Valoración del proceso docente de la asignatura de Genética Médica por estudiantes de una facultad de medicina cubana.

Background: The Medical Genetics subject is taught in the fourth semester of the Medicine degree. During the 2022-2023 academic year, a strategy was implemented to improve the educational teaching process. What assessment do medical students have of the educational teaching process of the subject of medical genetics during the 2022-2023 academic year?. Objective: to present the assessment of the teaching process of the Medical Genetics subject by Cuban students of the Manuel Fajardo Faculty of Medicine in the 2022-2023 academic year. Methods: A cross-sectional analytical observational study was carried out on a sample of 115 students of the fourth semester of the Medicine career of the Manuel Fajardo Faculty of Medical Sciences in the capital of Cuba. Fifteen variables related to the educational teaching process previously validated by expert teachers were characterized. Results: 68.5% of the students had a favorable expectation. 60.5% of the students stated that it was difficult to understand the language used in the subject. There was a good student-teacher relationship (95.5%), support from the study group in clarifying doubts (88.5%) team study (69.8%) and the class schedule contributed to the study of the subject (64.0%). More than 94% of the students perceived the teacher's preparation, the quality of the teaching aids, the student-teacher communication, among other aspects, as satisfactory. Conclusions: The evaluation of the teaching-educational process of the subject of Medical Genetics by Cuban students of the Manuel Fajardo Faculty of Medicine in the 2022-2023 academic year was favorable.Antecedentes: La asignatura de Genética Médica se imparte en el cuarto semestre de la carrera de Medicina. Durante el curso académico 2022-2023 se implementó una estrategia para perfeccionar el proceso docente educativo. Qué valoración tienen los estudiantes de medicina sobre el proceso docente educativo de la asignatura de genética médica durante el curso 2022-2023?  Objetivo: exponer la valoración del proceso docente de la asignatura de Genética Médica por estudiantes cubanos de la Facultad de Medicina Manuel Fajardo en el curso académico 2022-2023. Métodos: Se realizó un estudio observacional analítico transversal a una muestra de 115 alumnos del cuarto semestre de la carrera de Medicina de la Facultad de Ciencias Médicas Manuel Fajardo de la capital de Cuba. Se caracterizaron 15 variables relacionadas con el proceso docente educativo previamente validadas por profesores expertos. Resultados: El 68,5% de los estudiantes tuvieron una expectativa favorable. El 60,5% de los estudiantes afirmaron dificultad para entender el lenguaje usado en la asignatura. Hubo buena relación alumno-profesor (95,5%), apoyo del colectivo de estudio en la aclaración de dudas (88,5%) estudio en equipo (69,8%) y el horario de las clases contribuyó para el estudio individual de la asignatura (64,0%). Más del 94% de los alumnos percibieron como satisfactoria la preparación del profesor, la calidad en los medios de enseñanza, la comunicación alumno-profesor, entre otros aspectos.  Conclusiones: Resultó favorable la valoración del proceso docente-educativo de la asignatura de Genética Médica por estudiantes cubanos de la Facultad de Medicina Manuel Fajardo en el curso académico 2022-2023

Estudio preliminar de las mineralizaciones de la mina de oro romana de Llamas de Cabrera (León, NO de España)

[ES] La mina de Llamas de Cabrera (León, España) es un yacimiento de oro explotado en época romana, en el que coexisten mineralizaciones de oro primario y de oro secundario. Las mineralizaciones de oro primario arman sobre todo en los tramos superiores de la Cuarcita Armoricana. Se trata de mineralizaciones filonianas, siendo muy abundantes las que encajan en fracturas tensionales de dirección N180°E/70-85°E y ocasionales las asociadas a fracturas de direcciones N70°E y N125°E. Están formadas por cuarzo y arsenopirita muy dominante sobre pirita, galena, oro, calcopirita, bismutina, tetraedrita y covellina. Las alteraciones hidrotermales acompañantes son silicificaciones, sericitizaciones y cloritizaciones. Los minerales supergénicos determinados son escorodita, goethita y anglesita. El oro explotado es oro libre dispuesto generalmente en microfisuras en arsenopirita o cuarzo. Su contenido en plata varía desde 1,99 a 7,62%, mientras que el contenido en cobre es muy bajo, permaneciendo por debajo del límite de detección instrumental. El estudio realizado pone de manifiesto la existencia de dos fases de mineralización, producidas durante dos eventos hidrotermales de edad hercínica, además de la fase supergénica. Las mineralizaciones de oro secundario, explotadas en sedimentos aluviales y coluviales, se produjeron por la actuación del ciclo exógeno sobre los yacimientos de oro primario. Se estima que el volumen total de material movido en época romana ascendió a 2 Mm3.[EN] The mine of Llamas de Cabrera (Leon, Spain) is a gold deposit operated during the Roman Empire, in which primary and secondary gold ores coexist. The primary gold ores were hosted mainly in the upper layers of the Armorican Quartzite. They are lodes, being very abundant those hosted in N180°E/70-85°E tensional fractures and rare the ones associated to N70°E and N125°E fractures. They are formed by quartz and arsenopyrite very dominant over pyrite, galena, gold, chalcopyrite, bismuthinite, tetrahedrite and covellite. The accompanying hydrothermal alteration is silicification, sericitization and chloritization. The determined supergene minerals are scorodite, goethite and anglesite. The operated gold is free gold located generally in microfractures in arsenopyrite or quartz. Its content in silver varies from 1,99 to 7,62%, whereas the copper content is very low, remaining below the limit of instrumental detection. This study shows the existence of two phases of mineralization, deposited during two hydrothermal events of hercinian age, in addition to the supergenic phase. The secondary gold ores, operated in alluvial and colluvial sediments, were deployed by the action of the exogenous cycle on the primary gold deposits. We consider that the total volume of material moved at roman time ascended to 2 Mm3.SIEste trabajo ha sido realizado en el marco del Proyecto de Investigación «Evaluación y génesis de los depósitos primarios de oro de los Montes de León (Sierras del Teleno y Cabrera)», financiado por la Excma. Diputación provincial de León (Ayudas a Proyectos de Investigación con destino en la Universidad de León, año 2004)

Complexity analysis of spontaneous brain activity: effects of depression and antidepressant treatment

Magnetoencephalography (MEG) allows the real-time recording of neural activity and oscillatory activity in distributed neural networks. We applied a non-linear complexity analysis to resting-state neural activity as measured using whole-head MEG. Recordings were obtained from 20 unmedicated patients with major depressive disorder and 19 matched healthy controls. Subsequently, after 6 months of pharmacological treatment with the antidepressant mirtazapine 30 mg/day, patients received a second MEG scan. A measure of the complexity of neural signals, the Lempel–Ziv Complexity (LZC), was derived from the MEG time series. We found that depressed patients showed higher pre-treatment complexity values compared with controls, and that complexity values decreased after 6 months of effective pharmacological treatment, although this effect was statistically significant only in younger patients. The main treatment effect was to recover the tendency observed in controls of a positive correlation between age and complexity values. Importantly, the reduction of complexity with treatment correlated with the degree of clinical symptom remission. We suggest that LZC, a formal measure of neural activity complexity, is sensitive to the dynamic physiological changes observed in depression and may potentially offer an objective marker of depression and its remission after treatment

Deep Sequencing of the Mexican Avocado Transcriptome, an Ancient Angiosperm with a High Content of Fatty Acids

Background: Avocado (Persea americana) is an economically important tropical fruit considered to be a good source of fatty acids. Despite its importance, the molecular and cellular characterization of biochemical and developmental processes in avocado is limited due to the lack of transcriptome and genomic information. Results: The transcriptomes of seeds, roots, stems, leaves, aerial buds and flowers were determined using different sequencing platforms. Additionally, the transcriptomes of three different stages of fruit ripening (pre-climacteric, climacteric and post-climacteric) were also analyzed. The analysis of the RNAseqatlas presented here reveals strong differences in gene expression patterns between different organs, especially between root and flower, but also reveals similarities among the gene expression patterns in other organs, such as stem, leaves and aerial buds (vegetative organs) or seed and fruit (storage organs). Important regulators, functional categories, and differentially expressed genes involved in avocado fruit ripening were identified. Additionally, to demonstrate the utility of the avocado gene expression atlas, we investigated the expression patterns of genes implicated in fatty acid metabolism and fruit ripening. Conclusions: A description of transcriptomic changes occurring during fruit ripening was obtained in Mexican avocado, contributing to a dynamic view of the expression patterns of genes involved in fatty acid biosynthesis and the fruit ripening process

Experimental Techniques to Measure Hypnotic Levels During Surgery

[Abstract] The administration of anesthetics during a surgical procedure has been done historically in a manual way with the anesthesiologist deciding what amounts and at what rates to use. Over the last few decades there has been a rapid increase in the automation of many medical areas including anesthesiology, with that increased level of automation have also appeared new ways to measure the level of sedation in patients. Historically, one of the most frequently index used has been the BIS, which has proven rather reliable as an indicator. More recently, another index called PSI has attracted interest of practitioners. In this article a comparison of these two indexes was performed. Data recording BIS and PSI values from surgical operations for several patients were collected and analyzed. The results seem to indicate that it is to be expected that in 95% of the cases the correlation between the BIS and PSI index will be at least 0.6866.This work has been supported by the grant DPI2010-18278 of the Spanish Governmenthttps://doi.org/10.17979/spudc.978849749808

Propuesta en Supply Chain Management y Logística en la Empresa Permoda Ltda.

Tabla de Procesos de Activación Modelo SCOR. Análisis Comparativo Índice de Desempeño Logístico según Banco Mundial. Elementos Fundamentales del Conpes 3547 Política Nacional Logística. Cuestionario: Instrumento de consulta para develar la forma de Inventarios. Plano General Layout propuesto, vistas en detalle. Mapa conceptual con el tema “TMS” (Transportation Management System). Cuestionario Procesos Logísticos en Aprovisionamiento. Formato de Evaluación de proveedores Permoda Ltda. Mapa conceptual “DRP” (Planeación de los Recursos de Distribución). Mapa conceptual “Mega tendencias en Supply Chain Management y Logística.La logística era el proceso que las empresas manejaban para traer las materias primas a la fábrica para luego llevar un producto terminado a sus cliente, ahora la dinámica es más compleja y la logística se volvió parte fundamental de la evolución del proceso que hoy llamamos Supply Chain o cadena de suministro. La cadena de suministro es la cooperación de todos los involucrados en el proceso que se realiza para tomar la materia prima, convertirla en un producto y llevar el producto terminado y de buena calidad al cliente final, para que esto se desarrolle adecuadamente debe haber una globalización de procesos con actualizaciones constantes y trabajo en equipo. En este trabajo tomamos la empresa Permoda LTDA. Del sector textil en la cual se desarrolla la metodología de Supply Chain buscando problemas como cuellos de botella que frenan la cadena de suministro, utilizando las herramientas ya establecidas de esta metodología, también se da un vistazo de cómo esta Colombia frente a otros países a nivel logístico y de infraestructura.Logistics was the process that companies managed to bring raw materials to the factory and then bring a finished product to their customers, now the dynamics are more complex and the logistics became a fundamental part of the evolution of the process that we now call Supply Chain or supply chain. The supply chain is the cooperation of all those involved in the process that is carried out to take the raw material, turn it into a product and bring the finished and good quality product to the end customer, so that this is properly developed there must be a globalization of processes with constant updates and teamwork. In this work we take the company Permoda LTDA. From the textile sector in which Supply Chain's methodology is developed looking for problems such as bottlenecks that slow down the supply chain, using the established tools of this methodology, there is also a glimpse of how Colombia is facing other countries at the logistic and infrastructure level

Acercando los archivos a los ciudadanos. Una experiencia desde el <em>Portal de Archivos Españoles (PARES)</em> del Ministerio de Educación, Cultura y Deporte

The Spanish Archives Portal is the third generation in the computerization of the State Archives. It is intended to provide citizens and researchers with integrated on-line access to the archival databases of the eight state general archives distributed across Spain, while facsimiles or digital versions of the documents are added to the archival description catalogue. At the same time, PARES is producing a line of tools for electronic management of the public services offered in the network of the State Archives to researchers and members of the public visiting the archive in person. And thirdly, PARES is an archival platform intended to promote the whole range of possible dissemination strategies. The platform today is fundamentally a repository for the creation, management and dissemination of historical records. However, also it is involved in a process of transformation to accommodate the concepts of “open files” and web 2.0 principles. To do this, different courses of action are being pursued such as converting PARES into an OAI-PMH repository, which allows interoperability with other archival information systems, both Spanish and international, and the development of new tools and standards for the incorporating multilingual access Points.<br><br>El <em>Portal de Archivos Españoles</em> supone la tercera generación en la informatización de los Archivos Estatales. Está destinado a facilitar a los investigadores y a los ciudadanos el acceso integrado en red a las bases de datos archivísticas de los ocho grandes archivos de titularidad estatal distribuidos por la geografía española, al mismo tiempo que se van incorporando los facsímiles u objetos digitales de los documentos. Al mismo tiempo, <em>PARES</em> elabora una línea de herramientas para la gestión electrónica de los servicios públicos ofrecidos en la red de centros a los investigadores y ciudadanos que acceden presencialmente. Y en tercer lugar, <em>PARES</em> es una plataforma destinada a favorecer todas las estrategias de difusión posibles. Fundamentalmente, la plataforma es a día de hoy un repositorio para la creación, gestión y difusión de los archivos históricos; no obstante, se encuentra en proceso de transformación para adecuarse a los conceptos de “archivos abiertos”, al mismo tiempo que hacia los presupuestos de la Web 2.0. Para ello, se están llevando a cabo diferentes líneas de actuación como es la conversión de <em>PARES</em> en un repositorio <em>OAI-PMH</em>, que permita interoperar con otros sistemas de información archivístico, tanto españoles como internacionales; y se están elaborando nuevas herramientas y estándares para la incorporación de Puntos de Acceso multilingües