United on Sunday: The effects of secular rituals on social bonding and affect

Religious rituals are associated with health benefits, potentially produced via social bonding. It is unknown whether secular rituals similarly increase social bonding. We conducted a field study with individuals who celebrate secular rituals at Sunday Assemblies and compared them with participants attending Christian rituals. We assessed levels of social bonding and affect before and after the rituals. Results showed the increase in social bonding taking place in secular rituals is comparable to religious rituals. We also found that both sets of rituals increased positive affect and decreased negative affect, and that the change in positive affect predicted the change in social bonding observed. Together these results suggest that secular rituals might play a similar role to religious ones in fostering feelings of social connection and boosting positive affect

Explaining cross-cultural pragmatic findings: moving from politeness maxims to sociopragmatic interactional principles (SIPs)

This paper focuses on how culture can be treated as an explanatory variable in cross-cultural pragmatic studies. It starts with a review of pragmatic maxims [Grice, H. Paul, 1989. Logic and Conversation. William James Lectures, 1967. (Reprinted in Grice, H.P. (Ed.), Studies in the Way of Words, pp. 22–40); Leech, Geoffrey N., 1983. Principles of Pragmatics. London: Longman; Journal of Pragmatics 14 (1990)237], discussing the strengths and weaknesses of the concept. It then presents the findings from a British-Chinese replication of Kim's [Human Communication Research 21(1996)128] cross-cultural study of conversational constraints, and argues that the notion of maxims should be reconceptualised as sociopragmatic interactional principles (SIPs). The notion of SIPs is defined and explained, referring to the sociopragmatic-pragmalinguistic distinction [Leech, Geoffrey N., 1983. Principles of Pragmatics. London: Longman; Applied Linguistics 4(1983)91] and other cross-cultural pragmatic approaches [House, Julianne, 2000. Understanding misunderstanding: a pragmatic-discourse approach to analyzing mismanaged rapport in talk across cultures. In: Spencer-Oatey, H. (Ed.), Culturally Speaking. Managing Rapport through Talk across Cultures. Continuum, London; 145–164; Journal of Pragmatics 9 (1985)145]. SIPs are also discussed in relation to Brown and Levinson's [Brown, Penelope, Levinson, Stephen C., 1987. Politeness. Some Universals in Language Usage. CUP, Cambridge (Originally published ad ‘Universals in language usage: politeness phenomenon’ In: Goody, E. (1987), Questions and Politeness: Strategies in Social Interaction. CUP, New York.)] perspectives on the impact of culture on language use. The paper ends with a call for more research to establish on an empirical basis the types of interactional principles that exist, and their interrelationships

Managing rapport in talk: using rapport sensitive incidents to explore the motivational concerns underlying the management of relations

This paper focuses on the motivational concerns that underlie the management of relations. In linguistics, the management of relations has been discussed extensively within politeness theory, and so the paper starts by identifying four key issues of controversy in politeness theory: (a) should ‘polite’ language use be explained in terms of face (e.g. Brown, Penelope, Levinson, Stephen C., 1987. Politeness. Some Universals in Language Usage, CUP, Cambridge. [Originally published as Universals in Language Usage: Politeness Phenomenon. In: Goody, Esther, (Ed.), Questions and Politeness: Strategies in Social Interaction. CUP, New York, 1978), conversational maxims (e.g. Leech, Geoffrey N., 1983. Principles of Pragmatics. Longman, London), and/or conversational rights (e.g. Fraser, Bruce, 1990. Perspectives on politeness. Journal of Pragmatics 14 (2), 219–236); (b) why are speech acts such as orders interpersonally sensitive — is it because they are a threat to our autonomy (Brown and Levinson, 1987 [1978]), or because of cost–benefit concerns (Leech, 1983); (c) is Brown and Levinson's concept of negative face too individually focused, and should a social identity component be included (Matsumoto, Yoshiko, 1988. Reexamination of the universality of face: politeness phenomena in Japanese. Journal of Pragmatics 12, 403–426); and (d) is face just a personal/individual concern or can it be a group concern (Gao, Ge, 1996. Self and other: a Chinese perspective on interpersonal relationships. In: Gudykunst, W.B., Ting-Toomey, S., Nishida, T. (Eds.), Communication in Personal Relationships Across Cultures, Sage, London. pp. 81–101.)? The paper then uses reports of authentic rapport sensitive incidents to throw light on these controversial issues and to find out the relational management concerns that people perceive in their everyday lives. It maintains that such data is important to politeness theory, because linguistic politeness needs to be studied within the situated social psychological context in which it occurs. The paper ends by presenting and arguing for a conceptual framework that draws a fundamental distinction between face and sociality rights, and that incorporates an independent/interdependent perspective, thus providing a more comprehensive framework for analysing the management of relations than is currently available

Blocking mu-opioid receptors inhibits social bonding in rituals

Religious rituals are universal human practices that play a seminal role in community bonding. In two experiments, we tested the role of mu-opioids as the active factor fostering social bonding. We used a mu-opioid blocker (naltrexone) in two double-blind studies of rituals from different religious traditions. We found the same effect across both studies, with naltrexone leading to significantly lower social bonding compared with placebo. These studies suggest that mu-opioids play a significant role in experiences of social bonding within ritual contexts

Nonparametric survival analysis of epidemic data

This paper develops nonparametric methods for the survival analysis of epidemic data based on contact intervals. The contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j, where we define infectious contact as a contact sufficient to infect a susceptible individual. We show that the Nelson-Aalen estimator produces an unbiased estimate of the contact interval cumulative hazard function when who-infects-whom is observed. When who-infects-whom is not observed, we average the Nelson-Aalen estimates from all transmission networks consistent with the observed data using an EM algorithm. This converges to a nonparametric MLE of the contact interval cumulative hazard function that we call the marginal Nelson-Aalen estimate. We study the behavior of these methods in simulations and use them to analyze household surveillance data from the 2009 influenza A(H1N1) pandemic. In an appendix, we show that these methods extend chain-binomial models to continuous time.Comment: 30 pages, 6 figure

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice.

When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer's disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the brain, Aβ exists as a pool of distinct C-terminal variants with lengths ranging from 37 to 43 amino acids, yet the relative contribution of individual C-terminal Aβ variants to the seeding behavior of Aβ aggregates remains unknown. Here, we have investigated the relative seeding activities of Aβ aggregates composed exclusively of recombinant Aβ38, Aβ40, Aβ42, or Aβ43. Cerebral Aβ42 levels were not increased in AppNL-F knock-in mice injected with Aβ38 or Aβ40 aggregates and were only increased in a subset of mice injected with Aβ42 aggregates. In contrast, significant accumulation of Aβ42 was observed in the brains of all mice inoculated with Aβ43 aggregates, and the extent of Aβ42 induction was comparable to that in mice injected with brain-derived Aβ seeds. Mice inoculated with Aβ43 aggregates exhibited a distinct pattern of cerebral Aβ pathology compared to mice injected with brain-derived Aβ aggregates, suggesting that recombinant Aβ43 may polymerize into a unique strain. Our results indicate that aggregates containing longer Aβ C-terminal variants are more potent inducers of cerebral Aβ deposition and highlight the potential role of Aβ43 seeds as a crucial factor in the initial stages of Aβ pathology in AD