Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins

Indexación: Web of ScienceThe evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class I deals predominantly with intracellular infections (e.g., viruses) and MHC class II with extracellular infections (e.g., bacteria). Therefore, patterns of MHC I and II diversity may differ between species and across populations of species depending on the relative effect of local and global environmental selective pressures, genetic drift, and gene flow. We hypothesize that high gene flow among populations of Humboldt and Magellanic penguins limits local adaptation in MHC I and MHC II, and signatures of selection differ between markers, locations, and species. We evaluated the MHC I and II diversity using 454 next-generation sequencing of 100 Humboldt and 75 Magellanic penguins from seven different breeding colonies. Higher genetic diversity was observed in MHC I than MHC II for both species, explained by more than one MHC I loci identified. Large population sizes, high gene flow, and/or similar selection pressures maintain diversity but limit local adaptation in MHC I. A pattern of isolation by distance was observed for MHC II for Humboldt penguin suggesting local adaptation, mainly on the northernmost studied locality. Furthermore, trans species alleles were found due to a recent speciation for the genus or convergent evolution. High MHC I and MHC II gene diversity described is extremely advantageous for the long term survival of the species.http://onlinelibrary.wiley.com/doi/10.1002/ece3.2502/epd

Windowed SHE-PWM of Interleaved Four-Quadrant Converters for Resonance Suppression in Traction Power Supply Systems

© 1986-2012 IEEE. AC electric locomotives that use a number of interleaved four-quadrant converters generate high-frequency switching harmonics which may stimulate certain resonances in traction power supply systems (TPSSs). A windowed selective harmonic elimination pulse-width modulation (SHE-PWM) method is proposed to suppress such resonances. Owing to the windowed design and the precalculated solutions, the proposed method covers the wide potential resonant frequency range and addresses the resonant frequency variation while keeping the low switching frequency of the traction converters. The proposed windowed SHE-PWM is fully tested with a closed-loop controller in a simulation model with the TPSS and the ac electric locomotive. Comparative simulation results show that the windowed SHE-PWM is an effective alternative that overcomes the resonance suppression limitations of the conventional phase-shifted PWM (PS-PWM). The performance of proposed windowed SHE-PWM on an experimental equivalent resonant circuit is further evaluated and compared with PS-PWM. Both simulation and experimental results verify the effectiveness and feasibility of the proposed method

Predictive Control of Cascaded H-Bridge Converters under Unbalanced Power Generation

© 1982-2012 IEEE. This paper presents a predictive control strategy for grid-connected cascaded H-bridge (CHB) converters under unbalanced power generation among each converter phase. The proposed controller belongs to the finite-control-set model predictive control (FCS-MPC) family and is designed to extract unbalanced power from each CHB converter phase while providing balanced power to the grid. The key novelty of this strategy lies in the way the unbalanced power generation among the phases is explicitly considered into the optimal control problem. Power balance is achieved by enforcing the CHB converter to work with a suitable zero-sequence voltage component. The proposed predictive controller is directly formulated in the original abc-framework to account for the common-mode voltage. Simulation and experimental results are provided to verify the effectiveness of the proposed FCS-MPC strategy

Predictive Control algorithm to achieve power balance of Cascaded H-Bridge converters

© 2015 IEEE. This work proposes a Model Predictive Control (MPC) strategy for Cascaded H-Bridge (CHB) converters under unbalanced power generation among each converter phase. Therefore, the control target is to extract unbalanced power from the dc-sources while providing balanced power to the grid. The key novelty of this proposal lies in the way the unbalanced power generation issue is explicitly considered into the optimal control problem. The power balance is achieved by enforcing the CHB to work with a suitable zero voltage components. Thus, to account for the common-mode voltage, the proposed MPC is directly formulated in the original abc-framework. To verify the effectiveness of this proposal, simulation results of the proposed MPC governing a five-level CHB converter are provided

Coronal mass ejections, magnetic clouds, and relativistic magnetospheric electron events: ISTP

The role of high-speed solar wind streams in driving relativistic electron acceleration within the Earth\u27s magnetosphere during solar activity minimum conditions has been well documented. The rising phase of the new solar activity cycle (cycle 23) commenced in 1996, and there have recently been a number of coronal mass ejections (CMEs) and related “magnetic clouds” at 1 AU. As these CME/cloud systems interact with the Earth\u27s magnetosphere, some events produce substantial enhancements in the magnetospheric energetic particle population while others do not. This paper compares and contrasts relativistic electron signatures observed by the POLAR, SAMPEX, Highly Elliptical Orbit, and geostationary orbit spacecraft during two magnetic cloud events: May 27–29, 1996, and January 10–11, 1997. Sequences were observed in each case in which the interplanetary magnetic field was first strongly southward and then rotated northward. In both cases, there were large solar wind density enhancements toward the end of the cloud passage at 1 AU. Strong energetic electron acceleration was observed in the January event, but not in the May event. The relative geoeffectiveness for these two cases is assessed, and it is concluded that large induced electric fields (∂B/∂t) caused in situ acceleration of electrons throughout the outer radiation zone during the January 1997 event

A Comprehensive View of the 2006 December 13 CME: From the Sun to Interplanetary Space

The biggest halo coronal mass ejection (CME) since the Halloween storm in 2003, which occurred on 2006 December 13, is studied in terms of its solar source and heliospheric consequences. The CME is accompanied by an X3.4 flare, EUV dimmings and coronal waves. It generated significant space weather effects such as an interplanetary shock, radio bursts, major solar energetic particle (SEP) events, and a magnetic cloud (MC) detected by a fleet of spacecraft including STEREO, ACE, Wind and Ulysses. Reconstruction of the MC with the Grad-Shafranov (GS) method yields an axis orientation oblique to the flare ribbons. Observations of the SEP intensities and anisotropies show that the particles can be trapped, deflected and reaccelerated by the large-scale transient structures. The CME-driven shock is observed at both the Earth and Ulysses when they are separated by 74$^{\circ}$ in latitude and 117$^{\circ}$ in longitude, the largest shock extent ever detected. The ejecta seems missed at Ulysses. The shock arrival time at Ulysses is well predicted by an MHD model which can propagate the 1 AU data outward. The CME/shock is tracked remarkably well from the Sun all the way to Ulysses by coronagraph images, type II frequency drift, in situ measurements and the MHD model. These results reveal a technique which combines MHD propagation of the solar wind and type II emissions to predict the shock arrival time at the Earth, a significant advance for space weather forecasting especially when in situ data are available from the Solar Orbiter and Sentinels.Comment: 26 pages, 10 figures. 2008, ApJ, in pres

In-hospital mortality of non-st segment elevation myocardial infarction in a Puerto Rican population

Introduction: Currently, there is limited published information on in-hospital mortality regarding ST segment elevation and non-ST segment elevation myocardial infarction. This information is even scarcer on the Hispanic population. We aim to study if there is a difference on in-hospital mortality between ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI) in a mostly Hispanic population. Methods: A secondary data analysis of a non-concurrent prospective study was performed using the Puerto Rican Heart Attack study database. Dependent variable was in-hospital mortality and independent variable was type of myocardial infarction (STEMI or NSTEMI). We conducted, sequentially, a descriptive, bivariate and multivariate analysis. The chi-squared test was used to compare categorical variables and t-test for continuous variables. Finally, a logistic regression model was used to perform the multivariate analysis. Results: From the 838 Puerto Rican patients hospitalized with ST classification, 310 (37%) were diagnosed with STEMI. Patients with STEMI were younger (65 years vs 68 years; p=0.008), more likely to receive invasive treatment (47.9% vs 27.5%, p<0.001), and less likely to have a history of hypertension (72.5% vs 79.0%, p=0.033) compared to NSTEMI patients. For every 1- year increase in age, there is a 4% increase in in-hospital mortality. Patients with hyperlipidemia were approximately two times more likely to die in the hospital compared to patients without hyperlipidemia. In the unadjusted analysis, there was no significant association between STEMI and NSTEMI patients and in-hospital mortality. After adjusting for confounders, patients with STEMI had twice the risk of dying than those with NSTEMI. Conclusions: Findings from this study suggest that Puerto Ricans with STEMI have double the risk of in-hospital mortality than NSTEMI patients. Our findings were similar to those reported in the literature. A timely recognition of at-risk patients, especially among STEMI patients, may help reduce short-term morality among patients hospitalized with acute myocardial infarction in Puerto Rico

Application of a MHD hybrid solar wind model with latitudinal dependences to Ulysses data at minimum

In a previous work, Ulysses data was analyzed to build a complete axisymmetric MHD solution for the solar wind at minimum including rotation and the initial flaring of the solar wind in the low corona. This model has some problems in reproducing the values of magnetic field at 1 AU despite the correct values of the velocity. Here, we intend to extend the previous analysis to another type of solutions and to improve our modelling of the wind from the solar surface to 1 AU. We compare the previous results to those obtained with a fully helicoidal model and construct a hybrid model combining both previous solutions, keeping the flexibility of the parent models in the appropriate domain. From the solar surface to the Alfven, point, a three component solution for velocity and magnetic field is used, reproducing the complex wind geometry and the well-known flaring of the field lines observed in coronal holes. From the Alfven radius to 1 AU and further, the hybrid model keeps the latitudinal dependences as flexible as possible, in order to deal with the sharp variations near the equator and we use the helicoidal solution, turning the poloidal streamlines into radial ones. Despite the absence of the initial flaring, the helicoidal model and the first hybrid solution suffer from the same low values of the magnetic field at 1 AU. However, by adjusting the parameters with a second hybrid solution, we are able to reproduce both the velocity and magnetic profiles observed by Ulysses and a reasonable description of the low corona, provided that a certain amount of energy deposit exists along the flow. The present paper shows that analytical axisymmetric solutions can be constructed to reproduce the solar structure and dynamics from 1 solar radius up to 1 AU.Comment: 12 pages, 16 figure

For which infants with viral bronchiolitis could it be deemed appropriate to use albuterol, at least on a therapeutic trial basis?

Although there is increasing evidence showing that infants with viral bronchiolitis exhibit a high degree of heterogeneity, a core uncertainty shared by many clinicians is with regard to understanding which patients are most likely to benefit from bronchodilators such as albuterol. Based on our review, we concluded that older infants with rhinovirus (RV) bronchiolitis, especially those with a nasopharyngeal microbiome dominated by Haemophilus influenzae; those affected during nonpeak months or during non-respiratory syncytial virus (RSV) predominant months; those with wheezing at presentation; those with clinical characteristics such as atopic dermatitis or a family history of asthma in a first-degree relative; and those infants infected with RSV genotypes ON1 and BA, have the greatest likelihood of benefiting from albuterol. Presently, this patient profile could serve as the basis for rational albuterol administration in patients with viral bronchiolitis, at least on a therapeutic trial basis, and it could also be the starting point for future targeted randomized clinical trials (RCTs) on the use of albuterol among a subset of infants with bronchiolitis