256 research outputs found
The Effect of Regional Airline Attendance Policies on Pilot Self-Removal from Duty for Illness or Fatigue
The purpose of this paper was to study the effect of current regional airline attendance policies on the willingness of crewmembers to remove themselves from duty when ill or fatigued. This study sought to determine if the current punitive attendance policies are encouraging crewmembers to operate contrary to federal regulation. A survey was given to current pilots of four regional airlines with similar attendance policies. The responses were correlated with supplied demographic and experiential data. The goal of the paper was to examine the major areas of concern and suggested solutions. The overwhelming majority of respondents felt that their companies’ fatigue, illness, and attendance policies were punitive, either by design or implementation, and were also more likely to state that these policies affected their decision to remove themselves from duty when ill or fatigued
Migration routes of the Chestnut Teal
This is where the abstract of this record would appear. This is only demonstration data
Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARgamma) agonist with potent glucose-lowering properties
AIMS/HYPOTHESIS: The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is an important gene regulator in glucose and lipid metabolism. Unfortunately, PPARgamma-activating drugs of the thiazolidinedione class provoke adverse side effects. As recently shown, amorfrutin A1 is a natural glucose-lowering compound that selectively modulates PPARgamma. In this study we aimed to characterise, in vitro, a large spectrum of the amorfrutins and similar molecules, which we isolated from various plants. We further studied in vivo the glucose-lowering effects of the so far undescribed amorfrutin B, which featured the most striking PPARgamma-binding and pharmacological properties of this family of plant metabolites. METHODS: Amorfrutins were investigated in vitro by binding and cofactor recruitment assays and by transcriptional activation assays in primary human adipocytes and murine preosteoblasts, as well as in vivo using insulin-resistant high-fat-diet-fed C57BL/6 mice treated for 27 days with 100 mg kg(-1) day(-1) amorfrutin B. RESULTS: Amorfrutin B showed low nanomolar binding affinity to PPARgamma, and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Amorfrutin B selectively modulated PPARgamma activity at low nanomolar concentrations. In insulin-resistant mice, amorfrutin B considerably improved insulin sensitivity, glucose tolerance and blood lipid variables after several days of treatment. Amorfrutin B treatment did not induce weight gain and furthermore showed liver-protecting properties. Additionally, amorfrutins had no adverse effects on osteoblastogenesis and fluid retention. CONCLUSIONS/INTERPRETATION: The application of plant-derived amorfrutins or synthetic analogues thereof constitutes a promising approach to prevent or treat complex metabolic diseases such as insulin resistance or type 2 diabetes
Data compression for the First G-APD Cherenkov Telescope
The First Geiger-mode Avalanche photodiode (G-APD) Cherenkov Telescope (FACT)
has been operating on the Canary island of La Palma since October 2011.
Operations were automated so that the system can be operated remotely. Manual
interaction is required only when the observation schedule is modified due to
weather conditions or in case of unexpected events such as a mechanical
failure. Automatic operations enabled high data taking efficiency, which
resulted in up to two terabytes of FITS files being recorded nightly and
transferred from La Palma to the FACT archive at ISDC in Switzerland. Since
long term storage of hundreds of terabytes of observations data is costly, data
compression is mandatory. This paper discusses the design choices that were
made to increase the compression ratio and speed of writing of the data with
respect to existing compression algorithms.
Following a more detailed motivation, the FACT compression algorithm along
with the associated I/O layer is discussed. Eventually, the performances of the
algorithm is compared to other approaches.Comment: 17 pages, accepted to Astronomy and Computing special issue on
astronomical file format
FACT - Monitoring Blazars at Very High Energies
The First G-APD Cherenkov Telescope (FACT) was built on the Canary Island of
La Palma in October 2011 as a proof of principle for silicon based photosensors
in Cherenkov Astronomy. The scientific goal of the project is to study the
variability of active galatic nuclei (AGN) at TeV energies. Observing a small
sample of TeV blazars whenever possible, an unbiased data sample is collected.
This allows to study the variability of the selected objects on timescales from
hours to years. Results from the first three years of monitoring will be
presented. To provide quick flare alerts to the community and trigger
multi-wavelength observations, a quick look analysis has been installed on-site
providing results publicly online within the same night. In summer 2014,
several flare alerts were issued. Results of the quick look analysis are
summarized.Comment: 2014 Fermi Symposium proceedings - eConf C14102.
Geo-Biological Investigations on Azooxanthellate Cold-Water Coral Reefs on the Carbonate Mounds Along the Celtic Continental Slope
Northeast Atlantic 2004 Cruise No. 61, Leg 1 April 19 to May 4, 2004, Lisbon – Cor
Calibration and performance of the photon sensor response of FACT -- The First G-APD Cherenkov telescope
The First G-APD Cherenkov Telescope (FACT) is the first in-operation test of
the performance of silicon photo detectors in Cherenkov Astronomy. For more
than two years it is operated on La Palma, Canary Islands (Spain), for the
purpose of long-term monitoring of astrophysical sources. For this, the
performance of the photo detectors is crucial and therefore has been studied in
great detail. Special care has been taken for their temperature and voltage
dependence implementing a correction method to keep their properties stable.
Several measurements have been carried out to monitor the performance. The
measurements and their results are shown, demonstrating the stability of the
gain below the percent level. The resulting stability of the whole system is
discussed, nicely demonstrating that silicon photo detectors are perfectly
suited for the usage in Cherenkov telescopes, especially for long-term
monitoring purpose
FACT -- Operation of the First G-APD Cherenkov Telescope
Since more than two years, the First G-APD Cherenkov Telescope (FACT) is
operating successfully at the Canary Island of La Palma. Apart from its purpose
to serve as a monitoring facility for the brightest TeV blazars, it was built
as a major step to establish solid state photon counters as detectors in
Cherenkov astronomy.
The camera of the First G-APD Cherenkov Telesope comprises 1440 Geiger-mode
avalanche photo diodes (G-APD aka. MPPC or SiPM) for photon detection. Since
properties as the gain of G-APDs depend on temperature and the applied voltage,
a real-time feedback system has been developed and implemented. To correct for
the change introduced by temperature, several sensors have been placed close to
the photon detectors. Their read out is used to calculate a corresponding
voltage offset. In addition to temperature changes, changing current introduces
a voltage drop in the supporting resistor network. To correct changes in the
voltage drop introduced by varying photon flux from the night-sky background,
the current is measured and the voltage drop calculated. To check the stability
of the G-APD properties, dark count spectra with high statistics have been
taken under different environmental conditions and been evaluated.
The maximum data rate delivered by the camera is about 240 MB/s. The recorded
data, which can exceed 1 TB in a moonless night, is compressed in real-time
with a proprietary loss-less algorithm. The performance is better than gzip by
almost a factor of two in compression ratio and speed. In total, two to three
CPU cores are needed for data taking. In parallel, a quick-look analysis of the
recently recorded data is executed on a second machine. Its result is publicly
available within a few minutes after the data were taken.
[...]Comment: 19th IEEE Real-Time Conference, Nara, Japan (2014
Inter-areal coordination of columnar architectures during visual cortical development
The occurrence of a critical period of plasticity in the visual cortex has
long been established, yet its function in normal development is not fully
understood. Here we show that as the late phase of the critical period unfolds,
different areas of cat visual cortex develop in a coordinated manner.
Orientation columns in areas V1 and V2 become matched in size in regions that
are mutually connected. The same age trend is found for such regions in the
left and right brain hemisphere. Our results indicate that a function of
critical period plasticity is to progressively coordinate the functional
architectures of different cortical areas - even across hemispheres.Comment: 30 pages, 1 table, 6 figure
- …