High magnetic field transport measurement of charge-ordered Pr0.5_{0.5}Ca0.5_{0.5}MnO3_3 strained thin films

We have investigated the magnetic-field-induced phase transition of charge-ordered (CO) Pr$_{0.5}$Ca$_{0.5}$MnO$_3$ thin films, deposited onto (100)-oriented LaAlO$_3$ and (100)-oriented SrTiO$_3$ substrates using the pulsed laser deposition technique, by measuring the transport properties with magnetic fields up to 22T. The transition to a metallic state is observed on both substrates by application of a critical magnetic field ($H_C>10T$ at 60K). The value of the field required to destroy the charge-ordered insulating state, lower than the bulk compound, depends on both the substrate and the thickness of the film. The difference of the critical magnetic field between the films and the bulk material is explained by the difference of in-plane parameters at low temperature (below the CO transition). Finally, these results confirm that the robustness of the CO state, depends mainly on the stress induced by the difference in the thermal dilatations between the film and the substrate.Comment: 10 pages, 6 figures. To be published in Phys. Rev.

Non-linear electrical response in a charge/orbital ordered Pr⁡0.63\Pr_{0.63}Ca0.37_{0.37}MnO3_3 crystal : the charge density wave analogy

Non-linear conduction in a charge-ordered manganese oxide Pr$_{0.63}$Ca$_{0.37}$MnO$_3$ is reported. To interpret such a feature, it is usually proposed that a breakdown of the charge or orbitally ordered state is induced by the current. The system behaves in such a way that the bias current may generate metallic paths giving rise to resistivity drop. One can describe this feature by considering the coexistence of localized and delocalized electron states with independent paths of conduction. This situation is reminiscent of what occurs in charge density wave systems where a similar non-linear conduction is also observed. In the light of recent experimental results suggesting the development of charge density waves in charge and orbitally ordered manganese oxides, a phenomenological model for charge density waves motion is used to describe the non-linear conduction in Pr$_{0.63}$Ca$_{0.37}$MnO$_3$. In such a framework, the non-linear conduction arises from the motion of the charge density waves condensate which carries a net electrical current.Comment: 13 pages, 6 figure

Religious education for spiritual bricoleurs? the perceptions of students in ten Christian-ethos secondary schools in England and Wales

Religious Education (RE) in England and Wales functions within a post-secular culture. In the last fifty years, approaches characterised by academic rigour, impartiality, and professionalism have been prioritised. In this post-secular culture, the notion of bricolage aptly describes how some young people seek meaning, explore the spiritual dimension of life, with fragmented understandings of, experiences and encounters with the religious traditions. This paper draws on data from an empirical research project involving 350 students, to explore why students in ten Christian-ethos secondary schools in England and Wales recognised Religious Education (RE) as a significant contributor to their spiritual development. The analysis is illuminated by employing Roebben's (2009) concept of a narthical learning space (NLS) as the lens with which to examine young people’s experiences. Three aspects of RE are explored: the debating of existential questions; opportunities to theologise and reflect; and encounters with the beliefs, practices, and opinions of others. This article argues that the concept of RE as a narthical learning space alongside the notion of young people as spiritual bricoleurs illuminates how the students in this study interpret the contribution of RE to their spiritual development

Instability of metal-insulator transition against thermal cycling in phase separated Cr-doped manganites

We show that metal-insulator transition in Pr0.5Ca0.5Mn1-xCrxO3 (x = 0.015-0.025) is unstable against thermal cycling. Insulator-metal transition shifts down and low temperature resistivity increases each time when the sample is cycled between a starting temperature TS and a final temperature TF. The effect is dramatic lower is x. Insulator-metal transition in x = 0.015 can be completely destroyed by thermal cycling in absence of magnetic field as well as under H = 2 T. Magnetic measurements suggest that ferromagnetic phase fraction decreases with thermal cycling. We suggest that increase in strains in ferromagnetic- charge ordered interface could be a possible origin of the observed effect.Comment: 14 pages, 5 figures and 2 tables (revised

Anomaly in the dielectric response at the charge orbital ordering transition of crystalline Pr0.67Ca0.33MnO3

The complex impedance of a Pr0.67Ca0.33MnO3 crystal has been measured. The frequency dependence is studied for a wide range of temperatures (50K-403K) and is found to be characteristic of relaxation process with a single Debye time relaxation constant, which is interpreted as a dielectric constant of the material. A strong peak is observed in this dielectric constant (up to two millions) at the charge ordering transition suggesting an interpretation in terms of ordering of electric dipoles at TCO or in term of phase separation. Comparison with Pr0.63Ca0.37MnO3 - in which the phase separation is much smaller and the peak in the dielectric constant is absent - suggests an interpretation in term of phase separation between insulating and metallic states.Comment: pdf fil

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design

We found that spadin, a natural peptide derived from sortilin, blocks the mouse TREK-1 channel and might be an efficient and fast-acting antidepressant

Is the Morphological Subtype of Extra-Pulmonary Neuroendocrine Carcinoma Clinically Relevant?

From MDPI via Jisc Publications RouterHistory: accepted 2021-08-13, pub-electronic 2021-08-18Publication status: PublishedExtra-pulmonary neuroendocrine carcinomas (EP-NECs) are lethal cancers with limited treatment options. Identification of contributing factors to the observed heterogeneity of clinical outcomes within the EP-NEC family is warranted, to enable identification of effective treatments. A multicentre retrospective study investigated potential differences in “real-world” treatment/survival outcomes between small-cell (SC) versus (vs.) non-SC EP-NECs. One-hundred and seventy patients were included: 77 (45.3%) had SC EP-NECs and 93 (54.7%) had non-SC EP-NECs. Compared to the SC subgroup, the non-SC subgroup had the following features: (1) a lower mean Ki-67 index (69.3% vs. 78.7%; p = 0.002); (2) a lower proportion of cases with a Ki-67 index of ≥55% (73.9% vs. 88.7%; p = 0.025); (3) reduced sensitivity to first-line platinum/etoposide (objective response rate: 31.6% vs. 55.1%, p = 0.015; and disease control rate; 59.7% vs. 79.6%, p = 0.027); (4) worse progression-free survival (PFS) (adjusted-HR = 1.615, p = 0.016) and overall survival (OS) (adjusted-HR = 1.640, p = 0.015) in the advanced setting. Within the advanced EP-NEC cohort, subgroups according to morphological subtype and Ki-67 index (55% vs. ≥55%) had significantly different PFS (adjusted-p = 0.021) and OS (adjusted-p = 0.051), with the non-SC subgroup with a Ki-67 index of 55% and non-SC subgroup with a Ki-67 index of ≥55% showing the best and worst outcomes, respectively. To conclude, the morphological subtype of EP-NEC provides complementary information to the Ki-67 index and may aid identification of patients who could benefit from alternative first-line treatment strategies to platinum/etoposide