Long-term variability of AGN at hard X-rays

Variability at all observed wavelengths is a distinctive property of AGN. Hard X-rays provide us with a view of the innermost regions of AGN, mostly unbiased by absorption along the line of sight. Swift/BAT offers the unique opportunity to follow, on time scales of days to years and with a regular sampling, the 14-195 keV emission of the largest AGN sample available up to date for this kind of investigation. We study the amplitude of the variations, and their dependence on sub-class and on energy, for a sample of 110 radio quiet and radio loud AGN selected from the BAT 58-month survey. About 80% of the AGN in the sample are found to exhibit significant variability on months to years time scales, radio loud sources being the most variable. The amplitude of the variations and their energy dependence are incompatible with variability being driven at hard X-rays by changes of the absorption column density. In general, the variations in the 14-24 and 35-100 keV bands are well correlated, suggesting a common origin of the variability across the BAT energy band. However, radio quiet AGN display on average 10% larger variations at 14-24 keV than at 35-100 keV and a softer-when-brighter behavior for most of the Seyfert galaxies with detectable spectral variability on month time scale. In addition, sources with harder spectra are found to be more variable than softer ones. These properties are generally consistent with a variable power law continuum, in flux and shape, pivoting at energies >~ 50 keV, to which a constant reflection component is superposed. When the same time scales are considered, the timing properties of AGN at hard X-rays are comparable to those at lower energies, with at least some of the differences possibly ascribable to components contributing differently in the two energy domains (e.g., reflection, absorption).Comment: 17 pages, 11 figures, accepted for publication in A&

Conservation studies on threatened endemic plants of the Mediterranean area: a literature overview for Sardinia

Abstract Sardinia is the second-largest island in the Mediterranean Sea, situated in the West Mediterranean basin. Its isolation and high geological diversity have created a wide range of habitats, with high levels of endemism, especially on its mountain massifs. Despite the rich plant biodiversity of the Island and the threats to its endemic flora, few biological conservation studies have been conducted on Sardinian endemic plants. A literature analysis highlighted that 19 papers were published, with the 68% of them being focused on threatened species. These data highlight the poor knowledge on the conservation status of the endemic flora of Sardinia. However, the increasing number of papers detected in the last three years represents a good signal that more attention will be devoted to threatened endemic species of the Island in the near future. Key words: Biodiversity, Habitat Directive, Hot Spot, IUCN. Riassunto La Sardegna è la seconda isola per dimensioni del Mar Mediterraneo, situata nel bacino occidentale. Il lungo isolamento e l'elevata diversità geologica dell'Isola hanno determinato un'ampia diversificazione di habitat, con elevati livelli di specie endemiche, in particolar modo nei suoi massicci montuosi. Tuttavia, nonostante la ricca diversità vegetale dell'Isola e le minacce alla sua flora endemica, pochi studi di biologia della conservazione sono stati realizzati su piante endemiche della Sardegna. L'analisi bibliografica ha evidenziato che sono stati pubblicati 19 articoli su specie endemiche, il 68% dei quali focalizzati su specie minacciate. Questi dati evidenziano l'attuale scarsa conoscenza sullo stato di conservazione della flora endemica della Sardegna. Tuttavia, il crescente numero di pubblicazioni osservato negli ultimi tre anni rappresenta un segnale positivo per il futuro, evidenziando una crescente attenzione per le specie endemiche minacciate dell'Isola

In-flight calibration of the INTEGRAL/IBIS mask

Since the release of the INTEGRAL Offline Scientific Analysis (OSA) software version 9.0, the ghost busters module has been introduced in the INTEGRAL/IBIS imaging procedure, leading to an improvement of the sensitivity around bright sources up to a factor of 7. This module excludes in the deconvolution process the IBIS/ISGRI detector pixels corresponding to the projection of a bright source through mask elements affected by some defects. These defects are most likely associated with screws and glue fixing the IBIS mask to its support. Following these major improvements introduced in OSA 9, a second order correction is still required to further remove the residual noise, now at a level of 0.2-1% of the brightest source in the field of view. In order to improve our knowledge of the IBIS mask transparency, a calibration campaign has been carried out during 2010-2012. We present here the analysis of these data, together with archival observations of the Crab and Cyg X-1, that allowed us to build a composite image of the mask defects and to investigate the origin of the residual noise in the IBIS/ISGRI images. Thanks to this study, we were able to point out a simple modification of the ISGRI analysis software that allows to significantly improve the quality of the images in which bright sources are detected at the edge of the field of view. Moreover, a refinement of the area excluded by the ghost busters module is considered, and preliminary results show improvements to be further tested. Finally, this study indicates further directions to be investigated for improving the ISGRI sensitivity, such as taking into account the thickness of the screws in the mask model or studying the possible discrepancy between the modeled and actual mask element bridges.Comment: accepted for publication in the proceedings of "An INTEGRAL view of the high-energy sky (the first 10 years)" 9th INTEGRAL Workshop, October 15-19, 2012, Paris, France, in Proceedings of Science (INTEGRAL 2012), Eds. A. Goldwurm, F. Lebrun and C. Winkler, (http://pos.sissa.it/cgi-bin/reader/conf.cgi?confid=176), id 154; 6 pages, 4 figures, see the PoS website for the full resolution versio

A new species of Aquilegia (Ranunculaceae) from Sardinia (Italy)

The new species Aquilegia cremnophila (Ranunculaceae) from the Italian island of Sardinia is here described and illustrated. It occurs in shady rocky crevices, near the upper parts of Mt. Corrasi (Supramontes Region), where it is a member of chasmophilous communities. This species is morphologically, phenologically, ecologically and genetically well differentiated from the other Sardinian taxa, showing some relationships mainly with A. nugorensis, an endemic species of Central-Eastern Sardinia. Its conservation status is examined. A key of all taxa present in Sardinia is also provided. © 2012 Magnolia Press.Peer Reviewe

Spin-down rate and inferred dipole magnetic field of the soft gamma-ray repeater SGR 1627-41

Using Chandra data taken on 2008 June, we detected pulsations at 2.59439(4) s in the soft gamma-ray repeater SGR 1627-41. This is the second measurement of the source spin period and allows us to derive for the first time a long-term spin-down rate of (1.9 +/- 0.4)E-11 s/s. From this value we infer for SGR 1627-41 a characteristic age of 2.2 kyr, a spin-down luminosity of 4E+34 erg/s (one of the highest among sources of the same class), and a surface dipole magnetic field strength of 2E+14 G. These properties confirm the magnetar nature of SGR 1627-41; however, they should be considered with caution since they were derived on the basis of a period derivative measurement made using two epochs only and magnetar spin-down rates are generally highly variable. The pulse profile, double-peaked and with a pulsed fraction of (13 +/- 2)% in the 2-10 keV range, closely resembles that observed by XMM-Newton in 2008 September. Having for the first time a timing model for this SGR, we also searched for a pulsed signal in archival radio data collected with the Parkes radio telescope nine months after the previous X-ray outburst. No evidence for radio pulsations was found, down to a luminosity level 10-20 times fainter (for a 10% duty cycle and a distance of 11 kpc) than the peak luminosity shown by the known radio magnetars.Comment: 5 pages, 2 figures; accepted for publication in MNRAS Letter

Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program

OBJECTIVE: Endothelial dysfunction (ED) predisposes to venous thrombosis (VT) and post-thrombotic syndrome (PTS), a long-term VT-related complication. Sulodexide (SDX) is a highly purified glycosaminoglycan with antithrombotic, pro-fibrinolytic and anti-inflammatory activity used in the treatment of chronic venous disease (CVD), including patients with PTS. SDX has recently obtained clinical evidence in the “extension therapy” after initial-standard anticoagulant treatment for the secondary prevention of recurrent deep vein thrombosis (DVT). Herein, we investigated how SDX counteracts ED. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVEC) were used. Metabolic and non metabolic-induced ED was induced by treating with methylglyoxal (MGO) or irradiation (IR), respectively. Bafilomycin A1 was used to inhibit autophagy. The production of reactive oxygen species (ROS), tetrazolium bromide (MTT) assay for cell viability, terminal de-oxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for cell apoptosis, Real-time PCR and Western blot analysis for gene and protein expression were used. RESULTS: SDX protected HUVEC from MGO- or IR-induced apoptosis by counteracting the activation of the intrinsic and extrinsic caspase cascades. The cytoprotective effects of SDX resulted from a reduction in a) ROS production, b) neo-synthesis and release of pro-inflammatory cytokines (TNFα, IL1, IL6, IL8), c) DNA damage induced by MGO or IR. These effects were reduced when autophagy was inhibited. CONCLUSIONS: Data herein collected indicate the ability of SDX to counteract ED induced by metabolic or non-metabolic stresses by involving the intracellular autophagy pathway. Our experience significantly increases the knowledge of the mechanisms of action of SDX against ED and supports the use of SDX in the treatment of CVD, PTS and in the secondary prevention of recurrent DVT

Methotrexate and Rheumatoid Arthritis : Current Evidence Regarding Subcutaneous Versus Oral Routes of Administration

Methotrexate (MTX) is still considered the drug of choice in rheumatoid arthritis (RA) management. Comparing subcutaneous (MTX SC) and oral (MTX OR) routes of administration is important to optimize the everyday therapeutic strategy in the real-life setting. This review summarizes scientific evidence currently available on this topic. As shown by pharmacokinetic studies, at the same dose level, bioavailability of MTX SC is significantly higher and less variable than that of MTX OR. This difference is even more pronounced for medium-to-high dosages (i.e., >15 mg/week). With regard to clinical response (Disease Activity Score-28, American College of Rheumatology Criteria), randomized, double-blind studies and retrospective or longitudinal analyses in real-life settings showed that MTX SC is more effective than MTX OR. This is true both in MTX-naive patients with early RA, and in patients who switch from MTX OR to MTX SC due to previous treatment failure, lack of efficacy and/or adverse events. Finally, MTX SC has a better tolerability profile than MTX OR, with fewer gastroenterological side effects. Delaying the use of more expensive biological therapies by switching from MTX OR to MTX SC in non-responders might provide cost savings, with relevant implications in the management of patients with RA. Funding: Alfa Wassermann

A first XMM-Newton look at the relativistic double pulsar PSR J0737-3039

We present the results of a 50 ks long X-ray observation of the relativistic double pulsar system PSR J0737-3039 obtained with the XMM-Newton satellite in March 2004. The source has a soft spectrum (power law photon index = 3.5(+0.5,-0.3)) and a 0.2-10 keV luminosity of ~3x10^30 erg/s (assuming a distance of 500 pc), consistent with the values derived from a previous Chandra observation. No flux variations have been detected, implying the absence of large orbital modulations. The high time resolution of the EPIC instrument has allowed us to perform the first search for X-ray pulsations from this system. The result was negative, with an upper limit of 60% on the pulsed fraction of the 22 ms pulsar.Comment: 14 pages, 3 postscript figures. Accepted for publication in ApJ