5,280 research outputs found
Quantum Phase Transitions detected by a local probe using Time Correlations and Violations of Leggett-Garg Inequalities
In the present paper we introduce a way of identifying quantum phase
transitions of many-body systems by means of local time correlations and
Leggett-Garg inequalities. This procedure allows to experimentally determine
the quantum critical points not only of finite-order transitions but also those
of infinite order, as the Kosterlitz-Thouless transition that is not always
easy to detect with current methods. By means of simple analytical arguments
for a general spin- Hamiltonian, and matrix product simulations of
one-dimensional and anisotropic models, we argue that
finite-order quantum phase transitions can be determined by singularities of
the time correlations or their derivatives at criticality. The same features
are exhibited by corresponding Leggett-Garg functions, which noticeably
indicate violation of the Leggett-Garg inequalities for early times and all the
Hamiltonian parameters considered. In addition, we find that the infinite-order
transition of the model at the isotropic point can be revealed by the
maximal violation of the Leggett-Garg inequalities. We thus show that quantum
phase transitions can be identified by purely local measurements, and that
many-body systems constitute important candidates to observe experimentally the
violation of Leggett-Garg inequalities.Comment: Minor changes, 11 pages, 11 figures. Final version published in Phys.
Rev.
Can solar tower plants withstand the operational flexibility of combined cycle plants?
The aim of this work is to investigate the level of reliability of a 100 MWe solar tower plant operating as a load-following plant using actual operational data of combined cycle power plants. Despite the low cost, the steam generator has been identified as the main cause of unavailability of solar tower plants due to fatigue failures of tube-to-tubesheet joints, which can lead to steam/water leakage into the heat transfer fluid circuit, putting the plant performance at risk. A methodology based on the ASME code and EN standards is proposed to predict the fatigue failures of critical welded points of the steam generator, such as tube-to-tubesheet joints and other T-joints. The results show that the forced outages due to failures of the steam generator lead to an energy penalty that ranges over 230-453 GWh over the plant lifetime. The associated annual degradation rate ranges over 0.123-0.244%. Three tube leakage repair strategies are compared: tube-to-tubesheet weld crack repair, tube plugging and tube plugging with steam generator replacement. The latter strategy was shown to be the best practice because the lowest levelized cost of energy was obtained. In addition, the design of heat exchangers with a minimum of 20% extra area is highly recommended to not compromise the plant operation due to tube plugging. Last, the load-following operation of the solar tower plant increases the levelized cost of energy by approximately 1.6% in the case of tube repair and approximately 0.8% in the case of tube plugging with steam generator replacement.This research is partially funded by the Spanish government under the project RTI2018-096664-B-C21 (MICINN/FEDER, UE) and the fellowship "Programa de apoyo a la realización de proyectos interdisciplinares de I + D para jóvenes investigadores de la Universidad Carlos III de Madrid 2019-2020" under the project ZEROGASPAIN-CM-UC3M (2020/00033/001)
Broad N2H+ emission towards the protostellar shock L1157-B1
We present the first detection of N2H+ towards a low-mass protostellar
outflow, namely the L1157-B1 shock, at about 0.1 pc from the protostellar
cocoon. The detection was obtained with the IRAM 30-m antenna. We observed
emission at 93 GHz due to the J = 1-0 hyperfine lines. The analysis of the
emission coupled with the HIFI CHESS multiline CO observations leads to the
conclusion that the observed N2H+(1-0) line originates from the dense (> 10^5
cm-3) gas associated with the large (20-25 arcsec) cavities opened by the
protostellar wind. We find a N2H+ column density of few 10^12 cm-2
corresponding to an abundance of (2-8) 10^-9. The N2H+ abundance can be matched
by a model of quiescent gas evolved for more than 10^4 yr, i.e. for more than
the shock kinematical age (about 2000 yr). Modelling of C-shocks confirms that
the abundance of N2H+ is not increased by the passage of the shock. In summary,
N2H+ is a fossil record of the pre-shock gas, formed when the density of the
gas was around 10^4 cm-3, and then further compressed and accelerated by the
shock.Comment: ApJ, in pres
Relationship between heat shock proteins and cellular resistance to drugs and ageing
Background and aims
Ageing is a multifactorial degenerative process which causes a decrease in the cellular capacity for repair and adaptation to external stressors. In this way, it is important to maintain the proper balance of the proteome. Heat shock proteins (HSP) will intervene in this balance, which are responsible for the correct assembly, folding and translocation of other proteins when cells are subjected to stressors. This type of protein is overexpressed in human tumor cells, while its deficit, both in function and quantity, contributes to ageing processes. The present work aims to analyze the response of cells from studies carried out in normal and tumor cells that are subjected to stressors.
Methods and results
A PubMed search was performed using the keywords “cell ageing, cell longevity, resistance, HSP, heat shock proteins, thermal shock proteins”. This search generated 212 articles. Subsequently, a series of inclusion and exclusion criteria were applied to select the articles of interest to be evaluated. Normal cells subjected to external stressors at low doses increase the number of HSP, causing them to become more resistant. In addition, tumor cells expressing high levels of HSP show greater resistance to treatment and increased cell replication. HSP intervene in the cellular resistance of both normal and tumor cells.
Conclusions
In the case of normal cells, the increase in HSP levels makes them respond effectively to an external stressor, increasing their resistance and not causing cell death. In the case of tumor cells, there is an increase in resistance to treatment.Funding for open access charge: Universidad de Málaga/CBUA
Guía simplificada de intervención farmacéutica en normopeso con factores de riesgo, sobrepeso y obesidad
Según la Organización Mundial de la Salud (OMS), “la obesidad es la epidemia del siglo XXI”. Cerca del 20% de la población española es obesa y el 38% tiene sobrepeso. En Estados Unidos es la causa de 300.000 muertes al año y, en España, supone el 6,9% del gasto sanitario anual. Es, por tanto, un problema de salud pública frente al cual la intervención del farmacéutico está justificada por tratarse de una enfermedad crónica con una elevada prevalencia para la que existen tratamientos farmacológicos efectivos y seguros y un elevado número de pacientes en los que el tratamiento no resulta efectivo 1,2
Water-stress induced physiological changes in leaves of four container-grown grapevine cultivars (Vitis vinifera L.)
Predawn leaf water potential, night respiration, stomatal conductance, transpiration, and photosynthesis of 4 grapevine cultivars were assessed under irrigated and non-irrigated conditions in July, August and September 1994. Predawn leaf water potential was not significantly related to either stomatal conductance or photosynthesis. Water stress induced distinct stomatal closure in all cultivars at 11 a.m. For a given stomatal conductance rate, photosynthesis of stressed vines was lower than that of nonstressed vines. At similar stomatal conductance rate, photosynthesis was lower in cv. Chardonnay than in any other cultivar. Photosynthesis was the physiological parameter mostly affected by water stress. Dry matter production was linearly related to stomatal conductance, photosynthesis, and the night respiration to photosynthesis ratio for all vines pooled together. In contrast, under stress conditions dry matter production was not related to any physiological parameter.
Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia
Interactions between GluR2 and N-ethylmaleimide-sensitive factor (NSF) mediate AMPA receptors trafficking. This might be linked with molecular mechanisms related with memory formation. Previous research has shown basolateral amygdala (BLA) dependent activity changes in the perirhinal cortex (PRh) during the formation of taste memory. In the present experiments we investigate both the behavioral performance and the expression profile of NSF and GluR2 genes in several brain areas, including PRh, BLA, and hippocampus. Twenty-one naive male Wistar rats were exposed to a saccharin solution (0.4%) during the first (novel), the second (Familiar I), and the sixth presentation (Familiar II). Total RNA was extracted and gene expression was measured by quantitative PCR (qPCR) using TaqMan gene expression assays. In addition the expression of the synaptic plasticity related immediate early genes, Homer 1 and Narp, was also assessed. We have found increased expression of NSF gene in BLA and PRh in Group Familiar I in comparison with Familiar II. No changes in the expression of GluR2, Homer 1, and Narp genes were found. The results suggest the relevance of a potential network in the temporal lobe for taste recognition memory and open new possibilities for understanding the molecular mechanisms mediating the impact of sensory experience on brain circuit function.This research was supported by Grants PSI2011-23702 and PSI2014-57643-P (MINECO, Spain) and FPI fellowship to B. Gómez-Chacón (MINECO, Spain)
Composition of Kinetic Momenta: The U_q(sl(2)) case
The tensor products of (restricted and unrestricted) finite dimensional
irreducible representations of \uq are considered for a root of unity.
They are decomposed into direct sums of irreducible and/or indecomposable
representations.Comment: 27 pages, harvmac and tables macros needed, minor TeXnical revision
to allow automatic TeXin
The CHESS survey of the L1157-B1 bow-shock: high and low excitation water vapor
Molecular outflows powered by young protostars strongly affect the kinematics
and chemistry of the natal molecular cloud through strong shocks resulting in
substantial modifications of the abundance of several species. As part of the
"Chemical Herschel Surveys of Star forming regions" guaranteed time key
program, we aim at investigating the physical and chemical conditions of H20 in
the brightest shock region B1 of the L1157 molecular outflow. We observed
several ortho- and para-H2O transitions using HIFI and PACS instruments on
board Herschel, providing a detailed picture of the kinematics and spatial
distribution of the gas. We performed a LVG analysis to derive the physical
conditions of H2O shocked material, and ultimately obtain its abundance. We
detected 13 H2O lines probing a wide range of excitation conditions. PACS maps
reveal that H2O traces weak and extended emission associated with the outflow
identified also with HIFI in the o-H2O line at 556.9 GHz, and a compact (~10")
bright, higher-excitation region. The LVG analysis of H2O lines in the
bow-shock show the presence of two gas components with different excitation
conditions: a warm (Tkin~200-300 K) and dense (n(H2)~(1-3)x10^6 cm-3) component
with an assumed extent of 10" and a compact (~2"-5") and hot, tenuous
(Tkin~900-1400 K, n(H2)~10^3-10^4 cm-3) gas component, which is needed to
account for the line fluxes of high Eu transitions. The fractional abundance of
the warm and hot H2O gas components is estimated to be (0.7-2)x10^{-6} and
(1-3)x10^{-4}, respectively. Finally, we identified an additional component in
absorption in the HIFI spectra of H2O lines connecting with the ground state
level, probably arising from the photodesorption of icy mantles of a
water-enriched layer at the edges of the cloud.Comment: Accepted for publication in A&A. 12 pages, 9 figures, 4 table
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