424 research outputs found
Shear stress fluctuations in the granular liquid and solid phases
We report on experimentally observed shear stress fluctuations in both
granular solid and fluid states, showing that they are non-Gaussian at low
shear rates, reflecting the predominance of correlated structures (force
chains) in the solidlike phase, which also exhibit finite rigidity to shear.
Peaks in the rigidity and the stress distribution's skewness indicate that a
change to the force-bearing mechanism occurs at the transition to fluid
behaviour, which, it is shown, can be predicted from the behaviour of the
stress at lower shear rates. In the fluid state stress is Gaussian distributed,
suggesting that the central limit theorem holds. The fibre bundle model with
random load sharing effectively reproduces the stress distribution at the yield
point and also exhibits the exponential stress distribution anticipated from
extant work on stress propagation in granular materials.Comment: 11 pages, 3 figures, latex. Replacement adds journal reference and
addresses referee comment
Statistical properties of acoustic emission signals from metal cutting processes
Acoustic Emission (AE) data from single point turning machining are analysed
in this paper in order to gain a greater insight of the signal statistical
properties for Tool Condition Monitoring (TCM) applications. A statistical
analysis of the time series data amplitude and root mean square (RMS) value at
various tool wear levels are performed, �nding that ageing features can
be revealed in all cases from the observed experimental histograms. In
particular, AE data amplitudes are shown to be distributed with a power-law
behaviour above a cross-over value. An analytic model for the RMS values
probability density function (pdf) is obtained resorting to the Jaynes' maximum
entropy principle (MEp); novel technique of constraining the modelling function
under few fractional moments, instead of a greater amount of ordinary moments,
leads to well-tailored functions for experimental histograms.Comment: 16 pages, 7 figure
Superscars in the LiNC=LiCN isomerization reaction
We demonstrate the existence of superscarring in the LiNC=LiCN isomerization
reaction described by a realistic potential interaction in the range of readily
attainable experimental energies. This phenomenon arises as the effect of two
periodic orbits appearing "out of the blue"in a saddle--node bifurcation taking
place in the dynamics of the system. Potential practical consequences of this
superlocalization in the corresponding wave functions are also considered.Comment: 6 pages, 5 figures. to appear in EP
Solvable three-state model of a driven double-well potential and coherent destruction of tunneling
A simple model for a particle in a double well is derived from discretizing its configuration space. The model contains as many free parameters as the original system and it respects all the existing symmetries. In the presence of an external periodic force both the continuous system and the discrete model are shown to possess a generalized time-reversal symmetry in addition to the known generalized parity. The impact of the driving force on the spectrum of the Floquet operator is studied. In particular, the occurrence of degenerate quasienergies causing coherent destruction of tunneling is discussed—to a large extent analytically—for arbitrary driving frequencies and barrier heights
Effect of dissipation and measurement on a tunneling system
We consider a parametrically driven Kerr medium in which the pumping may be sinusoidally varied. It has been previously found that this system exhibits coherent tunneling between two fixed points which can be either enhanced or suppressed by altering the driving frequency and strength. We numerically investigate the dynamics when damping is included. This is done both by solving a master equation and using the quantum-trajectory method. In the latter case it is also possible to model the result of a continuous heterodyne measurement of the cavity output. The dissipation destroys the coherences which give rise to the tunneling, causing the sinusoidal oscillation of the mean to give way to a stochastic jumping between the fixed points, manifested as a random telegraph signal. In the quantum-trajectory picture we show that the coherences responsible for tunneling are an exponentially decreasing function of the signal-to-noise ratio for heterodyne measurements. However, evidence of both the bare tunneling rate and the driving modified tunneling rate are still apparent in the random telegraph signal
Core-coupled states and split proton-neutron quasi-particle multiplets in 122-126Ag
Neutron-rich silver isotopes were populated in the fragmentation of a 136Xe
beam and the relativistic fission of 238U. The fragments were mass analyzed
with the GSI Fragment separator and subsequently implanted into a passive
stopper. Isomeric transitions were detected by 105 HPGe detectors. Eight
isomeric states were observed in 122-126Ag nuclei. The level schemes of
122,123,125Ag were revised and extended with isomeric transitions being
observed for the first time. The excited states in the odd-mass silver isotopes
are interpreted as core-coupled states. The isomeric states in the even-mass
silver isotopes are discussed in the framework of the proton-neutron split
multiplets. The results of shell-model calculations, performed for the most
neutron-rich silver nuclei are compared to the experimental data
ICON 9-an international phase III randomized study to evaluate the efficacy of maintenance therapy with olaparib and cediranib or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer following a response to platinum-based chemotherapy
BACKGROUND: Two novel biological agents-cediranib targeting angiogenesis, and olaparib targeting DNA repair processes-have individually led to an improvement in ovarian cancer control. The aim of ICON9 is to investigate the combination of cediranib and olaparib maintenance in recurrent ovarian cancer following platinum-based therapy. PRIMARY OBJECTIVE: To assess the efficacy of maintenance treatment with olaparib in combination with cediranib compared with olaparib alone following a response to platinum-based chemotherapy in women with platinum-sensitive ovarian, fallopian tube or peritoneal cancer during first relapse. STUDY HYPOTHESIS: Maintenance therapy with cediranib and olaparib in combination is associated with improved patient outcomes compared with olaparib alone. TRIAL DESIGN: International phase III randomized controlled trial. Following a response to platinum-based chemotherapy patients are randomized 1:1 to either oral olaparib and cediranib (intervention arm) or oral olaparib alone (control arm). MAJOR INCLUSION CRITERIA: Patients with a known diagnosis of high grade serous or endometrioid carcinoma of the ovary, fallopian tube or peritoneum, progressing more than 6 months after first-line platinum-based chemotherapy, who have responded to second-line platinum-based chemotherapy. PRIMARY ENDPOINTS: Progression-free and overall survival. Co-primary endpoints to be assessed using a fixed-sequence gatekeeping approach: (1) progression-free survival, all patients; (2) progression-free survival, BRCA wild type; (3) overall survival, all patients; (4) overall survival, BRCA wild type. SAMPLE SIZE: 618 patients will be recruited. ESTIMATED DATES FOR COMPLETING ACCRUAL AND PRESENTING RESULTS: Accrual is expected to be completed in 2024 with presentation of results in 2025. TRIAL REGISTRATION: ClinicalTrials.gov: NCT03278717
The relation between media promotions and service volume for a statewide tobacco quitline and a web-based cessation program
<p>Abstract</p> <p>Background</p> <p>This observational study assessed the relation between mass media campaigns and service volume for a statewide tobacco cessation quitline and stand-alone web-based cessation program.</p> <p>Methods</p> <p>Multivariate regression analysis was used to identify how weekly calls to a cessation quitline and weekly registrations to a web-based cessation program are related to levels of broadcast media, media campaigns, and media types, controlling for the impact of external and earned media events.</p> <p>Results</p> <p>There was a positive relation between weekly broadcast targeted rating points and the number of weekly calls to a cessation quitline and the number of weekly registrations to a web-based cessation program. Additionally, print secondhand smoke ads and online cessation ads were positively related to weekly quitline calls. Television and radio cessation ads and radio smoke-free law ads were positively related to web program registration levels. There was a positive relation between the number of web registrations and the number of calls to the cessation quitline, with increases in registrations to the web in 1 week corresponding to increases in calls to the quitline in the subsequent week. Web program registration levels were more highly influenced by earned media and other external events than were quitline call volumes.</p> <p>Conclusion</p> <p>Overall, broadcast advertising had a greater impact on registrations for the web program than calls to the quitline. Furthermore, registrations for the web program influenced calls to the quitline. These two findings suggest the evolving roles of web-based cessation programs and Internet-use practices should be considered when creating cessation programs and media campaigns to promote them. Additionally, because different types of media and campaigns were positively associated with calls to the quitline and web registrations, developing mass media campaigns that offer a variety of messages and communicate through different types of media to motivate tobacco users to seek services appears important to reach tobacco users. Further research is needed to better understand the complexities and opportunities involved in simultaneous promotion of quitline and web-based cessation services.</p
Total Absorption Spectroscopy Study of Rb Decay: A Major Contributor to Reactor Antineutrino Spectrum Shape
The antineutrino spectra measured in recent experiments at reactors are
inconsistent with calculations based on the conversion of integral beta spectra
recorded at the ILL reactor. Rb makes the dominant contribution to the
reactor spectrum in the 5-8 MeV range but its decay properties are in question.
We have studied Rb decay with total absorption spectroscopy. Previously
unobserved beta feeding was seen in the 4.5-5.5 region and the GS to GS feeding
was found to be 87.5(25)%. The impact on the reactor antineutrino spectra
calculated with the summation method is shown and discussed.Comment: 6 pages, 3 figure
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