Conservation laws, exact travelling waves and modulation instability for an extended nonlinear Schr\"odinger equation

We study various properties of solutions of an extended nonlinear Schr\"{o}dinger (ENLS) equation, which arises in the context of geometric evolution problems -- including vortex filament dynamics -- and governs propagation of short pulses in optical fibers and nonlinear metamaterials. For the periodic initial-boundary value problem, we derive conservation laws satisfied by local in time, weak $H^2$ (distributional) solutions, and establish global existence of such weak solutions. The derivation is obtained by a regularization scheme under a balance condition on the coefficients of the linear and nonlinear terms -- namely, the Hirota limit of the considered ENLS model. Next, we investigate conditions for the existence of traveling wave solutions, focusing on the case of bright and dark solitons. The balance condition on the coefficients is found to be essential for the existence of exact analytical soliton solutions; furthermore, we obtain conditions which define parameter regimes for the existence of traveling solitons for various linear dispersion strengths. Finally, we study the modulational instability of plane waves of the ENLS equation, and identify important differences between the ENLS case and the corresponding NLS counterpart. The analytical results are corroborated by numerical simulations, which reveal notable differences between the bright and the dark soliton propagation dynamics, and are in excellent agreement with the analytical predictions of the modulation instability analysis.Comment: 27 pages, 5 figures. To be published in Journal of Physics A: Mathematical and Theoretica

Primary care physicians' perceptions of barriers and facilitators to management of chronic kidney disease: A mixed methods study.

BackgroundGiven the high prevalence of chronic kidney disease (CKD), primary care physicians (PCPs) frequently manage early stage CKD. Nonetheless, there are challenges in providing optimal CKD care in the primary care setting. This study sought to understand PCPs' perceptions of barriers and facilitators to the optimal management of CKD.Study designMixed methods study.Settings and participantsCommunity-based PCPs in four US cities: Baltimore, MD; St. Louis, MO; Raleigh, NC and San Francisco, CA.MethodologyWe used a self-administered questionnaire and conducted 4 focus groups of PCPs (n = 8 PCPs/focus group) in each city to identify key barriers and facilitators to management of patients with CKD in primary care.Analytic approachWe conducted descriptive analyses of the survey data. Major themes were identified from audio-recorded interviews that were transcribed and coded by the research team.ResultsOf 32 participating PCPs, 31 (97%) had been in practice for >10 years, and 29 (91%) practiced in a non-academic setting. PCPs identified multiple barriers to managing CKD in primary care including at the level of the patient (e.g., low awareness of CKD, poor adherence to treatment recommendations), the provider (e.g., staying current with CKD guidelines), and the health care system (e.g., inflexible electronic medical record, limited time and resources). PCPs desired electronic prompts and lab decision support, concise guidelines, and healthcare financing reform to improve CKD care.ConclusionsPCPs face substantial but modifiable barriers in providing care to patients with CKD. Interventions that address these barriers and promote facilitative tools may improve PCPs' effectiveness and capacity to care for patients with CKD

Comments and new results about the magnetospheric chaos hypothesis

International audienceIn this study we present theoretical concepts and results concerning the hypothesis test of the magnetospheric chaos. For this reason we compare the observational behavior of the magnetospheric system with results obtained by analysing different types of stochastic and deterministic input-output systems. The results of this comparison indicate that the hypothesis of lowdimensional chaos for the magnetospheric dynamics remains a possible and fruitful concept which must be developed further

Nonlinear analysis of magnetospheric data Part II. Dynamical characteristics of the AE index time series and comparison with nonlinear surrogate data

International audienceIn this study we have used dynamical characteristies such as Lyapunov exponents, nonlinear dynamic models and mutual information for the nonlinear analysis of the magnetospheric AE index time series. Similarly with the geometrical characteristic studied in Pavlos et al. (1999b), we have found significant differences between the original time series and its surrogate data. These results also suggest the rejection of the null hypothesis that the AE index belongs to the family of stochastic linear signals undergoing a static nonlinear distortion. Finally, we believe that these results support the hypothesis of nonlinearity and chaos for the magnetospheric dynamics

Safety Events in Kidney Transplant Recipients: Results from the Folic Acid for Vascular Outcome Reduction in Transplant Trial

Kidney transplant recipients are at increased risk for adverse safety events related to their reduced renal function and many medications

De Novo assembly and transcriptome analysis of the mediterranean fruit fly ceratitis capitata early embryos

The agricultural pest Ceratitis capitata, also known as the Mediterranean fruit fly or Medfly, belongs to the Tephritidae family, which includes a large number of other damaging pest species. The Medfly has been the first non-drosophilid fly species which has been genetically transformed paving the way for designing geneticbased pest control strategies. Furthermore, it is an experimentally tractable model, in which transient and transgene-mediated RNAi have been successfully used. We applied Illumina sequencing to total RNA preparations of 8-10 hours old embryos of C. capitata, This developmental window corresponds to the blastoderm cellularization stage. In summary, we assembled 42,614 transcripts which cluster in 26,319 unique transcripts of which 11,045 correspond to protein coding genes; we identified several hundreds of long ncRNAs; we found an enrichment of transcripts encoding RNA binding proteins among the highly expressed transcripts, such as CcTRA-2, known to be necessary to establish and, most likely, to maintain female sex of C. capitata. Our study is the first de novo assembly performed for Ceratitis capitata based on Illumina NGS technology during embryogenesis and it adds novel data to the previously published C. capitata EST databases. We expect that it will be useful for a variety of applications such as gene cloning and phylogenetic analyses, as well as to advance genetic research and biotechnological applications in the Medfly and other related Tephritidae

an introduction to personalized ehealth

Personalized medicine can be defined as the adaptation of medical treatments to the specific characteristics of patients. This approach allows health providers to develop therapies and interventions by taking into account the heterogeneity of illnesses and external factors such as the environment, patients' needs, and lifestyle. Technology could play an important role to achieve this new approach to medicine. An example of technology's utility regards real-time monitoring of individual well-being (subjective and objective), in order to improve disease management through data-driven personalized treatment recommendations. Another important example is an interface designed based on patient's capabilities and preferences. These could improve patient-doctor communication: on one hand, patients have the possibility to improve health decision-making; on the other hand, health providers could coordinate care services more easily, because of continual access to patient's data. This contribution deepens these technologies and related opportunities for health, as well as recommendation for successful development and implementation

The effect of postharvest calcium application on tissue calcium concentration, quality attributes, incidence of flesh browning and cell wall physicochemical aspects of peach fruits

The effects of postharvest calcium applications on cell wall properties and quality attributes of peach fruits (Prunus persica L. Batsch, cv. 'Andross') after harvest or cold storage up to 4 weeks were determined. The fruits were immersed in deionised water or in different calcium sources (calcium chloride, calcium lactate and calcium propionate) at two calcium concentrations (62.5 and 187.5 mM Ca). Calcium concentration profiles in fruits (peel and flesh), in cell wall and in pectin fractions were determined. The calcium content in the peel increased up to 2.7-fold, whereas flesh calcium increased up to 74%, 1 day after immersion. The increase of flesh calcium was accompanied by increase of cell wall calcium, which corresponded to a significant increase of calcium in the water-insoluble pectin fraction. However, calcium became saturated in the water-insoluble, but not water-soluble, pectin fraction with 62.5 mM Ca treatment. Treatment with 62.5 mM Ca salts was as effective as higher concentrations of calcium chloride maintaining tissue firmness during storage. Inversely, calcium lactate and calcium propionate at high concentrations (187.5 mM Ca) caused toxicity symptoms on the fruit surface, expressed as skin discoloration and superficial pitting, leading to additional chemical changes and reduced tissue firmness. Postharvest calcium applications limited the intense of chilling injury symptoms, expressed as flesh browning after 4 weeks cold storage. Peach fruits with severe flesh browning symptoms were characterized by reduced ethylene production, and reduced activities of the pectin modifying enzymes poly-galacturonase and pectin-methyl-esteras