Optimal Renormalization Group Transformation from Information Theory

Recently a novel real-space RG algorithm was introduced, identifying the relevant degrees of freedom of a system by maximizing an information-theoretic quantity, the real-space mutual information (RSMI), with machine learning methods. Motivated by this, we investigate the information theoretic properties of coarse-graining procedures, for both translationally invariant and disordered systems. We prove that a perfect RSMI coarse-graining does not increase the range of interactions in the renormalized Hamiltonian, and, for disordered systems, suppresses generation of correlations in the renormalized disorder distribution, being in this sense optimal. We empirically verify decay of those measures of complexity, as a function of information retained by the RG, on the examples of arbitrary coarse-grainings of the clean and random Ising chain. The results establish a direct and quantifiable connection between properties of RG viewed as a compression scheme, and those of physical objects i.e. Hamiltonians and disorder distributions. We also study the effect of constraints on the number and type of coarse-grained degrees of freedom on a generic RG procedure.Comment: Updated manuscript with new results on disordered system

Antiglycative effect of fruit and vegetable seed extracts: Inhibition of AGE formation and carbonyl-trapping abilities

BACKGROUND: Advanced glycation end-products (AGEs) are the final products derived from the non-enzymatic glycation process. AGEs are involved in the development of several health complications associated with diabetes and aging. Searching for anti- AGE extracts is necessary to mitigate the effects of age-related pathologies. RESULTS: The antioxidant and antiglycative activities of eight aqueous extracts of fruit and vegetable seeds were evaluated. All seed extracts (3.6 mg mL-1) exhibited anti-AGE activity in protein-glucose assay, ranging from 20 to 92% inhibition compared with aminoguanidine (4.87 mmol L-1). Green pepper extract exerted the highest anti-AGE activity. However, peach and pomegranate extracts exhibited the highest anti-AGE activity in protein-methylglyoxal assay, ranging from 0 to 79% inhibition. Hazelnut, almond and sesame extracts were not effective when methylglyoxal was the promoter. Apricot and peach extracts appeared to inhibit the formation of AGEs through their capacity for direct trapping of 1,2-dicarbonyls (IC50=0.14 mg mL-1). No relationship between antioxidant and phenolic compound content and antiglycative activity was found. Therefore other hydrophilic constituents in addition to phenolic acids must be involved in the antiglycative activity of the extracts. CONCLUSION: Aqueous extracts of fruits and vegetables can be considered in the prevention of glycation-associated complications of age-related pathologies. © 2012 Society of Chemical Industry.Peer Reviewe

Human semantic parsing for person re-identification

Person re-identification is a challenging task mainly dueto factors such as background clutter, pose, illuminationand camera point of view variations. These elements hinder the process of extracting robust and discriminative representations, hence preventing different identities from being successfully distinguished. To improve the representation learning, usually local features from human body partsare extracted. However, the common practice for such aprocess has been based on bounding box part detection.In this paper, we propose to adopt human semantic parsing which, due to its pixel-level accuracy and capabilityof modeling arbitrary contours, is naturally a better alternative. Our proposed SPReID integrates human semanticparsing in person re-identification and not only considerably outperforms its counter baseline, but achieves stateof-the-art performance. We also show that, by employinga simple yet effective training strategy, standard populardeep convolutional architectures such as Inception-V3 andResNet-152, with no modification, while operating solelyon full image, can dramatically outperform current stateof-the-art. Our proposed methods improve state-of-the-artperson re-identification on: Market-1501 [48] by ~17% inmAP and ~6% in rank-1, CUHK03 [24] by ~4% in rank-1and DukeMTMC-reID [50] by ~24% in mAP and ~10% inrank-1.Computer Vision FoundationWOS:000457843601020Scopus - Affiliation ID: 60105072Conference Proceedings Citation Index- ScienceProceedings PaperHaziran2018YÖK - 2017-1

Morphometric analysis of the lumbar vertebrae in the Turkish population using three-dimensional computed tomography: correlation with sex, age, and height

Background: Morphometric measurements of lumbar vertebrae are different in European and Asian populations. Transpedicular screws are candidates for the ideal method to treat instability of lumbar vertebrae and provide very strong stabilisation. Our study reflects the variation of morphometric measurements of lumbar vertebrae in the Turkish population according to sex, age, and height. The aim of our study was to measure the transverse pedicle diameter (TPD), vertical pedicle diameter (VPD), pedicle axis length (PAL), and transverse pedicle angle (TPA) of the lumbar vertebrae, using three-dimensional computed tomography (3D-CT), and assess variations according to sex, age, and height. Materials and methods: Prospective cohort, Therapeutic Level III, Urban Level III Trauma Centre. The study design adopted a morphometric analysis using 3D-CT of the lumbar vertebrae in the Turkish population, with variation in terms of sex, age, and height and comparison with previous studies. In 240 cases, measurements of TPC, VPD, PAL, and TPA with 3D-CT were performed on a total of 1200 lumbar vertebrae. The values at each lumbar level were compared in groups based on sex, age, and height. Results: The results of our study determined the normal values of TPD, VPD, PAL, and TPA of lumbar vertebrae in the Turkish population using 3D-CT. Additionally there were variations in TPD, VPD, and PAL according to sex, age, and height. TPA varied according to age, while no difference was found in terms of sex or height. Conclusions: The morphometric measurements of lumbar vertebrae in the Turkish population are similar to western populations. Sex, age, and height are factors affecting reliable screw choice

Biofortification and Localization of Zinc in Wheat Grain

Zinc (Zn) deficiency associated with low dietary intake is a well-documented public health problem, resulting in serious health and socioeconomic problems. Field experiments were conducted with wheat to test the role of both soil and foliar application of ZnSO4 in Zn concentration of whole grain and grain fractions (e.g., bran, embryo and endosperm) in 3 locations. Foliar application of ZnSO4 was realized at different growth stages (e.g., stem elongation, boot, milk, dough stages) to study the effect of timing of foliar Zn application on grain Zn concentration. The rate of foliar Zn application at each growth stage was 4 kg of ZnSO4 3 7H2O ha-1. Laser ablation (LA)-ICP-MS was used to follow the localization of Zn within grain. Soil Zn application at a rate of 50 kg of ZnSO4 3 7H2O ha-1 was effective in increasing grain Zn concentration in the Zn-deficient location, but not in the locations without soil Zn deficiency. In all locations, foliar application of Zn significantly increased Zn concentration in whole grain and in each grain fraction, particularly in the case of high soil N fertilization. In Zn-deficient location, grain Zn concentration increased from 11 mg kg-1 to 22 mg kg-1 with foliar Zn application and to 27 mg kg-1 with a combined application of ZnSO4 to soil and foliar. In locations without soil Zn deficiency, combination of high N application with two times foliar Zn application (e.g., at the booting and milk stages) increased grain Zn concentration, on average, from 28 mg kg-1 to 58 mg kg-1. Both ICP-OES and LA-ICP-MS data showed that the increase in Zn concentration of whole grain and grain fractions was pronounced when Zn was sprayed at the late growth stage (e.g., milk and dough). LA-ICP-MS data also indicated that Zn was transported into endosperm through the crease phloem. To our knowledge, this is the first study to show that the timing of foliar Zn application is of great importance in increasing grain Zn in wheat, especially in the endosperm part that is the predominant grain fraction consumed in many countries. Providing a large pool of Zn in vegetative tissues during the grain filling (e.g., via foliar Zn spray) is an important practice to increase grain Zn and contribute to human nutritio

Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women with Hormone Receptor-Positive, Early Breast Cancer

Background EarlyR gene signature in estrogen receptor–positive (ER+) breast cancer is computed from the expression values of ESPL1, SPAG5, MKI67, PLK1, and PGR. EarlyR has been validated in multiple cohorts profiled using microarrays. This study sought to verify the prognostic features of EarlyR in a case-cohort sample from BIG 1–98, a randomized clinical trial of ER+ postmenopausal breast cancer patients treated with adjuvant endocrine therapy (letrozole or tamoxifen). Methods Expression of EarlyR gene signature was estimated by Illumina cDNA-mediated Annealing, Selection, and Ligation assay of RNA from formalin-fixed, paraffin-embedded primary breast cancer tissues in a case-cohort subset of ER+ women (N = 1174; 216 cases of recurrence within 8 years) from BIG 1–98. EarlyR score and prespecified risk strata (≤25 = low, 26–75 = intermediate, >75 = high) were “blindly” computed. Analysis endpoints included distant recurrence–free interval and breast cancer–free interval at 8 years after randomization. Hazard ratios (HRs) and test statistics were estimated with weighted analysis methods. Results The distribution of the EarlyR risk groups was 67% low, 19% intermediate, and 14% high risk in this ER+ cohort. EarlyR was prognostic for distant recurrence–free interval; EarlyR high-risk patients had statistically increased risk of distant recurrence within 8 years (HR = 1.73, 95% confidence interval = 1.14 to 2.64) compared with EarlyR low-risk patients. EarlyR was also prognostic of breast cancer–free interval (HR = 1.74, 95% confidence interval = 1.21 to 2.62). Conclusions This study confirmed the prognostic significance of EarlyR using RNA from formalin-fixed, paraffin-embedded tissues from a case-cohort sample of BIG 1–98. EarlyR identifies a set of high-risk patients with relatively poor prognosis who may be considered for additional treatment. Further studies will focus on analyzing the predictive value of EarlyR signature

Biochemical and colour changes of watercress (Nasturtium officinale R. Br.) during freezing and frozen storage

The effects of water blanching, freezing, and frozen storage during 400 days at three different temperatures (-7, - 15 and -30 degrees C), on watercress (Nasturtium officinale R. Br.) colour Hunter Lab parameters, chlorophyll degradation, vitamin C content loss and peroxidase (POD) activity were evaluated. The blanching induced significant changes on colour values and chlorophylls and vitamin C contents. POD activity was reduced 85% from its initial value. Freezing did not affect chlorophylls and vitamin C levels, however, promoted significant differences in colour values and POD residual activity. During frozen storage, ascorbic acid (AA) and POD activity degradations followed first-order kinetics, and colour parameters (L(H) . a(H) . b(H), -a(H)/b(H,) L(H) . a(H)/b(H), L(H)/a(H) and hue (h(H)(0))) were Successfully described by zero-order kinetics. The Storage temperature effect Was Successfully described by the Arrhenius law. Chlorophylls and dehydroascorbic acid (DHAA) contents were kept constant during frozen storage. (C) 2008 Elsevier Ltd. All rights reserved

Isatuximab in combination with lenalidomide and dexamethasone in patients with high-risk smoldering multiple myeloma: Updated safety run-in results from the randomized phase 3 ithaca study

Background: Results from a randomized, Phase 3 study by the Spanish Myeloma Group (PETHEMA/GEM) previously showed that treatment with lenalidomide plus dexamethasone (Rd) may delay progression to active disease in patients (pts) with high-risk smoldering multiple myeloma (SMM), compared with observation. To further improve outcomes, addition of the anti-CD38 antibody isatuximab (Isa) to lenalidomide and dexamethasone (Isa-Rd) for the treatment of pts with high-risk SMM is being evaluated in the ongoing, randomized, multi-center, Phase 3 ITHACA study (NCT04270409). Initial findings from the safety run-in analysis of this trial have shown a manageable safety profile and encouraging, preliminary anti-myeloma activity. We now report updated safety and efficacy results from the safety run-in part of ITHACA at a median follow-up of 19.4 months. Methods: Pts were included in the study if they had been diagnosed within 5 years with SMM (per the International Myeloma Working Group [IMWG] criteria) and had high-risk SMM according to the Mayo '20-2-20' and/or updated PETHEMA model criteria. Pts who had received prior anti-myeloma treatment were not eligible. Enrolled pts received Isa 10 mg/kg IV on day (D) 1, 8, 15, and 22 in cycle (C) 1, D1 and D15 C2-12, D1 C13-36; plus R D1-21 (25 mg C1-9; 10 mg C10-24) and d weekly (40 mg, 20 mg for ≥75 yr-old pts C1-9; 20 mg C10-24). Cycle duration was 28 days. Safety evaluations included treatment-emergent AEs (TEAEs)/serious AEs and laboratory parameters, graded by NCI-CTCAE v5.0. Response was determined by IMWG criteria (2016). Mandatory imaging by MRI and/or low-dose whole-body CT/PET-CT, and assessments of minimal residual disease (MRD, by next-generation sequencing in pts with very good partial response [VGPR] or better), were performed at protocol-defined time points. The primary study objective for the safety run-in was to confirm the recommended dose of Isa in combination with Rd. Overall response rate (ORR) and MRD negativity rate at 10-5 sensitivity were included as secondary endpoints.Sanof