Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.

Social vigilance is a behavioral strategy commonly used in adverse or changing social environments. In animals, a combination of avoidance and vigilance allows an individual to evade potentially dangerous confrontations while monitoring the social environment to identify favorable changes. However, prolonged use of this behavioral strategy in humans is associated with increased risk of anxiety disorders, a major burden for human health. Elucidating the mechanisms of social vigilance in animals could provide important clues for new treatment strategies for social anxiety. Importantly, during adolescence the prevalence of social anxiety increases significantly. We hypothesize that many of the actions typically characterized as anxiety behaviors begin to emerge during this time as strategies for navigating more complex social structures. Here, we consider how the social environment and the pubertal transition shape neural circuits that modulate social vigilance, focusing on the bed nucleus of the stria terminalis and prefrontal cortex. The emergence of gonadal hormone secretion during adolescence has important effects on the function and structure of these circuits, and may play a role in the emergence of a notable sex difference in anxiety rates across adolescence. However, the significance of these changes in the context of anxiety is still uncertain, as not enough studies are sufficiently powered to evaluate sex as a biological variable. We conclude that greater integration between human and animal models will aid the development of more effective strategies for treating social anxiety

The connection between radio halos and cluster mergers and the statistical properties of the radio halo population

We discuss the statistical properties of the radio halo population in galaxy clusters. Radio bi-modality is observed in galaxy clusters: a fraction of clusters host giant radio halos while the majority of clusters do not show evidence of diffuse cluster-scale radio emission. The radio bi-modality has a correspondence in terms of dynamical state of the hosting clusters showing that merging clusters host radio halos and follow the well known radio--X-ray correlation, while more relaxed clusters do not host radio halos and populate a region well separated from that correlation. These evidences can be understood in the framework of a scenario where merger-driven turbulence re-accelerate the radio emitting electrons. We discuss the main statistical expectations of this scenario underlining the important role of upcoming LOFAR surveys to test present models.Comment: 11 pages, 2 figures, Invited talk at the conference "Diffuse Relativistic Plasmas", Bangalore, 1-4 March 2011; accepted for publication in the Journal of Astrophysics and Astronom

Harnack inequality and regularity for degenerate quasilinear elliptic equations

We prove Harnack inequality and local regularity results for weak solutions of a quasilinear degenerate equation in divergence form under natural growth conditions. The degeneracy is given by a suitable power of a strong $A_\infty$ weight. Regularity results are achieved under minimal assumptions on the coefficients and, as an application, we prove $C^{1,\alpha}$ local estimates for solutions of a degenerate equation in non divergence form

Comparative analysis of the diffuse radio emission in the galaxy clusters A1835, A2029, and Ophiuchus

We recently performed a study of a sample of relaxed, cooling core galaxy clusters with deep Very Large Array observations at 1.4 GHz. We find that in the central regions of A1835, A2029, and Ophiuchus the dominant radio galaxy is surrounded by a diffuse low-brightness radio emission that takes the form of a mini-halo. Here we present the results of the analysis of the extended diffuse radio emission in these mini-halos. In order to investigate the morphological properties of the diffuse radio emission in clusters of galaxies we propose to fit their azimuthally averaged brightness profile with an exponential, obtaining the central brightness and the e-folding radius from which the radio emissivity can be calculated. We investigate the radio properties of the mini-halos in A1835, A2029, and Ophiuchus in comparison with the radio properties of a representative sample of mini-halos and halos already known in the literature. We find that radio halos can have quite different length-scales but their emissivity is remarkably similar from one halo to the other. In contrast, mini-halos span a wide range of radio emissivity. Some of them, like the Perseus mini-halos, are characterized by a radio emissivity which is more than 100 times greater than that of radio halos. On the other hand, the new mini-halos in cooling core clusters analyzed in this work, namely A2029, Ophiuchus, and A1835, have a radio emissivity which is much more typical of halos in merging clusters rather than similar to that of the other mini-halos previously known.Comment: 17 pages, 11 figures, A&A in press. For a version with high quality figures, see http://erg.ca.astro.it/preprints/mini_halo_2

Revealing the magnetic field in a distant galaxy cluster: discovery of the complex radio emission from MACS J0717.5 +3745

Aims. To study at multiple frequencies the radio emission arising from the massive galaxy cluster MACS J0717.5+3745 (z=0.55). Known to be an extremely complex cluster merger, the system is uniquely suited for an investigation of the phenomena at work in the intra-cluster medium (ICM) during cluster collisions. Methods. We use multi-frequency and multi-resolution data obtained with the Very Large Array radio telescope, and X-ray features revealed by Chandra, to probe the non-thermal and thermal components of the ICM, their relations and interactions. Results. The cluster shows highly complex radio emission. A bright, giant radio halo is detected at frequencies as high as 4.8 GHz. MACS J0717.5+3745 is the most distant cluster currently known to host a radio halo. This radio halo is also the most powerful ever observed, and the second case for which polarized radio emission has been detected, indicating that the magnetic field is ordered on large scales.Comment: 14 pages, 13 figures, Astronomy and Astrophysics, accepte

Dependability of Alternative Computing Paradigms for Machine Learning: hype or hope?

Today we observe amazing performance achieved by Machine Learning (ML); for specific tasks it even surpasses human capabilities. Unfortunately, nothing comes for free: the hidden cost behind ML performance stems from its high complexity in terms of operations to be computed and the involved amount of data. For this reasons, custom Artificial Intelligence hardware accelerators based on alternative computing paradigms are attracting large interest. Such dedicated devices support the energy-hungry data movement, speed of computation, and memory resources that MLs require to realize their full potential. However, when ML is deployed on safety-/mission-critical applications, dependability becomes a concern. This paper presents the state of the art of custom Artificial Intelligence hardware architectures for ML, here Spiking and Convolutional Neural Networks, and shows the best practices to evaluate their dependability

A low-frequency radio halo associated with a cluster of galaxies

Clusters of galaxies are the largest gravitationally bound objects in the Universe, containing about 10^15 solar masses of hot (10^8 K) gas, galaxies and dark matter in a typical volume of about 10 Mpc^3. Magnetic fields and relativistic particles are mixed with the gas as revealed by giant radio haloes, which arise from diffuse, megaparsec-scale synchrotron radiation at cluster center. Radio haloes require that the emitting electrons are accelerated in situ (by turbulence), or are injected (as secondary particles) by proton collisions into the intergalactic medium. They are found only in a fraction of massive clusters that have complex dynamics, which suggests a connection between these mechanisms and cluster mergers. Here we report a radio halo at low frequencies associated with the merging cluster Abell 521. This halo has an extremely steep radio spectrum, which implies a high frequency cut-off; this makes the halo difficult to detect with observations at 1.4 GHz (the frequency at which all other known radio haloes have been best studied). The spectrum of the halo is inconsistent with a secondary origin of the relativistic electrons, but instead supports turbulent acceleration, which suggests that many radio haloes in the Universe should emit mainly at low frequencies.Comment: 18 pages, 4 figures, Nature 455, 94

Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease

Background: Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and have not yet been fully investigated in murine models. Methods: 18-month-old 3.Tg-AD Male mice and their wild-type Male littermates (non-Tg) were used. The open field test and the elevated plus maze test were used to evaluate anxiety-like behaviors, whereas the Porsolt forced swim test, the tail suspension test, and the sucrose preference test for antidepressant/depression-coping behaviors. Neurochemical study was conducted by microdialysis in freely-moving mice, analyzing the basal and K+-stimulated monoamine output in the frontal cortex and ventral hippocampus. Moreover by immunohistochemistry, we analysed the expression of Tyrosin hydroxylase and Tryptophan hydroxylase, which play a key role in the synthesis of monoamines. Results: Aged 3.Tg-AD mice exhibited a higher duration of immobility in the forced swim and tail suspension tests (predictors of depression-like behavior) which was not attenuated by a noradrenaline reuptake inhibitor, desipramine. In the sucrose preference test, 3.Tg-AD mice showed a significantly lower sucrose preference compared to the non-Tg group, without any difference in total fluid intake. In contrast, the motor functions and anxiety-related emotional responses of 3.Tg-AD mice were normal, as detected by the open-field and elevated plus-maze tests. To strengthen these results, we then evaluated the monoaminergic neurotransmissions by in vivo microdialysis and immunohistochemistry. In particular, with the exception of the basal hippocampal dopamine levels, 3.Tg-AD mice exhibited a lower basal extracellular output of amines in the frontal cortex and ventral hippocampus and also a decreased extracellular response to K+ stimulation. Such alterations occur with obvious local amyloid-β and tau pathologies and without gross alterations in the expression of Tyrosin and Tryptophan hydroxylase. Conclusions: These results suggest that 3.Tg-AD mice exhibit changes in depression-related behavior involving aminergic neurotrasmitters and provide an animal model for investigating AD with depression