Berry's Phases of Ground States of Interacting Spin-One Bosons: Chains of Monopoles and Monosegments

We study Berry's connection potentials of many-body ground states of spin-one bosons with antiferromagnetic interactions in adiabatically varying magnetic fields. We find that Berry's connection potentials are generally determined by, instead of usual singular monopoles, linearly positioned monosegments each of which carries one unit of topological charge; in the absence of a magnetic field gradient this distribution of monosegments becomes a linear chain of monopoles. Consequently, Berry's phases consist of a series of step functions of magnetic fields; a magnetic field gradient causes rounding of these step-functions. We also calculate Berry's connection fields, profiles of monosegments and show that the total topological charge is conserved in a parameter space

A review of abstract concept learning in embodied agents and robots.

This paper reviews computational modelling approaches to the learning of abstract concepts and words in embodied agents such as humanoid robots. This will include a discussion of the learning of abstract words such as 'use' and 'make' in humanoid robot experiments, and the acquisition of numerical concepts via gesture and finger counting strategies. The current approaches share a strong emphasis on embodied cognition aspects for the grounding of abstract concepts, and a continuum, rather than dichotomy, view of concrete/abstract concepts differences.This article is part of the theme issue 'Varieties of abstract concepts: development, use and representation in the brain'

Simultaneous Dependence of the Earthquake-Size Distribution on Faulting Style and Depth

We analyze two high-quality Southern Californian earthquake catalogues, one with focal mechanisms, to statistically model and test for dependencies of the earthquake-size distribution, the b values, on both faulting style and depth. In our null hypothesis, b is assumed constant. We then develop and calibrate one model based only on faulting style, another based only on depth dependence and two models that assume a simultaneous dependence on both parameters. We develop a new maximum-likelihood estimator corrected for the degrees of freedom to assess models' performances. Our results show that all models significantly reject the null hypothesis. The best performing is the one that simultaneously takes account of depth and faulting style. Our results suggest that differential stress variations in the Earth's crust systematically influence b values and that this variability should be considered for contemporary seismic hazard studies

HighSTEPS. A high strain temperature pèressure and speed apparatus to study earthquake mechanics

We present a state of-the-art biaxial apparatus able to study both earthquake rupture nucleation and propagation at conditions typical of the seismogenic crust. The HighSTEPS, High Strain TEmperature Pressure Speed, apparatus simulates fault deformation in a wide range of slip velocities, i.e., from 10-5m/s to 0.25 m/s. Within this velocity range, it is possible to study, the rate-and-state friction, the fault dynamic weakening, and healing under unique boundary conditions, i.e., normal stress up to 100 MPa, confining pressure up to 100 MPa, pore fluid pressure up to 100 MPa and temperature up to 120 °C. The apparatus consists of a hydraulic system integrated with four linear motors. The hydraulic system allows for the application of normal stress, confining pressure and pore fluid pressure. The main peculiarity of this apparatus is the system of four linear motors that are mounted in series in order to apply shearing velocities up to 0.25 m/s, accelerations up to 10 m/s2 and shear stresses up to 200 MPa. Moreover, both experiments in sliding velocity control or shear stress control on the experimental faults are possible. Preliminary experiments on carbonate and silicate bearing rocks are coherent with the previous literature. The investigation of fault friction under a wide range of velocities, normal stresses, confining pressures and pore fluid pressures will provide insights into the mechanics of earthquakes and reduce the gap between natural and laboratory observations

High Conservatism in the Composition of Scent Gland Secretions in Cyphophthalmid Harvestmen: Evidence from Pettalidae

The scent gland secretion of Austropurcellia forsteri was analyzed by gas chromatography–mass spectrometry, providing the first description of the secretion chemistry in the cyphophthalmid family Pettalidae. The secretion contained a total of 21 compounds: About 60% of the whole secretion consisted of a series of saturated, mono-unsaturated and doubly unsaturated methylketones, from C11 to C15, with a cluster of saturated and mono-unsaturated C13-methylketones dominating. A second fraction included several naphthoquinones such as 1,4-naphthoquinone (ca. 20% of secretion), 6-methyl-1,4-naphthoquinone (ca. 17%), and minor amounts of chloronaphthoquinones (ca. 2%). When compared with scent gland compositions of other representatives of cyphophthalmids (e.g. from families Sironidae and Stylocellidae), a highly conservative chemistry of cyphophthalmid secretions is apparent, based on a restricted number of methylketones and naphthoquinones

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indeed, several molecular mechanisms leading to imatinib resistance have already been reported, including overexpression of the MDR1/ABCB1 drug pump. We examined whether imatinib is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump that is frequently overexpressed in human tumors. Using a panel of well-defined BCRP-overexpressing cell lines, we provide the first evidence that imatinib is a substrate for BCRP, that it competes with mitoxantrone for drug export, and that BCRP-mediated efflux can be reversed by the fumitremorgin C analog Ko-143. Since BCRP is highly expressed in the gastrointestinal tract, BCRP might not only play a role in cellular resistance of tumor cells but also influence the gastrointestinal absorption of imatinib

High‐Density Sb2Te3 Nanopillars Arrays by Templated, Bottom‐Up MOCVD Growth

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RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response

PURPOSE: The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease. EXPERIMENTAL DESIGN: We determined mRNA levels of BCRP, LRP, MRP1, MRP2, and MDR1 in 59 primary breast tumor specimens of patients who

Short-term stability in refractive status despite large fluctuations in glucose levels in diabetes mellitus type 1 and 2

Purpose: This work investigates how short-term changes in blood glucose concentration affect the refractive components of the diabetic eye in patients with long-term Type 1 and Type 2 diabetes. Methods: Blood glucose concentration, refractive error components (mean spherical equivalent MSE, J0, J45), central corneal thickness (CCT), anterior chamber depth (ACD), crystalline lens thickness (LT), axial length (AL) and ocular aberrations were monitored at two-hourly intervals over a 12-hour period in: 20 T1DM patients (mean age ± SD) 38±14 years, baseline HbA1c 8.6±1.9%; 21 T2DM patients (mean age ± SD) 56±11 years, HbA1c 7.5±1.8%; and in 20 control subjects (mean age ± SD) 49±23 years, HbA1c 5.5±0.5%. The refractive and biometric results were compared with the corresponding changes in blood glucose concentration. Results: Blood glucose concentration at different times was found to vary significantly within (p0.05). Minor changes of marginal statistical or optical significance were observed in some biometric parameters. Similarly there were some marginally significant differences between the baseline biometric parameters of well-controlled and poorly-controlled diabetic subjects. Conclusion: This work suggests that normal, short-term fluctuations (of up to about 6 mM/l on a timescale of a few hours) in the blood glucose levels of diabetics are not usually associated with acute changes in refractive error or ocular wavefront aberrations. It is therefore possible that factors other than refractive error fluctuations are sometimes responsible for the transient visual problems often reported by diabetic patients