Octreotide and hepatocellular carcinoma

[No abstract available

Major variations in subtropical North Atlantic heat transport at short (5 day) timescales and their causes

Variability in the North Atlantic ocean heat transport at 26.5°N on short (5-day) timescales is identified and contrasted with different behaviour at monthly intervals using a combination of RAPID/MOCHA/WBTS measurements and the NEMO-LIM2 1/12° ocean circulation/sea ice model. Wind forcing plays the leading role in establishing the heat transport variability through the Ekman transport response of the ocean and the associated driving atmospheric conditions vary significantly with timescale. We find that at 5-day timescales the largest changes in the heat transport across 26.5°N coincide with north-westerly airflows originating over the American land mass that drive strong southward anomalies in the Ekman flow. During these events the northward heat transport reduces by 0.5-1.4 PW. In contrast, the Ekman transport response at longer monthly timescales is smaller in magnitude (up to 0.5 PW) and consistent with expected variations in the leading mode of North Atlantic atmospheric variability, the North Atlantic Oscillation. The north-westerly airflow mechanism can have a prolonged influence beyond the central 5-day timescale and on occasion can reduce the accumulated winter ocean heat transport into the North Atlantic by ∼40%

NEMO-ICB (v1.0): interactive icebergs in the NEMO ocean model globally configured at eddy-permitting resolution

An established iceberg module, ICB, is used interactively with the Nucleus for European Modelling of the Ocean (NEMO) ocean model in a new implementation, NEMO–ICB (v1.0). A 30-year hindcast (1976–2005) simulation with an eddy-permitting (0.25°) global configuration of NEMO–ICB is undertaken to evaluate the influence of icebergs on sea ice, hydrography, mixed layer depths (MLDs), and ocean currents, through comparison with a control simulation in which the equivalent iceberg mass flux is applied as coastal runoff, a common forcing in ocean models. In the Southern Hemisphere (SH), drift and melting of icebergs are in balance after around 5 years, whereas the equilibration timescale for the Northern Hemisphere (NH) is 15–20 years. Iceberg drift patterns, and Southern Ocean iceberg mass, compare favourably with available observations. Freshwater forcing due to iceberg melting is most pronounced very locally, in the coastal zone around much of Antarctica, where it often exceeds in magnitude and opposes the negative freshwater fluxes associated with sea ice freezing. However, at most locations in the polar Southern Ocean, the annual-mean freshwater flux due to icebergs, if present, is typically an order of magnitude smaller than the contribution of sea ice melting and precipitation. A notable exception is the southwest Atlantic sector of the Southern Ocean, where iceberg melting reaches around 50% of net precipitation over a large area. Including icebergs in place of coastal runoff, sea ice concentration and thickness are notably decreased at most locations around Antarctica, by up to ~ 20% in the eastern Weddell Sea, with more limited increases, of up to ~ 10% in the Bellingshausen Sea. Antarctic sea ice mass decreases by 2.9%, overall. As a consequence of changes in net freshwater forcing and sea ice, salinity and temperature distributions are also substantially altered. Surface salinity increases by ~ 0.1 psu around much of Antarctica, due to suppressed coastal runoff, with extensive freshening at depth, extending to the greatest depths in the polar Southern Ocean where discernible effects on both salinity and temperature reach 2500 m in the Weddell Sea by the last pentad of the simulation. Substantial physical and dynamical responses to icebergs, throughout the global ocean, are explained by rapid propagation of density anomalies from high-to-low latitudes. Complementary to the baseline model used here, three prototype modifications to NEMO–ICB are also introduced and discussed

Surface warming hiatus caused by increased heat uptake across multiple ocean basins

The first decade of the twenty-first century was characterised by a hiatus in global surface warming. Using ocean model hindcasts and reanalyses we show that heat uptake between the 1990s and 2000s increased by 0.7 ± 0.3Wm−2. Approximately 30% of the increase is associated with colder sea surface temperatures in the eastern Pacific. Other basins contribute via reduced heat loss to the atmosphere, in particular the Southern and subtropical Indian Oceans (30%), and the subpolar North Atlantic (40%). A different mechanism is important at longer timescales (1960s-present) over which the Southern Annular Mode trended upwards. In this period, increased ocean heat uptake has largely arisen from reduced heat loss associated with reduced winds over the Agulhas Return Current and southward displacement of Southern Ocean westerlies

Design and fabrication of recombinant reflectin-based multilayer reflectors: bio-design engineering and photoisomerism induced wavelength modulation

From Springer Nature via Jisc Publications RouterHistory: received 2020-10-03, accepted 2021-06-18, registration 2021-07-07, pub-electronic 2021-07-16, online 2021-07-16, collection 2021-12Publication status: PublishedFunder: Defence Science and Technology Laboratory; doi: http://dx.doi.org/10.13039/100010418Funder: Engineering and Physical Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000266; Grant(s): EP/S01778X/1, EP/S01778X/1, EP/S01778X/1Abstract: The remarkable camouflage capabilities of cephalopods have inspired many to develop dynamic optical materials which exploit certain design principles and/or material properties from cephalopod dermal cells. Here, the angle-dependent optical properties of various single-layer reflectin thin-films on Si wafers are characterized within the UV–Vis–NIR regions. Following this, initial efforts to design, fabricate, and optically characterize a bio-inspired reflectin-based multilayer reflector is described, which was found to conserve the optical properties of single layer films but exhibit reduced angle-dependent visible reflectivity. Finally, we report the integration of phytochrome visible light-induced isomerism into reflectin-based films, which was found to subtly modulate reflectin thin-film reflectivity

Spin‐up of UK Earth System Model 1 (UKESM1) for CMIP6

For simulations intended to study the influence of anthropogenic forcing on climate, temporal stability of the Earth's natural heat, freshwater and biogeochemical budgets is critical. Achieving such coupled model equilibration is scientifically and computationally challenging. We describe the protocol used to spin‐up the UK Earth system model (UKESM1) with respect to pre‐industrial forcing for use in the 6th Coupled Model Intercomparison Project (CMIP6). Due to the high computational cost of UKESM1's atmospheric model, especially when running with interactive full chemistry and aerosols, spin‐up primarily used parallel configurations using only ocean/land components. For the ocean, the resulting spin‐up permitted the carbon and heat contents of the ocean's full volume to approach equilibrium over ~5000 years. On land, a spin‐up of ~1000 years brought UKESM1's dynamic vegetation and soil carbon reservoirs towards near‐equilibrium. The end‐states of these parallel ocean‐ and land‐only phases then initialised a multi‐centennial period of spin‐up with the full Earth system model, prior to this simulation continuing as the UKESM1 CMIP6 pre‐industrial control (piControl). The realism of the fully‐coupled spin‐up was assessed for a range of ocean and land properties, as was the degree of equilibration for key variables. Lessons drawn include the importance of consistent interface physics across ocean‐ and land‐only models and the coupled (parent) model, the extreme simulation duration required to approach equilibration targets, and the occurrence of significant regional land carbon drifts despite global‐scale equilibration. Overall, the UKESM1 spin‐up underscores the expense involved and argues in favour of future development of more efficient spin‐up techniques

NEAT: An efficient network enrichment analysis test

Background: Network enrichment analysis is a powerful method, which allows to integrate gene enrichment analysis with the information on relationships between genes that is provided by gene networks. Existing tests for network enrichment analysis deal only with undirected networks, they can be computationally slow and are based on normality assumptions. Results: We propose NEAT, a test for network enrichment analysis. The test is based on the hypergeometric distribution, which naturally arises as the null distribution in this context. NEAT can be applied not only to undirected, but to directed and partially directed networks as well. Our simulations indicate that NEAT is considerably faster than alternative resampling-based methods, and that its capacity to detect enrichments is at least as good as the one of alternative tests. We discuss applications of NEAT to network analyses in yeast by testing for enrichment of the Environmental Stress Response target gene set with GO Slim and KEGG functional gene sets, and also by inspecting associations between functional sets themselves. Conclusions: NEAT is a flexible and efficient test for network enrichment analysis that aims to overcome some limitations of existing resampling-based tests. The method is implemented in the R package neat, which can be freely downloaded from CRAN ( https://cran.r-project.org/package=neat )

Morphological factors of the central whorl leaf associated with leaf surface wetness and resistance in sorghum to shoot fly, Atherigona soccata

Earlier studies showed that leaf surface water on the central whorl leaf of sorghum seedlings is associated with resistance to shoot fly. In this study, the results of an experiment to determine if leaf surface wetness (LSW) originates from atmospheric condensation or from the plant are described. Morphological structures: trichomes, stomata, leaf cuticle and quantity of surface wax of the central whorl leaf were also examined for their role in LSW production. The results suggest that LSW of the central whorl leaf originates from the plant and is not due to condensation of atmospheric moisture. The presence of trichomes was indirectly associated with LSW and resistance to shoot fly but stomatal density was not associated with LSW production. The amount of wax extracted per 100 mg of fresh weight varied significantly between genotypes and seedling age. It was more in susceptible than in resistant genotypes; however, cuticular thickness was not associated with resistance. It is suggested that LSW could be the result of some form of cuticular movement of water to the leaf surface