Is the Recent Rise in Type 2 Diabetes Incidence From 1984 to 2007 Explained by the Trend in Increasing BMI?: Evidence from a prospective study of British men

OBJECTIVE - To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007. RESEARCH DESIGN AND METHODS - A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up. RESULTS - Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m2 (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase. CONCLUSIONS - An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research. © 2010 by the American Diabetes Association

Jet breaks at the end of the slow decline phase of Swift GRB lightcurves

The Swift mission has discovered an intriguing feature of Gamma-Ray Burst (GRBs) afterglows, a phase of shallow decline of the flux in the X-ray and optical lightcurves. This behaviour is typically attributed to energy injection into the burst ejecta. At some point this phase ends, resulting in a break in the lightcurve, which is commonly interpreted as the cessation of the energy injection. In a few cases, however, while breaks in the X-ray lightcurve are observed, optical emission continues its slow flux decline. This behaviour suggests a more complex scenario. In this paper, we present a model that invokes a double component outflow, in which narrowly collimated ejecta are responsible for the X-ray emission while a broad outflow is responsible for the optical emission. The narrow component can produce a jet break in the X-ray lightcurve at relatively early times, while the optical emission does not break due to its lower degree of collimation. In our model both components are subject to energy injection for the whole duration of the follow-up observations. We apply this model to GRBs with chromatic breaks, and we show how it might change the interpretation of the GRBs canonical lightcurve. We also study our model from a theoretical point of view, investigating the possible configurations of frequencies and the values of GRB physical parameters allowed in our model.Comment: 19 pages, 3 figures. To be published by MNRA

The Andromeda Project. I. Deep HST-WFPC2 V,I photometry of 16 fields toward the disk and the halo of the M31 galaxy. Probing the stellar content and metallicity distribution

HST-WFPC2 F555W and F814W photometry were obtained for 16 fields of the luminous nearby spiral galaxy M31, sampling the stellar content of the disk and the halo at different distances from the center, from ~ 20 to ~ 150 arcmin (i.e. ~ 4.5 to 35 kpc), down to limiting V and I magnitudes of ~ 27. The Color-Magnitude diagrams (CMD) show the presence of complex stellar populations, including an intermediate age/young population and older populations with a wide range of metallicity. Those fields superposed on the disk of M31 generally show a blue plume of stars which we identify with main sequence members. Accordingly, the star formation rate over the last 0.5 Gyr appears to have varied dramatically with location in the disk. All the CMDs show a prominent Red Giant Branch (RGB) with a descending tip in the V band, characteristic of metallicity higher than 1/10 Solar. A red clump is detected in all of the fields, and a weak blue horizontal branch is frequently present. The metallicity distributions (MDs), obtained by comparison of the RGB stars with globular cluster templates, are basically similar in all the sampled fields: they all show a long, albeit scantly populated metal-poor tail and a main component at [Fe/H] ~ -0.6. However, some differences also exist, e.g. in some fields a very metal-rich ([Fe/H] >= -0.2) component is present. Whereas the fraction of metal-poor stars seems to be approximately constant in all fields, the fraction of very-metal-rich stars varies with position and seems to be more prominent in those fields superposed on the disk and/or with the presence of streams or substructures. This might indicate and possibly trace interaction effects with some companion, e.g. M32.Comment: 23 pages (including 5 tables), 22 figures, submitted to A&

Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures

The Ontario Neurodegenerative Research Initiative (ONDRI) is a 3 years multi-site prospective cohort study that has acquired comprehensive multiple assessment platform data, including 3T structural MRI, from neurodegenerative patients with Alzheimer\u27s disease, mild cognitive impairment, Parkinson\u27s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and cerebrovascular disease. This heterogeneous cross-section of patients with complex neurodegenerative and neurovascular pathologies pose significant challenges for standard neuroimaging tools. To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address many of the challenges resulting from this heterogeneity. The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that will be made publicly available online

Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario neurodegenerative disease research initiative

Objectives: Caregiving burdens are a substantial concern in the clinical care of persons with neurodegenerative disorders. In the Ontario Neurodegenerative Disease Research Initiative, we used the Zarit\u27s Burden Interview (ZBI) to examine: (1) the types of burdens captured by the ZBI in a cross-disorder sample of neurodegenerative conditions (2) whether there are categorical or disorder-specific effects on caregiving burdens, and (3) which demographic, clinical, and cognitive measures are related to burden(s) in neurodegenerative disorders?. Methods/Design: N = 504 participants and their study partners (e.g., family, friends) across: Alzheimer\u27s disease/mild cognitive impairment (AD/MCI; n = 120), Parkinson\u27s disease (PD; n = 136), amyotrophic lateral sclerosis (ALS; n = 38), frontotemporal dementia (FTD; n = 53), and cerebrovascular disease (CVD; n = 157). Study partners provided information about themselves, and information about the clinical participants (e.g., activities of daily living (ADL)). We used Correspondence Analysis to identify types of caregiving concerns in the ZBI. We then identified relationships between those concerns and demographic and clinical measures, and a cognitive battery. Results: We found three components in the ZBI. The first was “overall burden” and was (1) strongly related to increased neuropsychiatric symptoms (NPI severity r = 0.586, NPI distress r = 0.587) and decreased independence in ADL (instrumental ADLs r = −0.566, basic ADLs r = −0.43), (2) moderately related to cognition (MoCA r = −0.268), and (3) showed little-to-no differences between disorders. The second and third components together showed four types of caregiving concerns: current care of the person with the neurodegenerative disease, future care of the person with the neurodegenerative disease, personal concerns of study partners, and social concerns of study partners. Conclusions: Our results suggest that the experience of caregiving in neurodegenerative and cerebrovascular diseases is individualized and is not defined by diagnostic categories. Our findings highlight the importance of targeting ADL and neuropsychiatric symptoms with caregiver-personalized solutions