Fonksiyonel Kademelendirilmiş Plakalar ile Desteklenmiş Bal Peteği Sandviç Yapıların Düşük Hızlı Darbe Davranışlarının İncelenme

Konferans Bildirisi -- Teorik ve Uygulamalı Mekanik Türk Milli Komitesi, 2015Conference Paper -- Theoretical and Applied Mechanical Turkish National Committee, 2015Sandviç yapılar, sahip oldukları yüksek performans özelliklerinin farklı malzeme kombinasyonları ile elde edildiği kompozit malzeme alanının özel bir uygulamasıdır. Konvansiyonel malzemelere göre sahip oldukları birçok üstün özellikleri ile oldukça geniş bir uygulama alanına (havacılık ve uzay, otomotiv, savunma, vs.) sahiptirler. Sandviç yapı elemanları, uygulama alanına yönelik istenilen özelliklere sahip olması açısından farklı yüzey plakaları ve çekirdek malzemelerinden oluşabilir. Sandviç yapılar, kullanım alanlarına bağlı olarak darbeli yüklemelere maruz kalabildikleri için düşük hızlı darbe cevabının belirlenmesi oldukça önemli bir rol oynamaktadır. Fonksiyonel kademelendirilmiş plakalar ile desteklenmiş bal peteği sandviç yapıların düşük hızlı darbe yükleri altındaki deformasyonları ve enerji sönümleme kabiliyetleri LS-DYNA® sonlu elemanlar programı kullanılarak araştırılmıştır. Sandviç yapı, Al/SiC fonksiyonel kademelendirilmiş kompozit yüzey plakaları ve Al 3003-H19 alaşımı bal peteğinden oluşmaktadır. Sandviç yapının darbe cevabı, fonksiyonel kademelendirilmiş destek plakalarının farklı malzeme kompozisyonu, vurucu kütlesinin sabit olduğu farklı çarpma enerjileri ve bal peteği çekirdek malzemesinin farklı hücre duvar kalınlıkları için incelenmiştir.Sandwich structures are specific applications of the composite materials whose high performance properties are obtained by different material combinations. They have quite extensive usage areas (aeronautics and aerospace, automotive, defense, etc.) with their several high quality properties compared with the conventional materials. Sandwich structures can be consisted of different facesheets and core materials in order to have required properties for the application areas. The determination of the low-velocity impact response of the sandwich structures has an important role by reason of their working areas with impulsive loadings. The deformations and energy absorption capability of the honeycomb sandwich structures reinforced by the functionally graded plates under low-velocity impact loads were investigated using explicit finite element software, LS-DYNA®. The sandwich structure was consisted of Al/SiC FG facesheets and Al 3003-H19 aluminum honeycomb core. The impact response of the sandwich structure was investigated in terms of different material compositions of the FG plates, impact energies and cell wall thickness of the honeycomb core

Fonksiyonel Kademelendirilmiş Sandviç Plakaların Balistik Darbe Yükü Altındaki Davranışı Üzerinde Farklı Seramik Bileşenlerinin

Konferans Bildirisi -- Teorik ve Uygulamalı Mekanik Türk Milli Komitesi, 2015Conference Paper -- Theoretical and Applied Mechanical Turkish National Committee, 2015Günümüzde de gelişen tehditler karşısında daha etkin balistik koruma sağlayacak hafif ve yüksek performanslı zırhların geliştirilmesi kritik bir ihtiyaç haline gelmiş ve bu sahadaki yeni malzeme arayışları seramik ön yüzlü kompozit zırhları ön plana çıkarmıştır. Katmanlı yapıya sahip bu plakalar yüksek mukavemetleri ve yüksek rijitlikleri nedeniyle balistik sistemlerde yaygın olarak kullanılırlar. Ancak, katmanlardaki malzeme özelliklerinin ani olarak değişmesi nedeniyle ara yüzeylerde yüksek gerilmeler meydana gelir ve bu gerilmeler de katmanlar arasında ayrılmalara (delaminasyon) neden olur. Bu olumsuz etkiler fonksiyonel kademelendirilmiş malzemeler (FGM) kullanılarak azaltılabilir ya da ortadan kaldırılabilir. Bu çalışma ile farklı seramik bileşenlere sahip fonksiyonel kademelendirilmiş sandviç plakalarda balistik darbe yükleme altında meydana gelen hasar mekanizmaları ve deformasyonları deneysel olarak incelenmiştir.Today, the development of high-performance and light armors has become a critical requirement against emerging threats. The research for new materials in this field has brought ceramic-faced composite armors to the forefront. Layered composite structures are widely used in ballistic systems due to their high strength and high stiffness. An abrupt change in their material properties across an interface between discrete materials introduces large interlaminar stresses that could cause delamination. One way to overcome this adverse effect is to use a functionally graded material (FGM). The purpose of this study is to determine damage and deformation mechanisms of functionally graded sandwich plates, which have different ceramic components, under ballistic impact loads

A novel mutation of KIF11 in a child with 22q11.2 deletion syndrome associated with MCLMR

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR; OMIM 152950) is a rare autosomal dominantly inherited syndrome. Mutations in the kinesin family member 11 (KIF11) gene have been associated with this condition. Here, we report a de novo novel heterozygous missense mutation in exon 12 of the KIF11 gene [c.1402T>G; p.(Leu468Val)] in a boy with 22q11.2 microdeletion syndrome. His major features were microcephaly, ventricular septal defect, congenital lymphedema of the feet, and distinct facial appearance including upslanting palpebral fissures, a broad nose with rounded tip, anteverted nares, long philtrum with a thin upper lip, pointed chin, and prominent ears. His right eye was enucleated due to subretinal hemorrhage and retinal detachment at age 3 months. Lacunae of chorioretinal atrophy and the pale optic disc were present in the left eye. He also had a de novo 1.6-Mb microdeletion in the Di George/VCFS region of chromosome 22q11.2 in SNP array, which was confirmed by FISH analysis. In this study, for the first time, we describe the co-occurrence of a KIF11 mutation and 22q11.2 deletion syndrome in a patient with MCLMR

An Ensemble of Bayesian Neural Networks for Exoplanetary Atmospheric Retrieval

Machine learning is now used in many areas of astrophysics, from detecting exoplanets in Kepler transit signals to removing telescope systematics. Recent work demonstrated the potential of using machine learning algorithms for atmospheric retrieval by implementing a random forest to perform retrievals in seconds that are consistent with the traditional, computationally-expensive nested-sampling retrieval method. We expand upon their approach by presenting a new machine learning model, \texttt{plan-net}, based on an ensemble of Bayesian neural networks that yields more accurate inferences than the random forest for the same data set of synthetic transmission spectra. We demonstrate that an ensemble provides greater accuracy and more robust uncertainties than a single model. In addition to being the first to use Bayesian neural networks for atmospheric retrieval, we also introduce a new loss function for Bayesian neural networks that learns correlations between the model outputs. Importantly, we show that designing machine learning models to explicitly incorporate domain-specific knowledge both improves performance and provides additional insight by inferring the covariance of the retrieved atmospheric parameters. We apply \texttt{plan-net} to the Hubble Space Telescope Wide Field Camera 3 transmission spectrum for WASP-12b and retrieve an isothermal temperature and water abundance consistent with the literature. We highlight that our method is flexible and can be expanded to higher-resolution spectra and a larger number of atmospheric parameters

Simulation-Based Inference for Global Health Decisions

The COVID-19 pandemic has highlighted the importance of in-silico epidemiological modelling in predicting the dynamics of infectious diseases to inform health policy and decision makers about suitable prevention and containment strategies. Work in this setting involves solving challenging inference and control problems in individual-based models of ever increasing complexity. Here we discuss recent breakthroughs in machine learning, specifically in simulation-based inference, and explore its potential as a novel venue for model calibration to support the design and evaluation of public health interventions. To further stimulate research, we are developing software interfaces that turn two cornerstone COVID-19 and malaria epidemiology models COVID-sim, (https://github.com/mrc-ide/covid-sim/) and OpenMalaria (https://github.com/SwissTPH/openmalaria) into probabilistic programs, enabling efficient interpretable Bayesian inference within those simulators

Histopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial area

Background: An abscess is a pocket of pus that forms around the root of an infected tooth. In this study, we aimed to investigate the extracellular matrix proteases ADAMTS1, ADAMTS4, osteonectin, and osteopontin expressions in abscess fluid cells in jaws after implantation and prosthesis operation. Materials and methods: In this clinical study, abscess fluids belonging to 17 patients who applied to the Department of Oral and Maxillofacial Surgery were examined histopathologically and immunohistochemically. In the histopathological examination of the abscess fluid, separation of chromatin bridges in the nuclei of neutrophil cells, pyknosis and apoptotic changes in the nucleus, degenerative change in the cytoplasm, and occasional vacuolar structures were observed. Results: The positive reaction of ADAMTS1 was observed in fibroblast cells, plasma cells, and macrophage cells. The positive reaction of ADAMTS4 was observed in fibroblast cells, osteoclast cells, and some apoptotic leukocyte cells. Osteopontin expression in osteoclastic cells and polymorphonuclear cells was defined as positive. Osteonectin expression was positive in polymorphonuclear leukocytes and hypertrophic fibroblast cells. Conclusions: ADAMTS1 and ADAMTS4 may induce bone destruction with its distinctive property in alveolar bone resorption, which promotes the activation of osteoclasts, which can accelerate the destruction of the extracellular matrix in the acute phase. Furthermore, osteoclastic activity increased with the increase of osteonectin and osteopontin protein expression due to inflammation in the abscess cases

Kırka Boraks atıklarının soda liçi

Bor, çok geniş kullanım alanları ile, insanlığın bugünkü ve gelecekteki yaşamlarında, vazgeçilmez bir endüstriyel hammadde olarak önemini gittikçe arttıracaktır. Ülkemiz bu açıdan şanslı bir konumda olup, toplam dünya bor rezervlerinin yaklaşık %60 'mı içermektedir Bu nedenlerden dolayı, bor cevherlerimizin en verimli bir şekilde üretimi ülkemiz açısından çok fazla önem arz etmektedir. Kırka boraks konsantratöründe, her yıl yaklaşık %10-12 B2O3 tenörlü 250 bin ton yaş artık oluşmakta ve bunun yanında artık göletinde de benzer tenörlü yaklaşık 4 milyon ton birikmiş katı artık bulunmaktadır. Artıkların teknolojik koşullara uygun olarak değerlendirilmesi gerekmektedir. Bu çalışmada, kırka boraks artıklarının soda liçi ile değerlendirilmesinde etken olan parametreler ayrıntılı bir şekilde araştırılmıştır. Bu amaçla, boraks artıklarının Na2C03 ve NaHCC>3 liçi; değişik sıcaklık, çözücü"miktarları, katı/sıvı oranlan ve çözeltine sürelerinde denenmiş olup, düşük çözücü oranlarında, optimal sıcaklık ve sürede başarılı sonuçlar alınmıştır. Sonuçta, seyreltik soda çözeltisi ile yapılan deneylerde, artiklardaki boraks yüksek verimle çözünmüş ve elde edilen bulgulardan yararlanılarak, tesisin mevcut çalışma koşullarına uygun optimum öneri akım şemalan geliştirilmiştir. Aynca, bu yöntemle boraks artıklarının değerlendirilmesinde, çözücü olarak tronanın kullanılması ile ülkemizde büyük bir potansiyele sahip olan trona yataklan yem bir kullanım alam bulmuş olacaktır.Boron will continue its importance in the recent world and in the future as a very well-known and necessary industrial rawmaterial with common use areas. Our country is very advantegeous in this point and contains approximately 60 % of total world reserves of boron. Thus production of boron ores is greatly significant for our country. In the Kırka Tincal Concentrator, approximately 250 000 tons wet tailings with a grade of 10 -12 % are produced and separately 4 million tons tailings with similar grade are disposed. Beneficiation from the Kırka Tincal tailings is thereby necessary. In this study, the effective parameters m soda leaching of the Kırka Tincal tailings have been investigated in detail. For this aim, Na2CC>3 and NaHCC>3 leaching of the tailings at different temperature, concentration, solid/liquid ratio and leaching time were carried out. As a conclusion, in the experiments made with aqueous soda solutions, tincal were efficiently extracted and an optimum processing plant proposal was developed. Furthermore, with use of trona in this processing method of the tailings, the great trona deposits will find a different use

A systematic review of nutrition-based practices in prevention of hypertension among healthy youth

The aim of this systematic review was to analyze the results of observational and interventional research/studies on nutrition-based practices in the prevention of hypertension among healthy youth. The MEDLINE/PubMed database was searched using the key words, "hypertension," "nutrition/diet," "prevention" and "youth." Inclusion criteria were: 1) sample with a majority of adolescents, defined as 10-24 years of age, or findings for adolescents reported separately from other age groups; 2) primary research reports; 3) studies with normotensive participants; and 4) studies that focused on preventing hypertension/lowering blood pressure through at least one nutritional practice. Results of the analysis indicated that increased consumption of unsaturated fats, fruits, vegetables and low-fat dietary products, decreased consumption of dietary sodium and beverages containing caffeine, and breastfeeding were found to have preventive effects against high blood pressure in later years of life. The effects of training given during youth to encourage a healthy lifestyle and behavior changes based on diet and physical activity were also noted.publisher versio

Redox, haem and CO in enzymatic catalysis and regulation

The present paper describes general principles of redox catalysis and redox regulation in two diverse systems. The first is microbial metabolism of CO by the Wood–Ljungdahl pathway, which involves the conversion of CO or H2/CO2 into acetyl-CoA, which then serves as a source of ATP and cell carbon. The focus is on two enzymes that make and utilize CO, CODH (carbon monoxide dehydrogenase) and ACS (acetyl-CoA synthase). In this pathway, CODH converts CO2 into CO and ACS generates acetyl-CoA in a reaction involving Ni·CO, methyl-Ni and acetyl-Ni as catalytic intermediates. A 70 Å (1 Å=0.1 nm) channel guides CO, generated at the active site of CODH, to a CO ‘cage’ near the ACS active site to sequester this reactive species and assure its rapid availability to participate in a kinetically coupled reaction with an unstable Ni(I) state that was recently trapped by photolytic, rapid kinetic and spectroscopic studies. The present paper also describes studies of two haem-regulated systems that involve a principle of metabolic regulation interlinking redox, haem and CO. Recent studies with HO2 (haem oxygenase-2), a K+ ion channel (the BK channel) and a nuclear receptor (Rev-Erb) demonstrate that this mode of regulation involves a thiol–disulfide redox switch that regulates haem binding and that gas signalling molecules (CO and NO) modulate the effect of haem.National Institutes of Health (U.S.) (NIH grant GM69857)National Institutes of Health (U.S.) (NIH grant GM39451)National Institutes of Health (U.S.) (NIH grant HL 102662)National Institutes of Health (U.S.) (NIH grant GM65440)National Institutes of Health (U.S.) (NIH grant GM48242)National Institutes of Health (U.S.) (NIH grant Y1-GM- 1104)National Institutes of Health (U.S.) (NIH grant GM065318)National Institutes of Health (U.S.) (NIH grant AG027349)National Science Foundation (U.S.) (grant number CHE-0745353)United States. Dept. of Energy. Office of Biological and Environmental ResearchHoward Hughes Medical Institute (Investigator

Religious Officials' knowledge, attitude, and behavior towards smoking and the new tobacco law in Kahramanmaras, Turkey

<p>Abstract</p> <p>Background</p> <p>Tobacco control effort should be first started in people that are looked upon as role models for the general population. We aimed to determine the knowledge, attitude, and behavior of religious officials towards smoking and the new tobacco law.</p> <p>Method</p> <p>The study group was comprised of 492 Imams and 149 Quran course instructors working in Kahramanmaras city of Turkey, 641 religious officials in total, and our survey form was applied on 406 (63.3%) of those religious officials who agreed to participate in the study.</p> <p>Results</p> <p>Twenty-eight (6.9%) participants were current smokers and 35 (8.6%) were ex-smokers. 99.8% of the religious officials believed that smoking was harmful and/or prohibited in terms of religion. While 43.6% respondents thought smoking was "<it>haram</it>" (forbidden by Islam), 56.2% believed it was "<it>makruh</it>" (something regarded as reprehensible, though not forbidden by God according to Islam). 85.2% of the participants were aware of the recent tobacco law. 55.5% of the respondents, who were aware of the recent tobacco law, evaluated their knowledge level on the law as adequate, whereas 44.5% evaluated it as inadequate 92.4% of the participants noted that religious officials should play active roles in tobacco control effort.</p> <p>Conclusion</p> <p>Smoking rate among religious officials is much lower than that of general public. In order to help religious officials to take a more active role on this issue, they should be trained on the subject and appropriate platforms should be established.</p