685 research outputs found
How glassy are neural networks?
In this paper we continue our investigation on the high storage regime of a
neural network with Gaussian patterns. Through an exact mapping between its
partition function and one of a bipartite spin glass (whose parties consist of
Ising and Gaussian spins respectively), we give a complete control of the whole
annealed region. The strategy explored is based on an interpolation between the
bipartite system and two independent spin glasses built respectively by
dichotomic and Gaussian spins: Critical line, behavior of the principal
thermodynamic observables and their fluctuations as well as overlap
fluctuations are obtained and discussed. Then, we move further, extending such
an equivalence beyond the critical line, to explore the broken ergodicity phase
under the assumption of replica symmetry and we show that the quenched free
energy of this (analogical) Hopfield model can be described as a linear
combination of the two quenched spin-glass free energies even in the replica
symmetric framework
Prognostic factors and biomarkers of responses to immune checkpoint inhibitors in lung cancer
Manipulation of the immune response is a game changer in lung cancer treatment, revolutionizing management. PD1 and CTLA4 are dynamically expressed on different T cell subsets that can either disrupt or sustain tumor growth. Monoclonal antibodies (MoAbs) against PD1/PDL1 and CTLA4 have shown that inhibitory signals can be impaired, blocking T cell activation and function. MoAbs, used as both single-agents or in combination with standard therapy for the treatment of advanced non-small cell lung cancer (NSCLC), have exhibited advantages in terms of overall survival and response rate; nivolumab, pembrolizumab, atezolizumab and more recently, durvalumab, have already been approved for lung cancer treatment and more compounds are in the pipeline. A better understanding of signaling elicited by these antibodies on T cell subsets, as well as identification of biological determinants of sensitivity, resistance and correlates of efficacy, will help to define the mechanisms of antitumor responses. In addition, the relevance of T regulatory cells (Treg) involved in immune responses in cancer is attracting increasing interest. A major challenge for future research is to understand why a durable response to immune checkpoint inhibitors (ICIs) occurs only in subsets of patients and the mechanisms of resistance after an initial response. This review will explore current understanding and future direction of research on ICI treatment in lung cancer and the impact of tumor immune microenvironment n influencing clinical responses
Continuing Evidence Supporting the Role of Early Kinetic Monitoring (RVR) in Predicting SVR for HIV/HCV Coinfected Patients
Oxidation of single-walled carbon nanotubes under controlled chemical conditions
Single-walled carbon nanotubes are oxidized in the presence of H2SO4/HNO3 mixtures containing distinct concentrations of the nitronium ion, [NO2+]. The spectroscopic analyses of the final samples suggest a higher structural disorder in the oxidized systems with increasing [NO2+]. This is due to a considerable oxygen amount on the tube surface, reaching up to 30%, depending on the reaction time and [NO2+]. Interestingly, if long reaction time is considered, the oxygen amount on the tube surface is maximum for low [NO2+] and reduces slightly for larger [NO2+]. On the other hand, the oxidation process occurs gradually at 4 h, allowing a fine control of the oxidation process. Therefore, if fine tuning of the oxidation degree is desirable, the reaction must be conducted during short time (4 h) using increasing [NO2+] as those obtained from 2:1, 2.5:1 and 3:1 H2SO4/HNO3 acid mixtures to produce increasing content of functionalization.
Quantum ergodicity for graphs related to interval maps
We prove quantum ergodicity for a family of graphs that are obtained from
ergodic one-dimensional maps of an interval using a procedure introduced by
Pakonski et al (J. Phys. A, v. 34, 9303-9317 (2001)). As observables we take
the L^2 functions on the interval. The proof is based on the periodic orbit
expansion of a majorant of the quantum variance. Specifically, given a
one-dimensional, Lebesgue-measure-preserving map of an interval, we consider an
increasingly refined sequence of partitions of the interval. To this sequence
we associate a sequence of graphs, whose directed edges correspond to elements
of the partitions and on which the classical dynamics approximates the
Perron-Frobenius operator corresponding to the map. We show that, except
possibly for subsequences of density 0, the eigenstates of the quantum graphs
equidistribute in the limit of large graphs. For a smaller class of observables
we also show that the Egorov property, a correspondence between classical and
quantum evolution in the semiclassical limit, holds for the quantum graphs in
question.Comment: 20 pages, 1 figur
On composite systems of dilute and dense couplings
Composite systems, where couplings are of two types, a combination of strong
dilute and weak dense couplings of Ising spins, are examined through the
replica method. The dilute and dense parts are considered to have independent
canonical disordered or uniform bond distributions; mixing the models by
variation of a parameter alongside inverse temperature we
analyse the respective thermodynamic solutions. We describe the variation in
high temperature transitions as mixing occurs; in the vicinity of these
transitions we exactly analyse the competing effects of the dense and sparse
models. By using the replica symmetric ansatz and population dynamics we
described the low temperature behaviour of mixed systems.Comment: 35 pages, 9 figures, submitted to JPhys
Birth attendants’ hand hygiene compliance in healthcare facilities in low and middle-income countries: a systematic review
© 2020, The Author(s). Background: With an increasing number of women delivering in healthcare facilities in Low and Middle Income Countries (LMICs), healthcare workers’ hand hygiene compliance on labour wards is pivotal to preventing infections. Currently there are no estimates of how often birth attendants comply with hand hygiene, or of the factors influencing compliance in healthcare facilities in LMICs. Methods: We conducted a systematic review to investigate the a) level of compliance, b) determinants of compliance and c) interventions to improve hand hygiene during labour and delivery among birth attendants in healthcare facilities of LMICs. We also aimed to assess the quality of the included studies and to report the intra-cluster correlation for studies conducted in multiple facilities. Results: We obtained 797 results across four databases and reviewed 71 full texts. Of these, fifteen met our inclusion criteria. Overall, the quality of the included studies was particularly compromised by poorly described sampling methods and definitions. Hand hygiene compliance varied substantially across studies from 0 to 100%; however, the heterogeneity in definitions of hand hygiene did not allow us to combine or compare these meaningfully. The five studies with larger sample sizes and clearer definitions estimated compliance before aseptic procedures opportunities, to be low (range: 1–38%). Three studies described two multi-component interventions, both were shown to be feasible. Conclusions: Hand hygiene compliance was low for studies with larger sample sizes and clear definitions. This poses a substantial challenge to infection prevention during birth in LMICs facilities. We also found that the quality of many studies was suboptimal. Future studies of hand hygiene compliance on the labour ward should be designed with better sampling frames, assess inter-observer agreement, use measures to improve the quality of data collection, and report their hand hygiene definitions clearly.The Soapbox Collaborative contributed by funding the corresponding author, GG. The writing of this paper provided part of the background needed for the HANDS study funded by the Medical Research Council−PHIND scheme, award number MR/N015975/1, and the CLEAN Study, funded by the United Kingdom Joint Global Health Trials (Wellcome, MRC, DFID, and DOH), award number MR/R019274/1. SN is supported by an award jointly funded by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement which is also part of the EDCTP2 programme supported by the European Union. Grant Reference MR/K012126/1
Biodiesel synthesis: influence of alkaline catalysts in methanol-oil dispersion
CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORFAPERJ - FUNDAÇÃO DE AMPARO A PESQUISA DO ESTADO DO RIO DE JANEIROCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOBiodiesel synthesis from soybean oil using methanol and alkaline catalysts occurs in the following two consecutive steps: dispersion of methanol in the oil and methanolysis. The effect of the alkaline catalysts NaOCH3, KOCH3, NaOH, and KOH in the dispersi302342349CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORFAPERJ - FUNDAÇÃO DE AMPARO A PESQUISA DO ESTADO DO RIO DE JANEIROCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORFAPERJ - FUNDAÇÃO DE AMPARO A PESQUISA DO ESTADO DO RIO DE JANEIROCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOsem informaçãosem informaçãosem informaçãoThe authors would like to thank CAPES, FAPERJ, and CNPq (Brazilian agencies) for their financial suppor
Sumário Nacional de Touros da Raça Holandesa: 2004.
bitstream/item/81958/1/Sumario-nacional-de-touros.pd
Magnetic Anisotropy in the Molecular Complex V15
We apply degenerate perturbation theory to investigate the effects of
magnetic anisotropy in the magnetic molecule V15. Magnetic anisotropy is
introduced via Dzyaloshinskii-Moriya (DM) interaction in the full Hilbert space
of the system. Our model provides an explanation for the rounding of
transitions in the magnetization as a function of applied field at low
temperature, from which an estimate for the DM interaction is found. We find
that the calculated energy differences of the lowest energy states are
consistent with the available data. Our model also offers a novel explanation
for the hysteretic nature of the time-dependent magnetization data.Comment: Final versio
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