Leg ulcer in Werner syndrome (adult progeria): a case report

Werner syndrome (WS; MIM#277700) or adult progeria, is a rare disease, associated with mutations of a single gene (RECQL2 or WRN), located on chromosome 8 (8p12). It codes a DNA-helicase, whose defects cause genomic instability. The highest incidences are reported in Japan and Sardinia (Italy). On this major island of the Mediterranean Basin, the WS cases have been observed in the northern areas. The authors describe the apparently first case reported in southern Sardinia, a 51-year-old woman, who was born in and resides in the province of Cagliari. She presented with a 9-year history of an intractable leg ulcer and other characteristic symptoms, including "bird-like" face, high-pitched voice, premature greying, short stature, abdominal obesity in contrast with thin body type, scleroderma-like legs, decreased muscle mass, diabetes, atherosclerosis, and premature menopause. A specialized genetic Institute of Research (IRCCS-IDI, Rome) confirmed the clinical diagnosis. There is no cure or specific treatment and patients must be periodically screened for an increased risk of cardiovascular and cerebrovascular disease and malignancies. Among the many findings, leg ulcers significantly affect the patient's quality of life. This problem may send the patient to the dermatologist, who finally suspects the diagnosis. Poor response to medical treatment may require aggressive repeated surgery, with poor or temporary results

Refurbishment of public housing villas in the United Arab Emirates (UAE): energy and economic impact

© 2016, Springer Science+Business Media Dordrecht. This study aims at assessing the technical and economic benefits of refurbishing existing public housing villas in the UAE. Four representative federal public housing villas built between 1980s and 2010s were modeled and analyzed. The Integrated Environmental Solutions-Virtual Environment (IES-VE) energy modeling software was used to estimate the energy consumption and savings due to different refurbishment configurations applied to the villas. The refurbishment technical configurations were based on the UAE’s Estidama green buildings sustainability assessment system. The refurbishment configurations include upgrading three elements: the wall and roof insulation as well as replacing the glazing. The annual electricity savings results indicated that the most cost-efficient refurbishment strategy is upgrading of wall insulation (savings up to 20.8 %) followed by upgrading the roof’s insulation (savings up to 11.6 %) and lastly replacing the glazing (savings up to 3.2 %). When all three elements were refurbished simultaneously, savings up to 36.7 % were achieved (villa model 670). The savings translated to CO2 emission reduction of 22.6 t/year. The simple and discounted payback periods for the different configurations tested ranged between 8 and 28 and 10 and 50 years, respectively

Solar pond powered liquid desiccant evaporative cooling

Liquid desiccant cooling systems (LDCS) are energy efficient means of providing cooling, especially when powered by low-grade thermal sources. In this paper, the underlying principles of operation of desiccant cooling systems are examined, and the main components (dehumidifier, evaporative cooler and regenerator) of the LDCS are reviewed. The evaporative cooler can take the form of direct, indirect or semi-indirect. Relative to the direct type, the indirect type is generally less effective. Nonetheless, a certain variant of the indirect type - namely dew-point evaporative cooler - is found to be the most effective amongst all. The dehumidifier and the regenerator can be of the same type of equipment: packed tower and falling film are popular choices, especially when fitted with an internal heat exchanger. The energy requirement of the regenerator can be supplied from solar thermal collectors, of which a solar pond is an interesting option especially when a large scale or storage capability is desired

ESFuelCell2011-54162 COMPARATIVE ANALYSIS OF SOLAR THERMAL COOLING AND SOLAR PHOTOVOLTAIC COOLING SYSTEMS

ABSTRACT 1 The Energy Information Administration of the United States Department of Energy projects that more than 80% of the energy consumption of the U.S. by 2035 will come from fossil fuels. This projection should be the fuel to promote projects related to renewable energy in order to reduce energy consumption from fossil fuels to avoid their undesirable consequences such as carbon dioxide emissions. Since solar radiation match pretty well building cooling demands, solar cooling systems will be an important factor in the next decades to meet or exceed the green gases reduction that will be demanded by the society and regulations in order to mitigate environmental consequences such as global warming. Solar energy can be used as source of energy to produce cooling through different technologies. Solar thermal energy applies to technology such as absorption chillers and desiccant cooling, while electricity from solar photovoltaic can be used to drive vapor compression electric chillers. This study focuses on the comparison of a Solar Thermal Cooling System that uses an absorption chiller driven by solar thermal energy, and a Solar Photovoltaic Cooling System that uses a vapor compression system (electric chiller) driven by solar electricity (solar photovoltaic system). Both solar cooling systems are compared against a standard air cooled cooling system that uses electricity from the grid. The models used in the simulations to obtain the results are described in the paper along with the parameters (inputs) used. Results are presented in two figures. Each figure has one curve for the Solar Thermal Cooling System and one for the Solar Photovoltaic Cooling System. One figure allows estimation of savings calculated based the net present value of energy consumption cost. The other figure allows estimating 1 For date of the conference the author is not longer affiliated to Mississippi State but University of Texas at Tyler. primary energy consumption reduction and emissions reduction. Both figures presents the result per ton of refrigeration and as a function of area of solar collectors or/and area of photovoltaic modules. This approach to present the result of the simulations of the systems makes these figures quite general. This means that the results can be used to compare both solar cooling systems independently of the cooling demand (capacity of the system), as well as allow the analysis for different sizes of the solar system used to harvest the solar energy (collectors or photovoltaic modules)