1,814 research outputs found
Substituent effects on the mutagenicity of phenyl glycidyl ethers in Salmonella typhimurium
Phenyl glycidyl ether and 6 para-substituted derivatives, the methoxy, tert-butyl, methyl, chloro, bromo and nitro compounds, were tested in the Ames' test for mutagenicity. With the exception of the tert-butyl derivative in TA1535, all 7 compounds were mutagenic in both strains TA100 and TA1535. Electron-donating groups in the para position decreased mutagenicity while electron-withdrawing groups increased this mutagenicity. The mutagenicity of the series of compounds in both strains could be correlated to the Hammett substituent constants for the para-substituent groups. The glycidyl ether results might best be considered in terms of a normal reaction with bionucleophiles as compared to the literature report for the correlation of mutagenicity with abnormal product formation for a styrene oxide series.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24019/1/0000268.pd
Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)
The snub-nosed monkey genus (Rhinopithecus) comprises five closely related species (R. avunculus, R. bieti, R. brelichi, R. roxellana, and R. strykeri). All are among the world's rarest and most endangered primates. However, the genomic impact associated with their population decline remains unknown. We analyzed population genomic data of all five snub-nosed monkey species to assess their genetic diversity, inbreeding level, and genetic load. For R. roxellana, R. bieti, and R. strykeri, population size is positively correlated with genetic diversity and negatively correlated with levels of inbreeding. Other species, however, which possess small population sizes, such as R. brelichi and R. avunculus, show high levels of genetic diversity and low levels of genomic inbreeding. Similarly, in the three populations of R. roxellana, the Shennongjia population, which possesses the lowest population size, displays a higher level of genetic diversity and lower level of genomic inbreeding. These findings suggest that although R. brelichi and R. avunculus and the Shennongjia population might be at risk, it possess significant genetic diversity and could thus help strengthen their long-term survival potential. Intriguingly, R. roxellana with large population size possess high genetic diversity and low level of genetic load, but they show the highest recent inbreeding level compared with the other snub-nosed monkeys. This suggests that, despite its large population size, R. roxellana has likely been experiencing recent inbreeding, which has not yet affected its mutational load and fitness. Analyses of homozygous-derived deleterious mutations identified in all snub-nosed monkey species indicate that these mutations are affecting immune, especially in smaller population sizes, indicating that the long-term consequences of inbreeding may be resulting in an overall reduction of immune capability in the snub-nosed monkeys, which could provide a dramatic effect on their long-term survival prospects. Altogether, our study provides valuable information concerning the genomic impact of population decline of the snub-nosed monkeys. We revealed multiple counterintuitive and unexpected patterns of genetic diversity in small and large population, which will be essential for conservation management of these endangered species
CHARIS Science: Performance Simulations for the Subaru Telescope's Third-Generation of Exoplanet Imaging Instrumentation
We describe the expected scientific capabilities of CHARIS, a high-contrast
integral-field spectrograph (IFS) currently under construction for the Subaru
telescope. CHARIS is part of a new generation of instruments, enabled by
extreme adaptive optics (AO) systems (including SCExAO at Subaru), that promise
greatly improved contrasts at small angular separation thanks to their ability
to use spectral information to distinguish planets from quasistatic speckles in
the stellar point-spread function (PSF). CHARIS is similar in concept to GPI
and SPHERE, on Gemini South and the Very Large Telescope, respectively, but
will be unique in its ability to simultaneously cover the entire near-infrared
, , and bands with a low-resolution mode. This extraordinarily broad
wavelength coverage will enable spectral differential imaging down to angular
separations of a few , corresponding to 0.\!\!''1. SCExAO
will also offer contrast approaching at similar separations,
0.\!\!''1--0.\!\!''2. The discovery yield of a CHARIS survey will
depend on the exoplanet distribution function at around 10 AU. If the
distribution of planets discovered by radial velocity surveys extends unchanged
to 20 AU, observations of 200 mostly young, nearby stars targeted
by existing high-contrast instruments might find 1--3 planets. Carefully
optimizing the target sample could improve this yield by a factor of a few,
while an upturn in frequency at a few AU could also increase the number of
detections. CHARIS, with a higher spectral resolution mode of , will
also be among the best instruments to characterize planets and brown dwarfs
like HR 8799 cde and And b.Comment: 13 pages, 7 figures, proceedings from SPIE Montrea
Relevance of baseline hard proton-proton spectra for high-energy nucleus-nucleus physics
We discuss three different cases of hard inclusive spectra in proton-proton
collisions: high single hadron production at 20 GeV and
at = 62.4 GeV, and direct photon production at = 200 GeV;
with regard to their relevance for the search of Quark Gluon Plasma signals in
A+A collisions at SPS and RHIC energies.Comment: Proceeds. Hot Quarks 2004 Int. Workshop on the Physics of
Ultrarelativistic Nucleus-Nucleus Collisions. 26 pages. 26 figs. [minor
corrs., refs. added
Scope and Mechanistic Study of the Coupling Reaction of α,β-Unsaturated Carbonyl Compounds with Alkenes: Uncovering Electronic Effects on Alkene Insertion vs Oxidative Coupling Pathways
The cationic ruthenium-hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4– (1) was found to be a highly effective catalyst for the intermolecular conjugate addition of simple alkenes to α,β-unsaturated carbonyl compounds to give (Z)-selective tetrasubstituted olefin products. The analogous coupling reaction of cinnamides with electron-deficient olefins led to the oxidative coupling of two olefinic C–H bonds in forming (E)-selective diene products. The intramolecular version of the coupling reaction efficiently produced indene and bicyclic fulvene derivatives. The empirical rate law for the coupling reaction of ethyl cinnamate with propene was determined as follows: rate = k[1]1[propene]0[cinnamate]−1. A negligible deuterium kinetic isotope effect (kH/kD = 1.1 ± 0.1) was measured from both (E)-C6H5CH═C(CH3)CONHCH3 and (E)-C6H5CD═C(CH3)CONHCH3 with styrene. In contrast, a significant normal isotope effect (kH/kD = 1.7 ± 0.1) was observed from the reaction of (E)-C6H5CH═C(CH3)CONHCH3 with styrene and styrene-d8. A pronounced carbon isotope effect was measured from the coupling reaction of (E)-C6H5CH═CHCO2Et with propene (13C(recovered)/13C(virgin) at Cβ = 1.019(6)), while a negligible carbon isotope effect (13C(recovered)/13C(virgin) at Cβ = 0.999(4)) was obtained from the reaction of (E)-C6H5CH═C(CH3)CONHCH3 with styrene. Hammett plots from the correlation of para-substituted p-X-C6H4CH═CHCO2Et (X = OCH3, CH3, H, F, Cl, CO2Me, CF3) with propene and from the treatment of (E)-C6H5CH═CHCO2Et with a series of para-substituted styrenes p-Y-C6H4CH═CH2 (Y = OCH3, CH3, H, F, Cl, CF3) gave the positive slopes for both cases (ρ = +1.1 ± 0.1 and +1.5 ± 0.1, respectively). Eyring analysis of the coupling reaction led to the thermodynamic parameters, ΔH⧧ = 20 ± 2 kcal mol–1 and ΔS⧧ = −42 ± 5 eu. Two separate mechanistic pathways for the coupling reaction have been proposed on the basis of these kinetic and spectroscopic studies
The Vector Probe in Heavy-Ion Reactions
We review essential elements in using the channel as a probe for
hot and dense matter as produced in (ultra-) relativistic collisions of heavy
nuclei. The uniqueness of the vector channel resides in the fact that it
directly couples to photons, both real and virtual (dileptons), enabling the
study of thermal radiation and in-medium effects on both light () and heavy () vector mesons. We emphasize the importance
of interrelations between photons and dileptons, and characterize relevant
energy/mass regimes through connections to Quark-Gluon-Plasma emission and
chiral symmetry restoration. Based on critical analysis of our current
understanding of data from fixed-target energies, we identify open key
questions to be addressed.Comment: Invited Talk at the Hot Quarks 2004 Workshop, July 18-24, 2004 (Taos
Valley, NM, USA), 15 pages latex incl 14 figs and iop style files, to appear
in the proceeding
Innate immunity and remodelling
A wide variety of cardiac disease states can induce remodelling and lead to the functional consequence of heart failure. These complex disease states involve a plethora of parallel signal transduction events, which may be associated with tissue injury or tissue repair. Innate immunity is activated in hearts injured in different ways, evident as cytokine release from the heart, activation of toll-like receptors involved in recognizing danger, and activation of the transcription factor nuclear factor kappa B. Nuclear factor kappa B regulates gene programmes involved in inflammation as well as the resolution of inflammation. The impact of this is an enigma; while cytokines, toll-like receptors, and nuclear factor kappa B appear to elicit myocardial protection in studies of preconditioning, the literature strongly indicates a detrimental role for activation of innate immunity in studies of acute ischaemia–reperfusion injury. The impact of activation of cardiac innate immunity on the long-term outcome in in vivo models of hypertrophy and remodelling is less clear, with conflicting results as to whether it is beneficial or detrimental. More research using genetically engineered mice as tools, different models of evoking remodelling, and long-term follow-up is required for us to conclude whether activation of the innate immune system is good, bad, or unimportant in chronic injury models
Expression of Actin-interacting Protein 1 Suppresses Impaired Chemotaxis of Dictyostelium Cells Lacking the Na+-H+ Exchanger NHE1
Dictyostelium cells lacking the intracellular pH regulator NHE1 have defective chemotaxis. A modifier screen and reconstitution studies show expression of recombinant actin interacting protein 1 (Aip1) suppresses the Ddnhe1-phenotype. Aip1 promotes cofilin-dependent actin remodeling, which is likely a major determinant in pH-dependent chemotaxis
Thermal Dileptons at LHC
We predict dilepton invariant-mass spectra for central 5.5 ATeV Pb-Pb
collisions at LHC. Hadronic emission in the low-mass region is calculated using
in-medium spectral functions of light vector mesons within hadronic many-body
theory. In the intermediate-mass region thermal radiation from the Quark-Gluon
Plasma, evaluated perturbatively with hard-thermal loop corrections, takes
over. An important source over the entire mass range are decays of correlated
open-charm hadrons, rendering the nuclear modification of charm and bottom
spectra a critical ingredient.Comment: 2 pages, 2 figures, contributed to Workshop on Heavy Ion Collisions
at the LHC: Last Call for Predictions, Geneva, Switzerland, 14 May - 8 Jun
2007 v2: acknowledgment include
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