Evaluating kernels on Xeon Phi to accelerate Gysela application

This work describes the challenges presented by porting parts ofthe Gysela code to the Intel Xeon Phi coprocessor, as well as techniques used for optimization, vectorization and tuning that can be applied to other applications. We evaluate the performance of somegeneric micro-benchmark on Phi versus Intel Sandy Bridge. Several interpolation kernels useful for the Gysela application are analyzed and the performance are shown. Some memory-bound and compute-bound kernels are accelerated by a factor 2 on the Phi device compared to Sandy architecture. Nevertheless, it is hard, if not impossible, to reach a large fraction of the peek performance on the Phi device,especially for real-life applications as Gysela. A collateral benefit of this optimization and tuning work is that the execution time of Gysela (using 4D advections) has decreased on a standard architecture such as Intel Sandy Bridge.Comment: submitted to ESAIM proceedings for CEMRACS 2014 summer school version reviewe

Operations on integral lifts of K(n)

This very rough sketch is a sequel to arXiv:1808.08587; it presents evidence that operations on lifts of the functors K(n) to cohomology theories with values in modules over valuation rings of local number fields, indexed by Lubin-Tate groups of such fields, are extensions of the groups of automorphisms of the indexing group laws, by the exterior algebras on the normal bundle to the orbits of the group laws in the space of lifts.Comment: \S 2.0 hopefully less cryptic. To appear in the proceedings of the 2015 Nagoya conference honoring T Ohkawa. Comments very welcome

Low-energy graceful exit in anisotropic string cosmology backgrounds

We discuss the possibility of a smooth transition from the pre- to the post-big bang regime, in the context of the lowest-order string effective action (without higher-derivative corrections), taking into account with a phenomenological model of source the repulsive gravitational effects due to the back-reaction of the quantum fluctuations outside the horizon. We determine a set of necessary conditions for a successful and realistic transition, and we find that such conditions can be satisfied (by an appropriate model of source), provided the background is higher-dimensional and anisotropic.Comment: 13 pages, latex, 2 figures included using epsfi

Cosmological perturbations across a curvature bounce

String-inspired cosmologies, whereby a non-singular curvature bounce is induced by a general-covariant, $T$-duality-invariant, non-local dilaton potential, are used to study numerically how inhomogeneities evolve and to compare the outcome with analytic expressions obtained through different matching conditions across the bounce. Good agreement is found if continuity across the bounce is assumed to hold for $\cal{R}$, the curvature perturbation on comoving hypersurfaces, rather than for the Bardeen potential.Comment: 36 pages, 5 included figure

Tachyonic perturbations in AdS5_5 orbifolds

We show that scalar as well as vector and tensor metric perturbations in the Randall-Sundrum II braneworld allow normalizable tachyonic modes, i.e., possible instabilities. These instabilities require nonvanishing initial anisotropic stresses on the brane. We show with a specific example that within the Randall-Sundrum II model, even though the tachyonic modes are excited, no instability develops. We argue, however, that in the cosmological context instabilities might in principle be present. We conjecture that the tachyonic modes are due to the singularity of the orbifold construction. We illustrate this with a simple but explicit toy model.Comment: 11 pages, matches published versio

On graviton production in braneworld cosmology

We study braneworlds in a five dimensional bulk, where cosmological expansion is mimicked by motion through AdS$_5$. We show that the five dimensional graviton reduces to the four dimensional one in the late time approximation of such braneworlds. Inserting a fixed regulator brane far from the physical brane, we investigate quantum graviton production due to the motion of the brane. We show that the massive Kaluza-Klein modes decouple completely from the massless mode and they are not generated at all in the limit where the regulator brane position goes to infinity. In the low energy limit, the massless four dimensional graviton obeys the usual 4d equation and is therefore also not generated in a radiation-dominated universe.Comment: 9 pages, minor changes, references correcte

Uniform generation in trace monoids

We consider the problem of random uniform generation of traces (the elements of a free partially commutative monoid) in light of the uniform measure on the boundary at infinity of the associated monoid. We obtain a product decomposition of the uniform measure at infinity if the trace monoid has several irreducible components-a case where other notions such as Parry measures, are not defined. Random generation algorithms are then examined.Comment: Full version of the paper in MFCS 2015 with the same titl

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in this study we aim to investigate in vitro in a neuroblastoma cellular model of HD, the effect of CYP46A1 overexpression, an essential enzyme in cholesterol metabolism, on huntingtin aggregation and levels. Results We found that CYP46A1 reduces the quantity and size of mutant huntingtin aggregates in cells, as well as the levels of mutant huntingtin protein. Additionally, our results suggest that the observed beneficial effects of CYP46A1 in HD cells are linked to the activation of autophagy. Taken together, our results further demonstrate that CYP46A1 is a pertinent target to counteract HD progression.This work was supported by Brainvectis and E.rare: E-Rare Joint Transnational Call for Proposals 2017 “Transnational Research Projects for Innovative Therapeutic Approaches for Rare Diseases”. CN laboratory is supported by the French Muscular Dystrophy Association (AFM-Téléthon), the Ataxia UK, and the Fundação para a Ciência e Tecnologia (project ALG-01-0145-FEDER-29480 “SeGrPolyQ”). AM is supported by a Ph.D. fellowship from FCT (SFRH/BD/133192/2017)info:eu-repo/semantics/publishedVersio