Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2

Apropiación social del conocimiento en cuatro grados de desarrollo empresarial en organizaciones productivas mexicanas en la frontera Sur México/ Belice. Análisis del modelo OCDE

Social appropriation of knowledge in four degrees of business development in Mexican production organizations in the Southern Mexico / Belize border. Analysis of the Model OECD Abstract From the inclusion of Mexico in the OECD, this research paper attempts to answer the question of technological innovation for increasing the competitiveness of the four largest firms in the state of Quintana Roo, Mexico economically and socially based on their size and characteristics. The research was part of a study conducted in the southeast of Mexico and it was sponsored by the FORDECyT. The current model of the OECD (2009-2010) with standards on the appropriation of knowledge, adapted to the direct interview method was used for the analysis.Although the results showed a noticeable backwardness in the four companies analyzed regarding the appropriation of knowledge, they also show ethnic and cultural differences in the Maya peoples living in this region when it comes to social businesses. They adopt complete technological packages and / or globalizing market models. When facing the impossibility of adopting or appropriating socially the knowledge, they are dependent on their workforce or their ancestral patterns of production and exploitation of the main resource

Apropriação social do conhecimento em quatro grados de desenvolvimento empresarial em organizações produtivas mexicanas na fronteira Sul México/Belize. Análise do modelo OCDE

From the inclusion of Mexico in the OECD, this research paper attempts to answer the question of technological innovation for increasing the competitiveness of the four largest firms in the state of Quintana Roo, Mexico economically and socially based on their size and characteristics. The research was part of a study conducted in the southeast of Mexico and it was sponsored by the FORDECyT. The current model of the OECD (2009-2010) with standards on the appropriation of knowledge, adapted to the direct interview method was used for the analysis.Although the results showed a noticeable backwardness in the four companies analyzed regarding the appropriation of knowledge, they also show ethnic and cultural differences in the Maya peoples living in this region when it comes to social businesses. They adopt complete technological packages and / or globalizing market models. When facing the impossibility of adopting or appropriating socially the knowledge, they are dependent on their workforce or their ancestral patterns of production and exploitation of the main resourceA partir de la inserción de México en la OCDE, el presente artículo de investigación intenta darrespuesta al tema de la innovación tecnológica para el incremento de la competitividad de las cuatroempresas más importantes del estado de Quintana Roo, México económica y socialmente,en funciónde su tamaño y características. La investigación formó parte de un estudio al sureste de Méxicofinanciado por el FORDEC y T. El modelo vigente de la OCDE (2009-2010) con estándares sobreapropiación del conocimiento, adaptado al método de entrevista directa sirvió de análisis. Aunque losresultados mostraron un marcado atraso en las cuatro empresas analizadas en cuanto apropiacióndel conocimiento, los resultados arrojan diferencias étnicas y culturales de los mayas que habitan enesta región cuando se trata de empresas de tipo social. Ellos adoptan paquetes tecnológicos completosy/o modelos de mercado globalizantes; ante la imposibilidad de adoptar o apropiar socialmenteel conocimiento, son dependientes de su fuerza de trabajo o bien, de sus modelos ancestrales deproducción o explotación del recurso principal.A partir da inserção do México na OCDE, o presente artigo de pesquisa tenta dar resposta à questão da inovação tecnológica para o incremento da competitividade das quatro empresas mais importantes do Estado de Quintana Roo, México, económica e socialmente, em função do seu tamanho e características. A pesquisa formou parte de um estudo ao sudeste do México financiado pelo FORDECyT. O modelo vigente da OCDE (2009-2010) com padrões sobre apropriação do conhecimento, adaptado ao método de entrevista direta serviu de análise. Embora os resultados mostraram um atraso marcante nas quatro empresas analisadas em quanto apropriação do conhecimento, os resultados mostram diferenças étnicas e culturais dos maias que habitam nesta região quando se tratou de empresas de tipo social. Eles adotaram pacotes tecnológicos completos e/ou modelos de mercado globalizantes; perante à impossibilidade de adotar ou apropriar socialmente o conhecimento, são dependentes da sus forca de trabalho ou bem, dos modelos ancestrais de produção ou exploração do recurso principa

Apropriação social do conhecimento em quatro grados de desenvolvimento empresarial em organizações produtivas mexicanas na fronteira Sul México/Belize. Análise do modelo OCDE

From the inclusion of Mexico in the OECD, this research paper attempts to answer the question of technological innovation for increasing the competitiveness of the four largest firms in the state of Quintana Roo, Mexico economically and socially based on their size and characteristics. The research was part of a study conducted in the southeast of Mexico and it was sponsored by the FORDECyT. The current model of the OECD (2009-2010) with standards on the appropriation of knowledge, adapted to the direct interview method was used for the analysis.Although the results showed a noticeable backwardness in the four companies analyzed regarding the appropriation of knowledge, they also show ethnic and cultural differences in the Maya peoples living in this region when it comes to social businesses. They adopt complete technological packages and / or globalizing market models. When facing the impossibility of adopting or appropriating socially the knowledge, they are dependent on their workforce or their ancestral patterns of production and exploitation of the main resourceA partir de la inserción de México en la OCDE, el presente artículo de investigación intenta darrespuesta al tema de la innovación tecnológica para el incremento de la competitividad de las cuatroempresas más importantes del estado de Quintana Roo, México económica y socialmente,en funciónde su tamaño y características. La investigación formó parte de un estudio al sureste de Méxicofinanciado por el FORDEC y T. El modelo vigente de la OCDE (2009-2010) con estándares sobreapropiación del conocimiento, adaptado al método de entrevista directa sirvió de análisis. Aunque losresultados mostraron un marcado atraso en las cuatro empresas analizadas en cuanto apropiacióndel conocimiento, los resultados arrojan diferencias étnicas y culturales de los mayas que habitan enesta región cuando se trata de empresas de tipo social. Ellos adoptan paquetes tecnológicos completosy/o modelos de mercado globalizantes; ante la imposibilidad de adoptar o apropiar socialmenteel conocimiento, son dependientes de su fuerza de trabajo o bien, de sus modelos ancestrales deproducción o explotación del recurso principal.A partir da inserção do México na OCDE, o presente artigo de pesquisa tenta dar resposta à questão da inovação tecnológica para o incremento da competitividade das quatro empresas mais importantes do Estado de Quintana Roo, México, económica e socialmente, em função do seu tamanho e características. A pesquisa formou parte de um estudo ao sudeste do México financiado pelo FORDECyT. O modelo vigente da OCDE (2009-2010) com padrões sobre apropriação do conhecimento, adaptado ao método de entrevista direta serviu de análise. Embora os resultados mostraram um atraso marcante nas quatro empresas analisadas em quanto apropriação do conhecimento, os resultados mostram diferenças étnicas e culturais dos maias que habitam nesta região quando se tratou de empresas de tipo social. Eles adotaram pacotes tecnológicos completos e/ou modelos de mercado globalizantes; perante à impossibilidade de adotar ou apropriar socialmente o conhecimento, são dependentes da sus forca de trabalho ou bem, dos modelos ancestrais de produção ou exploração do recurso principa

Dietary polyphenol intake is associated with HDL-cholesterol and a better profile of other components of the metabolic syndrome: a PREDIMED-Plus sub-study

Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.The PREDIMED-Plus trial was supported by official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects led by J.S.-S. and J.Vi., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Special Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), a grant from the Fundació la Marató de TV3 (PI044003), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018),grants from the Generalitat Valenciana (PROMETEO/2017/017, APOSTD/2019/136), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R) and funds from the European Regional Development Fund (CB06/03). The Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU17/00785) contract. Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA), American Pistachio Growers (Fresno, CA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA) donated nuts. This call is co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands