Національно-культурні особливості українських і російських фразеологічних одиниць

Статья посвящена анализу национально-культурной семнтики собственно украинских и собственно русских фразеологических единиц. Делается вывод о том, що таке языковые единицы могут репрезентовать наиболее разнообразные сферы бытия украинского и руского народов (историю, народные обычаи и обряды, своеобразие растительного мира и прочее), отражать национальные особенности своим фразеологическим значением, отдельными компонетами, своими прототипами – генетически свободными словосочетаниями.Стаття присвячена аналізу національно-культурної семантики власне українських і власне російських фразеологічних одиниць. Робиться висновок про те, що такі мовні одиниці можуть репрезентувати найрізноманітніші сфери буття українського і російського народів (історію, народні звичаї і обряди, своєрідність рослинного світу тощо), відображати національні особливості своїм фразеологічним значенням, окремими компонетами, своїми прототипами – генетично вільними словосполученнями.The article is devoted to the analysis of national-cultural semantics of Ukrainian and Russian phraseological units. The conclusion is that such language units can represent the most different spheres of life of Ukrainian and Russian peoples (history, national customs and rituals, peculiarity of flora and other things), to reflect national peculiarities by their own phraseological meaning, separate components, their prototypes-genetic free word-combinations

Downsizing the electric machines of energy-efficient electro-hydraulic drives for mobile hydraulics

The poor energy efficiency of state-of-the-art mobile hydraulics affects the carbon dioxide released into the atmosphere and the operating costs. These crucial factors require urgent improvements that can be addressed by the electrification of fluid power. This approach has already generated electro-hydraulic drives that remove flow throttling and enable energy recovery. However, the entire power managed by the actuators of conventional systems must pass through the electric machines. This characteristic is unfeasible for medium-to-high power applications since they need electric motors and electronics with high power ratings and large onboard generation of electricity. Thus, this paper applies to a hydraulic excavator’s boom the idea of splitting the power being transferred to/from the actuator between the hydraulic and electric domains (i.e., a centralized hydraulic power supply is involved). The objective is downsizing the power rating of the boom’s electric components while maintaining the highpower output of the hydraulic actuator. The results show the expected behavior of the hybrid excavator in terms of motion control, but only 57% of the boom’s peak power is now exchanged electrically. The resulting electric machine with 61% downsizing favors the system’s cost and compactness supporting the electrification process that is aligned with the low-carbon economy

Energy analysis of a hybrid electro-hydraulic system for efficient mobile hydraulics

Energy efficiency plays a significant role in mobile hydraulics due to the high amount of carbon dioxide and pollutants being released into the atmosphere. Efficiency improvements are urgently needed, so the electrification of mobile hydraulics represents a fantastic opportunity in this regard. This approach leads to electro-hydraulic systems that remove functional flow throttling in control valves and enable energy recovery. Fuels savings were already demonstrated in simulation, but the literature does not offer entire energy analyses of these electro-hydraulic solutions. This limitation prevents complete system-level comprehension and does not give enough insight to pinpoint areas for further efficiency improvements. Thus, this paper focuses on a hybrid system for excavators based on electro-hydraulic drives that is compared against the original valve-controlled layout. The objective is to quantify the energy flows insight the excavator during relevant operations and highlight the resulting energy losses. The outcomes confirm that electro-hydraulic solutions are suitable for a low-carbon economy. They indicate hydraulic actuators, speed-controlled pumps, and electric motors as the critical components for further energy efficiency enhancement excluding the combustion engine

TRANSCRANIAL DIRECT CURRENT STIMULATION ENHANCES SUCKING OF A LIQUID BOLUS IN HEALTHY HUMANS

BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive technique used for modulating cortical excitability in vivo in humans. Here we evaluated the effect of tDCS on behavioral and electrophysiological aspects of physiological sucking and swallowing. METHODS: Twelve healthy subjects underwent three tDCS sessions (anodal, cathodal and sham stimulation) on separate days in a double-blind randomized order. The active electrode was placed over the right swallowing motor cortex. Repeated sucking and swallowing acts were performed at baseline and at 15 and 60 min after each tDCS session and the mean liquid bolus volume ingested at each time point was measured. We also calculated average values of the following electrophysiological parameters: 1) area and 2) duration of the rectified EMG signal from the suprahyoid/submental muscles related to the sucking and swallowing phases; 3) EMG peak amplitude for the sucking and swallowing phases; 4) area and peak amplitude of the laryngeal-pharyngeal mechanogram; 5) oropharyngeal delay. RESULTS: The volume of the ingested bolus significantly increased (by an average of about 30% compared with the baseline value) both at 15 and at 60 min after the end of anodal tDCS. The electrophysiological evaluation after anodal tDCS showed a significant increase in area and duration of the sucking phase-related EMG signal. CONCLUSIONS: Anodal tDCS leads to stronger sucking of a liquid bolus in healthy subjects, likely by increasing recruitment of cortical areas of the swallowing network. This finding might open up interesting perspectives for the treatment of patients suffering from dysphagia due to various pathological conditions

5G Radio Access above 6 GHz

Designing and developing a millimetre-wave(mmWave) based mobile Radio Access Technology (RAT) in the 6-100 GHz frequency range is a fundamental component in the standardization of the new 5G radio interface, recently kicked off by 3GPP. Such component, herein called the new mmWave RAT, will not only enable extreme mobile broadband (eMBB) services,but also support UHD/3D streaming, offer immersive applications and ultra-responsive cloud services to provide an outstanding Quality of Experience (QoE) to the mobile users. The main objective of this paper is to develop the network architectural elements and functions that will enable tight integration of mmWave technology into the overall 5G radio access network (RAN). A broad range of topics addressing mobile architecture and network functionalities will be covered-starting with the architectural facets of network slicing, multiconnectivity and cells clustering, to more functional elements of initial access, mobility, radio resource management (RRM) and self-backhauling. The intention of the concepts presented here is to lay foundation for future studies towards the first commercial implementation of the mmWave RAT above 6 GHz.Comment: 7 pages, 5 figure

By-catch associated with fisheries of Heterocarpus vicarius (Costa Rica) and Heterocarpus reedi (Chile) (Decapoda: Pandalidae): a six-year study (2004-2009)

artículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigaciones en Ciencias del Mar y Limnología (CIMAR), 2013Growing concern about the quantity and diversity of by-catch species caught in the bottom trawling nets of crustacean fisheries led us to compare the quantity of by-catch recorded in Chilean and Costa Rican deep-water shrimp fisheries by year, latitude, and bathymetry. We analyzed catches from 2143 trawl hauls between 2004 and 2009 from the fisheries of the northern nylon shrimp,Heterocarpus vicarius, and the kolibri shrimp,Solenocera agassizii, off Costa Rica and the Chilean nylon shrimp, Heterocarpus reedi, off Chile. A catch index was estimated to determine the quantity of by-catch retained for each kilogram of shrimp. The by-catch associated with the shrimp fisheries of Costa Rica and Chile was mainly fishes and crustaceans; by-catch species diversity was considerably higher in Costa Rica compared to that of Chile. In Chile, catches of H. reediand by-catch were greater in the central and southern zone, whereas in Costa Rica, catches of shrimp (H. vicarius, S. agassizii) and by-catch were higher in the central zone. In terms of bathymetry, the largest catches of shrimp and by-catch came from the deep stratum (between 251 and 400 m) for both countries; the by-catch was noticeably larger in this stratum in Costa Rica. The catch index revealed that for every 1 kg of shrimp caught in Costa Rica, 5.7 kg of by-catch were caught; in Chile, this ratio was 1.1:1. However, the projected global by-catch was considerably higher for the fishery forH. reedithan for that ofH. vicarius,which is related to the landed volumes of the target species in Costa Rica and Chile. The encouraging results in the H. reedi-fishery concerning technical measures to reduce by-catch and discards rates should be also considered for Central American deep-water shrimp fisheries.The authors (PA and JCO) thank the Fondo de Investigación Pesquera (FIP) for funding the fishery assessment projects carried out off the central coast of Chile and for the availability of the data bases used to develop the present project. The researchers from Costa Rica (ISW, VNM and FVR) are thankful to the company The Rainbow Jewels, S.A., Puntarenas, for their ongoing support for monitoring the deepwater resources of Pacific Costa Rica. Likewise, thanks a lot to the captains (Rigo and Esteban: “Mecate”), crews of the shrimp trawlers ONUVA and SULTANA, and all the students who helped us with the collection and handling of the samples. Financial support was made available from the German company Ristic AG, Oberferrieden, the Costa Rican company The Rainbow Jewels S.A., Puntarenas, and the University of Costa Rica (projects V.I. No. 111-A4-508, V.I. No. 808-A9-536 and V.I. No. 808-A9-537). Additional funding was provided by the “Program University – Enterprise for Sustainable Development” (PUEDES) of the Council of Central American Universities (CSUCA), the German Society for Technical Cooperation (GTZ) and the University of Kassel, Germany. Furthermore, we are grateful for the logistic support provided by the Center of Marine Research and Limnology (CIMAR) and the School of Biology, University of Costa Rica. We are grateful to Ing. Álvaro De Caso for his collaboration with the statistical analysis of the fishery data. Danielle Barriga and Tayler Clarke revised and improved the English, which is greatly appreciated. Finally, we are thankful to Raquel Romero-Emilia, who helped us to prepare the final version of the figures.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Ciencias del Mar y Limnología (CIMAR

Genomic comparison of two strains of Mycobacterium avium subsp. paratuberculosis with contrasting pathogenic phenotype

In a previous study, we evaluated the degree of virulence of Mycobacterium avium subsp. paratuberculosis (Map) strains isolated from cattle in Argentina in a murine model. This assay allowed us to differentiate between high-virulent MapARG1347 and low-virulent MapARG1543 strains. To corroborate whether the differences in virulence could be attributed to genetic differences between the strains, we performed Whole Genome Sequencing and compared the genomes and gene content between them and determined the differences related to the reference strain MapK10. We found 233 SNPs/INDELS in one or both strains relative to Map K10. The two strains share most of the variations, but we found 15 mutations present in only one of the strains. Considering NS-SNP/INDELS that produced a severe effect in the coding sequence, we focus the analysis on four predicted proteins, putatively related to virulence. Survival of MapARG1347 strain in bMDM was higher than MapARG1543 and was more resistant to acidic pH and H2O2 stresses than MapK10. The genomic differences between the two strains found in genes MAP1203 (a putative peptidoglycan hydrolase), MAP0403 (a putative serine protease) MAP1003c (a member of the PE-PPE family) and MAP4152 (a putative mycofactocin binding protein) could contribute to explain the contrasting phenotype previously observed in mice models.Fil: Colombatti Olivieri, María Alejandra. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Fresia, P.. Instituto Pasteur de Montevideo; UruguayFil: Graña, M.. Instituto Pasteur de Montevideo; UruguayFil: Cuerda, Maria Ximena. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Nagel, Ariel Gastón. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Alvarado Pinedo, María Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; ArgentinaFil: Romano, Maria Isabel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Caimi, Karina Cynthia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Berná, L.. Instituto Pasteur de Montevideo; UruguayFil: Santangelo, María de la Paz. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentin

Stromal MED12 exon 2 mutations in complex fibroadenomas of the breast

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.Aims: Here we explore the presence of mediator complex subunit 12 (MED12) exon 2 and telomerase reverse transcriptase (TERT) promoter hotspot mutations in complex fibroadenomas (CFAs) of the breast. Methods: The stromal components from 18 CFAs were subjected to Sanger sequencing of MED12 exon 2 and the TERT promoter hotspot loci. The epithelial and stromal components of two MED12 mutated CFAs were subjected to laser capture microdissection, and Sanger sequencing of MED12 exon 2, TERT promoter and PIK3CA exons 9 and 20, separately. Results: MED12 exon 2 mutations were identified in the stroma of 17% of CFAs. The analyses of epithelial and stromal components, microdissected separately, revealed that MED12 mutations were restricted to the stroma. No TERT promoter or PIK3CA mutations in exons 9 and 20 were detected in analysed CFAs. Conclusions: Like conventional fibroadenomas, MED12 exon 2 mutations appear to be restricted to the stromal component of CFAs, supporting the notion that CFAs are stromal neoplasms.This study was funded by the Breast Cancer Research Foundation. BW is funded by a Cycle for Survival grant, CS by a Fundação para a Ciência e Tecnologia grant (SFRH/BDE/110544/2015). FP is partially funded by a K12 CA184746 grant. The research reported in this paper was supported in part by a Cancer Centre Support Grant of the National Institutes of Health/National Cancer Institute (grant No P30CA008748).info:eu-repo/semantics/publishedVersio

Genomic profiling of primary and recurrent Adult Granulosa Cell Tumors of the Ovary

Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97% of cases. These tumors are considered to have a favorable prognosis, however aGCTs have a tendency for local spread and late recurrences, which are associated with poor survival rates. We sought to determine the genetic alterations associated with aGCT disease progression. We subjected primary non-recurrent aGCTs (n = 7), primary aGCTs that subsequently recurred (n = 9) and their matched recurrences (n = 9), and aGCT recurrences without matched primary tumors (n = 10) to targeted massively parallel sequencing of ≥410 cancer-related genes. In addition, three primary non-recurrent aGCTs and nine aGCT recurrences were subjected to FOXL2 and TERT promoter Sanger sequencing analysis. All aGCTs harbored the FOXL2 C134W hotspot mutation. TERT promoter mutations were found to be significantly more frequent in recurrent (18/28, 64%) than primary aGCTs (5/19, 26%, p = 0.017). In addition, mutations affecting TP53, MED12, and TET2 were restricted to aGCT recurrences. Pathway annotation of altered genes demonstrated that aGCT recurrences displayed an enrichment for genetic alterations affecting cell cycle pathway-related genes. Analysis of paired primary and recurrent aGCTs revealed that TERT promoter mutations were either present in both primary tumors and matched recurrences or were restricted to the recurrence and absent in the respective primary aGCT. Clonal composition analysis of these paired samples further revealed that aGCTs display intra-tumor genetic heterogeneity and harbor multiple clones at diagnosis and relapse. We observed that in a subset of cases, recurrences acquired additional genetic alterations not present in primary aGCTs, including TERT, MED12, and TP53 mutations and CDKN2A/B homozygous deletions. Albeit harboring relatively simple genomes, our data provide evidence to suggest that aGCTs are genetically heterogeneous tumors and that TERT promoter mutations and/or genetic alterations affecting other cell cycle-related genes may be associated with disease progression and recurrences