6,807 research outputs found
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Asset liability management using stochastic programming
This chapter sets out to explain an important financial planning model
called asset liability management (ALM); in particular, it discusses why in
practice, optimum planning models are used. The ability to build an integrated
approach that combines liability models with that of asset allocation
decisions has proved to be desirable and more efficient in that it can lead to
better ALM decisions. The role of uncertainty and quantification of risk in
these planning models is considered
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Software tools for stochastic programming: A Stochastic Programming Integrated Environment (SPInE)
SP models combine the paradigm of dynamic linear programming with
modelling of random parameters, providing optimal decisions which hedge
against future uncertainties. Advances in hardware as well as software
techniques and solution methods have made SP a viable optimisation tool.
We identify a growing need for modelling systems which support the creation
and investigation of SP problems. Our SPInE system integrates a number of
components which include a flexible modelling tool (based on stochastic
extensions of the algebraic modelling languages AMPL and MPL), stochastic
solvers, as well as special purpose scenario generators and database tools.
We introduce an asset/liability management model and illustrate how SPInE
can be used to create and process this model as a multistage SP application
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A review of portfolio planning: Models and systems
In this chapter, we first provide an overview of a number of portfolio planning models
which have been proposed and investigated over the last forty years. We revisit the
mean-variance (M-V) model of Markowitz and the construction of the risk-return
efficient frontier. A piecewise linear approximation of the problem through a
reformulation involving diagonalisation of the quadratic form into a variable
separable function is also considered. A few other models, such as, the Mean
Absolute Deviation (MAD), the Weighted Goal Programming (WGP) and the
Minimax (MM) model which use alternative metrics for risk are also introduced,
compared and contrasted. Recently asymmetric measures of risk have gained in
importance; we consider a generic representation and a number of alternative
symmetric and asymmetric measures of risk which find use in the evaluation of
portfolios. There are a number of modelling and computational considerations which
have been introduced into practical portfolio planning problems. These include: (a)
buy-in thresholds for assets, (b) restriction on the number of assets (cardinality
constraints), (c) transaction roundlot restrictions. Practical portfolio models may also
include (d) dedication of cashflow streams, and, (e) immunization which involves
duration matching and convexity constraints. The modelling issues in respect of these
features are discussed. Many of these features lead to discrete restrictions involving
zero-one and general integer variables which make the resulting model a quadratic
mixed-integer programming model (QMIP). The QMIP is a NP-hard problem; the
algorithms and solution methods for this class of problems are also discussed. The
issues of preparing the analytic data (financial datamarts) for this family of portfolio
planning problems are examined. We finally present computational results which
provide some indication of the state-of-the-art in the solution of portfolio optimisation
problems
Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus : studies in the pig model of influenza
Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 pandemic H1N1 (pH1N1) virus and three different European H1 swine influenza virus (SIV) lineages, and b) these H1 viruses and a European H3N2 SIV. Pigs were inoculated intranasally with representative strains of each virus lineage with 6- and 17-week intervals between H1 inoculations and between H1 and H3 inoculations, respectively. Virus titers in nasal swabs and/or tissues of the respiratory tract were determined after each inoculation. There was substantial though differing cross-protection between pH1N1 and other H1 viruses, which was directly correlated with the relatedness in the viral hemagglutinin (HA) and neuraminidase (NA) proteins. Cross-protection against H3N2 was almost complete in pigs with immunity against H1N2, but was weak in H1N1/pH1N1-immune pigs. In conclusion, infection with a live, wild type influenza virus may offer substantial cross-lineage protection against viruses of the same HA and/or NA subtype. True heterosubtypic protection, in contrast, appears to be minimal in natural influenza virus hosts. We discuss our findings in the light of the zoonotic and pandemic risks of SIVs
In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis
Contrast-induced nephropathy accounts for >10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay and represents a powerful predictor of poor early and late outcome. Mechanisms of contrast-induced nephropathy are not completely understood. In vitro data suggests that contrast media (CM) induces a direct toxic effect on renal tubular cells through the activation of the intrinsic apoptotic pathway. It is unclear whether this effect has a role in the clinical setting. In this work, we evaluated the effects of CM both in vivo and in vitro. By analyzing urine samples obtained from patients who experienced contrast-induced acute kidney injury (CI-AKI), we verified, by western blot and immunohistochemistry, that CM induces tubular renal cells apoptosis. Furthermore, in cultured cells, CM caused a dose–response increase in reactive oxygen species (ROS) production, which triggered Jun N-terminal kinases (JNK1/2) and p38 stress kinases marked activation and thus apoptosis. Inhibition of JNK1/2 and p38 by different approaches (i.e. pharmacological antagonists and transfection of kinase-death mutants of the upstream p38 and JNK kinases) prevented CM-induced apoptosis. Interestingly, N-acetylcysteine inhibited ROS production, and thus stress kinases and apoptosis activation. Therefore, we conclude that CM-induced tubular renal cells apoptosis represents a key mechanism of CI-AKI
Search for the glueball candidates f0(1500) and fJ(1710) in gamma gamma collisions
Data taken with the ALEPH detector at LEP1 have been used to search for gamma
gamma production of the glueball candidates f0(1500) and fJ(1710) via their
decay to pi+pi-. No signal is observed and upper limits to the product of gamma
gamma width and pi+pi- branching ratio of the f0(1500) and the fJ(1710) have
been measured to be Gamma_(gamma gamma -> f0(1500)). BR(f0(1500)->pi+pi-) <
0.31 keV and Gamma_(gamma gamma -> fJ(1710)). BR(fJ(1710)->pi+pi-) < 0.55 keV
at 95% confidence level.Comment: 10 pages, 3 figure
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