Novel modelling of ultra-compact X-ray binary evolution - stable mass transfer from white dwarfs to neutron stars

Tight binaries of helium white dwarfs (He WDs) orbiting millisecond pulsars (MSPs) will eventually "merge" due to gravitational damping of the orbit. The outcome has been predicted to be the production of long-lived ultra-compact X-ray binaries (UCXBs), in which the WD transfers material to the accreting neutron star (NS). Here we present complete numerical computations, for the first time, of such stable mass transfer from a He WD to a NS. We have calculated a number of complete binary stellar evolution tracks, starting from pre-LMXB systems, and evolved these to detached MSP+WD systems and further on to UCXBs. The minimum orbital period is found to be as short as 5.6 minutes. We followed the subsequent widening of the systems until the donor stars become planets with a mass of ~0.005 Msun after roughly a Hubble time. Our models are able to explain the properties of observed UCXBs with high helium abundances and we can identify these sources on the ascending or descending branch in a diagram displaying mass-transfer rate vs. orbital period.Comment: 6 pages, 4 figures, MNRAS Letters, in pres

Impact of Educational Intervention Measures on Knowledge regarding HIV/ Occupational Exposure and Post Exposure Prophylaxis among Final Year Nursing Students of a Tertiary Care Hospital in Central India

Amongst the different Health Care Personnel nurses are at a greater risk of being accidentally exposed to HIV and other Blood Borne Pathogens. The present study was conducted among 50 final year nursing students of a Medical College Hospital to assess the knowledge regarding HIV, occupational exposure and Post Exposure Prophylaxis (PEP) among the students and analyses the impact of educational intervention measures on the issues amongst the study subjects. A Pre-designed and Pre-tested semi-structured questionnaire was used to evaluate the level of knowledge before and after educational intervention sessions. Knowledge regarding risk of transmission of HIV by needle-stick injury and body fluids against which universal precautions were mandatory increased by 72% following the intervention sessions (χ2 = 53.202, p <0.001). 72% and 36% respondents correctly knew the duration within which to start PEP and the drugs available for PEP, post educational sessions 98% and 96% students were aware of it: the difference being statistically significant (χ2 = 11.294, p <0.001) and (χ2 = 37.748, p <0.001) respectively. The mean pre-intervention score was 8.32; mean post-intervention score was 14.40: statistical analysis showed the results to be significant (t= 13.857, p< 0.001). The study reflects that there is a dearth of knowledge among the study group. Incorporating the concerned issues in the academic curriculum to provide the students with adequate knowledge and information during their formative years is needed

ICG-loaded mesoporous nanohybrid (Nd-doped Hydroxyapatite/Fe3O4) for photonic/magnetic hyperthermia and photodynamic therapy

Background: Multimodality nanoplatforms play a crucial role in advancing medical interventions by integrating multiple functionalities into a single system. However, issues like intricate production processes and biocompatibility persist. Herein, a facile synthesis of a biomaterial-based mesoporous nanocarrier, HAp:Nd+SPIONs@mSiO2, loaded with the near-infrared (NIR) emitting dye indocyanine green (ICG) is reported. Methods: HAp:Nd nanoparticles were synthesized via combustion methods. Thereafter, commercial SPIONs and HAp:Nd were integrated within a mesoporous silica via a modified Stöber approach. HAp:Nd+SPIONs@mSiO2 nanoplatform was characterized for particle size, porosity, and luminescence using TEM, BET, and luminescence spectroscopy. The synthesized nanoplatform was further loaded with ICG dye and the loading efficiency was analyzed via UV-Vis spectroscopy. Photonic and magnetic thermal heating of the ICG-loaded nanoplatform was also analyzed along with the photo-stimulated ROS generation ability. Finally, cytotoxicity and therapeutic analysis was performed in vitro using triple-negative breast cancer cells (MDA-MB-231). Results: The nanohybrid with ~100 nm average size, comprised of Nd-doped hydroxyapatite (HAp), Fe3O4 superparamagnetic iron oxide nanoparticles (SPIONs), and mesoporous silica, exhibiting magneto-luminescent properties. The mesoporous structure was loaded with ICG as a model drug (4.3 μg/mg of nanoparticles) where a pH-dependent release was observed. The nanocarrier demonstrated dual functionality by generating heat through magnetic and photonic stimulation, as well as producing reactive oxygen species (ROS) upon excitation with 808 nm light. In vitro bioevaluation on aggressive triple-negative breast cancer cells (MDA-MB-231) showed the high biocompatibility of nanohybrid with and without ICG and exhibited significant toxicity after irradiation of NIR light. Noticeably, the nanohybrids also exhibit the ability to monitor temperature changes via Nd3+ associated NIR luminescence. Conclusions: The nanoplatform integrates clinically relevant components, highlighting its potential for translation from the laboratory to clinical applications. The developed nanohybrids, with combined NIR-mediated photothermal and photodynamic effects, magnetic photothermal capabilities, and NIR/MR imaging, offer promise in addressing cancer heterogeneity and improving conventional treatments with reduced side effects

Cuantificación de aceites de salvado de arroz en mezcla de aceites

Blends consisting of physically refined rice bran oil (PRBO): sunflower oil (SnF) and PRBO: safflower oil (SAF) in different proportions were analyzed for various physicochemical parameters. The quantification of pure rice bran oil in the blended oils was carried out using different methods including gas chromatographic, HPLC, ultrasonic velocity and methods based on physico-chemical parameters. The physicochemical parameters such as ultrasonic velocity, relative association and acoustic impedance at 2 MHz, iodine value, palmitic acid content and oryzanol content reflected significant changes with increased proportions of PRBO in the blended oils. These parameters were selected as dependent parameters and % PRBO proportion was selected as independent parameters. The study revealed that regression equations based on the oryzanol content, palmitic acid composition, ultrasonic velocity, relative association, acoustic impedance, and iodine value can be used for the quantification of rice bran oil in blended oils. The rice bran oil can easily be quantified in the blended oils based on the oryzanol content by HPLC even at a 1% level. The palmitic acid content in blended oils can also be used as an indicator to quantify rice bran oil at or above the 20% level in blended oils whereas the method based on ultrasonic velocity, acoustic impedance and relative association showed initial promise in the quantification of rice bran oil.Se analizaron diversos parámetros físico-químicos para la evaluación de mezclas de aceites en diferentes proporciones que incluyen: aceite de salvado de arroz físícamente refinado (PRBO): aceite de girasol (SNF) y las mezclas PRBO: aceite de cártamo (SAF) en diferentes proporciones. La cuantificación de la presencia del aceite de salvado de arroz en las mezclas se llevó a cabo por diferentes métodos, como cromatografía de gases (GC), cromatografía líquida (HPLC), ultrasonidos y métodos basados en otros parámetros físico-químicos. Los parámetros físico-químicos como la velocidad de ultrasonidos, la asociación y la impedancia acústica a 2 MHz, el índice de yodo, el contenido en ácido palmítico y el contenido de orizanol reflejan cambios significativos con el aumento de la proporción de PRBO en las mezclas de aceites. Estos parámetros fueron seleccionados como parámetros dependientes y las proporciones de PRBO fue seleccionado como parámetro independiente. El estudio reveló que las ecuaciones de regresión basadas en el contenido de orizanol, la composición de ácido palmítico, la velocidad de ultrasonidos, la asociación relativa, la impedancia acústica, y el índice de yodo pueden ser utilizados para la cuantificación de aceite de salvado de arroz en las mezclas de aceites. El aceite de salvado de arroz puede ser cuantificado en las mezclas de aceites mediante el contenido orizanol determinado por HPLC, incluso a nivel de 1%. El contenido de ácido palmítico en los aceites de mezcla también se puede utilizar como un indicador para cuantificar el aceite de salvado de arroz en 20% o más nivel en los aceites de mezcla, donde el método basado en la velocidad ultrasónica, la impedancia acústica y de asociación relativa parecía prometer inicialmente en la cuantificación de arroz aceite de salvado

Performance Evaluation of Kiln for Cashew Nut Shell Carbonization and Liquid.

Abstract Cashew nut shell (CNS) was utilized for carbonization in developed prototype kiln. Prototype kiln was evaluated with direct and indirect methods and characteristics of CNS and CNS char were determined by proximate and ultimate analysis. The maximum CNS temperatures obtained inside the kiln during direct and indirect method were recorded as 452.2℃ and 458.8℃ respectively. Maximum oil percentage, charcoal percentage and ash percentage in direct method were observed as 21.1 per cent, 21.04 per cent and 3.34 per cent respectively whereas 23.8 per cent, 18.3 per cent and 1.27 per cent in indirect method respectively. Hydrogen content in CNS was found about 6 to 7 per cent and nitrogen content in CNS was found about 0.70 to 0.75 per cent. Oxygen content in CNS was observed about 29 to 31 percent. Carbon, hydrogen and nitrogen content of the CNS char were observed in the range of 73 to 76 per cent, 4 to 5 per cent and 1 to 2 per cent respectively. It was found that nitrogen content has increased in CNS char after the carbonization of CNS. Oxygen content in the CNS char gets reduced to 13 to 14 percent, which was comparatively very less than CNS. It was observed that indirect method is more suitable for carbonization than direct method for obtaining higher calorific value char and maximum fixed carbon percentage as found in cashew nut shell char as 60 per cent

Extraction of hydrocarbons from freshwater green microalgae (Botryococcus sp.) biomass after phycoremediation of domestic wastewater

This study was undertaken to analyze the efficiency of Botryococcus sp. in the phycoremediation of domestic wastewater and to determine the variety of hydrocarbons derived from microalgal oil after phycoremediation. The study showed a significant (p < 0.05) reduction of pollutant loads of up to 93.9% chemical oxygen demand, 69.1% biochemical oxygen demand, 59.9% total nitrogen, 54.5% total organic carbon, and 36.8%phosphate. The average dry weight biomass produce was 0.1 g/L of wastewater. In addition, the dry weight biomass of Botryococcus sp. was found to contain 72.5% of crude oil. The composition analysis using Gas Chromatogram - Mass Spectrometry (GC-MS) found that phthalic acid, 2-ethylhexyltridecyl ester (C29H48O4), contributed the highest percentage (71.6%) of the total hydrocarbon compounds to the extracted algae oil. The result of the study suggests that Botryococcus sp. can be used for effective phycoremediation, as well as to provide a sustainable hydrocarbon source as a value-added chemical for the bio-based plastic industry

The International Collaboration for Research methods Development in Oncology (CReDO) workshops: shaping the future of global oncology research

Low-income and middle-income countries (LMICs) have a disproportionately high burden of cancer and cancer mortality. The unique barriers to optimum cancer care in these regions necessitate context-specific research. The conduct of research in LMICs has several challenges, not least of which is a paucity of formal training in research methods. Building capacity by training early career researchers is essential to improve research output and cancer outcomes in LMICs. The International Collaboration for Research methods Development in Oncology (CReDO) workshop is an initiative by the Tata Memorial Centre and the National Cancer Grid of India to address gaps in research training and increase capacity in oncology research. Since 2015, there have been five CReDO workshops, which have trained more than 250 oncologists from India and other countries in clinical research methods and protocol development. Participants from all oncology and allied fields were represented at these workshops. Protocols developed included clinical trials, comparative effectiveness studies, health services research, and observational studies, and many of these protocols were particularly relevant to cancer management in LMICs. A follow-up of these participants in 2020 elicited an 88% response rate and showed that 42% of participants had made progress with their CReDO protocols, and 73% had initiated other research protocols and published papers. In this Policy Review, we describe the challenges to research in LMICs, as well as the evolution, structure, and impact of CReDO and other similar workshops on global oncology research