Foundations of uncertainty in evaluation of nominal properties

Measurement uncertainty is a key component of metrology but, as it is defined, it does not apply to nominal properties. The possibility to define, evaluate, and express the uncertainty in the examination of nominal properties is then a critical prerequisite for a harmonized treatment of nominal properties in metrology. The assumption at the basis of this paper is that examination uncertainty can be understood in analogy with and as a generalization of measurement uncertainty. To this aim a foundational framework is introduced, grounded on a generic concept of evaluation uncertainty that applies equally to quantitative and non-quantitative evaluations. Based on this, a concept of examination uncertainty is presented and some examples of mathematical functions of examination uncertainty are proposed

Activation of brain interleukin-1β in schizophrenia

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Cosmic Dynamics in the Chameleon Cosmology

We study in this paper chameleon cosmology applied to Friedmann-Robertson-Walker space, which gives rise to the equation of state (EoS) parameter larger than -1 in the past and less than -1 today, satisfying current observations. We also study cosmological constraints on the model using the time evolution of the cosmological redshift of distant sources which directly probes the expansion history of the universe. Due to the evolution of the universe's expansion rate, the model independent Cosmological Redshift Drift (CRD)test is expected to experience a small, systematic drift as a function of time. The model is supported by the observational data obtained from the test.Comment: 16 pages, 9 figure

Developing a catalogue of explainability methods to support expert and non-expert users.

Organisations face growing legal requirements and ethical responsibilities to ensure that decisions made by their intelligent systems are explainable. However, provisioning of an explanation is often application dependent, causing an extended design phase and delayed deployment. In this paper we present an explainability framework formed of a catalogue of explanation methods, allowing integration to a range of projects within a telecommunications organisation. These methods are split into low-level explanations, high-level explanations and co-created explanations. We motivate and evaluate this framework using the specific case-study of explaining the conclusions of field engineering experts to non-technical planning staff. Feedback from an iterative co-creation process and a qualitative evaluation is indicative that this is a valuable development tool for use in future company projects

NTT and NOT spectroscopy of SDSS-II supernovae

Context. The SDSS-II Supernova Survey, conducted between 2005 and 2007, was designed to detect a large number of Type Ia supernovae (SNe Ia) around z~0.2, the redshift "gap" between low-z and high-z SN searches. The survey has provided multi-band photometric lightcurves for variable targets, and SN candidates were scheduled for spectroscopic observations, primarily to provide SN classification and accurate redshifts. We present SN spectra obtained in 2006 and 2007 using the NTT and the NOT. Aims. We provide an atlas of SN spectra in the range z =0.03-0.32 that complements the well-sampled lightcurves from SDSS-II in the forthcoming three-year SDSS SN cosmology analysis. The sample can, for example, be used for spectral studies of SNe Ia, which are critical for understanding potential systematic effects when SNe are used to determine cosmological distances. Methods. The spectra were reduced in a uniform manner, and special care was taken in estimating the uncertainties for the different processing steps. Host-galaxy light was subtracted when possible and the SN type fitted using the SuperNova IDentification code (SNID). We also present comparisons between spectral and photometric dating using SALT lightcurve fits to the photometry from SDSS-II, as well as the global distribution of our sample in terms of the lightcurve parameters: stretch and colour. Results. We report new spectroscopic data from 141 SNe Ia, mainly between -9 and +15 days from lightcurve maximum, including a few cases of multi-epoch observations. This homogeneous, host-galaxy subtracted, SN Ia spectroscopic sample is among the largest such data sets and unique in its redshift interval. The sample includes two potential SN 1991T-like SNe (SN 2006on and SN 2007ni) and one potential SN 2002cx-like SN (SN 2007ie). In addition, the new compilation includes spectra from 23 confirmed Type II and 8 Type Ib/c SNe.Comment: Accepted for publication in A&

Reducing Zero-point Systematics in Dark Energy Supernova Experiments

We study the effect of filter zero-point uncertainties on future supernova dark energy missions. Fitting for calibration parameters using simultaneous analysis of all Type Ia supernova standard candles achieves a significant improvement over more traditional fit methods. This conclusion is robust under diverse experimental configurations (number of observed supernovae, maximum survey redshift, inclusion of additional systematics). This approach to supernova fitting considerably eases otherwise stringent mission calibration requirements. As an example we simulate a space-based mission based on the proposed JDEM satellite; however the method and conclusions are general and valid for any future supernova dark energy mission, ground or space-based.Comment: 30 pages,8 figures, 5 table, one reference added, submitted to Astroparticle Physic

Development and validation of the ACE tool: Assessing medical trainees' competency in evidence based medicine

BACKGROUND: While a variety of instruments have been developed to assess knowledge and skills in evidence based medicine (EBM), few assess all aspects of EBM - including knowledge, skills attitudes and behaviour - or have been psychometrically evaluated. The aim of this study was to develop and validate an instrument that evaluates medical trainees’ competency in EBM across knowledge, skills and attitude. METHODS: The ‘Assessing Competency in EBM’ (ACE) tool was developed by the authors, with content and face validity assessed by expert opinion. A cross-sectional sample of 342 medical trainees representing ‘novice’, ‘intermediate’ and ‘advanced’ EBM trainees were recruited to complete the ACE tool. Construct validity, item difficulty, internal reliability and item discrimination were analysed. RESULTS: We recruited 98 EBM-novice, 108 EBM-intermediate and 136 EBM-advanced participants. A statistically significant difference in the total ACE score was observed and corresponded to the level of training: on a 0-15-point test, the mean ACE scores were 8.6 for EBM-novice; 9.5 for EBM-intermediate; and 10.4 for EBM-advanced (p < 0.0001). Individual item discrimination was excellent (Item Discrimination Index ranging from 0.37 to 0.84), with internal reliability consistent across all but three items (Item Total Correlations were all positive ranging from 0.14 to 0.20). CONCLUSION: The 15-item ACE tool is a reliable and valid instrument to assess medical trainees’ competency in EBM. The ACE tool provides a novel assessment that measures user performance across the four main steps of EBM. To provide a complete suite of instruments to assess EBM competency across various patient scenarios, future refinement of the ACE instrument should include further scenarios across harm, diagnosis and prognosis

A Calibration of NICMOS Camera 2 for Low Count-Rates

NICMOS 2 observations are crucial for constraining distances to most of the existing sample of z > 1 SNe Ia. Unlike the conventional calibration programs, these observations involve long exposure times and low count rates. Reciprocity failure is known to exist in HgCdTe devices and a correction for this effect has already been implemented for high and medium count-rates. However observations at faint count-rates rely on extrapolations. Here instead, we provide a new zeropoint calibration directly applicable to faint sources. This is obtained via inter-calibration of NIC2 F110W/F160W with WFC3 in the low count-rate regime using z ~ 1 elliptical galaxies as tertiary calibrators. These objects have relatively simple near-IR SEDs, uniform colors, and their extended nature gives superior signal-to-noise at the same count rate than would stars. The use of extended objects also allows greater tolerances on PSF profiles. We find ST magnitude zeropoints (after the installation of the NICMOS cooling system, NCS) of 25.296 +- 0.022 for F110W and 25.803 +- 0.023 for F160W, both in agreement with the calibration extrapolated from count-rates 1,000 times larger (25.262 and 25.799). Before the installation of the NCS, we find 24.843 +- 0.025 for F110W and 25.498 +- 0.021 for F160W, also in agreement with the high-count-rate calibration (24.815 and 25.470). We also check the standard bandpasses of WFC3 and NICMOS 2 using a range of stars and galaxies at different colors and find mild tension for WFC3, limiting the accuracy of the zeropoints. To avoid human bias, our cross-calibration was "blinded" in that the fitted zeropoint differences were hidden until the analysis was finalized.Comment: Accepted for Publication in the Astronomical Journal. New version contains added referenc

L(+) and D(−) Lactate Are Increased in Plasma and Urine Samples of Type 2 Diabetes as Measured by a Simultaneous Quantification of L(+) and D(−) Lactate by Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry

Background. Plasma and urinary levels of D-lactate have been linked to the presence of diabetes. Previously developed techniques have shown several limitations to further evaluate D-lactate as a biomarker for this condition. Methods. D- and L-lactate were quantified using ultraperformance liquid chromatography tandem mass spectrometry with labelled internal standard. Samples were derivatized with diacetyl-L-tartaric anhydride and separated on a C18-reversed phase column. D- and L-lactate were analysed in plasma and urine of controls, patients with inflammatory bowel disease (IBD), and patients with type 2 diabetes (T2DM). Results. Quantitative analysis of D- and L-lactate was achieved successfully. Calibration curves were linear (r2 > 0.99) over the physiological and pathophysiological ranges. Recoveries for urine and plasma were between 96% and 113%. Inter- and intra-assay variations were between 2% and 9%. The limits of detection of D-lactate and L-lactate in plasma were 0.7 μmol/L and 0.2 μmol/L, respectively. The limits of detection of D-lactate and L-lactate in urine were 8.1 nmol/mmol creatinine and 4.4 nmol/mmol creatinine, respectively. Plasma and urinary levels of D- and L-lactate were increased in patients with IBD and T2DM as compared with controls. Conclusion. The presented method proved to be suitable for the quantification of D- and L-lactate and opens the possibility to explore the use of D-lactate as a biomarker