Low optical polarisation at the core of the optically-thin jet of M87

We study the optical linear and circular polarisation in the optically-thin regime of the core and jet of M87. Observations were acquired two days before the Event Horizon Telescope (EHT) campaign in early April 2017. A high degree ($\sim 20$ per cent) of linear polarisation (P$_{\rm lin}$) is detected in the bright jet knots resolved at $\sim 10\, \rm{arcsec}$ to $23\, \rm{arcsec}$ ($0.8$-$1.8\, \rm{kpc}$) from the centre, whereas the nucleus and inner jet show P$_{\rm lin} \lesssim 5$ per cent. The position angle of the linear polarisation shifts by $\sim 90$ degrees from each knot to the adjacent ones, with the core angle perpendicular to the first knot. The nucleus was in a low level of activity (P$_{\rm lin} \sim 2$-$3$ per cent), and no emission was detected from HST-1. No circular polarisation was detected either in the nucleus or the jet above a $3\sigma$ level of P$_{\rm circ} \leq 1.5$ per cent, discarding the conversion of P$_{\rm lin}$ into P$_{\rm circ}$. A disordered magnetic field configuration or a mix of unresolved knots polarised along axes with different orientations could explain the low P$_{\rm lin}$. The latter implies a smaller size of the core knots, in line with current interferometric observations. Polarimetry with EHT can probe this scenario in the future. A steep increase of both P$_{\rm lin}$ and P$_{\rm circ}$ with increasing frequency is expected for the optically-thin domain, above the turnover point. This work describes the methodology to recover the four Stokes parameters using a $\lambda/4$ wave-plate polarimeter.Comment: Accepted for publication in MNRAS. 10 pages, 8 figure

The BarYon CYCLE Project (ByCycle): Identifying and Localizing MgII Metal Absorbers with Machine Learning

The upcoming ByCycle project on the VISTA/4MOST multi-object spectrograph will offer new prospects of using a massive sample of $\sim 1$ million high spectral resolution ($R$ = 20,000) background quasars to map the circumgalactic metal content of foreground galaxies (observed at $R$ = 4000 - 7000), as traced by metal absorption. Such large surveys require specialized analysis methodologies. In the absence of early data, we instead produce synthetic 4MOST high-resolution fibre quasar spectra. To do so, we use the TNG50 cosmological magnetohydrodynamical simulation, combining photo-ionization post-processing and ray tracing, to capture MgII ($\lambda2796$, $\lambda2803$) absorbers. We then use this sample to train a Convolutional Neural Network (CNN) which searches for, and estimates the redshift of, MgII absorbers within these spectra. For a test sample of quasar spectra with uniformly distributed properties ($\lambda_{\rm{MgII,2796}}$, $\rm{EW}_{\rm{MgII,2796}}^{\rm{rest}} = 0.05 - 5.15$ \AA, $\rm{SNR} = 3 - 50$), the algorithm has a robust classification accuracy of 98.6 per cent and a mean wavelength accuracy of 6.9 \AA. For high signal-to-noise spectra ($\rm{SNR > 20}$), the algorithm robustly detects and localizes MgII absorbers down to equivalent widths of $\rm{EW}_{\rm{MgII,2796}}^{\rm{rest}} = 0.05$ \AA. For the lowest SNR spectra ($\rm{SNR=3}$), the CNN reliably recovers and localizes EW$_{\rm{MgII,2796}}^{\rm{rest}}$ $\geq$ 0.75 \AA\, absorbers. This is more than sufficient for subsequent Voigt profile fitting to characterize the detected MgII absorbers. We make the code publicly available through GitHub. Our work provides a proof-of-concept for future analyses of quasar spectra datasets numbering in the millions, soon to be delivered by the next generation of surveys.Comment: 13 pages, 9 figures, 1 table. Accepted for publication in MNRA

Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of Labisia pumila benth : from microwave obtained extracts.

Background: Labisia pumila, locally known as Kacip Fatimah, is a forest-floor plant that has tremendous potential in the herbal industry. It is one of the five herbal plants identified by the government as one of the national key economic areas to be developed for commercial purposes. There are three varieties of L. pumila namely, L. pumila var. pumila, L. pumila var. alata and L. pumila var. lanceolata and each has its own use.Methods: The leaves and roots of the three varieties of L. pumila Benth. were extracted using microwave assisted extraction (MAE). Antifungal activity of all plant extracts were characterized against Fusarium sp., Candida sp. and Mucor using the agar diffusion disc. Anti-inflammatory assays were performed using NO production by macrophage RAW 264.7 cell lines induced by LPS/IFN-g and cytotoxic activity was determined using several cancer cell lines and one normal cell line.Results: The overall result demonstrated that leaf and root extracts of all three varieties of L. pumila exhibited moderate to appreciable antifungal activity against Fusarium sp., Candida sp. and Mucor compared to streptomycin used as positive control. Leaf and root extracts of all varieties significantly decreased NO release. However, the root extracts showed higher activity compared to the leaf extracts. Cytotoxic activity against MCF-7, MDA-MB-231 and Chang cell lines were observed with all extracts.Conclusions: These findings suggest the potential use of L. pumila Benth. as a natural medicine and indicated the possible application of this medicinal plant such anti inflammatory activity and cytotoxic agents

Algorithmic iteration for computational intelligence

Machine awareness is a disputed research topic, in some circles considered a crucial step in realising Artificial General Intelligence. Understanding what that is, under which conditions such feature could arise and how it can be controlled is still a matter of speculation. A more concrete object of theoretical analysis is algorithmic iteration for computational intelligence, intended as the theoretical and practical ability of algorithms to design other algorithms for actions aimed at solving well-specified tasks. We know this ability is already shown by current AIs, and understanding its limits is an essential step in qualifying claims about machine awareness and Super-AI. We propose a formal translation of algorithmic iteration in a fragment of modal logic, formulate principles of transparency and faithfulness across human and machine intelligence, and consider the relevance to theoretical research on (Super)-AI as well as the practical import of our results

In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines

<p>Abstract</p> <p>Background</p> <p>Ginger is one of the most important spice crops and traditionally has been used as medicinal plant in Bangladesh. The present work is aimed to find out antioxidant and anticancer activities of two Bangladeshi ginger varieties (Fulbaria and Syedpuri) at young age grown under ambient (400 μmol/mol) and elevated (800 μmol/mol) CO₂concentrations against two human breast cancer cell lines (MCF-7 and MDA-MB-231).</p> <p>Methods</p> <p>The effects of ginger on MCF-7 and MDA-MB-231 cell lines were determined using TBA (thiobarbituric acid) and MTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assays. Reversed-phase HPLC was used to assay flavonoids composition among Fulbaria and Syedpuri ginger varieties grown under increasing CO₂concentration from 400 to 800 μmol/mol.</p> <p>Results</p> <p>Antioxidant activities in both varieties found increased significantly (P ≤ 0.05) with increasing CO₂concentration from 400 to 800 μmol/mol. High antioxidant activities were observed in the rhizomes of Syedpuri grown under elevated CO₂concentration. The results showed that enriched ginger extract (rhizomes) exhibited the highest anticancer activity on MCF-7 cancer cells with IC₅₀values of 34.8 and 25.7 μg/ml for Fulbaria and Syedpuri respectively. IC₅₀values for MDA-MB-231 exhibition were 32.53 and 30.20 μg/ml for rhizomes extract of Fulbaria and Syedpuri accordingly.</p> <p>Conclusions</p> <p>Fulbaria and Syedpuri possess antioxidant and anticancer properties especially when grown under elevated CO₂concentration. The use of ginger grown under elevated CO₂concentration may have potential in the treatment and prevention of cancer.</p

Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells

<div><h3>Background</h3><p>Polyphenols, a group of complex naturally occurring compounds, are widely distributed throughout the plant kingdom and are therefore readily consumed by humans. The relationship between their chemical structure and intestinal absorption, transport, and first-pass metabolism remains unresolved, however.</p> <h3>Methods</h3><p>Here, we investigated the intestinal absorption and first-pass metabolism of four polyphenol compounds, apigenin, resveratrol, emodin and chrysophanol, using the <em>in vitro</em> Caco-2 cell monolayer model system and <em>in situ</em> intestinal perfusion and <em>in vivo</em> pharmacokinetic studies in rats, so as to better understand the relationship between the chemical structure and biological fate of the dietary polyphenols.</p> <h3>Conclusion</h3><p>After oral administration, emodin and chrysophanol exhibited different absorptive and metabolic behaviours compared to apigenin and resveratrol. The differences in their chemical structures presumably resulted in differing affinities for drug-metabolizing enzymes, such as glucuronidase and sulphatase, and transporters, such as MRP2, SGLT1, and P-glycoprotein, which are found in intestinal epithelial cells.</p> </div

Resilience and Vulnerability of Northern Regions to Social and Environmental Change

The arctic tundra and boreal forest were once considered the last frontiers on earlh because of their vast expanses remote from agriculturaland-use change and industrial development. These regions are now, however, experiencing environmental and social changes that are as rapid as those occurring anywhere on eadh. This paper summarizes the role of northern regions in the global system and provides a blueprint for assessing the factors that govern their sensitivity to social and environmental chanqe