Jostling for position: what determines where candidates are placed on electoral lists during European elections?

Several EU countries use a closed list system to elect their members of the European Parliament. But what determines the position where a candidate is placed on these lists? Based on a recent study, Elena Frech writes that parties tend to prioritise MEPs who have previously been part of powerful committees in the European Parliament, but that candidates also need to maintain close links with the party organisation to receive a favourable position on the list

Candidate Selection and Parliamentary Activity in the EU’s Multi-Level System: Opening a Black-Box

Members of the European Parliament (MEPs) have a multitude of parliamentary duties and, accordingly, have to prioritize some parliamentary activities over others. So far, we know comparably little about this prioritization process. Based on principal–agent theory, we argue first, that MEPs’ parliamentary activities are systematically determined by the “visibility” and usefulness of parliamentary instruments for their key principal; second, we expect the exclusiveness of candidate selection procedures of an MEP’s national party—the nomination and the final list placement—to determine her/his key principal (i.e., elites or members of national parties). Combining multi-level mixed effects linear regression models and expert interviews, we show that MEPs who are nominated and whose final list placement is decided by an exclusive circle of national party elites prioritize speeches, whereas MEPs who are nominated or whose final list placement is decided by more inclusive procedures prioritize written questions and opinions or reports. In other words, speeches seem particularly useful to communicate with national party elites, while other activities are used to serve larger groups of party members. These findings open up the black-box of the “national party principal” and illustrate how a complex principal–agent relationship stimulates very specific parliamentary activity patterns in the EU’s multi-level system

Candidate Selection and Parliamentary Activity in the EU’s Multi-Level System: Opening a Black-Box

Members of the European Parliament (MEPs) have a multitude of parliamentary duties and, accordingly, have to prioritize some parliamentary activities over others. So far, we know comparably little about this prioritization process. Based on principal–agent theory, we argue first, that MEPs’ parliamentary activities are systematically determined by the “visibility” and usefulness of parliamentary instruments for their key principal; second, we expect the exclusiveness of candidate selection procedures of an MEP’s national party—the nomination and the final list placement—to determine her/his key principal (i.e., elites or members of national parties). Combining multi-level mixed effects linear regression models and expert interviews, we show that MEPs who are nominated and whose final list placement is decided by an exclusive circle of national party elites prioritize speeches, whereas MEPs who are nominated or whose final list placement is decided by more inclusive procedures prioritize written questions and opinions or reports. In other words, speeches seem particularly useful to communicate with national party elites, while other activities are used to serve larger groups of party members. These findings open up the black-box of the “national party principal” and illustrate how a complex principal–agent relationship stimulates very specific parliamentary activity patterns in the EU’s multi-level system

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis

In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising 4,017 SSc cases and 5,935 controls was carried out for several selected non-HLA variants, reaching a total of 5,850 cases and 9,401 controls of European ancestry. Following this strategy, we identified and validated three SSc risk loci, including DNASE1L3 at 3p14, the SCHIP1-IL12A locus at 3q25, and ATG5 at 6q21, as well as a suggested association of the TREH-DDX6 locus at 11q23. The associations of several previously reported SSc risk loci were validated and further refined, and the observed peak of association in PXK was related to DNASE1L3. Our study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci

Survival and Predictors of Mortality in Systemic Sclerosis‐Associated Pulmonary Arterial Hypertension: Outcomes From the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Registry

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106105/1/acr22121.pd

Validation of the Body Concealment Scale for Scleroderma (BCSS): Replication in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort

© 2016 Elsevier Ltd Body concealment is an important component of appearance distress for individuals with disfiguring conditions, including scleroderma. The objective was to replicate the validation study of the Body Concealment Scale for Scleroderma (BCSS) among 897 scleroderma patients. The factor structure of the BCSS was evaluated using confirmatory factor analysis and the Multiple-Indicator Multiple-Cause model examined differential item functioning of SWAP items for sex and age. Internal consistency reliability was assessed via Cronbach's alpha. Construct validity was assessed by comparing the BCSS with a measure of body image distress and measures of mental health and pain intensity. Results replicated the original validation study, where a bifactor model provided the best fit. The BCSS demonstrated strong internal consistency reliability and construct validity. Findings further support the BCSS as a valid measure of body concealment in scleroderma and provide new evidence that scores can be compared and combined across sexes and ages

The Open Anchoring Quest Dataset: Anchored Estimates from 96 Studies on Anchoring Effects

People’s estimates are biased toward previously considered numbers (anchoring). We have aggregated all available data from anchoring studies that included at least two anchors into one large dataset. Data were standardized to comprise one estimate per row, coded according to a wide range of variables, and are available for download and analyses online (https://metaanalyses.shinyapps.io/OpAQ/). Because the dataset includes both original and meta-data it allows for fine-grained analyses (e.g., correlations of estimates for different tasks) but also for meta-analyses (e.g., effect sizes for anchoring effects)

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Re-selecting members of the European Parliament : candidate selection, party goals, and re-election probabilities

Elena Frech addresses the issue of candidate (re-)selection for the European elections. Studying German parties, the author investigates both, the rules and practice of candidate selection. The study is one of the first to shed light on the goals political parties pursue when selecting candidates in the European context. First, the author provides a detailed account of the formal and informal procedures German parties use to construct the electoral lists for the European elections. Then she turns towards the individual candidates, showing which factors determine the list placement of incumbent parliamentarians. The findings highlight the importance of individual candidate characteristics as well as party institutions and are of interest not only to scientists but also to parties, politicians, and citizens