RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response

Burger, H. (Herman); Foekens, J.A. (John); Klijn, J.G.M. (Jan); Look, M.P. (Maxime); Meijer van Gelder, M.E. (Marion); Nooter, K. (Kees); Stoter, G. (Gerrit); Wiemer, E.A.C. (Erik)

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RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response

Authors: H. (Herman) Burger
J.A. (John) Foekens
J.G.M. (Jan) Klijn
M.P. (Maxime) Look
M.E. (Marion) Meijer van Gelder
K. (Kees) Nooter
G. (Gerrit) Stoter
E.A.C. (Erik) Wiemer
Publication date: 1 January 2003
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Abstract

PURPOSE: The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease. EXPERIMENTAL DESIGN: We determined mRNA levels of BCRP, LRP, MRP1, MRP2, and MDR1 in 59 primary breast tumor specimens of patients who