Coronal loop widths and pressure scale heights

The scale heights of stratification and the widths of steady solar coronal loops exhibit properties unexplained by standard theory: observed scale heights are often much greater than static theory predicts, while the nearly-constant widths of loop emission signatures defy theoretical expectations for large flux tubes in stratified media. In this work we relate the cross-sectional profile of a coronal flux tube to its density scale height in steady-state plasma flow regimes. Steady flows may shorten or lengthen the scale height according to how the tube cross-sectional area varies with arclength. In a near-potential corona the flux tubes are expected to be sufficiently expansive in many active regions for scale heights to be increased by steady flows. On the other hand, cases where scale lengths are actually increased to observed sizes form a small part of the solution space, close to regimes where density profiles reverse. Therefore, although steady flows are the only steady process known to be capable of extending scale heights significantly, they are not expected to be not responsible for the majority of extended active region scale heights

Ronald G. Eaglin, oral history interview

Dr. Ronald G. Eaglin was Chancellor of the University of South Carolina – Coastal Carolina College from 1985 to 1992. Dr. Eaglin was chosen by then President of the University of South Carolina, Dr. James Holderman to lead the Coastal campus. Eaglin had previously served as Vice Chancellor for Academic Affairs from 1974-1983 at the USC- Spartanburg campus, now called USC-Upstate. Prior to his career at the University of South Carolina, Eaglin held many collegiate and higher education positions. He served as the regional director of the Southeast office of the American College Testing Program from 1970 – 1974. He was assistant dean of students at the University of Nebraska, assistant director of residence halls at University of Utah and coordinator for group housing at southern Illinois University. His time at Coastal Carolina played an important pivotal role in Coastal’s independence from the University of South Carolina.https://digitalcommons.coastal.edu/oral-history-project/1016/thumbnail.jp

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is associated with increased risk of breast cancer. We report on three independent prospective nested case-control studies from the European Prospective Investigation into Cancer and Nutrition (EPIC-Italy; n = 162 matched case-control pairs), the Norwegian Women and Cancer study (NOWAC; n = 168 matched pairs), and the Breakthrough Generations Study (BGS; n = 548 matched pairs). We used the Illumina 450k array to measure methylation in the EPIC and NOWAC cohorts. Whole-genome bisulphite sequencing (WGBS) was performed on the BGS cohort using pooled DNA samples, combined to reach 50× coverage across ~16 million CpG sites in the genome including 450k array CpG sites. Mean β values over all probes were calculated as a measurement for epigenome-wide methylation

Podoconiosis in East and West Gojam Zones, Northern Ethiopia

Background: Podoconiosis is a neglected tropical disease (NTD) that is prevalent in red clay soil-covered highlands of tropical Africa, Central and South America, and northern India. It is estimated that up to one million cases exist in Ethiopia. This study aimed to estimate the prevalence of podoconiosis in East and West Gojam Zones of Amhara Region in northern Ethiopia. Methodology/Principal Findings: A cross-sectional household survey was conducted in Debre Eliyas and Dembecha woredas (districts) in East and West Gojam Zones, respectively. The survey covered all 17,553 households in 20 kebeles (administrative subunits) randomly selected from the two woredas. A detailed structured interview was conducted on 1,704 cases of podoconiosis identified in the survey. Results: The prevalence of podoconiosis in the population aged 15 years and above was found to be 3.3% (95% CI, 3.2% to 3.6%). 87% of cases were in the economically active age group (15–64 years). On average, patients sought treatment five years after the start of the leg swelling. Most subjects had second (42.7%) or third (36.1%) clinical stage disease, 97.9% had mossy lesions, and 53% had open wounds. On average, patients had five episodes of acute adenolymphangitis (ALA) per year and spent a total of 90 days per year with ALA. The median age of first use of shoes and socks were 22 and 23 years, respectively. More men than women owned more than one pair of shoes (61.1% vs. 50.5%; x2 = 11.6 p = 0.001). At the time of interview, 23.6% of the respondents were barefoot, of whom about two-thirds were women. Conclusions: This study showed high prevalence of podoconiosis and associated morbidities such as ALA, mossy lesions and open wounds in northern Ethiopia. Predominance of cases at early clinical stage of podoconiosis indicates the potential for reversing the swelling and calls for disease prevention interventions

Signatures of Alfven waves in the polar coronal holes as seen by EIS/Hinode

Context. We diagnose the properties of the plume and interplume regions in a polar coronal hole and the role of waves in the acceleration of the solar wind. Aims. We attempt to detect whether Alfven waves are present in the polar coronal holes through variations in EUV line widths. Methods. Using spectral observations performed over a polar coronal hole region with the EIS spectrometer on Hinode, we study the variation in the line width and electron density as a function of height. We use the density sensitive line pairs of Fe xii 186.88 A & 195.119 A and Fe xiii 203.82 A & 202.04 A . Results. For the polar region, the line width data show that the nonthermal line-of-sight velocity increases from 26 km/s at 1000 above the limb to 42 km/s some 15000 (i.e. 110,000 km) above the limb. The electron density shows a decrease from 3:3 10^9 cm^-3 to 1:9 10^8 cm^-3 over the same distance. Conclusions. These results imply that the nonthermal velocity is inversely proportional to the quadratic root of the electron density, in excellent agreement with what is predicted for undamped radially propagating linear Alfven waves. Our data provide signatures of Alfven waves in the polar coronal hole regions, which could be important for the acceleration of the solar wind.Comment: 5 pages, 11 figures. Astronomy and Astrophysics Letters (accepted) http://www.aanda.org/articles/aa/pdf/forth/aa12242-09.pd

Selective spatial damping of propagating kink wavesto resonant absorption

There is observational evidence of propagating kink waves driven by photospheric motions. These disturbances, interpreted as kink magnetohydrodynamic (MHD) waves are attenuated as they propagate upwards in the solar corona. In this paper we show that resonant absorption provides a simple explanation to the spatial damping of these waves. Kink MHD waves are studied using a cylindrical model of solar magnetic flux tubes which includes a non-uniform layer at the tube boundary. Assuming that the frequency is real and the longitudinal wavenumber complex, the damping length and damping per wavelength produced by resonant absorption are analytically calculated. The damping length of propagating kink waves due resonant absorption is a monotonically decreasing function of frequency. For kink waves with low frequencies the damping length is exactly inversely proportional to frequency and we denote this as the TGV relation. When moving to high frequencies the TGV relation continues to be an exceptionally good approximation of the actual dependency of the damping length on frequency. This dependency means that resonant absorption is selective as it favours low frequency waves and can efficiently remove high frequency waves from a broad band spectrum of kink waves. It is selective as the damping length is inversely proportional to frequency so that the damping becomes more severe with increasing frequency. This means that radial inhomogeneity can cause solar waveguides to be a natural low-pass filter for broadband disturbances. Hence kink wave trains travelling along, e.g., coronal loops, will have a greater proportion of the high frequency components dissipated lower down in the atmosphere. This could have important consequences with respect to the spatial distribution of wave heating in the solar atmospher

CYP3A variation, premenopausal estrone levels, and breast cancer risk.

BACKGROUND: Epidemiological studies have provided strong evidence for a role of endogenous sex steroids in the etiology of breast cancer. Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in premenopausal women. METHODS: We measured urinary levels of estrone glucuronide (E1G) using a protocol specifically developed to account for cyclic variation in hormone levels during the menstrual cycle in 729 healthy premenopausal women. We genotyped 642 single-nucleotide polymorphisms (SNPs) in these women; a single SNP, rs10273424, was further tested for association with the risk of breast cancer using data from 10 551 breast cancer case patients and 17 535 control subjects. All statistical tests were two-sided. RESULTS: rs10273424, which maps approximately 50 kb centromeric to the cytochrome P450 3A (CYP3A) gene cluster at chromosome 7q22.1, was associated with a 21.8% reduction in E1G levels (95% confidence interval [CI] = 27.8% to 15.3% reduction; P = 2.7 × 10(-9)) and a modest reduction in the risk of breast cancer in case patients who were diagnosed at or before age 50 years (odds ratio [OR] = 0.91, 95% CI = 0.83 to 0.99; P = .03) but not in those diagnosed after age 50 years (OR = 1.01, 95% CI = 0.93 to 1.10; P = .82). CONCLUSIONS: Genetic variation in noncoding sequences flanking the CYP3A locus contributes to variance in premenopausal E1G levels and is associated with the risk of breast cancer in younger patients. This association may have wider implications given that the most predominantly expressed CYP3A gene, CYP3A4, is responsible for metabolism of endogenous and exogenous hormones and hormonal agents used in the treatment of breast cancer

Individual correlates of podoconiosis in areas of varying endemicity: a case-control study

BACKGROUND Podoconiosis is a non-filarial form of elephantiasis resulting in lymphedema of the lower legs. Previous studies have suggested that podoconiosis arises from the interplay of individual and environmental factors. Here, our aim was to understand the individual-level correlates of podoconiosis by comparing 460 podoconiosis-affected individuals and 707 unaffected controls. METHODS/PRINCIPAL FINDINGS This was a case-control study carried out in six kebeles (the lowest governmental administrative unit) in northern Ethiopia. Each kebele was classified into one of three endemicity levels: 'low' (prevalence 5%). A total of 142 (30.7%) households had two or more cases of podoconiosis. Compared to controls, the majority of the cases, especially women, were less educated (OR = 1.7, 95% CI = 1.3 to 2.2), were unmarried (OR = 3.4, 95% CI = 2.6-4.6) and had lower income (t = -4.4, p<0.0001). On average, cases started wearing shoes ten years later than controls. Among cases, age of first wearing shoes was positively correlated with age of onset of podoconiosis (r = 0.6, t = 12.5, p<0.0001). Among all study participants average duration of shoe wearing was less than 30 years. Between both cases and controls, people in 'high' and 'medium' endemicity kebeles were less likely than people in 'low' endemicity areas to 'ever' have owned shoes (OR = 0.5, 95% CI = 0.4-0.7). CONCLUSIONS Late use of shoes, usually after the onset of podoconiosis, and inequalities in education, income and marriage were found among cases, particularly among females. There were clustering of cases within households, thus interventions against podoconiosis will benefit from household-targeted case tracing. Most importantly, we identified a secular increase in shoe-wearing over recent years, which may give opportunities to promote shoe-wearing without increasing stigma among those at high risk of podoconiosis

The random disc thrower problem

We describe a number of approaches to a question posed by Philips Research, described as the "random disc thrower" problem. Given a square grid of points in the plane, we cover the points by equal-sized planar discs according to the following random process. At each step, a random point of the grid is chosen from the set of uncovered points as the centre of a new disc. This is an abstract model of spatial reuse in wireless networks. A question of Philips Research asks what, as a function of the grid length, is the expected number of discs chosen before the process can no longer continue? Our main results concern the one-dimensional variant of this problem, which can be solved reasonably well, though we also provide a number of approaches towards an approximate solution of the original two-dimensional problem. The two-dimensional problem is related to an old, unresolved conjecture ([6]) that has been the object of close study in both probability theory and statistical physics. Keywords: generating functions, Markov random fields, random sequential adsorption, Rényi’s parking problem, wireless network