Towards a Funambulist Leadership in Researches Well-Being: Managing Equilibriums and Tensions in the Hybrid Work Era

The chaotic adaptation to hybrid work during the COVID-19 pandemic has meant that workers still do not know how professional dynamics function correctly in this new context. In this paper, we focus on new issues that have arisen in this era of hybrid work, with the aim of improving performance, conciliation, and well-being in the specific professional environments of universities and research institutes. We will show the results from a non-representative survey comprising 451 scientists. Aspects such as management and leadership over their work, the purpose to achieve something innovative in their work, and promoting well-being in their work spaces and co-workers, have been observed and identified in the survey. The figure of a leader emerges as someone who is communicative, collaborative, and that helps colleagues and their professional development. We suggest that a tightrope walker leader, that is, one who knows how to strike a balance between individual needs and collective interests, could be the key to ensuring the well-being of scientists.Depto. de Antropología Social y Psicología SocialFac. de Ciencias Políticas y SociologíaTRUEpu

Ontology in software engineering

© 2018 authors. During the past years, ontological thinking and design have become more and more popular in the field of Artificial Intelligence (AI). More recently, Software Engineering (SE) has evolved towards more conceptual approaches based on the extensive adoption of models and meta-models. This paper briefly discusses the role of ontologies in SE according to a perspective that closely matches the theoretical life-cycle. These roles vary considerably across the development lifecycle. The use of ontologies to improve SE development activities is still relatively new (2000 onward), but it is definitely no more a novelty. Indeed, the role of such structures is well consolidated in certain SE aspects, such as requirement engineering. On the other hand, despite their well-known potential as knowledge representation mechanisms, ontologies are not completely exploited in the area of SE. We first (i) proposes a brief overview of ontologies and their current understanding within the Semantic Web with a focus on the benefits provided; then, the role that ontologies play in the more specific context of SE is addressed (ii); finally, we deal with (iii) some brief considerations looking at specific types of software architecture, such as Multi-Agent Systems (MAS) and Service-Oriented Architecture (SOA). The main limitation of our research is that we are focusing on traditional developments, where phases occur mostly sequentially. However, industry has fully embraced agile developments. It is unclear that agile practitioners are willing to adopt ontologies as a tool, unless we ensure that they can provide a clear benefit and they be used in a lean way, without introducing significant overhead to the agile development process

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles

Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/ A/dDt c(lhatbt.pw:/e/dbstc.cloabm.w/seobfst.wcoamre/-stoofotlws aarned-tools and http://teqip.jdvu.ac.in/QSAR_Tools/). SDG. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB. In the present study, we have carried out an extensive structure-activity relationship analysis of a series of 41 aryloxypropanolamine compounds based on three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. This is the first combined comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) study in a series of selective aryloxypropanolamines displaying anti-diabetes and anti-obesity pharmacological profiles. The best CoMFA and CoMSIA models presented values of r2 ncv = 0.993 and 0.984 and values of r2 test = 0.865 and 0.918, respectively. The results obtained were subjected to extensive external validation (q2, r2, r2 m, etc.) and a final series of compounds was designed and their biological activity was predicted (best pEC50 = 8.561). © 2018 by the authors.https://www.mdpi.com/1420-3049/23/5/119

Ontology in software engineering

During the past years, ontological thinking and design have become more and more popular in the field of Artificial Intelligence (AI). More recently, Software Engineering (SE) has evolved towards more conceptual approaches based on the extensive adoption of models and meta-models. This paper briefly discusses the role of ontologies in SE according to a perspective that closely matches the theoretical life-cycle. These roles vary considerably across the development lifecycle. The use of ontologies to improve SE development activities is still relatively new (2000 onward), but it is definitely no more a novelty. Indeed, the role of such structures is well consolidated in certain SE aspects, such as requirement engineering. On the other hand, despite their well-known potential as knowledge representation mechanisms, ontologies are not completely exploited in the area of SE. We first (i) proposes a brief overview of ontologies and their current understanding within the Semantic Web with a focus on the benefits provided; then, the role that ontologies play in the more specific context of SE is addressed (ii); finally, we deal with (iii) some brief considerations looking at specific types of software architecture, such as Multi-Agent Systems (MAS) and Service-Oriented Architecture (SOA). The main limitation of our research is that we are focusing on traditional developments, where phases occur mostly sequentially. However, industry has fully embraced agile developments. It is unclear that agile practitioners are willing to adopt ontologies as a tool, unless we ensure that they can provide a clear benefit and they be used in a lean way, without introducing significant overhead to the agile development process

First order radiative corrections to Bhabha scattering in dd dimensions

The luminosity measurement at the projected International Linear $e^+e^-$ Collider ILC is planned to be performed with forward Bhabha scattering with an accuracy of the order of $10^{-4}$. A theoretical prediction of the differential cross-section has to include one-loop weak corrections, with leading higher order terms, and the complete two-loop QED corrections. Here, we present the weak part and the virtual one-loop photonic corrections. For the photonic corrections, the expansions in $\epsilon = (4-d)/2$ are derived with inclusion of the terms of order $\epsilon$ in order to match the two-loop accuracy. For the photonic box master integral in $d$ dimensions we compare several different methods of evaluation.Comment: 35 pages, 3 figures, 2 tables, uses feynmp.sty, references update

Surgical treatment of pressure injuries in children: A multicentre experience

Pressure injuries (PI) are infrequent in paediatric patients, prevalence estimates ranging from 1.4% to 8.2%, and reaching values as high as 43.1% in critical care areas. They can be associated with congenital neurological or metabolic disorders that cause reduced mobility or require the need for medical devices. In children, most pressure injuries heal spontaneously. However, a small percentage of ulcers that is refractory to conservative management or is too severe at presentation (Stage 3 or 4) will be candidates for surgery. We retrospectively reviewed the clinical history of paediatric patients affected by pressure injuries from four European Plastic Surgery Centres. Information was collected from clinical and radiology records, and laboratory reports. An accurate search of the literature revealed only two articles reporting on the surgical treatment of pressure injuries in children. After debridement, we performed surgical coverage of the pressure injuries. We report here our experience with 18 children aged 1-17 years, affected by pressure injury Stages 3 and 4. They were successfully treated with pedicled (17 patients) or free flaps (1 patient). The injuries involved the sacrum (6/18 patients), lower limb (3/18 patients), thoracic spine (2/18 patients), ischium (3/18 patients, bilateral in one patient), temporal area (3/18 patients), hypogastrium (1/18 patients) and were associated to medical devices in three cases. Flaps were followed for a minimum of 19 months and up to 13 years. Only two patients developed true recurrences that were treated again surgically. Pressure injuries are infrequent in children and rarely need surgical treatment. Pedicled flaps have a high success rate. Recurrences, contrary to what is reported in the literature, were rare

On the Global Stability of a Generalized Cholera Epidemiological Model

In this paper, we conduct a careful global stability analysis for a generalized cholera epidemiological model originally proposed in [J. Wang and S. Liao, A generalized cholera model and epidemic/endemic analysis, J. Biol. Dyn. 6 (2012), pp. 568-589]. Cholera is a water-and food-borne infectious disease whose dynamics are complicated by the multiple interactions between the human host, the pathogen, and the environment. Using the geometric approach, we rigorously prove the endemic global stability for the cholera model in three-dimensional (when the pathogen component is a scalar) and four-dimensional (when the pathogen component is a vector) systems. This work unifies the study of global dynamics for several existing deterministic cholera models. The analytical predictions are verified by numerical simulation results

A New 5-Flavour LO Analysis and Parametrization of Parton Distributions in the Real Photon

New, radiatively generated, LO quark (u,d,s,c,b) and gluon densities in a real, unpolarized photon are presented. We perform a global 3-parameter fit, based on LO DGLAP evolution equations, to all available data for the structure function F2^gamma(x,Q^2). We adopt a new theoretical approach called ACOT(chi), originally introduced for the proton, to deal with the heavy-quark thresholds. This defines our basic model (CJKL model), which gives a very good description of the experimental data on F2^gamma(x,Q^2), for both Q^2 and x dependences. For comparison we perform a standard fit using the Fixed Flavour-Number Scheme (FFNS_CJKL model), updated with respect to the previous fits of this type. We show the superiority of the CJKL fit over the FFNS_CJKL one and other LO fits to the F2^gamma(x,Q^2) data. The CJKL model gives also the best description of the LEP data on the Q^2 dependence of the F2^gamma, averaged over various x-regions, and the F_2,c^gamma, which were not used directly in the fit. Finally, a simple analytic parametrization of the resulting parton densities obtained with the CJKL model is given.Comment: 43 pages, RevTeX4 using axodraw style, 3 tex and 12 postscript figures, version submitted to Phys. Rev. D, small text changes, one reference added, FORTRAN program available at http://www.fuw.edu.pl/~pjank/param.html and at http://www-zeuthen.desy.de/~alorca/id4.htm

Neurexin and neuroligin genes in Alzheimer's disease

Póster presentado en la 11th International Conference on Alzheimer's & Parkinson's Diseases, celebrada en Florencia del 6 al 10 de marzo de 2013.-- Alzheimers Disease Neuroimaging Inititive[Objectives] The interaction between neurexins and neuroligins promotes the formation of functional synaptic structures. Recently, it has been reported that neurexins and neuroligins are proteolytically processed by presenilins at synapses. Based on this interaction and the role of presenilins in familial Alzheimer's disease (AD), we hypothesized that dysfunction of the neuroligin-neurexin pathway might be associated with AD.[Methods] To explore this hypothesis we carried out a meta-analysis of five genome-wide association studies (GWAS) comprising 1256 SNPs in the NRXN1, NRXN2, NRXN3 and NLGN1 genes (3009 cases and 3006 control individuals) using PLINK software.[Results] We identified a marker in the NRXN3 gene (rs17757879) that showed a consistent protective effect in all GWAS, however the statistical significance obtained did not resist multiple testing corrections (OR=0.851, p=0.002). Nonetheless, gender analysis revealed that this effect was restricted to males. A replication study with SNP rs17757879 in a Spanish population (1785 cases and 1634 controls) confirmed this observation (OR=0.752, C.I.=0.570-0.991, p=0.042).[Conclusions] We conclude that NRXN3 might have a role in susceptibility to AD in males (rs17757879, OR=0.742, 95% C.I.=0.632-0.872, p=0.00028, final meta-analysis).Peer Reviewe

Genetic study of neurexin and neuroligin genes in Alzheimer's disease

The interaction between neurexins and neuroligins promotes the formation of functional synaptic structures. Recently, it has been reported that neurexins and neuroligins are proteolytically processed by presenilins at synapses. Based on this interaction and the role of presenilins in familial Alzheimer's disease (AD), we hypothesized that dysfunction of the neuroligin-neurexin pathway might be associated with AD. To explore this hypothesis, we carried out a meta-analysis of five genome-wide association studies (GWAS) comprising 1, 256 SNPs in the NRXN1, NRXN2, NRXN3, and NLGN1 genes (3,009 cases and 3,006 control individuals). We identified a marker in the NRXN3 gene (rs17757879) that showed a consistent protective effect in all GWAS, however, the statistical significance obtained did not resist multiple testing corrections (OR = 0.851, p = 0.002). Nonetheless, gender analysis revealed that this effect was restricted to males. A combined meta-analysis of the former five GWAS together with a replication Spanish sample consisting of 1,785 cases and 1,634 controls confirmed this observation (rs17757879, OR = 0.742, 95% CI = 0.632-0.872, p = 0.00028, final meta-analysis). We conclude that NRXN3 might have a role in susceptibility to AD in males.Peer Reviewe