333 research outputs found
Distribution of the color fields around static quarks: Flux tube profiles
We report detailed calculations of the profiles of energy and action
densities in the quark-antiquark string in SU(2) lattice gauge theory.Comment: 40 pages, LSUHE 94-15
Towards real-time topical detection and characterization of FDG dose infiltration prior to PET imaging
To dynamically detect and characterize 18F-fluorodeoxyglucose (FDG) dose infiltrations and evaluate their effects on positron emission tomography (PET) standardized uptake values (SUV) at the injection site and in control tissue
TCT-75 Cangrelor Improves Ischemic Outcomes In Patients With Multivessel Disease And Single Vessel Disease Undergoing PCI: Insights From The CHAMPION PHOENIX Trial
YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules
<p>Abstract</p> <p>Background</p> <p>YB-1 is a major regulator of gene expression in eukaryotic cells. In addition to its role in transcription, YB-1 plays a key role in translation and stabilization of mRNAs.</p> <p>Results</p> <p>We show here that YB-1 interacts with tubulin and microtubules and stimulates microtubule assembly <it>in vitro</it>. High resolution imaging via electron and atomic force microscopy revealed that microtubules assembled in the presence of YB-1 exhibited a normal single wall ultrastructure and indicated that YB-1 most probably coats the outer microtubule wall. Furthermore, we found that YB-1 also promotes the assembly of MAPs-tubulin and subtilisin-treated tubulin. Finally, we demonstrated that tubulin interferes with RNA:YB-1 complexes.</p> <p>Conclusion</p> <p>These results suggest that YB-1 may regulate microtubule assembly <it>in vivo </it>and that its interaction with tubulin may contribute to the control of mRNA translation.</p
The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through syk kinase
11 pags, 7 figsCLECSF8 is a poorly characterized member of the "Dectin-2 cluster" of C-type lectin receptors and was originally thought to be expressed exclusively by macrophages. We show here that CLECSF8 is primarily expressed by peripheral blood neutrophils and monocytes and weakly by several subsets of peripheral blood dendritic cells. However, expression of this receptor is lost upon in vitro differentiation of monocytes into dendritic cells or macrophages. Like the other members of the Dectin-2 family, which require association of their transmembrane domains with signaling adaptors for surface expression, CLECSF8 is retained intracellularly when expressed in non-myeloid cells. However, we demonstrate that CLECSF8 does not associate with any known signaling adaptor molecule, including DAP10, DAP12, or the FcRγ chain, and we found that the C-type lectin domain of CLECSF8 was responsible for its intracellular retention. Although CLECSF8 does not contain a signaling motif in its cytoplasmic domain, we show that this receptor is capable of inducing signaling via Syk kinase in myeloid cells and that it can induce phagocytosis, proinflammatory cytokine production, and the respiratory burst. These data therefore indicate that CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule. Characterization of the CLECSF8-deficient mice and screening for ligands using oligosaccharide microarrays did not provide further insights into the physiological function of this receptor. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.This work was funded by the Wellcome Trust, the National Research Foundation, the Deutscher Akademischer Austauschdienst, the University of Cape Town, the UK Research Council Basic Technology Initiative “Glycoar-rays” (GRS/79268), and the UK Medical Research Council. A. S. P is a fellowof the Fundação para a Ciência e Tecnologia (SFRH/BPD/26515/2006, Portugal) and M. A. C. of the Consejo Superior de Investigaciones Cientificas, Programe “Junta para la Ampliación de Estudios” (JaeDoc/098/2011) cofinanced by the Fondo Social Europeo
Cross-shell excitations in Si 31
The Si31 nucleus was produced through the O18(O18, αn) fusion-evaporation reaction at Elab=24MeV. Evaporated α particles from the reaction were detected and identified in the Microball detector array for channel selection. Multiple γ-ray coincidence events were detected in Gammasphere. The energy and angle information for the α particles was used to determine the Si31 recoil kinematics on an event-by-event basis for a more accurate Doppler correction. A total of 22 new states and 52 new γ transitions were observed, including 14 from states above the neutron separation energy. The positive-parity states predicted by the shell-model calculations in the sd model space agree well with experiment. The negative-parity states were compared with shell-model calculations in the psdpf model space with some variations in the N=20 shell gap. The best agreement was found with a shell gap intermediate between that originally used for A≈20 nuclei and that previously adapted for P32,34. This variation suggests the need for a more universal cross-shell interaction
Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms
Chromosome 22q11.2 deletion syndrome (22q11DS) is associated with neurocognitive impairments. The neural substrates of cognitive impairments in 22q11DS remain poorly understood. Because the corpus callosum (CC) is found to be abnormal in a variety of neurodevelopmental disorders, we obtained volumetric measurements of the CC and its subregions, examined the relationship between these regions and neurocognition and selected genotypes within candidate genes in the 22q11.2 interval in 59 children with 22q11DS and 53 control subjects. The total CC, splenium and genu were significantly larger in children with 22q11DS and the enlargement was associated with better neurocognitive functioning in the 22q11DS group, suggestive of a compensatory increase in the CC volumes. The expected age-related increase in the volume of the CC was not seen in children with 22q11DS, indicative of dysmaturation of the CC in these children. The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with polymorphisms within the candidate genes: COMT (rs4680), ZDHHC8 (rs175174) and UFD1L (rs5992403). These findings indicate that alterations in the CC volume in children with 22q11DS are associated with cognition and specific genotypes in the 22q11.2 interval
Inhomogeneous Bulk Viscous Fluid Universe with Electromagnetic Field and Variable -Term
Cylindrically symmetric inhomogeneous cosmological model for bulk viscous
fluid distribution with electromagnetic field is obtained. The source of the
magnetic field is due to an electric current produced along the z-axis.
is the non-vanishing component of electromagnetic field tensor. To get
the deterministic solution, it has been assumed that the expansion in
the model is proportional to the shear . The values of cosmological
constant for these models are found to be small and positive at late time,
which are consistent with the results from recent supernovae Ia observations.
Physical and geometric aspects of the models are also discussed in presence and
absence of magnetic field.Comment: 21 pages, 8 figure
The evolution of the star formation activity in galaxies and its dependence on environment
We study how the proportion of star-forming galaxies evolves between z=0.8
and z=0 as a function of galaxy environment, using the [OII] line in emission
as a signature of ongoing star formation. Our high-z dataset comprises 16
clusters, 10 groups and another 250 galaxies in poorer groups and the field at
z=0.4-0.8 from the ESO Distant Cluster Survey, plus another 9 massive clusters
at similar redshifts. As a local comparison, we use samples of galaxy systems
selected from the Sloan Digital Sky Survey at 0.04< z < 0.08. At high-z most
systems follow a broad anticorrelation between the fraction of star-forming
galaxies and the system velocity dispersion. At face value, this suggests that
at z=0.4-0.8 the mass of the system largely determines the proportion of
galaxies with ongoing star formation. At these redshifts the strength of star
formation (as measured by the [OII] equivalent width) in star-forming galaxies
is also found to vary systematically with environment. Sloan clusters have much
lower fractions of star-forming galaxies than clusters at z=0.4-0.8 and, in
contrast with the distant clusters, show a plateau for velocity dispersions , where the fraction of galaxies with [OII] emission does not
vary systematically with velocity dispersion. We quantify the evolution of the
proportion of star-forming galaxies as a function of the system velocity
dispersion and find it is strongest in intermediate-mass systems (sigma ~
500-600 km s^-1 at z=0). To understand the origin of the observed trends, we
use the Press-Schechter formalism and the Millennium Simulation and show that
galaxy star formation histories may be closely related to the growth history of
clusters and groups. We propose a scheme that is able to account for the
observed relations between the star-forming fraction and \sigma [abridged].Comment: 28 pages, 19 figures, ApJ in pres
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