139 research outputs found

    The design and implementation of EPL: An event pattern language for active databases

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    The growing demand for intelligent information systems requires closer coupling of rule-based reasoning engines, such as CLIPS, with advanced data base management systems (DBMS). For instance, several commercial DBMS now support the notion of triggers that monitor events and transactions occurring in the database and fire induced actions, which perform a variety of critical functions, including safeguarding the integrity of data, monitoring access, and recording volatile information needed by administrators, analysts, and expert systems to perform assorted tasks; examples of these tasks include security enforcement, market studies, knowledge discovery, and link analysis. At UCLA, we designed and implemented the event pattern language (EPL) which is capable of detecting and acting upon complex patterns of events which are temporally related to each other. For instance, a plant manager should be notified when a certain pattern of overheating repeats itself over time in a chemical process; likewise, proper notification is required when a suspicious sequence of bank transactions is executed within a certain time limit. The EPL prototype is built in CLIPS to operate on top of Sybase, a commercial relational DBMS, where actions can be triggered by events such as simple database updates, insertions, and deletions. The rule-based syntax of EPL allows the sequences of goals in rules to be interpreted as sequences of temporal events; each goal can correspond to either (1) a simple event, or (2) a (possibly negated) event/condition predicate, or (3) a complex event defined as the disjunction and repetition of other events. Various extensions have been added to CLIPS in order to tailor the interface with Sybase and its open client/server architecture

    Towards More Data-Aware Application Integration (extended version)

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    Although most business application data is stored in relational databases, programming languages and wire formats in integration middleware systems are not table-centric. Due to costly format conversions, data-shipments and faster computation, the trend is to "push-down" the integration operations closer to the storage representation. We address the alternative case of defining declarative, table-centric integration semantics within standard integration systems. For that, we replace the current operator implementations for the well-known Enterprise Integration Patterns by equivalent "in-memory" table processing, and show a practical realization in a conventional integration system for a non-reliable, "data-intensive" messaging example. The results of the runtime analysis show that table-centric processing is promising already in standard, "single-record" message routing and transformations, and can potentially excel the message throughput for "multi-record" table messages.Comment: 18 Pages, extended version of the contribution to British International Conference on Databases (BICOD), 2015, Edinburgh, Scotlan

    PRS36 The Cost-Effectiveness of Step Down from High Dose ICS/Laba Combination Therapy in Asthma in the UK Setting

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    PRS72 How Much Would the Universal Uptake of Gold Recommendations for Italian COPD Patients Cost?

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    PercepĆ§Ć£o ambiental de docentes e discentes da rede de ensino pĆŗblico superior do municĆ­pio de Parintins - CESP/ UEA.

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    As questƵes ambientais sĆ£o pautas das arenas de discussĆ£o locais e globais. Todos reconhecem que o nosso ambiente estĆ” sendo devastado, pois sĆ£o constantes as notĆ­cias vinculadas na mĆ­dia falada e escrita sobre mudanƧas climĆ”ticas, poluiĆ§Ć£o de rios e do ar, destruiĆ§Ć£o da floresta, extinĆ§Ć£o de espĆ©cies, esgotamento dos recursos minerais. A importĆ¢ncia da pesquisa em percepĆ§Ć£o ambiental para o planejamento ambiental Ć© uma aĆ§Ć£o coordenada para minimizar estes impactos antrĆ³picos negativos gerados por nossas aƧƵes ao ambiente. "Uma das dificuldades para a proteĆ§Ć£o dos ecossistemas naturais estĆ” na existĆŖncia de diferenƧas nas percepƧƵes dos valores e da importĆ¢ncia dos mesmos entre indivĆ­duos de culturas diferentes ou de grupos sĆ³cio-econĆ“micos que desempenham funƧƵes, no plano social. Neste cenĆ”rio, caracterizar o conhecimento e a percepĆ§Ć£o ambiental dos atores envolvidos, docentes e discentes da rede de ensino pĆŗblico (superior) do municĆ­pio de Parintins, instigando-os atravĆ©s de abordagem participativa na construĆ§Ć£o de estratĆ©gias e aƧƵes transformadoras, pode ajudar a clarear os passos a serem trilhados na expectativa de implantaĆ§Ć£o de um programa de educaĆ§Ć£o ambiental com comeƧo, meio e fim

    Retrieval effectiveness of written and spoken queries : an experimental evaluation

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    With the fast growing speech technologies, the world is emerging to a new speech era. Speech recognition has now become a practical technology for real world applications. While some work has been done to facilitate retrieving information in speech format using textual queries, the characteristics of speech as a way to express an information need has not been extensively studied. If one compares written versus spoken queries, it is intuitive to think that users would issue longer spoken queries than written ones, due to the ease of speech. Is this in fact the case in reality? Also, if this is the case, would longer spoken queries be more effective in helping retrieving relevant document than written ones? This paper presents some new findings derived from an experimental study to test these intuitions

    Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

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    Poly(ADP-ribose) (pADPr) is a polymer assembled from the enzymatic polymerization of the ADP-ribosyl moiety of NAD by poly(ADP-ribose) polymerases (PARPs). The dynamic turnover of pADPr within the cell is essential for a number of cellular processes including progression through the cell cycle, DNA repair and the maintenance of genomic integrity, and apoptosis. In spite of the considerable advances in the knowledge of the physiological conditions modulated by poly(ADP-ribosyl)ation reactions, and notwithstanding the fact that pADPr can play a role of mediator in a wide spectrum of biological processes, few pADPr binding proteins have been identified so far. In this study, refined in silico prediction of pADPr binding proteins and large-scale mass spectrometry-based proteome analysis of pADPr binding proteins were used to establish a comprehensive repertoire of pADPr-associated proteins. Visualization and modeling of these pADPr-associated proteins in networks not only reflect the widespread involvement of poly(ADP-ribosyl)ation in several pathways but also identify protein targets that could shed new light on the regulatory functions of pADPr in normal physiological conditions as well as after exposure to genotoxic stimuli
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