHODS: This retrospective cohort study of prognostic factors analyzed all cases of adults hospitalized for severe COVID-19 in the state of Rio Grande do Sul, Brazil. The occurrence of obesity by hospital teams was primarily measured observing individualsā€™ medical records. The outcome assessed was hospital deaths caused by severe COVID-19. Poisson regression was used to estimate RRs and 95% confidence intervals (95%CI). RESULTS: The study sample consisted of 100,099 patients hospitalized for severe COVID-19, most of whom were White (84.7%) and male (54.7%). The effect of obesity was strongly modified by age. For the 18ā€“39-year-old age group, RR = 2.54 (95%CI: 2.33ā€“2.77), and in individuals 70 years and above, RR = 1.09 (95%CI: 1.05ā€“1.13). For the 18ā€“39-year-old age range, AFo = 60.6% and AFo = 42.5% in individuals 40ā€“59 years old. For all hospitalizations, the hospitalized population attributable risk (hospitalized PAR) measuring obesity for individuals 18ā€“39 years old was 25.3%, while in the 40ā€“59-year-old range, the hospitalized PAR = 11.2%. The hospitalized PAR was 31.7% in the Black population aged 18ā€“39 years and 24.8% in non-Blacks. The hospitalized PAR was also larger in Blacks aged 40-59 years. CONCLUSIONS: Obesity largely impacted in-hospital case-fatality rates among young adults and Black people contaminated by COVID-19. These data highlight the extent of the risk concerning obesity, a highly prevalent chronic condition
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