Prospects for computing airfoil aerodynamics with Reynolds averaged Navier-Stokes codes

The Reynolds averaged Navier-Stokes equations are solved numerically for a variety of transonic airfoil configurations where viscous phenomena are important. Illustrative examples include flows past sensitive geometries, Reynolds number effects, and buffet phenomena

MEMS reagent and sample handling procedure: Feasibility of viral antibody detection by passive immune agglutination

An attempt was made to develop a test requiring no preadsorption steps for the assessment of antibodies to rubella and mumps viruses using the passive immune agglutination (PIA) method. Both rubella and mumps antigens and antibodies were prepared. Direct PIA tests, using rubella antigen-coated beads, and indirect PIA tests, using rubella antibody-coated beads, were investigated. Attempts, using either method, were unsuccessful. Serum interference along with nonspecific agglutination of beads by the rubella antigen resulted in no specific response under the test conditions investigated. A new, highly sensitive approach, the enzyme immunoassay (EIA) test system, is recommended to overcome the nonspecificity. This system is a logical outgrowth of some of the solid phase work done on MEMS and represents the next generation tests system that can be directly applied to early disease detection and monitoring

An Evaluation of a Battery of Functional and Structural Tests as Predictors of Likely Risk of Progression of Age-Related Macular Degeneration.

Purpose: To evaluate the ability of visual function and structural tests to identify the likely risk of progression from early/intermediate to advanced AMD, using the Age-Related Eye Disease Study (AREDS) simplified scale as a surrogate for risk of progression. The secondary aim was to determine the relationship between disease severity grade and the observed functional and structural deficits. Methods: A total of 100 participants whose AMD status varied from early to advanced were recruited. Visual function was assessed using cone dark adaptation, 14 Hz flicker and chromatic threshold tests and retinal structure was assessed by measuring drusen volume and macular thickness. The predictive value of the tests was estimated using ordinal regression analysis. Group comparisons were assessed using analysis of covariance. Results: Change in cone dark adaptation (cone τ) and yellow-blue (YB) chromatic sensitivity were independent predictors for AMD progression risk (cone τ, pseudo R2 = 0.35, P < 0.001; YB chromatic threshold, pseudo R2 = 0.16, P < 0.001). The only structural predictor was foveal thickness (R2 = 0.05, P = 0.047). Chromatic sensitivity and cone dark adaptation were also the best functional tests at distinguishing between severity groups. Drusen characteristics clearly differentiated between participants with early and advanced disease, but were not able to differentiate between those with early AMD and controls. Mean differences in retinal thickness existed between severity groups at the foveal (P = 0.040) and inner (P = 0.001) subfields. Conclusions: This study indicates that cone τ, YB chromatic threshold and foveal thickness are independent predictors of likely risk of AMD progression

Parental Perspectives of a Childhood Obesity Intervention in Mississippi: A Phenomenological Study

Family - based, community intervention s have been suggested as effective methods of modifying unhealthy behaviors of overweight children. To avoid unsuccessful completion rates, understanding motivating factors and potential barriers for participating families is important. The purpose of this study was to investigate influencing factors that either promote or deter successful completion of a childhood obesity intervention. In - depth interviews were conducted with 10 parents whose child participated in an intervention conducted in central Mississippi. Interviews were audio - taped, transcribed verbatim, and analyzed by a two - person coding team. The research question driving this study was: What do parents perceive as motivators or barriers for completion of an intervention for childhood obesity? Motivating factors of parents included desire to reverse the family’s obesity cycle and desire for their child to realize full potential. They perceived their children were motivated by social aspects of the group setting, improved self - confidence, and supportive staff. Scheduling conflicts and lack of complete family support were identified as main barriers. By understanding the experience of parents, programs can tailor instructive materials to meet family needs throughout the intervention. Emphasis should be placed on parental education for sustained promotion of a healthy lifestyle. Continued support and follow - up are also warranted to ensure long - term succes

Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom

Prevalence of three sulfonamide resistance genes, sul1, sul2 and sul3 and sulfachloropyridazine (SCP) resistance was determined in bacteria isolated from UK manured agricultural clay soils and slurry samples, over a two year period. Slurry from tylosin-fed pigs amended with SCP and oxytetracycline (OTC) was used for manuring. Sul gene positive isolates were further screened for the presence of class 1 and 2 integrons. Phenotypic resistance to SCP was significantly higher in pig slurry and post application soil than in pre-application soil. Of 5isolates, 23 % carried sul1, 18 % sul2 and 9 % sul3 only. Two percent of isolates contained all three sul genes. Class 1 and class 2 integrons were identified in 5 % and 11.7 % of sul positive isolates. In previous reports, sul1 was linked to class 1 integrons, but in this study only 8 % of sul1 positive isolates carried the intI1 gene. Sulfonamide resistant pathogens were identified in slurry amended soil and soil leachate, including Shigella flexneri, Aerococcus spp. and Acinetobacter baumanni, suggesting a potential environmental reservoir. Sulfonamide resistance in Psychrobacter, Enterococcus and Bacillus spp. is reported for the first time, and this study also provides the first description of the genotype sul1, sul2 and sul3 outside the Enterobacteriacae, and in the soil environment

D→K,lνD \rightarrow K, l \nu Semileptonic Decay Scalar Form Factor and ∣Vcs∣|V_{cs}| from Lattice QCD

We present a new study of D semileptonic decays on the lattice which employs the Highly Improved Staggered Quark (HISQ) action for both the charm and the light valence quarks. We work with MILC unquenched $N_f = 2 + 1$ lattices and determine the scalar form factor $f_0(q^2)$ for $D \rightarrow K, l \nu$ semileptonic decays. The form factor is obtained from a scalar current matrix element that does not require any operator matching. We develop a new approach to carrying out chiral/continuum extrapolations of $f_0(q^2)$. The method uses the kinematic "$z$" variable instead of $q^2$ or the kaon energy $E_K$ and is applicable over the entire physical $q^2$ range. We find $f^{D \rightarrow K}_0(0) \equiv f^{D \rightarrow K}_+(0) = 0.747(19)$ in the chiral plus continuum limit and hereby improve the theory error on this quantity by a factor of $\sim$4 compared to previous lattice determinations. Combining the new theory result with recent experimental measurements of the product $f^{D \rightarrow K}_+(0) * |V_{cs}|$ from BaBar and CLEO-c leads to the most precise direct determination of the CKM matrix element $|V_{cs}|$ to date, $|V_{cs}| = 0.961(11)(24)$, where the first error comes from experiment and the second is the lattice QCD theory error. We calculate the ratio $f^{D \rightarrow K}_+(0)/f_{D_s}$ and find $2.986 \pm 0.087$ GeV$^{-1}$ and show that this agrees with experiment.Comment: 23 pages, 31 figures, 11 tables. Added a paragraph in sction VII, and updated with PDG 2010 instead of PDG 200

Generalized MICZ-Kepler Problems and Unitary Highest Weight Modules

For each integer $n\ge 1$, we demonstrate that a $(2n+1)$-dimensional generalized MICZ-Kepler problem has an \mr{Spin}(2, 2n+2) dynamical symmetry which extends the manifest \mr{Spin}(2n+1) symmetry. The Hilbert space of bound states is shown to form a unitary highest weight \mr{Spin}(2, 2n+2)-module which occurs at the first reduction point in the Enright-Howe-Wallach classification diagram for the unitary highest weight modules. As a byproduct, we get a simple geometric realization for such a unitary highest weight \mr{Spin}(2, 2n+2)-module.Comment: 27 pages, Refs. update

Complying With Feed Additive and Drug Withdrawl Periods

Most drugs are accumulated in excretory organs such as the kidneys and liver , and they are found in higher levels for a longer time in these organs than in other tissue. Due to a continuous excretion of the drugs from these organs, tissue levels are usually rapidly reduced after the drug is no longer fed or injected. The rate of excretion of a drug and its end products from animal tissues must be established before it can be considered for approval by the Food and Drug Administration. Then withdrawal periods that are sufficiently long enough to permit complete or near complete elimination of the drug from animal tissues , milk or eggs are established. Once a feed additive is approved it means that the FDA considers it completely safe for use in animal feeds without unsafe levels of residues occurring in the animal tis sue or its products if the withdrawal period is observed and it is fed at recommended levels

Scabies Research with Injectable Ivermectin

Scabies is a parasitic skin disease caused by tiny mites resulting in skin irritation. These mites are spread from animal to animal by direct contact. The mites puncture the skin and feed on the body fluids released from the wounds. These fluids ooze from wounds and dry to form scabs. Hence the name “scabies.” This disease costs the cattle industry millions of dollars each year. Cattle with scabies lick, rub and scratch themselves to relieve the intense itching. They often lose weight and are more susceptible to complications such as pneumonia. As the number of mites increase, the animal’s hair falls out or is rubbed off and lesions spread. If not treated, large areas of the body may be covered with thick, rough crusts. Scabies is a year-round problem. However, in warm weather skin lesions may disappear because mites are less active. This improvement is only temporary; and, as environmental temperature gets colder, the mites become active and lesions return. Under normal conditions, mites will survive for a maximum of 3 days off the host animal. It is possible for mites to spread from fences or trucks that have been in contact with infected animals. However, the greatest possibility of spread is directly animal to animal

qq-Trinomial identities

We obtain connection coefficients between $q$-binomial and $q$-trinomial coefficients. Using these, one can transform $q$-binomial identities into a $q$-trinomial identities and back again. To demonstrate the usefulness of this procedure we rederive some known trinomial identities related to partition theory and prove many of the conjectures of Berkovich, McCoy and Pearce, which have recently arisen in their study of the $\phi_{2,1}$ and $\phi_{1,5}$ perturbations of minimal conformal field theory.Comment: 21 pages, AMSLate