928 research outputs found
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
The transcription factor RUNX1 is a critical regulator of developmental hematopoiesis and is frequently disrupted in leukemia. Runx1 is a large, complex gene that is expressed from two alternative promoters under the spatiotemporal control of multiple hematopoietic enhancers. To dissect the dynamic regulation of Runx1 in hematopoietic development, we analyzed its three-dimensional chromatin conformation in mouse embryonic stem cell (ESC) differentiation cultures. Runx1 resides in a 1.1 Mb topologically associating domain (TAD) demarcated by convergent CTCF motifs. As ESCs differentiate to mesoderm, chromatin accessibility, Runx1 enhancer-promoter (E-P) interactions, and CTCF-CTCF interactions increase in the TAD, along with initiation of Runx1 expression from the P2 promoter. Differentiation to hematopoietic progenitor cells is associated with the formation of tissue-specific sub-TADs over Runx1, a shift in E-P interactions, P1 promoter demethylation, and robust expression from both Runx1 promoters. Deletion of promoter-proximal CTCF sites at the sub-TAD boundaries has no obvious effects on E-P interactions but leads to partial loss of domain structure, mildly affects gene expression, and delays hematopoietic development. Together, our analysis of gene regulation at a large multi-promoter developmental gene reveals that dynamic sub-TAD chromatin boundaries play a role in establishing TAD structure and coordinated gene expression
Direct measurement of the mass difference between top and antitop quarks
We present a direct measurement of the mass difference between top and
antitop quarks (dm) in lepton+jets top-antitop final states using the "matrix
element" method. The purity of the lepton+jets sample is enhanced for
top-antitop events by identifying at least one of the jet as originating from a
b quark. The analyzed data correspond to 3.6 fb-1 of proton-antiproton
collisions at 1.96 TeV acquired by D0 in Run II of the Fermilab Tevatron
Collider. The combination of the e+jets and mu+jets channels yields dm = 0.8
+/- 1.8 (stat) +/- 0.5 (syst) GeV, which is in agreement with the standard
model expectation of no mass difference.Comment: submitted to Phys. Rev.
A search for charged massive long-lived particles
We report on a search for charged massive long-lived particles (CMLLPs),
based on 5.2 fb of integrated luminosity collected with the D0 detector
at the Fermilab Tevatron collider. We search for events in which one
or more particles are reconstructed as muons but have speed and ionization
energy loss inconsistent with muons produced in beam collisions.
CMLLPs are predicted in several theories of physics beyond the standard model.
We exclude pair-produced long-lived gaugino-like charginos below 267 GeV and
higgsino-like charginos below 217 GeV at 95% C.L., as well as long-lived scalar
top quarks with mass below 285 GeV.Comment: submitted to Phys. Rev. Letter
Zgamma production and limits on anomalous ZZgamma and Zgammagamma couplings in ppbar collisions at sqrt(s)=1.96 TeV
We present a measurement of ppbar->Zgamma->ll+gamma (l = e, mu) production
with a data sample corresponding to an integrated luminosity of 6.2 fb^{-1}
collected by the D0 detector at the Fermilab Tevatron ppbar Collider. The
results of the electron and muon channels are combined, and we measure the
total production cross section and the differential cross section
dsigma/dp_T^gamma, where p_T^gamma is the momentum of the photon in the plane
transverse to the beamline. The results obtained are consistent with the
standard model predictions from next-to-leading order calculations. We use the
transverse momentum spectrum of the photon to place limits on anomalous ZZgamma
and Zgammagamma couplings
Precise measurement of the top quark mass in the dilepton channel at D0
We measure the top quark mass (mt) in ppbar collisions at a center of mass
energy of 1.96 TeV using dilepton ttbar->W+bW-bbar->l+nubl-nubarbbar events,
where l denotes an electron, a muon, or a tau that decays leptonically. The
data correspond to an integrated luminosity of 5.4 fb-1 collected with the D0
detector at the Fermilab Tevatron Collider. We obtain mt = 174.0 +- 1.8(stat)
+- 2.4(syst) GeV, which is in agreement with the current world average mt =
173.3 +- 1.1 GeV. This is currently the most precise measurement of mt in the
dilepton channel.Comment: 7 pages, 4 figure
Search for a Narrow ttbar Resonance in ppbar Collisions at sqrt{s}=1.96 TeV
We report a search for a narrow ttbar resonance that decays into a
lepton+jets final state based on an integrated luminosity of 5.3/fb of
proton-antiproton collisions at sqrt{s}=1.96 TeV collected by the D0
Collaboration at the Fermilab Tevatron Collider. We set upper limits on the
production cross section of such a resonance multiplied by its branching
fraction to ttbar which we compare to predictions for a leptophobic topcolor Z'
boson. We exclude such a resonance at the 95% confidence level for masses below
835 GeV.Comment: 7 pages, 3 figures, submitted to Physical Review Letter
Search for Decay
We have searched for the charmless hadronic decay of B0 mesons into two
neutral pions. Using 9.13fb^-1 taken at the Upsilon(4S) with the CLEO detector,
we obtain an improved upper limit for the branching fraction BR(B0-->pi0pi0) <
5.7*10^-6 at the 90% confidence level.Comment: pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Search for Zgamma events with large missing transverse energy in ppbar collisions at sqrt(s)=1.96 TeV
We present the first search for supersymmetry (SUSY) in Zgamma final states
with large missing transverse energy using data corresponding to an integrated
luminosity of 6.2 fb-1 collected with the D0 experiment in ppbar collisions at
sqrt(s)=1.96 TeV. This signature is predicted in gauge-mediated SUSY-breaking
models, where the lightest neutralino is the next-to-lightest supersymmetric
particle (NLSP) and is produced in pairs, possibly through decay from heavier
supersymmetric particles. The NLSP can decay either to a Z boson or a photon
and an associated gravitino that escapes detection. We exclude this model at
the 95% C.L. for SUSY breaking scales of Lambda < 87 TeV, corresponding to
neutralino masses of < 151 GeV.Comment: submitted to Phys. Rev. Let
Search for first generation leptoquark pair production in the electron + missing energy + jets final state
We present a search for the pair production of first generation scalar
leptoquarks (LQ) in data corresponding to an integrated luminosity of 5.4
fb collected with the D0 detector at the Fermilab Tevatron Collider in
ppbar collisions at TeV. In the channel , where q, q' are u or d quarks, no significant excess
of data over background is observed, and we set a 95% C.L. lower limit of 326
GeV on the leptoquark mass, assuming equal probabilities of leptoquark decays
to eq and .Comment: 7 pages, 6 figures, submitted to PRD-R
Search for the standard model and a fermiophobic Higgs boson in diphoton final states
We present a search for the standard model Higgs boson and a fermiophobic
Higgs boson in the diphoton final states based on 8.2 fb-1 of ppbar collisions
collected with the D0 detector at the Fermilab Tevatron Collider. No excess of
data above background predictions is observed and upper limits at the 95% C.L.
on the cross section multiplied by the branching fraction are set which are the
most restrictive to date. A fermiophobic Higgs boson with a mass below 112.9
GeV is excluded at the 95% C.L.Comment: 12 pages, 21 figures, submitted to PR
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