386 research outputs found
Kartografske projekcije – praktični odabir, upotreba i aktualne smjernice istraživanja
The 2022 AutoCarto conference took place on November 1st – 4th. The conference venue was the campus of the Environmental Systems Research Institute (Esri) in Redlands, California. A pre-conference workshop titled “Map Projections – Practical Selection with Use and Current Research Directions” was organized by Sarah Battersby and Fritz Kessler and held on November 1st. There were 12 participants in attendance. Representatives from private industry, government, and academia were represented at the workshop.Konferencija AutoCarto 2022. održana je od 1. do 4. studenoga 2022. Konferencija je održana u kampusu Instituta za istraživanje sustava okoliša (Esri) u Redlandsu u Kaliforniji. Pretkonferencijsku radionicu pod nazivom „Kartografske projekcije – Praktični odabir, upotreba i aktualne smjernice istraživanja“ organizirali su Sarah Battersby i Fritz Kessler, a održana je 1. studenoga 2022. Bilo je nazočno 12 sudionika. Na radionici su bili zastupljeni predstavnici privatnih poduzeća, vlade i akademske zajednice
Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study
INTRODUCTION: The inflammatory response to an invading pathogen in sepsis leads to complex alterations in hemostasis by dysregulation of procoagulant and anticoagulant factors. Recent treatment options to correct these abnormalities in patients with sepsis and organ dysfunction have yielded conflicting results. Using thromboelastometry (ROTEM(R)), we assessed the course of hemostatic alterations in patients with sepsis and related these alterations to the severity of organ dysfunction. METHODS: This prospective cohort study included 30 consecutive critically ill patients with sepsis admitted to a 30-bed multidisciplinary intensive care unit (ICU). Hemostasis was analyzed with routine clotting tests as well as thromboelastometry every 12 hours for the first 48 hours, and at discharge from the ICU. Organ dysfunction was quantified using the Sequential Organ Failure Assessment (SOFA) score. RESULTS: Simplified Acute Physiology Score II and SOFA scores at ICU admission were 52 +/- 15 and 9 +/- 4, respectively. During the ICU stay the clotting time decreased from 65 +/- 8 seconds to 57 +/- 5 seconds (P = 0.021) and clot formation time (CFT) from 97 +/- 63 seconds to 63 +/- 31 seconds (P = 0.017), whereas maximal clot firmness (MCF) increased from 62 +/- 11 mm to 67 +/- 9 mm (P = 0.035). Classification by SOFA score revealed that CFT was slower (P = 0.017) and MCF weaker (P = 0.005) in patients with more severe organ failure (SOFA >or= 10, CFT 125 +/- 76 seconds, and MCF 57 +/- 11 mm) as compared with patients who had lower SOFA scores (SOFA <10, CFT 69 +/- 27, and MCF 68 +/- 8). Along with increasing coagulation factor activity, the initially increased International Normalized Ratio (INR) and prolonged activated partial thromboplastin time (aPTT) corrected over time. CONCLUSIONS: Key variables of ROTEM(R) remained within the reference ranges during the phase of critical illness in this cohort of patients with severe sepsis and septic shock without bleeding complications. Improved organ dysfunction upon discharge from the ICU was associated with shortened coagulation time, accelerated clot formation, and increased firmness of the formed blood clot when compared with values on admission. With increased severity of illness, changes of ROTEM(R) variables were more pronounced
Global patterns and drivers of phylogenetic structure in island floras
Islands are ideal for investigating processes that shape species assemblages because they are isolated and have discrete boundaries. Quantifying phylogenetic assemblage structure allows inferences in-situ speciation. Here, we link phylogenetic assemblage structure to island characteristics across 393 islands worldwide and 37,041 vascular plant species (representing angiosperms overall, palms and ferns). Physical and bioclimatic factors, especially those impeding colonization and promoting speciation, explained more variation in phylogenetic structure of angiosperms overall (49%) and palms (52%) than of ferns consistent with their dispersal- and speciation-related traits and climatic adaptations. Phylogenetic diversity was negatively related to isolation for palms, but unexpectedly it was positively related large-seeded, animal-dispersed palm family whereas colonization from biogeographically distinct in-situ among taxonomic groups on islands, which sheds light on the origin of insular plant diversity.</p
Spitzer Observations of 3C Quasars and Radio Galaxies: Mid-Infrared Properties of Powerful Radio Sources
We have measured mid-infrared radiation from an orientation-unbiased sample
of 3CRR galaxies and quasars at redshifts 0.4 < z < 1.2 with the IRS and MIPS
instruments on the Spitzer Space Telescope. Powerful emission (L_24micron >
10^22.4 W/Hz/sr) was detected from all but one of the sources. We fit the
Spitzer data as well as other measurements from the literature with synchrotron
and dust components. The IRS data provide powerful constraints on the fits. At
15 microns, quasars are typically four times brighter than radio galaxies with
the same isotropic radio power. Based on our fits, half of this difference can
be attributed to the presence of non-thermal emission in the quasars but not
the radio galaxies. The other half is consistent with dust absorption in the
radio galaxies but not the quasars. Fitted optical depths are anti-correlated
with core dominance, from which we infer an equatorial distribution of dust
around the central engine. The median optical depth at 9.7 microns for objects
with core-dominance factor R > 10^-2 is approximately 0.4; for objects with R <
10^-2, it is 1.1. We have thus addressed a long-standing question in the
unification of FR II quasars and galaxies: quasars are more luminous in the
mid-infrared than galaxies because of a combination of Doppler-boosted
synchrotron emission in quasars and extinction in galaxies, both
orientation-dependent effects.Comment: 42 pages, 14 figures plus two landscape tables. Accepted for
publication in Ap
USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins
The ubiquitin-like modifier ISG15 can modulate host and viral proteins to restrict viral and microbial infections, and act as a cytokine. Its expression and conjugation are strongly up-regulated by type I interferons. Here we identify the deubiquitinating enzyme USP16 as an ISG15 cross-reactive protease. Ubiquitin-specific protease 16 (USP16) was found to react with an ISG15 activity-based probe in pull-down experiments using chronic myeloid leukaemia-derived human cells (HAP1). Supporting this finding, recombinant USP16 cleaved pro-ISG15 and ISG15 iso-peptide linked model substrates in vitro, as well as ISGylated substrates present in cell lysates. Moreover, the interferon-induced stimulation of ISGylation in human HAP1 cells was increased by knockdown or knockout of USP16. Depletion of USP16 did not affect interferon signaling, and interferon treatment did not affect USP16 expression or enzymatic activity either. A USP16-dependent ISG15 interactome was established by anti-ISG15 immunoprecipitation mass spectrometry (IP-MS), which indicated that the deISGylating function of USP16 may regulate metabolic pathways involving GOT1, ALDOA, SOD1 and MDH1, all of which were further confirmed to be deISGylated by USP16 in HEK293T cells. Together, our results indicate that USP16 may contribute to regulating the ISGylation status of a subset of proteins related to metabolism during type I interferon responses
Modelling Galaxy and AGN Evolution in the IR: Black Hole Accretion versus Star-Formation Activity
We present a new backward evolution model for galaxies and AGNs in the
infrared (IR). What is new in this model is the separate study of the
evolutionary properties of the different IR populations (i.e. spiral galaxies,
starburst galaxies, low-luminosity AGNs, "unobscured" type 1 AGNs and
"obscured" type 2 AGNs) defined through a detailed analysis of the spectral
energy distributions (SEDs) of large samples of IR selected sources. The
evolutionary parameters have been constrained by means of all the available
observables from surveys in the mid- and far-IR (source counts, redshift and
luminosity distributions, luminosity functions). By decomposing the SEDs
representative of the three AGN classes into three distinct components (a
stellar component emitting most of its power in the optical/near-IR, an AGN
component due to hot dust heated by the central black hole peaking in the
mid-IR, and a starburst component dominating the far-IR spectrum) we have
disentangled the AGN contribution to the monochromatic and total IR luminosity
emitted by the different populations considered in our model from that due to
star-formation activity. We have then obtained an estimate of the total IR
luminosity density (and star-formation density - SFD - produced by IR galaxies)
and the first ever estimate of the black hole mass accretion density (BHAR)
from the IR. The derived evolution of the BHAR is in agreement with estimates
from X-rays, though the BHAR values we derive from IR are slightly higher than
the X-ray ones. Finally, we have simulated source counts, redshift
distributions and SFD and BHAR that we expect to obtain with the future
cosmological Surveys in the mid-/far-IR that will be performed with JWST-MIRI
and SPICA-SAFARI.Comment: 19 pages, 15 figures, 3 tables. Accepted for publication in MNRA
The Sloan Digital Sky Survey-II Supernova Survey: Search Algorithm and Follow-up Observations
The Sloan Digital Sky Survey-II Supernova Survey has identified a large
number of new transient sources in a 300 sq. deg. region along the celestial
equator during its first two seasons of a three-season campaign. Multi-band
(ugriz) light curves were measured for most of the sources, which include solar
system objects, Galactic variable stars, active galactic nuclei, supernovae
(SNe), and other astronomical transients. The imaging survey is augmented by an
extensive spectroscopic follow-up program to identify SNe, measure their
redshifts, and study the physical conditions of the explosions and their
environment through spectroscopic diagnostics. During the survey, light curves
are rapidly evaluated to provide an initial photometric type of the SNe, and a
selected sample of sources are targeted for spectroscopic observations. In the
first two seasons, 476 sources were selected for spectroscopic observations, of
which 403 were identified as SNe. For the Type Ia SNe, the main driver for the
Survey, our photometric typing and targeting efficiency is 90%. Only 6% of the
photometric SN Ia candidates were spectroscopically classified as non-SN Ia
instead, and the remaining 4% resulted in low signal-to-noise, unclassified
spectra. This paper describes the search algorithm and the software, and the
real-time processing of the SDSS imaging data. We also present the details of
the supernova candidate selection procedures and strategies for follow-up
spectroscopic and imaging observations of the discovered sources.Comment: Accepted for publication in The Astronomical Journal (66 pages, 13
figures); typos correcte
Long term drivers of change in Polylepis woodland distribution in the central Andes
Question: Is the modern patchy distribution of highly biodiverse Polylepis woodlands a consequence of human activity or, natural fluctuations in environmental conditions? What are the consequences of changing climate for the tree genus Polylepis?
Location: High central tropical Andes.
Methods: We characterise the ecological baseline conditions for Polylepis woodlands over the last ca. 370,000 years through: i) examination of fossil pollen records (Salar de Uyuni and Lake Titicaca) and, ii) a review of autecological information concerning Polylepis.
Results: Fossil pollen data reveal fluctuations in the abundance (c. 0-34%) of Polylepis pollen prior to the arrival of humans in South America (>12,000 years ago). Indicating that Polylepis did not form permanent continuous woodland prior to the arrival of humans and that climatic factors can drive rapid vegetation change. Autecological assessment of Polylepis reveals: i) negative moisture balance, ii) fire, iii) waterlogging, and iv) cloud cover to be critical to determining the niche space available for Polylepis.
Conclusions: Polylepis niche space in the central Andes was at a maximum during warm and wet conditions in the past, but might be at a minimum during the warmer and drier-than-modern conditions predicted for later this century. The sensitivity to past global climate change emphasises the need for conservation planners to consider model predictions of a warmer central Andes in the coming decades when developing planting schemes. Natural fluctuations in woodland abundance suggest the most effective way for conservation efforts to 'mimic' the natural baseline would be to develop a reproductively connected patchwork of communities
First-Year Spectroscopy for the SDSS-II Supernova Survey
This paper presents spectroscopy of supernovae discovered in the first season
of the Sloan Digital Sky Survey-II Supernova Survey. This program searches for
and measures multi-band light curves of supernovae in the redshift range z =
0.05 - 0.4, complementing existing surveys at lower and higher redshifts. Our
goal is to better characterize the supernova population, with a particular
focus on SNe Ia, improving their utility as cosmological distance indicators
and as probes of dark energy. Our supernova spectroscopy program features
rapid-response observations using telescopes of a range of apertures, and
provides confirmation of the supernova and host-galaxy types as well as precise
redshifts. We describe here the target identification and prioritization, data
reduction, redshift measurement, and classification of 129 SNe Ia, 16
spectroscopically probable SNe Ia, 7 SNe Ib/c, and 11 SNe II from the first
season. We also describe our efforts to measure and remove the substantial host
galaxy contamination existing in the majority of our SN spectra.Comment: Accepted for publication in The Astronomical Journal(47pages, 9
figures
- …